Functional roles of Syk in macrophage-mediated inflammatory responses

Mediators of Inflammation

Volumn 2014, Issue , 2014, Pages

  Yi, Young Su ^a   Son, Young Jin ^b   Ryou, Chongsuk ^c   Sung, Gi Ho ^d   Kim, Jong Hoon ^e   Cho, Jae Youl ^a  

^a Sungkyunkwan University   (South Korea)

^b Sunchon National University   (South Korea)

^c Hanyang University   (South Korea)

^d Rural Development Administration   (South Korea)

^e Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARCHIDENDRON CLYPEARIA EXTRACT; ARTEMISIA ASIATICA EXTRACT; CAFFEIC ACID; CERBERA MANGHAS EXTRACT; CINNAMOMUM CASSIA EXTRACT; EVODIA LEPTA EXTRACT; HOPEA ODORATA EXTRACT; MYRSINE SEGUINII EXTRACT; OXIDIZED LOW DENSITY LIPOPROTEIN; PICEATANNOL; PLANT EXTRACT; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; QUERCETIN; RHODOMYRTUS TOMENTOSA EXTRACT; UNCLASSIFIED DRUG; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE;

ADAPTIVE IMMUNITY; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARCHIDENDRON CLYPEARIA; BIOLOGICAL FUNCTIONS; CAENORHABDITIS ELEGANS; CELL ADHESION; CELL MATURATION; CELL NUCLEUS MEMBRANE; CERBERA MANGHAS; CHRONIC INFLAMMATION; CINNAMOMUM CASSIA; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEMATOPOIETIC CELL; HOPEA ODORATA; HUMAN; IMMUNORECEPTOR TYROSINE BASED ACTIVATION MOTIF; INFLAMMATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LYMPHOCYTE; MACROPHAGE; MAST CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PROTEIN PROCESSING; REVIEW; RHODOMYRTUS TOMENTOSA; SIGNAL TRANSDUCTION; TANDEM REPEAT; TISSUE SPECIFICITY; ANIMAL; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

ANIMALS; HUMANS; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 84904119059     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2014/270302     Document Type: Review

References (122)

1. Ferrero-Miliani L., Nielsen O. H., Andersen P. S., Girardin S. E., Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 β generation. Clinical and Experimental Immunology 2007 147 2 227 235 2-s2.0-33846257261 10.1111/j.1365-2249.2006.03261.x (Pubitemid 46095999)
2. Kayama H., Nishimura J., Takeda K., Regulation of intestinal homeostasis by innate immune cells. Immune Network 2013 13 6 227 234 2-s2.0-84868115886
3. Kaur M., Singh M., Silakari O., Inhibitors of switch kinase "spleen tyrosine kinase" in inflammation and immune-mediated disorders: a review. European Journal of Medicinal Chemistry 2013 67 434 446 2-s2.0-84881000237 10.1016/j.ejmech.2013.04.070
4. Cha Y. I., Kim H. S., Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. BMB Reports 2013 46 9 429 438
5. Park M. H., Igarashi K., Polyamines and their metabolites as diagnostic Markers of human diseases. Biomolecules & Therapeutics 2013 21 1 1 9 2-s2.0-84873392592 10.4062/biomolther.2012.097
6. Ham M., Moon A., Inflammatory and microenvironmental factors involved in breast cancer progression. Archives of Pharmacal Research 2013 36 12 1419 1431
7. Lee J., Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes. Archives of Pharmacal Research 2013 36 2 208 222 2-s2.0-84879498251 10.1007/s12272-013-0023-8
8. Jeon J. W., Park B. C., Jung J. G., Jang Y. S., Shin E. C., Park Y. W., The soluble form of the cellular prion protein enhances phagocytic activity and cytokine production by human monocytes via activation of ERK and NF- B. Immune Network 2013 13 4 148 156
9. Taylor P. R., Martinez-Pomares L., Stacey M., Lin H.-H., Brown G. D., Gordon S., Macrophage receptors and immune recognition. Annual Review of Immunology 2005 23 901 944 2-s2.0-11844254888 10.1146/annurev.immunol.23.021704. 115816 (Pubitemid 40563189)
10. Han J., Lee J.-D., Bibbs L., Ulevitch R. J., A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994 265 5173 808 811 2-s2.0-0027936755 (Pubitemid 24266145)
11. Yu T., Yi Y.-S., Yang Y., Oh J., Jeong D., Cho J. Y., The pivotal role of TBK1 in inflammatory responses mediated by macrophages. Mediators of Inflammation 2012 2012 8 2-s2.0-84871649863 10.1155/2012/979105 979105
12. Byeon S. E., Yi Y.-S., Oh J., Yoo B. C., Hong S., Cho J. Y., The role of Src kinase in macrophage-mediated inflammatory responses. Mediators of Inflammation 2012 2012 18 2-s2.0-84871369699 10.1155/2012/512926 512926
13. Cho J.-E., Park S., Lee H., Cho S.-N., Kim Y. S., Mycobacterium tuberculosis-induced expression of granulocyte-macrophage colony stimulating factor is mediated by PI3-K/MEK1/p38 MAPK signaling pathway. BMB Reports 2013 46 4 213 218 2-s2.0-84880634088 10.5483/BMBRep.2013.46.4.200
14. Lee J.-W., Kim N. H., Kim J.-Y., Park J.-H., Shin S.-Y., Kwon Y.-S., Lee H. J., Kim S.-S., Chun W., Aromadendrin inhibits lipopolysaccharide-induced nuclear translocation of NF- B and phosphorylation of JNK in RAW 264.7 macrophage cells. Biomolecules & Therapeutics 2013 21 3 216 221 2-s2.0-84878433906 10.4062/biomolther.2013.023
15. Duan Y., Chen F., Zhang A., Zhu B., Sun J., Xie Q., Chen Z., Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity. BMB Reports 2014 47 1 45 50
16. Taniguchi T., Kobayashi T., Kondo J., Takahashi K., Nakamura H., Suzuki J., Nagai K., Yamada T., Nakamura S.-I., Yamamura H., Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. The Journal of Biological Chemistry 1991 266 24 15790 15796 2-s2.0-0025946132 (Pubitemid 21907727)
17. Fütterer K., Wong J., Grucza R. A., Chan A. C., Waksman G., Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. Journal of Molecular Biology 1998 281 3 523 537 2-s2.0-0032555744 10.1006/jmbi.1998.1964 (Pubitemid 28372129)
18. Mócsai A., Ruland J., Tybulewicz V. L. J., The SYK tyrosine kinase: a crucial player in diverse biological functions. Nature Reviews Immunology 2010 10 6 387 402 2-s2.0-77952887713 10.1038/nri2765
19. Turner M., Schweighoffer E., Colucci F., di Santo J. P., Tybulewicz V. L., Tyrosine kinase Syk: essential functions for immunoreceptor signalling. Immunology Today 2000 21 3 148 154 2-s2.0-0033997615 10.1016/S0167-5699(99) 01574-1 (Pubitemid 30122705)
20. Wang L., Duke L., Zhang P. S., Arlinghaus R. B., Symmans W. F., Sahin A., Mendez R., Dai J. L., Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer. Cancer Research 2003 63 15 4724 4730 2-s2.0-0043136678 (Pubitemid 36951053)
21. Andres A.-C., Zuercher G., Djonov V., Flueck M., Ziemiecki A., Protein tyrosine kinase expression during the estrous cycle and carcinogenesis of the mammary gland. International Journal of Cancer 1995 63 2 288 296 2-s2.0-0028788451 10.1002/ijc.2910630224
22. Ziegenfuss J. S., Biswas R., Avery M. A., Hong K., Sheehan A. E., Yeung Y.-G., Stanley E. R., Freeman M. R., Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature 2008 453 7197 935 939 2-s2.0-45149101493 10.1038/nature06901 (Pubitemid 351832559)
23. Steele R. E., Stover N. A., Sakaguchi M., Appearance and disappearance of Syk family protein-tyrosine kinase genes during metazoan evolution. Gene 1999 239 1 91 97 2-s2.0-0032823311 10.1016/S0378-1119(99)00373-X (Pubitemid 29462570)
24. Suga H., Koyanagi M., Hoshiyama D., Ono K., Iwabe N., Kuma K.-I., Miyata T., Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra. Journal of Molecular Evolution 1999 48 6 646 653 2-s2.0-0033035138 10.1007/PL00006508 (Pubitemid 29287954)
25. Sohn H. W., Gu H., Pierce S. K., Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. Journal of Experimental Medicine 2003 197 11 1511 1524 2-s2.0-0037944241 10.1084/jem.20021686 (Pubitemid 36682548)
26. Furlong M. T., Mahrenholz A. M., Kim K.-H., Ashendel C. L., Harrison M. L., Geahlen R. L., Identification of the major site of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochimica et Biophysica Acta-Molecular Cell Research 1997 1355 2 177 190 2-s2.0-0031552069 10.1016/S0167-4889(96)00131- 0 (Pubitemid 27064044)
27. Kurosaki T., Takata M., Yamanashi Y., Inazu T., Taniguchi T., Yamamoto T., Yamamura H., Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. Journal of Experimental Medicine 1994 179 5 1725 1729 2-s2.0-0028355565 (Pubitemid 24129594)
