Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-β-lactamases

Journal of Medicinal Chemistry

Volumn 53, Issue 13, 2010, Pages 4862-4876

  Lassaux, Patricia ^a   Hamel, Matthieu ^b   Gulea, Mihaela ^b   Delbrück, Heinrich ^c   Mercuri, Paola Sandra ^a   Horsfall, Louise ^a   Dehareng, Dominique ^a   Kupper, Michaël ^c   Frère, Jean Marie ^a   Hoffmann, Kurt ^c   Galleni, Moreno ^a   Bebrone, Carine ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITÉ DE CAEN   (France)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE INHIBITOR; MERCAPTOPHOSPHONATE DERIVATIVE; METALLO BETA LACTAMASE; SULFUR; UNCLASSIFIED DRUG; ZINC;

ANTIBIOTIC THERAPY; ARTICLE; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG INHIBITION; MOLECULAR MODEL;

BETA-LACTAMASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; PHOSPHONIC ACIDS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SULFHYDRYL COMPOUNDS;

EID: 77954347954     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100213c     Document Type: Article

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