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Volumn 228, Issue 1, 2009, Pages 41-57

The structure, regulation, and function of ZAP-70

Author keywords

Autoinhibition; ITAM; Pre TCR signals; Signal transduction; T cell receptor; ZAP 70

Indexed keywords

PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70;

EID: 61849166005     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2008.00753.x     Document Type: Article
Times cited : (161)

References (75)
  • 1
    • 0037188899 scopus 로고    scopus 로고
    • Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation
    • Gil D, Schamel WW, Montoya M, Sanchez-Madrid F, Alarcon B. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 2002 109 : 901 912.
    • (2002) Cell , vol.109 , pp. 901-912
    • Gil, D.1    Schamel, W.W.2    Montoya, M.3    Sanchez-Madrid, F.4    Alarcon, B.5
  • 2
    • 0029063151 scopus 로고
    • Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance
    • Bu JY, Shaw AS, Chan AC. Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance. Proc Natl Acad Sci USA 1995 92 : 5106 5110.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5106-5110
    • Bu, J.Y.1    Shaw, A.S.2    Chan, A.C.3
  • 3
    • 84988043558 scopus 로고
    • Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor
    • Hatada MH, et al. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 1995 377 : 32 38.
    • (1995) Nature , vol.377 , pp. 32-38
    • Hatada, M.H.1
  • 4
    • 0031964602 scopus 로고    scopus 로고
    • Tandem SH2 domains confer high specificity in tyrosine kinase signaling
    • Ottinger EA, Botfield MC, Shoelson SE. Tandem SH2 domains confer high specificity in tyrosine kinase signaling. J Biol Chem 1998 273 : 729 735.
    • (1998) J Biol Chem , vol.273 , pp. 729-735
    • Ottinger, E.A.1    Botfield, M.C.2    Shoelson, S.E.3
  • 5
    • 0032502717 scopus 로고    scopus 로고
    • Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions
    • Grazioli L, Germain V, Weiss A, Acuto O. Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions. J Biol Chem 1998 273 : 8916 8921.
    • (1998) J Biol Chem , vol.273 , pp. 8916-8921
    • Grazioli, L.1    Germain, V.2    Weiss, A.3    Acuto, O.4
  • 6
    • 0037016021 scopus 로고    scopus 로고
    • Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: Two bikes rather than a tandem
    • Folmer RH, Geschwindner S, Xue Y. Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem. Biochemistry 2002 41 : 14176 14184.
    • (2002) Biochemistry , vol.41 , pp. 14176-14184
    • Folmer, R.H.1    Geschwindner, S.2    Xue, Y.3
  • 7
    • 0029783430 scopus 로고    scopus 로고
    • Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function
    • Kong G, Dalton M, Bubeck Wardenburg J, Straus D, Kurosaki T, Chan AC. Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. Mol Cell Biol 1996 16 : 5026 5035.
    • (1996) Mol Cell Biol , vol.16 , pp. 5026-5035
    • Kong, G.1    Dalton, M.2    Bubeck Wardenburg, J.3    Straus, D.4    Kurosaki, T.5    Chan, A.C.6
  • 8
    • 0029968995 scopus 로고    scopus 로고
    • Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70
    • Zhao Q, Weiss A. Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70. Mol Cell Biol 1996 16 : 6765 6774.
    • (1996) Mol Cell Biol , vol.16 , pp. 6765-6774
    • Zhao, Q.1    Weiss, A.2
  • 9
    • 17944383162 scopus 로고    scopus 로고
    • T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase
    • Magnan A, et al. T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase. J Exp Med 2001 194 : 491 505.
    • (2001) J Exp Med , vol.194 , pp. 491-505
    • Magnan, A.1
  • 10
    • 14444276991 scopus 로고    scopus 로고
    • The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70
    • Lupher ML Jr., Songyang Z, Shoelson SE, Cantley LC, Band H. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J Biol Chem 1997 272 : 33140 33144.
    • (1997) J Biol Chem , vol.272 , pp. 33140-33144
    • Lupher Jr., M.L.1    Songyang, Z.2    Shoelson, S.E.3    Cantley, L.C.4    Band, H.5
  • 11
    • 0035854665 scopus 로고    scopus 로고
    • Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70
    • Wang HY, et al. Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70. J Biol Chem 2001 276 : 26004 26011.