28. Hong J. J., Yankee T. M., Harrison M. L., Geahlen R. L., Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines: a mechanism for negative signaling by the Lyn tyrosine kinase. The Journal of Biological Chemistry 2002 277 35 31703 31714 2-s2.0-0037199989 10.1074/jbc.M201362200 (Pubitemid 34968974)
29. Keshvara L. M., Isaacson C. C., Yankee T. M., Sarac R., Harrison M. L., Geahlen R. L., Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. Journal of Immunology 1998 161 10 5276 5283 2-s2.0-0032534071 (Pubitemid 28519087)
30. Cox D., Greenberg S., Phagocytic signaling strategies: Fc γ receptor-mediated phagocytosis as a model system. Seminars in Immunology 2001 13 6 339 345 2-s2.0-0035205569 10.1006/smim.2001.0330 (Pubitemid 33121959)
31. Bohnenberger H., Oellerich T., Engelke M., Hsiao H.-H., Urlaub H., Wienands J., Complex phosphorylation dynamics control the composition of the Syk interactome in B cells. European Journal of Immunology 2011 41 6 1550 1562 2-s2.0-79957565599 10.1002/eji.201041326
32. Kulathu Y., Grothe G., Reth M., Autoinhibition and adapter function of Syk. Immunological Reviews 2009 232 1 286 299 2-s2.0-70350356241 10.1111/j.1600-065X.2009.00837.x
33. Ma H., Yankee T. M., Hu J., Asai D. J., Harrison M. L., Geahlen R. L., Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. Journal of Immunology 2001 166 3 1507 1516 2-s2.0-0035253720 (Pubitemid 32114629)
34. Yanagi S., Kurosaki T., Yamamura H., The structure and function of nonreceptor tyrosine kinase p72SYK expressed in hematopoietic cells. Cellular Signalling 1995 7 3 185 193 2-s2.0-0029054412
35. Yanagi S., Inatome R., Takano T., Yamamura H., Syk expression and novel function in a wide variety of tissues. Biochemical and Biophysical Research Communications 2001 288 3 495 498 2-s2.0-0035798199 10.1006/bbrc.2001.5788 (Pubitemid 33030056)
36. Lee Y. G., Chain B. M., Cho J. Y., Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of B α via activation of the phosphoinositide-3-kinase and Akt pathways. The International Journal of Biochemistry and Cell Biology 2009 41 4 811 821 2-s2.0-59649090426 10.1016/j.biocel.2008.08.011
37. Galan J. A., Paris L. L., Zhang H.-J., Adler J., Geahlen R. L., Tao W. A., Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Journal of the American Society for Mass Spectrometry 2011 22 2 319 328 2-s2.0-79952509222 10.1007/s13361-010-0030-7
38. Oda H., Fujimoto M., Patrick M. S., Chida D., Sato Y., Azuma Y., Aoki H., Abe T., Suzuki H., Shirai M., RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells. Journal of Immunology 2009 182 2 957 962 2-s2.0-60549106290
39. Ohtsuka M., Arase H., Takeuchi A., Yamasaki S., Shiina R., Suenaga T., Sakurai D., Yokosuka T., Arase N., Iwashima M., Kitamura T., Moriya H., Saito T., NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. Proceedings of the National Academy of Sciences of the United States of America 2004 101 21 8126 8131 2-s2.0-2542629731 10.1073/pnas.0401119101 (Pubitemid 38698065)
40. Chaudhary A., Fresquez T. M., Naranjo M. J., Tyrosine kinase Syk associates with toll-like receptor 4 and regulates signaling in human monocytic cells. Immunology and Cell Biology 2007 85 3 249 256 2-s2.0-34247895577 10.1038/sj.icb7100030 (Pubitemid 46701428)
41. Saitoh S., Arudchandran R., Manetz T. S., Zhang W., Sommers C. L., Love P. E., Rivera J., Samelson L. E., LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity 2000 12 5 525 535 2-s2.0-0033678973
42. Hendricks-Taylor L. R., Motto D. G., Zhang J., Siraganian R. P., Koretzky G. A., SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. The Journal of Biological Chemistry 1997 272 2 1363 1367 2-s2.0-0031021586 10.1074/jbc.272.2. 1363 (Pubitemid 27034641)
43. Fu C., Turck C. W., Kurosaki T., Chan A. C., BLNK: a central linker protein in B cell activation. Immunity 1998 9 1 93 103 2-s2.0-0032127159 10.1016/S1074-7613(00)80591-9 (Pubitemid 28361298)
