Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

Nature Immunology

Volumn 3, Issue 3, 2002, Pages 288-294

  Colucci, Francesco ^a   Schweighoffer, Edina ^b   Tomasello, Elena ^c   Turner, Martin ^d   Ortaldo, John R ^e   Vivier, Eric ^c   Tybulewicz, Victor L J ^b   Di Santo, James P ^a  

^a INSTITUT PASTEUR   (France)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c INSERM   (France)

^d BABRAHAM INSTITUTE   (United Kingdom)

^e National Cancer Institute   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; ENZYME INHIBITION; FETUS; IN VITRO STUDY; IN VIVO STUDY; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR; TUMOR CELL;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; ENZYME PRECURSORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PROTEIN-TYROSINE KINASES; RECEPTORS, IMMUNOLOGIC; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0036194976     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni764     Document Type: Article

References (34)

1. On guard-activating NK cell receptors
2. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
3. An activating immunoreceptor complex formed by NKG2D and DAP10
4. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
5. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
6. Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages
7. Role of immunoreceptor tyrosine-based activation motif in signal transduction from antigen and Fc receptors
8. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
9. Essential role for ZAP-70 in both positive and negative selection of thymocytes
10. Differential requirements for ZAP-70 in TCR signaling and T cell development
11. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
12. Syk tyrosine kinase required for mouse viability and B-cell development
13. Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation
14. Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity
15. Tyrosine kinase Syk: Essential functions for immunoreceptor signalling revealed by gene targeted mice
16. Dissecting NK cell development using a novel alymphoid mouse model: Investigating the role of the c-abl proto-oncogene in murine NK cell differentiation
17. Natural" killer cells in the mouse. 1. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype
18. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice
19. T cell development in mice lacking all T cell receptors ζ family members
20. −/− mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex
21. Alteration of the natural killer repertoire in H-2 transgenic mice: Specificity of rapid lymphoma cell clearance determined by the H-2 pheno-type of the target
22. Functional dichotomy in NK cell signaling:Vav1-dependent and independent mechanisms
23. The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing
24. Vital involvement of a natural killer cell activation receptor in resistance to viral infection
25. Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to ly49h
26. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily
27. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation
28. Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity
29. The Syk family of protein tyrosine kinases in T-cell activation and development
30. Mechanisms of phagocytosis in macrophages
31. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells
32. 1 integrin-induced interleukin-8 production in human natural killer cells
33. ICAM-2 redistributed by ezrin as a target for killer cells
34. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice