Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis

Nephrology Dialysis Transplantation

Volumn 26, Issue 9, 2011, Pages 2770-2779

  Washida, Naoki ^a   Wakino, Shu ^a   Tonozuka, Yukio ^b   Homma, Koichiro ^a   Tokuyama, Hirobumi ^a   Hara, Yoshikazu ^a   Hasegawa, Kazuhiro ^a   Minakuchi, Hitoshi ^a   Fujimura, Keiko ^a   Hosoya, Kohji ^a   Hayashi, Koichi ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY   (Japan)

^b Baxter Inc   (Japan)

Author keywords

angiogenesis; peritoneal dialysis; peritoneal fibrosis; peritonium; Rho kinase inhibitor

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA SMOOTH MUSCLE ACTIN; CD8 ANTIGEN; CHLORHEXIDINE; FASUDIL; FIBRONECTIN; GLUCOSE; RHO KINASE; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE MIGRATION; MALE; MESOTHELIUM CELL; NONHUMAN; PATHOGENESIS; PERITONEAL FIBROSIS; PRIORITY JOURNAL; RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMIDES; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CELLS, CULTURED; CHLORHEXIDINE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EPITHELIUM; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; NEOVASCULARIZATION, PATHOLOGIC; PERITONEAL FIBROSIS; PLEURAL CAVITY; PYRIDINES; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RHO-ASSOCIATED KINASES; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80053187979     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr012     Document Type: Article

References (46)