    • (2001) J Biol Chem , vol.276 , pp. 26004-26011
    • Wang, H.Y.1
  • 12
    • 0037450822 scopus 로고    scopus 로고
    • A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase
    • Thien CB, Scaife RM, Papadimitriou JM, Murphy MA, Bowtell DD, Langdon WY. A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase. J Exp Med 2003 197 : 503 513.
    • (2003) J Exp Med , vol.197 , pp. 503-513
    • Thien, C.B.1    Scaife, R.M.2    Papadimitriou, J.M.3    Murphy, M.A.4    Bowtell, D.D.5    Langdon, W.Y.6
  • 13
    • 0030914118 scopus 로고    scopus 로고
    • The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction
    • Wu J, Zhao Q, Kurosaki T, Weiss A. The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction. J Exp Med 1997 185 : 1877 1882.
    • (1997) J Exp Med , vol.185 , pp. 1877-1882
    • Wu, J.1    Zhao, Q.2    Kurosaki, T.3    Weiss, A.4
  • 14
    • 0034049330 scopus 로고    scopus 로고
    • ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells
    • Salojin KV, Zhang J, Meagher C, Delovitch TL. ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells. J Biol Chem 2000 275 : 5966 5975.
    • (2000) J Biol Chem , vol.275 , pp. 5966-5975
    • Salojin, K.V.1    Zhang, J.2    Meagher, C.3    Delovitch, T.L.4
  • 15
    • 29144441366 scopus 로고    scopus 로고
    • T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315
    • Gelkop S, Gish GD, Babichev Y, Pawson T, Isakov N. T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315. J Immunol 2005 175 : 8123 8132.
    • (2005) J Immunol , vol.175 , pp. 8123-8132
    • Gelkop, S.1    Gish, G.D.2    Babichev, Y.3    Pawson, T.4    Isakov, N.5
  • 16
    • 0031771750 scopus 로고    scopus 로고
    • Physiological signals and oncogenesis mediated through Crk family adapter proteins
    • Feller SM, et al. Physiological signals and oncogenesis mediated through Crk family adapter proteins. J Cell Physiol 1998 177 : 535 552.
    • (1998) J Cell Physiol , vol.177 , pp. 535-552
    • Feller, S.M.1
  • 17
    • 0036928182 scopus 로고    scopus 로고
    • Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation
    • Sasahara Y, et al. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell 2002 10 : 1269 1281.
    • (2002) Mol Cell , vol.10 , pp. 1269-1281
    • Sasahara, Y.1
  • 18
    • 0034326619 scopus 로고    scopus 로고
    • Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity
    • Epler JA, Liu R, Chung H, Ottoson NC, Shimizu Y. Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity. J Immunol 2000 165 : 4941 4949.
    • (2000) J Immunol , vol.165 , pp. 4941-4949
    • Epler, J.A.1    Liu, R.2    Chung, H.3    Ottoson, N.C.4    Shimizu, Y.5
  • 19
    • 2142659430 scopus 로고    scopus 로고
    • Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein
    • Goda S, Quale AC, Woods ML, Felthauser A, Shimizu Y. Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein. J Immunol 2004 172 : 5379 5387.
    • (2004) J Immunol , vol.172 , pp. 5379-5387
    • Goda, S.1    Quale, A.C.2    Woods, M.L.3    Felthauser, A.4    Shimizu, Y.5
  • 20
    • 0035889958 scopus 로고    scopus 로고
    • Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70
    • Morgan MM, Labno CM, Van Seventer GA, Denny MF, Straus DB, Burkhardt JK. Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70. J Immunol 2001 167 : 5708 5718.
    • (2001) J Immunol , vol.167 , pp. 5708-5718
    • Morgan, M.M.1    Labno, C.M.2    Van Seventer, G.A.3    Denny, M.F.4    Straus, D.B.5    Burkhardt, J.K.6
  • 21
    • 0035920572 scopus 로고    scopus 로고
    • Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development
    • Gong Q, et al. Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development. J Exp Med 2001 194 : 507 518.
    • (2001) J Exp Med , vol.194 , pp. 507-518
    • Gong, Q.1
  • 22
    • 0033553463 scopus 로고    scopus 로고
    • Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
    • Pelosi M, et al. Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck. J Biol Chem 1999 274 : 14229 14237.
