Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFβ expression

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Radstake, Timothy R D J ^a,b   van Bon, Lenny ^a,b   Broen, Jasper ^a,b   Wenink, Mark ^a   Santegoets, Kim ^a   Deng, Yanhui ^b   Hussaini, Anila ^b   Simms, Robert ^b   Cruikshank, William W ^b   Lafyatis, Robert ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; CYTOKINE ANTIBODY; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; HYDROXYCHLOROQUINE; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 3 ANTIBODY; INTERLEUKIN 7 RECEPTOR; L SELECTIN; METHOTREXATE; PREDNISOLONE; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CD3 ANTIGEN; INTERLEUKIN 7 RECEPTOR ALPHA; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY; T LYMPHOCYTE ANTIGEN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELL SUSPENSION; CONTROLLED STUDY; DISEASE DURATION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; INCUBATION TIME; LOW DRUG DOSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY T LYMPHOCYTE; SKIN DISEASE; SYSTEMIC SCLEROSIS; UPREGULATION; BIOSYNTHESIS; CASE CONTROL STUDY; CHEMISTRY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL;

ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CASE-CONTROL STUDIES; FEMALE; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; SCLERODERMA, SYSTEMIC; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 67650128154     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005981     Document Type: Article

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