1. Margetts PJ, Bonniaud P. Basic mechanisms and clinical implications of peritoneal fibrosis-in depth review. Perit Dial Int 2003; 23: 530-541 (Pubitemid 37527296)
2. Margetts PJ, Kolb M, Galt T et al. Gene transfer of transsorming growth factor-beta1 to the rat peritoneum: effects on membrane function. J Am Soc Nephrol 2001; 12: 2029-2039 (Pubitemid 32880339)
3. Krediet RT, Lindholm B, Rippe B. Pathophysiology of peritoneal membrane failure. Perit Dial Int 2000; 20: S222-S242
4. Leung JC, Chan LY, Tam KY et al. Regulation of CCN2/CTGF and related cytokines in cultured peritoneal cells under conditions simulating peritoneal dialysis. Nephrol Dial Transplant 2009; 24: 458-469
5. Xu ZG, Kim KS, Park HC et al. High glucose activates the p38 MAPK pathway in cultured human peritoneal mesothelial cells. Kidney Int 2003; 63: 958-968 (Pubitemid 36315573)
6. Mandl-Weber S, Cohen CD, Haslinger B et al. Vascular endothelial growth factor production and regulation in human peritoneal mesothelial cells. Kidney Int 2002; 61: 570-578 (Pubitemid 34102598)
7. Witowski J, Korybalska K, Ksiazek K et al. Peritoneal dialysis with solutions low in glucose degradation products is associated with improved biocompatibility profile towards peritoneal mesothelial cells. Nephrol Dial Transplant 2004; 19: 917-924 (Pubitemid 38455665)
8. Liu Y. Epithelial to messenchymal transition in renal fibrogenesis; Pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004; 15: 1-12 (Pubitemid 38020692)
9. Zweers MM, de Waart DR, Smit W et al. Growth factors VEGF and TGF-beta1 in peritoneal dialysis. J Lab Clin Med 1999; 134: 124-132 (Pubitemid 29375441)
10. Saxena R. Pathogenesis and treatment of peritoneal membrane failure. Pediatr Nephrol 2008; 23: 695-703 (Pubitemid 351486181)
11. Augustine T, Brown PW, Davies SD et al. Encapsulating peritoneal sclerosis: clinical significance and implications. Nephron Clin Pract 2009; 111: 149-154
12. Miyazaki M, Yuzawa Y. The role of peritoneal fibrosis in encapsulating peritoneal sclerosis. Perit Dial Int 2005; 25: 48-56
13. Schwartz SM. Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest 1997; 100: 87-89
14. Amano M, Chihara K, Kimura K et al. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 1997; 275: 1308-1311 (Pubitemid 27114159)
15. Olson MF. Applications for ROCK kinase inhibition. Curr Opin Cell Biol 2008; 20: 242-248
16. Nagatoya K, Moriyama T, Kawada N et al. Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Kidney Int 2002; 61: 1684-1695 (Pubitemid 34437922)
17. Murata T, Arii S, Nakamura T et al. Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells. J Hepatol 2001; 35: 474-481 (Pubitemid 32964446)
18. Vargha R, Endemann M, Kratochwill K et al. Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents. Nephrol Dial Transplant 2006; 21: 2943-2947 (Pubitemid 44542254)
19. Margetts PJ, Bonniaud P, Liu L et al. Transient overexpression of TGF-beta1 induces epithelial messenchymal transition in the rodent peritoneum. J Am Soc Nephrol 2005; 16: 425-436 (Pubitemid 41725138)
20. Patel S, Takagi KI, Suzuki J et al. RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation. J Am Soc Nephrol 2005; 16: 1977-1984 (Pubitemid 41716428)
21. Mizukami Y, Fujiki K, Duerr EM et al. Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J Biol Chem 2006; 281: 13957-13963 (Pubitemid 43848321)
22. Kanda T, Wakino S, Hayashi K et al. Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats. Kidney Int 2003; 64: 2009-2019 (Pubitemid 37449535)
23. Sasaki Y, Suzuki M, Hidaka H. The novel and specific Rho-kinase inhibitor (S)-(1)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. Pharmacol Ther 2002; 93: 225-232 (Pubitemid 34615563)
24. Mondello S, Mazzon E, Di Paola R et al. Erythropoietin suppresses peritoneal fibrosis in rat experimental model. Eur J Pharmacol 2009; 604: 138-149
25. Riesenhuber A, Kasper DC, Vargha R et al. Quercetin protects human mesothelial cells against exposure to peritoneal dialysis fluid. Pediatr Nephrol 2007; 22: 1205-1208
26. Arbeiter K, Bidmon B, Endemann M et al. Peritoneal dialysate fluid composition determines heat shock protein expression patterns in human mesothelial cells. Kidney Int 2001; 60: 1930-1937 (Pubitemid 32999999)
27. Bidmon B, Endemann M, Arbeiter K et al. Overexpression of HSP-72 confers cytoprotection in experimental peritoneal dialysis. Kidney Int 2004; 66: 2300-2307 (Pubitemid 41115293)
28. Kanda T, Wakino S, Homma K et al. Rho-kinase as a molecular target for insulin resistance and hypertension. FASEB J 2006; 20: 169-171 (Pubitemid 43100503)
29. Fusshoeller A. Histomorphological and functional changes of the peritoneal membrane during long-term peritoneal dialysis. Pediatr Nephrol 2008; 23: 19-25 (Pubitemid 350245968)
30. Io H, Hamada C, Ro Y et al. Morphologic changes of peritoneum and expression of VEGF in encapsulated peritoneal sclerosis rat models. Kidney Int 2004; 65: 1927-1936 (Pubitemid 38591045)
31. Hirahara I, Ogawa Y, Kusano E et al. Activation of matrix metalloproteinase-2 causes peritoneal injury during peritoneal dialysis in rats. Nephrol Dial Transplant 2004; 19: 1732-1741 (Pubitemid 38961381)
32. Bozkurt D, Cetin P, Sipahi S et al. The effects of renin-angiotensin system inhibition on regression of encapsulating peritoneal sclerosis. Perit Dial Int 2008; 28: S38-S42
33. Suga H, Teraoka S, Ota K et al. Preventive effect of pirfenidone against experimental sclerosing peritonitis in rats. Exp Toxicol Pathol 1995; 47: 287-291
34. Miyata K, Shimokawa H, Kandabashi T et al. Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler Thromb Vasc Biol 2000; 20: 2351-2358
35. Yanez-Mo M, Lara-Pezzl E, Selgas R et al. Peritoneal dialysis and epithelial-to-messenchymal transition of mesothelial cells. N Engl J Med 2003; 348: 403-413 (Pubitemid 36159357)
36. Margetts PJ, Gyorffy S, Kolb M et al. Antiangiogenic and antifibrotic gene therapy in a chronic infusion model of peritoneal dialysis in rats. J Am Soc Nephrol 2002; 13: 721-728 (Pubitemid 34183938)
37. Wakino S, Kanda T, Hayashi K. Rho/Rho kinase as a potential target for the treatment of renal disease. Drug News Perspect 2005; 18: 639-643
38. Masszi A, Di Ciano C, Sirokmány G et al. Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol 2003; 284: F911-F924 (Pubitemid 36443575)
39. Kolosionek E, Savai R, Ghofrani HA et al. Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. Mol Biol Cell 2009; 20: 4751-4765
40. Cho HJ, Yoo J. Rho activation is required for transforming growth factor-beta-induced epithelial-mesenchymal transition in lens epithelial cells. Cell Biol Int 2007; 31: 1225-1230 (Pubitemid 47030990)
41. Compton LA, Potash DA, Mundell NA et al. Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells. Dev Dyn 2006; 235: 82-93 (Pubitemid 46939705)
42. Sugano N, Wakino S, Kanda T et al. T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy. Kidney Int 2008; 73: 826-834 (Pubitemid 351398286)
43. Aroeira LS, Aguilera A, Sánchez-Tomero JA et al. Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions. J Am Soc Nephrol 2007; 18: 2004-2013 (Pubitemid 47041064)
44. Szeto CC, Wong TY, Lai KB et al. The role of vascular endothelial growth factor in peritoneal hyperpermeability during CAPD-related peritonitis. Perit Dial Int 2002; 22: 265-267 (Pubitemid 34546340)
45. Aroeira LS, Aguilera A, Selgas R et al. Mesenchymal conversion of mesothelial cells as a mechanism responsible for high solute transport rate in peritoneal dialysis: role of vascular endothelial growth factor. Am J Kidney Dis 2005; 46: 938-948 (Pubitemid 41505470)
46. van Nieuw Amerongen GP, Koolwijk P, Versteilen A et al. Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro. Arterioscler Thromb Vasc Biol 2003; 23: 211-217 (Pubitemid 36231930)