    • (1999) J Biol Chem , vol.274 , pp. 14229-14237
    • Pelosi, M.1
  • 23
    • 0033118329 scopus 로고    scopus 로고
    • Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation
    • Williams BL, et al. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation. EMBO J 1999 18 : 1832 1844.
    • (1999) EMBO J , vol.18 , pp. 1832-1844
    • Williams, B.L.1
  • 24
    • 0345369734 scopus 로고    scopus 로고
    • Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling
    • Di Bartolo V, et al. Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling. J Biol Chem 1999 274 : 6285 6294.
    • (1999) J Biol Chem , vol.274 , pp. 6285-6294
    • Di Bartolo, V.1
  • 25
    • 0029071585 scopus 로고
    • Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function
    • Chan AC, et al. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J 1995 14 : 2499 2508.
    • (1995) EMBO J , vol.14 , pp. 2499-2508
    • Chan, A.C.1
  • 26
    • 0029151944 scopus 로고
    • Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70
    • Wange RL, Guitian R, Isakov N, Watts JD, Aebersold R, Samelson LE. Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J Biol Chem 1995 270 : 18730 18733.
    • (1995) J Biol Chem , vol.270 , pp. 18730-18733
    • Wange, R.L.1    Guitian, R.2    Isakov, N.3    Watts, J.D.4    Aebersold, R.5    Samelson, L.E.6
  • 27
    • 5644297083 scopus 로고    scopus 로고
    • The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: Implications for the design of selective inhibitors
    • Jin L, et al. The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors. J Biol Chem 2004 279 : 42818 42825.
    • (2004) J Biol Chem , vol.279 , pp. 42818-42825
    • Jin, L.1
  • 28
    • 0032931262 scopus 로고    scopus 로고
    • Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes
    • Zhao Q, Williams BL, Abraham RT, Weiss A. Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Mol Cell Biol 1999 19 : 948 956.
    • (1999) Mol Cell Biol , vol.19 , pp. 948-956
    • Zhao, Q.1    Williams, B.L.2    Abraham, R.T.3    Weiss, A.4
  • 29
    • 20344406482 scopus 로고    scopus 로고
    • Intramolecular regulatory switch in ZAP-70: Analogy with receptor tyrosine kinases
    • Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Mol Cell Biol 2005 25 : 4924 4933.
    • (2005) Mol Cell Biol , vol.25 , pp. 4924-4933
    • Brdicka, T.1    Kadlecek, T.A.2    Roose, J.P.3    Pastuszak, A.W.4    Weiss, A.5
  • 30
    • 34249105476 scopus 로고    scopus 로고
    • Structural basis for the inhibition of tyrosine kinase activity of ZAP-70
    • Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J. Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell 2007 129 : 735 746.
    • (2007) Cell , vol.129 , pp. 735-746
    • Deindl, S.1    Kadlecek, T.A.2    Brdicka, T.3    Cao, X.4    Weiss, A.5    Kuriyan, J.6
  • 31
    • 0031034930 scopus 로고    scopus 로고
    • Crystal structure of the Src family tyrosine kinase Hck
    • Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. Nature 1997 385 : 602 609.
    • (1997) Nature , vol.385 , pp. 602-609
    • Sicheri, F.1    Moarefi, I.2    Kuriyan, J.3
  • 32
    • 0031025991 scopus 로고    scopus 로고
    • Three-dimensional structure of the tyrosine kinase c-Src
    • Xu W, Harrison SC, Eck MJ. Three-dimensional structure of the tyrosine kinase c-Src. Nature 1997 385 : 595 602.
    • (1997) Nature , vol.385 , pp. 595-602
    • Xu, W.1    Harrison, S.C.2    Eck, M.J.3
  • 34
    • 0034671563 scopus 로고    scopus 로고
    • Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors
    • Jeffrey PD, Tong L, Pavletich NP. Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Genes Dev 2000 14 : 3115 3125.
    • (2000) Genes Dev , vol.14 , pp. 3115-3125
    • Jeffrey, P.D.1    Tong, L.2    Pavletich, N.P.3
  • 35
    • 0029928988 scopus 로고    scopus 로고
    • Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5′-triphosphate
    • Robinson MJ, et al. Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5′-triphosphate. Biochemistry 1996 35 : 5641 5646.
    • (1996) Biochemistry , vol.35 , pp. 5641-5646
    • Robinson, M.J.1
  • 36
    • 34548250374 scopus 로고    scopus 로고
    • A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases
    • Chen H, et al. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol Cell 2007 27 : 717 730.
