2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6229-6232

  Chen, Pinhong ^a   Horton, Lori B ^a   Mikulski, Rose L ^a   Deng, Lisheng ^a   Sundriyal, Sandeep ^a   Palzkill, Timothy ^a   Song, Yongcheng ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Inhibitor; Metallo lactamase; Molecular modeling; Rational design

Indexed keywords

2 (3 AMINOPHENYL) 4,5 DIHYDROTHIAZOLE 4 CARBOXYLIC ACID; 2 BENZYLTHIAZOLE 4 CARBOXLIC ACID; 2 PHENYL 4,5 DIHYDROTHIAZOLE 4 CARBOXYLIC ACID; BETA LACTAMASE INHIBITOR; CAPTOPRIL; CARBOXYLIC ACID DERIVATIVE; EDETIC ACID; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; IC 50; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

BETA-LACTAMASES; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 84866426322     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.012     Document Type: Article

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