44. Okada T., Maeda A., Iwamatsu A., Gotoh K., Kurosaki T., BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 2000 13 6 817 827 2-s2.0-0034507903 10.1016/S1074-7613(00)00079-0 (Pubitemid 32041804)
45. Yamanashi Y., Fukuda T., Nishizumi H., Inazu T., Higashi K.-I., Kitamura D., Ishida T., Yamamura H., Watanabe T., Yamamoto T., Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. Journal of Experimental Medicine 1997 185 7 1387 1392 2-s2.0-0030894868 10.1084/jem.185.7.1387 (Pubitemid 27172919)
46. Nagai K., Takata M., Yamamura H., Kurosaki T., Tyrosine phosphorylation of Shc is mediated through Lyn and Syk in B cell receptor signaling. The Journal of Biological Chemistry 1995 270 12 6824 6829 2-s2.0-0028901649
47. Latour S., Fournel M., Veillette A., Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase. Molecular and Cellular Biology 1997 17 8 4434 4441 2-s2.0-0030795305 (Pubitemid 27318120)
48. Deckert M., Tartare-Deckert S., Hernandez J., Rottapel R., Altman A., Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity 1998 9 5 595 605 2-s2.0-19244369810 (Pubitemid 28557588)
49. Lupher M. L. Jr., Rao N., Lill N. L., Andoniou C. E., Miyake S., Clark E. A., Druker B., Band H., Cbl-mediated negative regulation of the Syk tyrosine kinase: a critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323. The Journal of Biological Chemistry 1998 273 52 35273 35281 2-s2.0-0032567438 10.1074/jbc.273.52.35273 (Pubitemid 29028235)
50. 2+ mobilization through distinct pathways. The EMBO Journal 1994 13 6 1341 1349 2-s2.0-0028180858
51. Hitomi T., Yanagi S., Inatome R., Yamamura H., Cross-linking of the B cell receptor induces activation of phospholipase D through Syk, Btk and phospholipase C- γ 2. FEBS Letters 1999 445 2-3 371 374 2-s2.0-0032978793 10.1016/S0014-5793(99)00153-2 (Pubitemid 29117247)
52. Kawakami Y., Kitaura J., Hartman S. E., Lowell C. A., Siraganian R. P., Kawakami T., Regulation of protein kinase C β I by two protein-tyrosine kinases, Btk and Syk. Proceedings of the National Academy of Sciences of the United States of America 2000 97 13 7423 7428 2-s2.0-0034691207 10.1073/pnas.120175097 (Pubitemid 30431479)
53. Okazaki H., Zhang J., Hamawy M. M., Siraganian R. P., Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in Fc ε RI signaling. The Journal of Biological Chemistry 1997 272 51 32443 32447 2-s2.0-0031437888 10.1074/jbc.272.51.32443 (Pubitemid 28011928)
54. Arudchandran R., Brown M. J., Peirce M. J., Song J. S., Zhang J., Siraganian R. P., Blank U., Rivera J., The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH2-terminal kinase 1. The Journal of Experimental Medicine 2000 191 1 47 60 2-s2.0-0034598312 10.1084/jem.191.1.47 (Pubitemid 30043647)
55. Beitz L. O., Fruman D. A., Kurosaki T., Cantley L. C., Scharenberg A. M., SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. The Journal of Biological Chemistry 1999 274 46 32662 32666 2-s2.0-0032705203 10.1074/jbc.274.46.32662 (Pubitemid 129535293)
56. Costello P. S., Turner M., Walters A. E., Cunningham C. N., Bauer P. H., Downward J., Tybulewicz V. L. J., Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 1996 13 12 2595 2605 2-s2.0-0030472724 (Pubitemid 27046115)
57. Zhang J., Berenstein E. H., Evans R. L., Siraganian R. P., Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. Journal of Experimental Medicine 1996 184 1 71 79 2-s2.0-0030018183 10.1084/jem.184.1.71 (Pubitemid 26247216)
58. 2 pathway by Fc ε R1 is not shared by a G protein-coupled receptor. The Journal of Biological Chemistry 1995 270 18 10960 10967 2-s2.0-0028916595 10.1074/jbc.270.18.10960
59. Peters J. D., Furlong M. T., Asai D. J., Harrison M. L., Geahlen R. L., Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates α -tubulin on tyrosine. The Journal of Biological Chemistry 1996 271 9 4755 4762 2-s2.0-0029867911 10.1074/jbc.271.9.4755 (Pubitemid 26074958)
60. Larbolette O., Wollscheid B., Schweikert J., Nielsen P. J., Wienands J., SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors. Molecular and Cellular Biology 1999 19 2 1539 1546 2-s2.0-0032952693 (Pubitemid 29046895)