    • (2007) Mol Cell , vol.27 , pp. 717-730
    • Chen, H.1
  • 37
    • 7944231534 scopus 로고    scopus 로고
    • Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
    • Palacios EH, Weiss A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 2004 23 : 7990 8000.
    • (2004) Oncogene , vol.23 , pp. 7990-8000
    • Palacios, E.H.1    Weiss, A.2
  • 38
    • 0028783322 scopus 로고
    • Syk tyrosine kinase required for mouse viability and B-cell development
    • Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T. Syk tyrosine kinase required for mouse viability and B-cell development. Nature 1995 378 : 303 306.
    • (1995) Nature , vol.378 , pp. 303-306
    • Cheng, A.M.1    Rowley, B.2    Pao, W.3    Hayday, A.4    Bolen, J.B.5    Pawson, T.6
  • 39
    • 0032211059 scopus 로고    scopus 로고
    • Differential requirements for ZAP-70 in TCR signaling and T cell development
    • Kadlecek TA, et al. Differential requirements for ZAP-70 in TCR signaling and T cell development. J Immunol 1998 161 : 4688 4694.
    • (1998) J Immunol , vol.161 , pp. 4688-4694
    • Kadlecek, T.A.1
  • 40
    • 0029133646 scopus 로고
    • Essential role for ZAP-70 in both positive and negative selection of thymocytes
    • Negishi I, et al. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 1995 376 : 435 438.
    • (1995) Nature , vol.376 , pp. 435-438
    • Negishi, I.1
  • 41
    • 0033526058 scopus 로고    scopus 로고
    • ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck)
    • Ashe JM, Wiest DL, Abe R, Singer A. ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck). J Exp Med 1999 189 : 1163 1168.
    • (1999) J Exp Med , vol.189 , pp. 1163-1168
    • Ashe, J.M.1    Wiest, D.L.2    Abe, R.3    Singer, A.4
  • 42
    • 0028889302 scopus 로고
    • Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
    • Turner M, et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 1995 378 : 298 302.
    • (1995) Nature , vol.378 , pp. 298-302
    • Turner, M.1
  • 43
    • 0030802798 scopus 로고    scopus 로고
    • Protein tyrosine kinases in thymocyte development
    • Cheng AM, Chan AC. Protein tyrosine kinases in thymocyte development. Curr Opin Immunol 1997 9 : 528 533.
    • (1997) Curr Opin Immunol , vol.9 , pp. 528-533
    • Cheng, A.M.1    Chan, A.C.2
  • 44
    • 34447290423 scopus 로고    scopus 로고
    • Distinct roles for Syk and ZAP-70 during early thymocyte development
    • Palacios EH, Weiss A. Distinct roles for Syk and ZAP-70 during early thymocyte development. J Exp Med 2007 204 : 1703 1715.
    • (2007) J Exp Med , vol.204 , pp. 1703-1715
    • Palacios, E.H.1    Weiss, A.2
  • 45
    • 0033197970 scopus 로고    scopus 로고
    • Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression
    • Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. J Immunol 1999 163 : 2610 2620.
    • (1999) J Immunol , vol.163 , pp. 2610-2620
    • Chu, D.H.1    Van Oers, N.S.2    Malissen, M.3    Harris, J.4    Elder, M.5    Weiss, A.6
  • 46
    • 0029952988 scopus 로고    scopus 로고
    • The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling
    • Chu DH, Spits H, Peyron JF, Rowley RB, Bolen JB, Weiss A. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J 1996 15 : 6251 6261.
    • (1996) EMBO J , vol.15 , pp. 6251-6261
    • Chu, D.H.1    Spits, H.2    Peyron, J.F.3    Rowley, R.B.4    Bolen, J.B.5    Weiss, A.6
  • 47
    • 0032401942 scopus 로고    scopus 로고
    • Beta-selection of immature thymocytes is less dependent on CD45 tyrosinephosphatase
    • Sato T, Kishihara K, Mak TW, Habu S. Beta-selection of immature thymocytes is less dependent on CD45 tyrosinephosphatase. Immunol Lett 1998 64 : 133 138.
