Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

Annals of the Rheumatic Diseases

Volumn 70, Issue 7, 2011, Pages 1304-1310

  Dees, Clara ^a   Tomcik, Michal ^a,b   Zerr, Pawel ^a   Akhmetshina, Alfiya ^a   Horn, Angelika ^a   Palumbo, Katrin ^a   Beyer, Christian ^a   Zwerina, Jochen ^a   Distler, Oliver ^c   Schett, Georg ^a   Distler, Jörg H W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; FC RECEPTOR; JAGGED1; NOTCH RECEPTOR; TRANSCRIPTION FACTOR HES 1;

ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; HES 1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MYOFIBROBLAST; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; SYSTEMIC SCLEROSIS;

ADULT; AGED; AMYLOID PRECURSOR PROTEIN SECRETASES; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MYOFIBROBLASTS; RECEPTORS, NOTCH; RECOMBINANT PROTEINS; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SKIN; YOUNG ADULT;

EID: 79957637197     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.134742     Document Type: Article

References (30)

1. Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007;117:557-67.
2. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008;214:199-210.
3. Fortini ME. Notch signaling: the core pathway and its posttranslational regulation. Dev Cell 2009;16:633-47.
4. Mohr OL. Character Changes Caused by Mutation of an Entire Region of a Chromosome in Drosophila. Genetics 1919;4:275-82.
5. Amsen D, Blander JM, Lee GR, et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 2004;117:515-26.
6. D'Souza B, Miyamoto A, Weinmaster G. The many facets of Notch ligands. Oncogene 2008;27:5148-67.
7. Pinnix CC, Herlyn M. The many faces of Notch signaling in skin-derived cells. Pigment Cell Res 2007;20:458-65.
8. Li L, Krantz ID, Deng Y, et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet 1997;16:243-51.
9. Liu ZJ, Xiao M, Balint K, et al. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer Res 2006;66:4182-90.
10. Oda T, Elkahloun AG, Pike BL, et al. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet 1997;16:235-42.
11. Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer. Curr Opin Genet Dev 2007;17:52-9.
12. Real PJ, Ferrando AA. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia. Leukemia 2009;23:1374-7.
13. LeRoy EC, Medsger TA Jr. Criteria for the classification of early systemic sclerosis. J Rheumatol 2001;28:1573-6.
14. Jüngel A, Distler O, Schulze-Horsel U, et al. Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1. Arthritis Rheum 2007;56:3564-74.
15. Czuwara-Ladykowska J, Shirasaki F, Jackers P, et al. Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem 2001;276:20839-48.
16. Akhmetshina A, Dees C, Pileckyte M, et al. Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis. FASEB J 2008;22:2214-22.
17. Distler JH, Jüngel A, Huber LC, et al. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum 2007;56:311-22.
18. Skhirtladze C, Distler O, Dees C, et al. Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis. Arthritis Rheum 2008;58:1475-84.
19. Wu J, Bresnick EH. Bare rudiments of notch signaling: how receptor levels are regulated. Trends Biochem Sci 2007;32:477-85.
20. Baldi A, De Falco M, De Luca L, et al. Characterization of tissue specific expression of Notch-1 in human tissues. Biol Cell 2004;96:303-11.
21. Büchler P, Gazdhar A, Schubert M, et al. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg 2005;242:791-800.
22. Koyanagi M, Bushoven P, Iwasaki M, et al. Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells. Circ Res 2007;101:1139-45.
23. Chigurupati S, Arumugam TV, Son TG, et al. Involvement of notch signaling in wound healing. PLoS ONE 2007;2:e1167.
24. Monsalve E, Ruiz-García A, Baladrón V, et al. Notch1 upregulates LPS-induced macrophage activation by increasing NF-kappaB activity. Eur J Immunol 2009;39:2556-70.
25. Kavian N, Servettaz A, Mongaret C, et al. Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model. Arthritis Rheum 2010;62:3477-87.
26. Guo X, Wang XF. Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res 2009;19:71-88.
27. Jögi A, Øra I, Nilsson H, et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci USA 2002;99:7021-6.
28. Morrissey J, Guo G, Moridaira K, et al. Transforming growth factor-beta induces renal epithelial jagged-1 expression in fibrotic disease. J Am Soc Nephrol 2002;13:1499-508.
29. Gridley T. Notch signaling in the vasculature. Curr Top Dev Biol 2010;92:277-309.
30. Li X, Zhang X, Leathers R, et al. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med 2009;15:1289-97.