61. Woodside D. G., Obergfell A., Talapatra A., Calderwood D. A., Shattil S. J., Ginsberg M. H., The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin β cytoplasmic domains. The Journal of Biological Chemistry 2002 277 42 39401 39408 2-s2.0-0037131428 10.1074/jbc.M207657200 (Pubitemid 35190914)
62. Jakus Z., Fodor S., Abram C. L., Lowell C. A., Mócsai A., Immunoreceptor-like signaling by β 2 and β 3 integrins. Trends in Cell Biology 2007 17 10 493 501 2-s2.0-35248851278 10.1016/j.tcb.2007.09.001 (Pubitemid 47562769)
63. Frommhold D., Mannigel I., Schymeinsky J., Mocsai A., Poeschl J., Walzog B., Sperandio M., Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo. BMC Immunology 2007 8 article 31 2-s2.0-38849189553 10.1186/1471-2172-8-31 (Pubitemid 351188970)
64. Vines C. M., Potter J. W., Xu Y., Geahlen R. L., Costello P. S., Tybulewicz V. L., Lowell C. A., Chang P. W., Gresham H. D., Willman C. L., Inhibition of β 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 2001 15 4 507 519 2-s2.0-17944366407 10.1016/S1074-7613(01)00221-7 (Pubitemid 33016437)
65. Mócsai A., Abram C. L., Jakus Z., Hu Y., Lanier L. L., Lowell C. A., Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nature Immunology 2006 7 12 1326 1333 2-s2.0-33846295127 10.1038/ni1407 (Pubitemid 46111254)
66. Urzainqui A., Serrador J. M., Viedma F., Yáñez-Mó M., Rodríguez A., Corbí A. L., Alonso-Lebrero J. L., Luque A., Deckert M., Vázquez J., Sánchez-Madrid F., ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Immunity 2002 17 4 401 412 2-s2.0-18644377589 10.1016/S1074-7613(02) 00420-X (Pubitemid 35223530)
67. Zarbock A., Lowell C. A., Ley K., Spleen tyrosine kinase Syk is necessary for E-selectin-induced α L β 2 integrin-mediated rolling on intercellular adhesion molecule-1. Immunity 2007 26 6 773 783 2-s2.0-34250180872 10.1016/j.immuni.2007.04.011 (Pubitemid 46907666)
68. Rogers N. C., Slack E. C., Edwards A. D., Nolte M. A., Schulz O., Schweighoffer E., Williams D. L., Gordon S., Tybulewicz V. L., Brown G. D., Reis e Sousa C., Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 2005 22 4 507 517 2-s2.0-20244363662 10.1016/j.immuni.2005.03.004 (Pubitemid 40545115)
69. Underhill D. M., Rossnagle E., Lowell C. A., Simmons R. M., Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 2005 106 7 2543 2550 2-s2.0-27144521657 10.1182/blood-2005-03-1239 (Pubitemid 41510832)
70. Gross O., Poeck H., Bscheider M., Dostert C., Hannesschläger N., Endres S., Hartmann G., Tardivel A., Schweighoffer E., Tybulewicz V., Mocsai A., Tschopp J., Ruland J., Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009 459 7245 433 436 2-s2.0-67349271142 10.1038/nature07965
71. Geijtenbeek T. B. H., Gringhuis S. I., Signalling through C-type lectin receptors: shaping immune responses. Nature Reviews Immunology 2009 9 7 465 479 2-s2.0-67649840704 10.1038/nri2569
72. van Ziffle J. A., Lowell C. A., Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 2009 114 23 4871 4882 2-s2.0-70350425052 10.1182/blood-2009-05-220806
73. Chen S.-T., Lin Y.-L., Huang M.-T., Wu M.-F., Cheng S.-C., Lei H.-Y., Lee C.-K., Chiou T.-W., Wong C.-H., Hsieh S.-L., CLEC5A is critical for dengue-virus-induced lethal disease. Nature 2008 453 7195 672 676 2-s2.0-44449097101 10.1038/nature07013 (Pubitemid 351769308)
74. Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T., Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nature Immunology 2008 9 10 1179 1188 2-s2.0-52549125928 10.1038/ni.1651
75. Sancho D., Joffre O. P., Keller A. M., Rogers N. C., Martínez D., Hernanz-Falcón P., Rosewell I., Sousa C. R. E., Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 2009 458 7240 899 903 2-s2.0-67249158956 10.1038/nature07750
76. Huysamen C., Willment J. A., Dennehy K. M., Brown G. D., CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. The Journal of Biological Chemistry 2008 283 24 16693 16701 2-s2.0-47749146942 10.1074/jbc.M709923200
