-
1
-
-
0026787698
-
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein
-
Stracke ML, Krutzsch HC, Unsworth EJ, Arestad A, Cioce V, Schiffmann E, Liotta LA: Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem (1992) 267(4):2524-2529.
-
(1992)
J. Biol. Chem.
, vol.267
, Issue.4
, pp. 2524-2529
-
-
Stracke, M.L.1
Krutzsch, H.C.2
Unsworth, E.J.3
Arestad, A.4
Cioce, V.5
Schiffmann, E.6
Liotta, L.A.7
-
2
-
-
0141593615
-
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate
-
Clair T, Aoki J, Koh E, Bandle RW, Nam SW, Ptaszynska MM, Mills GB, Schiffmann E, Liotta LA, Stracke ML: Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. Cancer Res (2003) 63(17):5446-5453.
-
(2003)
Cancer Res.
, vol.63
, Issue.17
, pp. 5446-5453
-
-
Clair, T.1
Aoki, J.2
Koh, E.3
Bandle, R.W.4
Nam, S.W.5
Ptaszynska, M.M.6
Mills, G.B.7
Schiffmann, E.8
Liotta, L.A.9
Stracke, M.L.10
-
3
-
-
0037131366
-
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase
-
Tokumura A, Majima E, Kariya Y, Tominaga K, Kogure K, Yasuda K, Fukuzawa K: Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem (2002) 277(42):39436-39442.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.42
, pp. 39436-39442
-
-
Tokumura, A.1
Majima, E.2
Kariya, Y.3
Tominaga, K.4
Kogure, K.5
Yasuda, K.6
Fukuzawa, K.7
-
4
-
-
1542359873
-
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
-
•• Describes ATX, a member of the nucleotide pyrophosphatase/PDE family of ecto-enzymes that is identical to plasma lysoPLD and acts by hydrolyzing LPC to LPA, a lipid mediator that promotes cell proliferation, migration and cell survival. The production of LPA by ATX accounts for the biological effect of ATX on various cancer cell lines in vitro
-
Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, Yamori T, Mills GB, Inoue K, Aoki J, Arai H: Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol (2002) 158(2):227-233. •• Describes ATX, a member of the nucleotide pyrophosphatase/PDE family of ecto-enzymes that is identical to plasma lysoPLD and acts by hydrolyzing LPC to LPA, a lipid mediator that promotes cell proliferation, migration and cell survival. The production of LPA by ATX accounts for the biological effect of ATX on various cancer cell lines in vitro.
-
(2002)
J. Cell. Biol.
, vol.158
, Issue.2
, pp. 227-233
-
-
Umezu-Goto, M.1
Kishi, Y.2
Taira, A.3
Hama, K.4
Dohmae, N.5
Takio, K.6
Yamori, T.7
Mills, G.B.8
Inoue, K.9
Aoki, J.10
Arai, H.11
-
5
-
-
56949095716
-
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
-
Pyne S, Lee SC, Long J, Pyne NJ: Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell Signal (2009) 21(1):14-21.
-
(2009)
Cell. Signal
, vol.21
, Issue.1
, pp. 14-21
-
-
Pyne, S.1
Lee, S.C.2
Long, J.3
Pyne, N.J.4
-
6
-
-
0027232391
-
The bioactive phospholipid lysophosphatidic acid is released from activated platelets
-
Eichholtz T, Jalink K, Fahrenfort I, Moolenaar WH: The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem J (1993) 291 (Pt 3) : 677-680.
-
(1993)
Biochem. J.
, vol.291
, Issue.3 PT.
, pp. 677-680
-
-
Eichholtz, T.1
Jalink, K.2
Fahrenfort, I.3
Moolenaar, W.H.4
-
7
-
-
0030961305
-
Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum
-
Yatomi Y, Igarashi Y, Yang L, Hisano N, Qi R, Asazuma N, Satoh K, Ozaki Y, Kume S: Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J Biochem (1997) 121(5):969-973.
-
(1997)
J. Biochem.
, vol.121
, Issue.5
, pp. 969-973
-
-
Yatomi, Y.1
Igarashi, Y.2
Yang, L.3
Hisano, N.4
Qi, R.5
Asazuma, N.6
Satoh, K.7
Ozaki, Y.8
Kume, S.9
-
8
-
-
69549103075
-
Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol
-
Makide K, Kitamura H, Sato Y, Okutani M, Aoki J: Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol. Prostaglandins Other Lipid Mediat (2009) 89 (3-4) : 135-139.
