Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5027-5037

  Minond, Dmitriy ^a   Saldanha, S Adrian ^a   Subramaniam, Prem ^a   Spaargaren, Michael ^a   Spicer, Timothy ^a   Fotsing, Joseph R ^a   Weide, Timo ^a   Fokin, Valery V ^a   Sharpless, K Barry ^a   Galleni, Moreno ^b   Bebrone, Carine ^b   Lassaux, Patricia ^b   Hodder, Peter ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Lactamase; Inhibitors; VIM 2

Indexed keywords

4 CHLOROMERCURIBENZOIC ACID; 4 IODO N [[4 (METHOXYMETHYL) 1H 1,2,3 TRIAZOL 5 YL]METHYL]BENZENESULFONAMIDE; BETA LACTAMASE; ENZYME INHIBITOR; IMIPENEM; MITOXANTRONE; N [[4 [(BUT 3 YNYLOXY)METHYL] 1H 1,2,3 TRIAZOL 5 YL]METHYL] 4 IODOBENZENESULFONAMIDE; PROTEIN VIM2; PROTEIN VIM2 INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMISTRY; CLICK CHEMISTRY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

ANALGESICS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CATALYTIC DOMAIN; DRUG SYNERGISM; ENZYME INHIBITORS; ESCHERICHIA COLI; IMIPENEM; MICROBIAL SENSITIVITY TESTS; MITOXANTRONE; MODELS, MOLECULAR; P-CHLOROMERCURIBENZOIC ACID; PROTEIN BINDING; SMALL MOLECULE LIBRARIES;

ESCHERICHIA COLI;

EID: 67650227781     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.070     Document Type: Article

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