77. Colucci F., Schweighoffer E., Tomasello E., Turner M., Ortaldo J. R., Vivier E., Tybulewicz V. L. J., di Santo J. P., Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nature Immunology 2002 3 3 288 294 2-s2.0-0036194976 10.1038/ni764 (Pubitemid 34213431)
78. Bae Y. S., Lee J. H., Choi S. H., Kim S., Almazan F., Witztum J. L., Miller Y. I., Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circulation Research 2009 104 2 210 218 2-s2.0-59849086158 10.1161/CIRCRESAHA.108.181040
79. Choi S.-H., Harkewicz R., Lee J. H., Boullier A., Almazan F., Li A. C., Witztum J. L., Bae Y. S., Miller Y. I., Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circulation Research 2009 104 12 1355 1363 2-s2.0-67650266902 10.1161/CIRCRESAHA.108.192880
80. Yoon J. Y., Jeong H. Y., Kim S. H., Kim H. G., Nam G., Kim J. P., Yoon D. H., Hwang H., Kimc T. W., Hong S., Cho J. Y., Methanol extract of Evodia lepta displays Syk/Src-targeted anti-inflammatory activity. Journal of Ethnopharmacology 2013 148 3 999 1007 2-s2.0-84880312884 10.1016/j.jep.2013.05. 030
81. Jeong D., Yang W. S., Yang Y., Nam G., Kim J. H., Yoon D. H., Noh H. J., Lee S., Kim T. W., Sung G.-H., Cho J. Y., In vitro and in vivo anti-inflammatory effect of Rhodomyrtus tomentosa methanol extract. Journal of Ethnopharmacology 2013 146 1 205 213 2-s2.0-84874113222 10.1016/j.jep.2012.12.034
82. Yang W. S., Lee J., Kim T. W., Kim J. H., Lee S., Rhee M. H., Hong S., Cho J. Y., Src/NF- B-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract. Journal of Ethnopharmacology 2012 142 1 287 293 2-s2.0-84861962403 10.1016/j.jep.2012.04.026
83. Yu T., Lee S., Yang W. S., Jang H.-J., Lee Y. J., Kim T. W., Kim S. Y., Lee J., Cho J. Y., The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action. Journal of Ethnopharmacology 2012 139 2 566 573 2-s2.0-84856007352 10.1016/j.jep.2011.11.051
84. Miller Y. I., Choi S.-H., Wiesner P., Bae Y. S., The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL. The British Journal of Pharmacology 2012 167 5 990 999 2-s2.0-84867304046 10.1111/j.1476-5381.2012.02097.x
85. Jeong D., Yi Y. S., Sung G. H., Yang W. S., Park J. G., Yoon K., Yoon D. H., Song C., Lee Y., Kim J. H., Rhee M. H., Kim T. W., Cho J. Y., Anti-inflammatory activities and mechanisms of Artemisia asiatica ethanol extract. Journal of Ethnopharmacology 2014 152 3 87 496 10.1016/j.jep.2014.01. 030
86. Jeong H. Y., Sung G. H., Kim J. H., Yoon J. Y., Yang Y., Park J. G., Kim S. H., Yi Y. S., Yang W. S., Yoon D. H., Kim T. W., Cho J. Y., Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity. Journal of Ethnopharmacology 2014 151 2 960 969 10.1016/j.jep.2013.12.009
87. Yang Y., Yu T., Lee Y. G., Yang W. S., Oh J., Jeong D., Lee S., Kim T. W., Park Y. C., Sung G.-H., Cho J. Y., Methanol extract of Hopea odorata suppresses inflammatory responses via the direct inhibition of multiple kinases. Journal of Ethnopharmacology 2013 145 2 598 607 2-s2.0-84872150085 10.1016/j.jep.2012.11.041
88. Yang W. S., Jeong D., Yi Y. S., Lee B. H., Kim T. W., Htwe K. M., Kim Y. D., Yoon K. D., Hong S., Lee W. S., Cho J. Y., Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1. Journal of Ethnopharmacology 2014 151 3 1165 1174 10.1016/j.jep.2013.12.033
89. Yang W. S., Jeong D., Yi Y. S., Park J. G., Seo H., Moh S. H., Hong S., Cho J. Y., IRAK1/4-targeted anti-inflammatory action of caffeic acid. Mediators of Inflammation 2013 2013 12 518183 10.1155/2013/518183
90. Endale M., Park S.-C., Kim S., Kim S.-H., Yang Y., Cho J. Y., Rhee M. H., Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF- B-induced inflammatory mediators production in RAW 264.7 cells. Immunobiology 2013 218 12 1452 1467 2-s2.0-84878251463 10.1016/j.imbio.2013.04. 019
91. Hamerman J. A., Tchao N. K., Lowell C. A., Lanier L. L., Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nature Immunology 2005 6 6 579 586 2-s2.0-58449111876 (Pubitemid 41710728)
