Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Chen, Yixiong ^a   Zheng, Shaoping ^a   Qi, Dan ^a   Zheng, Shaojiang ^b   Guo, Junli ^b   Zhang, Shuling ^a   Weng, Zhihong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

[N (3,5 DIFLUOROPHENACETYL) LEVO ALANYL]PHENYLGLYCINE TERT BUTYL ESTER; CARBON TETRACHLORIDE; GAMMA SECRETASE INHIBITOR; JAGGED1; NOTCH RECEPTOR; NOTCH3 RECEPTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; EPITHELIAL MESENCHYMAL TRANSITION; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ENZYME INHIBITORS; LIVER CIRRHOSIS; RATS; RECEPTORS, NOTCH; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

GASTROPODA; RATTUS;

EID: 84867068023     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046512     Document Type: Article

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