    • (1998) Immunol Lett , vol.64 , pp. 133-138
    • Sato, T.1    Kishihara, K.2    Mak, T.W.3    Habu, S.4
  • 48
    • 0027296521 scopus 로고
    • Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice
    • Kishihara K, et al. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell 1993 74 : 143 156.
    • (1993) Cell , vol.74 , pp. 143-156
    • Kishihara, K.1
  • 49
    • 0029076731 scopus 로고
    • Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase
    • Kong GH, Bu JY, Kurosaki T, Shaw AS, Chan AC. Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase. Immunity 1995 2 : 485 492.
    • (1995) Immunity , vol.2 , pp. 485-492
    • Kong, G.H.1    Bu, J.Y.2    Kurosaki, T.3    Shaw, A.S.4    Chan, A.C.5
  • 50
    • 37049019860 scopus 로고    scopus 로고
    • Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions
    • Siggs OM, et al. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 2007 27 : 912 926.
    • (2007) Immunity , vol.27 , pp. 912-926
    • Siggs, O.M.1
  • 51
    • 0028486218 scopus 로고
    • Immunodeficiency diseases. Multiple roles for ZAP-70
    • Hivroz C, Fischer A. Immunodeficiency diseases. Multiple roles for ZAP-70. Curr Biol 1994 4 : 731 733.
    • (1994) Curr Biol , vol.4 , pp. 731-733
    • Hivroz, C.1    Fischer, A.2
  • 52
    • 0028292001 scopus 로고
    • Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
    • Elder ME, et al. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 1994 264 : 1596 1599.
    • (1994) Science , vol.264 , pp. 1596-1599
    • Elder, M.E.1
  • 53
    • 0029087530 scopus 로고
    • Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes
    • Gelfand EW, Weinberg K, Mazer BD, Kadlecek TA, Weiss A. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. J Exp Med 1995 182 : 1057 1065.
    • (1995) J Exp Med , vol.182 , pp. 1057-1065
    • Gelfand, E.W.1    Weinberg, K.2    Mazer, B.D.3    Kadlecek, T.A.4    Weiss, A.5
  • 54
    • 0028340167 scopus 로고
    • ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency
    • Chan AC, et al. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 1994 264 : 1599 1601.
    • (1994) Science , vol.264 , pp. 1599-1601
    • Chan, A.C.1
  • 55
    • 0028269436 scopus 로고
    • Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase
    • Arpaia E, Shahar M, Dadi H, Cohen A, Roifman CM. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Cell 1994 76 : 947 958.
    • (1994) Cell , vol.76 , pp. 947-958
    • Arpaia, E.1    Shahar, M.2    Dadi, H.3    Cohen, A.4    Roifman, C.M.5
  • 56
    • 0033520933 scopus 로고    scopus 로고
    • Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37
    • Matsuda S, Suzuki-Fujimoto T, Minowa A, Ueno H, Katamura K, Koyasu S. Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37. J Biol Chem 1999 274 : 34515 34518.
    • (1999) J Biol Chem , vol.274 , pp. 34515-34518
    • Matsuda, S.1    Suzuki-Fujimoto, T.2    Minowa, A.3    Ueno, H.4    Katamura, K.5    Koyasu, S.6
  • 57
    • 0035159584 scopus 로고    scopus 로고
    • Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70
    • Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A. Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70. J Immunol 2001 166 : 656 661.
    • (2001) J Immunol , vol.166 , pp. 656-661
    • Elder, M.E.1    Skoda-Smith, S.2    Kadlecek, T.A.3    Wang, F.4    Wu, J.5    Weiss, A.6
  • 58
    • 0030802186 scopus 로고    scopus 로고
    • A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development
    • Wiest DL, et al. A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 1997 6 : 663 671.
    • (1997) Immunity , vol.6 , pp. 663-671
    • Wiest, D.L.1
  • 59
    • 0031788487 scopus 로고    scopus 로고
    • The Syk family of protein tyrosine kinases in T-cell activation and development
    • Chu DH, Morita CT, Weiss A. The Syk family of protein tyrosine kinases in T-cell activation and development. Immunol Rev 1998 165 : 167 180.
    • (1998) Immunol Rev , vol.165 , pp. 167-180
    • Chu, D.H.1    Morita, C.T.2    Weiss, A.3
  • 60
    • 0027379699 scopus 로고
    • + thymocytes by p56lck tyrosine kinase: Basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
    • + thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J Exp Med 1993 178 : 1701 1712.
