Succinic Acids as Potent Inhibitors of Plasmid-borne IMP-1 Metallo-β-lactamase

Journal of Biological Chemistry

Volumn 276, Issue 34, 2001, Pages 31913-31918

  Toney, Jeffrey H ^a   Hammond, Gail G ^a   Fitzgerald, Paula M D ^a   Sharma, Nandini ^a   Balkovec, James M ^a   Rouen, Gregory P ^a   Olson, Steven H ^a   Hammond, Milton L ^a   Greenlee, Mark L ^a   Gao, Ying Duo ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CRYSTAL STRUCTURE; ENZYME KINETICS; HYDROLYSIS; PATHOLOGY;

MOLECULAR MODELING;

BIOCHEMISTRY;

BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CARBAPENEM DERIVATIVE; IMIPENEM; INOSITOL MONOPHOSPHATE 1 METALLO BETA LACTAMASE; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG; BETA LACTAMASE IMP 1; BETA-LACTAMASE IMP-1; ENZYME INHIBITOR;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS CEREUS; BACTEROIDES FRAGILIS; CRYSTALLOGRAPHY; DRUG BINDING SITE; DRUG HYDROLYSIS; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MOLECULAR MODEL; PLASMID; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SERRATIA MARCESCENS; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; METABOLISM; X RAY CRYSTALLOGRAPHY;

BACILLUS CEREUS; BACTEROIDES; BACTEROIDES FRAGILIS; ESCHERICHIA COLI; KLEBSIELLA; KLEBSIELLA PNEUMONIAE; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; SERRATIA MARCESCENS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS; STENOTROPHOMONAS MALTOPHILIA;

BETA-LACTAMASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLASMIDS; SUCCINIC ACIDS;

EID: 0035943678     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104742200     Document Type: Article

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