92. Turner M., Mee P. J., Costello P. S., Williams O., Price A. A., Duddy L. P., Furlong M. T., Geahlen R. L., Tybulewicz V. L. J., Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 1995 378 6554 298 302 2-s2.0-0028889302
93. Gururajan M., Dasu T., Shahidain S., Jennings C. D., Robertson D. A., Rangnekar V. M., Bondada S., Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. Journal of Immunology 2007 178 1 111 121 2-s2.0-33845927271 (Pubitemid 46033592)
94. Ashikawa K., Majumdar S., Banerjee S., Bharti A. C., Shishodia S., Aggarwal B. B., Piceatannol inhibits TNF-induced NF- B activation and NF- B-mediated gene expression through suppression of I B α kinase and p65 phosphorylation. Journal of Immunology 2002 169 11 6490 6497 2-s2.0-0036885057 (Pubitemid 36903500)
95. Ruzza P., Biondi B., Calderan A., Therapeutic prospect of Syk inhibitors. Expert Opinion on Therapeutic Patents 2009 19 10 1361 1376 2-s2.0-70349781325 10.1517/13543770903207039
96. Yamamoto N., Takeshita K., Shichijo M., Kokubo T., Sato M., Nakashima K., Ishimori M., Nagai H., Li Y.-F., Yura T., Bacon K. B., The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c] pyrimidin-5-ylamino]-nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. Journal of Pharmacology and Experimental Therapeutics 2003 306 3 1174 1181 2-s2.0-0041932075 10.1124/jpet.103.052316 (Pubitemid 37025329)
97. Hisamichi H., Naito R., Toyoshima A., Kawano N., Ichikawa A., Orita A., Orita M., Hamada N., Takeuchi M., Ohta M., Tsukamoto S.-I., Synthetic studies on novel Syk inhibitors. Part 1: synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorganic & Medicinal Chemistry 2005 13 16 4936 4951 2-s2.0-21744434202 10.1016/j.bmc.2005.05.033 (Pubitemid 40943518)
98. Wong B. R., Grossbard E. B., Payan D. G., Masuda E. S., Targeting Syk as a treatment for allergic and autoimmune disorders. Expert Opinion on Investigational Drugs 2004 13 7 743 762 2-s2.0-3543143671 10.1517/13543784.13.7. 743 (Pubitemid 39028928)
99. Bajpai M., Chopra P., Dastidar S. G., Ray A., Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis. Expert Opinion on Investigational Drugs 2008 17 5 641 659 2-s2.0-44449118619 10.1517/13543784.17.5.641 (Pubitemid 351843609)
100. Blease K., Targeting kinases in asthma. Expert Opinion on Investigational Drugs 2005 14 10 1213 1220 2-s2.0-27144444110 10.1517/13543784.14.10.1213 (Pubitemid 41488870)
101. Masuda E. S., Schmitz J., Syk inhibitors as treatment for allergic rhinitis. Pulmonary Pharmacology & Therapeutics 2008 21 3 461 467 2-s2.0-43049113886 10.1016/j.pupt.2007.06.002 (Pubitemid 351625925)
102. Podolanczuk A., Lazarus A. H., Crow A. R., Grossbard E., Bussel J. B., Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk. Blood 2009 113 14 3154 3160 2-s2.0-65349104905 10.1182/blood-2008-07-166439
103. Bahjat F. R., Pine P. R., Reitsma A., Cassafer G., Baluom M., Grillo S., Chang B., Zhao F. F., Payan D. G., Grossbard E. B., Daikh D. I., An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis and Rheumatism 2008 58 5 1433 1444 2-s2.0-43949092440 10.1002/art.23428 (Pubitemid 351705932)
104. Chui C. H., Wong R. S. M., Cheng G. Y. M., Lau F. Y., Kok S. H. L., Cheng C. H., Cheung F., Tang W. K., Teo I. T. N., Chan A. S. C., Tang J. C. O., Antiproliferative ability of a combination regimen of crocodile egg extract, wild radix ginseng and natural Ganoderma lucidum on acute myelogenous leukemia. Oncology Reports 2006 16 6 1313 1316 2-s2.0-38349118162
105. Pine P. R., Chang B., Schoettler N., Banquerigo M. L., Wang S., Lau A., Zhao F., Grossbard E. B., Payan D. G., Brahn E., Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clinical Immunology 2007 124 3 244 257 2-s2.0-34547849752 10.1016/j.clim.2007.03.543 (Pubitemid 47247604)
106. Coffey G., DeGuzman F., Inagaki M., Pak Y., Delaney S. M., Ives D., Betz A., Jia Z. J., Pandey A., Baker D., Hollenbach S. J., Phillips D. R., Sinha U., Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. Journal of Pharmacology and Experimental Therapeutics 2012 340 2 350 359 2-s2.0-84856023801 10.1124/jpet.111.188441