    • (1993) J Exp Med , vol.178 , pp. 1701-1712
    • Wiest, D.L.1
  • 62
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • Rosenwald A, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001 194 : 1639 1647.
    • (2001) J Exp Med , vol.194 , pp. 1639-1647
    • Rosenwald, A.1
  • 63
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti LZ, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004 351 : 893 901.
    • (2004) N Engl J Med , vol.351 , pp. 893-901
    • Rassenti, L.Z.1
  • 64
    • 0030706136 scopus 로고    scopus 로고
    • Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells
    • Semichon M, Merle-Beral H, Lang V, Bismuth G. Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells. Leukemia 1997 11 : 1921 1928.
    • (1997) Leukemia , vol.11 , pp. 1921-1928
    • Semichon, M.1    Merle-Beral, H.2    Lang, V.3    Bismuth, G.4
  • 65
    • 0037114744 scopus 로고    scopus 로고
    • Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
    • Chen L, et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002 100 : 4609 4614.
    • (2002) Blood , vol.100 , pp. 4609-4614
    • Chen, L.1
  • 66
    • 14944352799 scopus 로고    scopus 로고
    • ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
    • Chen L, et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 2005 105 : 2036 2041.
    • (2005) Blood , vol.105 , pp. 2036-2041
    • Chen, L.1
  • 67
    • 41949140313 scopus 로고    scopus 로고
    • ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
    • Chen L, et al. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood 2008 111 : 2685 2692.
    • (2008) Blood , vol.111 , pp. 2685-2692
    • Chen, L.1
  • 68
    • 23844466900 scopus 로고    scopus 로고
    • B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia
    • Allsup DJ, et al. B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia. Cancer Res 2005 65 : 7328 7337.
    • (2005) Cancer Res , vol.65 , pp. 7328-7337
    • Allsup, D.J.1
  • 69
    • 29144449249 scopus 로고    scopus 로고
    • The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia
    • Del Poeta G, et al. The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia. Cancer 2005 104 : 2743 2752.
    • (2005) Cancer , vol.104 , pp. 2743-2752
    • Del Poeta, G.1
  • 70
    • 0345414139 scopus 로고    scopus 로고
    • Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
    • Sakaguchi N, et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 2003 426 : 454 460.
    • (2003) Nature , vol.426 , pp. 454-460
    • Sakaguchi, N.1
  • 71
    • 20244373339 scopus 로고    scopus 로고
    • A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
    • Yoshitomi H, et al. A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med 2005 201 : 949 960.
    • (2005) J Exp Med , vol.201 , pp. 949-960
    • Yoshitomi, H.1
  • 72
    • 33745156509 scopus 로고    scopus 로고
    • Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1
    • Sakaguchi S, Sakaguchi N, Yoshitomi H, Hata H, Takahashi T, Nomura T. Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1. Semin Immunol 2006 18 : 199 206.
    • (2006) Semin Immunol , vol.18 , pp. 199-206
    • Sakaguchi, S.1    Sakaguchi, N.2    Yoshitomi, H.3    Hata, H.4    Takahashi, T.5    Nomura, T.6
  • 73
    • 47249150250 scopus 로고    scopus 로고
    • Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling
    • Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem 2008 283 : 15419 15430.
    • (2008) J Biol Chem , vol.283 , pp. 15419-15430
    • Levin, S.E.1    Zhang, C.2    Kadlecek, T.A.3    Shokat, K.M.4    Weiss, A.5
  • 74
    • 0033063429 scopus 로고    scopus 로고
    • Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
    • Schindler T, Sicheri F, Pico A, Gazit A, Levitzki A, Kuriyan J. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol Cell 1999 3 : 639 648.
    • (1999) Mol Cell , vol.3 , pp. 639-648
    • Schindler, T.1    Sicheri, F.2    Pico, A.3    Gazit, A.4    Levitzki, A.5    Kuriyan, J.6
  • 75
    • 0033001789 scopus 로고    scopus 로고
    • Crystal structures of c-Src reveal features of its autoinhibitory mechanism
    • Xu W, Doshi A, Lei M, Eck MJ, Harrison SC. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol Cell 1999 3 : 629 638.
    • (1999) Mol Cell , vol.3 , pp. 629-638
    • Xu, W.1    Doshi, A.2    Lei, M.3    Eck, M.J.4    Harrison, S.C.5


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