Synthesis and Kinetic Testing of Tetrahydropyrimidine-2-thione and Pyrrole Derivatives as Inhibitors of the Metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Chemical Biology and Drug Design

Volumn 80, Issue 4, 2012, Pages 500-515

  Hussein, Waleed M ^a,b   Fatahala, Samar S ^a   Mohamed, Zainab M ^a   Mcgeary, Ross P ^b   Schenk, Gerhard ^b,c   Ollis, David L ^d   Mohamed, Mosaad S ^a  

^a Helwan   (Egypt)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Inhibition assays; Metallo lactamases; Pyrrole; Tetrahydropyrimidine 2 thione

Indexed keywords

(1 BENZYL 3 CYANO 4,5 DIPHENYL 1H PYRROL 2 YL)CARBONOHYDRAZONOYL DICYANIDE; 1 (6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 YL)ETHANONE; 1 (6 METHYL 4 STYRYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 YL)ETHANONE; 2 [(5 ACETYL 6 METHYL 4 STYRYL 1,2,3,4 TETRAHYDROPYRIMIDINE 2YL)SULFANYL]ACETIC ACID; 2 [1 [6 METHYL 4 (4 METHOXYPHENYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 YL]ETHYLIDENE]MALO NONITRILE; 4 STYRYL 5 (SULFADIAZINYL AMIDO) 6 METHYL ,2,3,4 TETRAHYDROPYRIMIDINE 2 THIONE; 5 [5 (2 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 3 YL] 6 METHYL 4 STYRYL 1,2,3,4 TETRAHYDROPYRIMIDINE 2(1H) THIONE; 7 (3,4 DICHLOROPHENYL) 5 PHENYL 2 THIOXO 2,3 DIHYDRO 1H PYRROLO[2,3 D]PYRIMIDINE 4(7H) ONE; BETA LACTAM ANTIBIOTIC; IMIPENEMASE 1; METALLO BETA LACTAMASE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; KLEBSIELLA PNEUMONIAE; MOLECULAR DOCKING; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MOLECULAR DOCKING SIMULATION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE; PSEUDOMONAS AERUGINOSA;

EID: 84866631880     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2012.01440.x     Document Type: Article

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