107. Ozaki N., Suzuki S., Ishida M., Harada Y., Tanaka K., Sato Y., Kono T., Kubo M., Kitamura D., Encinas J., Hara H., Yoshida H., Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis. International Immunology 2012 24 9 539 550 2-s2.0-84865572156 10.1093/intimm/dxs078
108. Yi Y.-S., Ayala-López W., Kularatne S. A., Low P. S., Folate-targeted hapten immunotherapy of adjuvant-induced arthritis: comparison of hapten potencies. Molecular Pharmaceutics 2009 6 4 1228 1236 2-s2.0-68249112814 10.1021/mp900070b
109. Weinblatt M. E., Kavanaugh A., Burgos-Vargas R., Dikranian A. H., Medrano-Ramirez G., Morales-Torres J. L., Murphy F. T., Musser T. K., Straniero N., Vicente-Gonzales A. V., Grossbard E., Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial. Arthritis and Rheumatism 2008 58 11 3309 3318 2-s2.0-55849114400 10.1002/art.23992
110. Kovarova M., Rivera J., A molecular understanding of mast cell activation and the promise of anti-allergic therapeutics. Current Medicinal Chemistry 2004 11 15 2083 2091 2-s2.0-3242803049 (Pubitemid 38967730)
111. Rossi A. B., Herlaar E., Braselmann S., Huynh S., Taylor V., Frances R., Issakani S. D., Argade A., Singh R., Payan D. G., Masuda E. S., Identification of the Syk kinase inhibitor R112 by a human mast cell screen. Journal of Allergy and Clinical Immunology 2006 118 3 749 755 2-s2.0-33748058807 10.1016/j.jaci.2006.05.023 (Pubitemid 44301399)
112. Meltzer E. O., Berkowitz R. B., Grossbard E. B., An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment. Journal of Allergy and Clinical Immunology 2005 115 4 791 796 2-s2.0-16244397342 10.1016/j.jaci.2005.01.040 (Pubitemid 40460855)
113. Pamuk O. N., Lapchak P. H., Rani P., Pine P., Dalle Lucca J. J., Tsokos G. C., Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion. The American Journal of Physiology-Gastrointestinal and Liver Physiology 2010 299 2 G391 G399 2-s2.0-77955622884 10.1152/ajpgi.00198. 2010
114. Lapchak P. H., Kannan L., Rani P., Pamuk O. N., Ioannou A., Dalle Lucca J. J., Pine P., Tsokos G. C., Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury. The American Journal of Physiology-Gastrointestinal and Liver Physiology 2012 302 12 G1416 G1422 2-s2.0-84862512151 10.1152/ajpgi.00026.2012
115. Rahman A., Isenberg D. A., Systemic lupus erythematosus. The New England Journal of Medicine 2008 358 9 929 939 2-s2.0-40049093765 10.1056/NEJMra071297 (Pubitemid 351397092)
116. Smith J., McDaid J. P., Bhangal G., Chawanasuntorapoj R., Masuda E. S., Cook H. T., Pusey C. D., Tam F. W. K., A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis. Journal of the American Society of Nephrology 2010 21 2 231 236 2-s2.0-77949363952 10.1681/ASN. 2009030263
117. Deng G.-M., Liu L., Bahjat F. R., Pine P. R., Tsokos G. C., Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis and Rheumatism 2010 62 7 2086 2092 2-s2.0-77954229590 10.1002/art.27452
118. Lin Y.-C., Huang D.-Y., Chu C.-L., Lin W.-W., Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway. Molecular Immunology 2010 47 7-8 1569 1578 2-s2.0-77950630062 10.1016/j.molimm.2010.01.008
119. Au-Yeung B. B., Deindl S., Hsu L.-Y., Palacios E. H., Levin S. E., Kuriyan J., Weiss A., The structure, regulation, and function of ZAP-70. Immunological Reviews 2009 228 1 41 57 2-s2.0-61849166005 10.1111/j.1600-065X. 2008.00753.x
120. Wang H., Kadlecek T. A., Au-Yeung B. B., Goodfellow H. E. S., Hsu L.-Y., Freedman T. S., Weiss A., ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harbor Perspectives in Biology 2010 2 5 a002279 2-s2.0-77955284816 10.1101/cshperspect.a002279
121. Kumar-Roiné S., Matsui M., Reybier K., Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages. Journal of Ethnopharmacology 2009 123 3 369 377
122. Reddy A. M., Lee J. Y., Seo J. H., Artemisolide from Artemisia asiatica: nuclear factor-kappaB (NF-kappaB) inhibitor suppressing prostaglandin E2 and nitric oxide production in macrophages. Archives of Pharmacal Research 2006 29 7 591 597