-
(2009)
Prostaglandins Other Lipid Mediat
, vol.89
, Issue.3-4
, pp. 135-139
-
-
Makide, K.1
Kitamura, H.2
Sato, Y.3
Okutani, M.4
Aoki, J.5
-
11
-
-
34249720998
-
Cytokines in the pathogenesis of rheumatoid arthritis
-
McInnes IB, Schett G: Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol (2007) 7(6):429-442.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, Issue.6
, pp. 429-442
-
-
McInnes, I.B.1
Schett, G.2
-
12
-
-
0023694150
-
Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis
-
Eastgate JA, Symons JA, Wood NC, Grinlinton FM, di Giovine FS, Duff GW: Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis. Lancet (1988) 2(8613):706-709.
-
(1988)
Lancet
, vol.2
, Issue.8613
, pp. 706-709
-
-
Eastgate, J.A.1
Symons, J.A.2
Wood, N.C.3
Grinlinton, F.M.4
Di Giovine, F.S.5
Duff, G.W.6
-
13
-
-
0023712236
-
Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fuid and serum
-
Saxne T, Palladino MA Jr, Heinegård D, Talal N, Wollheim FA: Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fuid and serum. Arthritis Rheum (1988) 31(8):1041-1045.
-
(1988)
Arthritis Rheum.
, vol.31
, Issue.8
, pp. 1041-1045
-
-
Saxne, T.1
Palladino Jr., M.A.2
Heinegård, D.3
Talal, N.4
Wollheim, F.A.5
-
14
-
-
0029855587
-
Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
-
Müller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, Gay S: Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol (1996) 149(5):1607-1615.
-
(1996)
Am. J. Pathol.
, vol.149
, Issue.5
, pp. 1607-1615
-
-
Müller-Ladner, U.1
Kriegsmann, J.2
Franklin, B.N.3
Matsumoto, S.4
Geiler, T.5
Gay, R.E.6
Gay, S.7
-
15
-
-
38549128932
-
Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: Implications for rheumatoid arthritis?
-
3 receptor and enhance inflammatory cytokines/chemokines in response to LPA, an effect that may exacerbate the disease process
-
3 receptor and enhance inflammatory cytokines/chemokines in response to LPA, an effect that may exacerbate the disease process.
-
(2008)
Mol. Pharmacol.
, vol.73
, Issue.2
, pp. 587-600
-
-
Zhao, C.1
Fernandes, M.J.2
Prestwich, G.D.3
Turgeon, M.4
Battista, J.D.5
Clair, T.6
Poubelle, P.E.7
Bourgoin, S.G.8
-
16
-
-
58149290244
-
Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fuid of patients with rheumatoid arthritis in fibroblast-like synovial cells
-
• Describes the monitoring of LPA levels in synovial fuids from patients with RA and OA
-
Nochi H, Tomura H, Tobo M, Tanaka N, Sato K, Shinozaki T, Kobayashi T, Takagishi K, Ohta H, Okajima F, Tamoto K: Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fuid of patients with rheumatoid arthritis in fibroblast-like synovial cells. J Immunol (2008) 181(7):5111-5119. • Describes the monitoring of LPA levels in synovial fuids from patients with RA and OA.
-
(2008)
J. Immunol.
, vol.181
, Issue.7
, pp. 5111-5119
-
-
Nochi, H.1
Tomura, H.2
Tobo, M.3
Tanaka, N.4
Sato, K.5
Shinozaki, T.6
Kobayashi, T.7
Takagishi, K.8
Ohta, H.9
Okajima, F.10
Tamoto, K.11
-
17
-
-
33644880217
-
Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: Regulation of synovial proliferation and inflammatory gene expression
-
2
-
2.
-
(2006)
Arthritis Rheum.
, vol.54
, Issue.3
, pp. 742-753
-
-
Kitano, M.1
Hla, T.2
Sekiguchi, M.3
Kawahito, Y.4
Yoshimura, R.5
Miyazawa, K.6
Iwasaki, T.7
Sano, H.8
Saba, J.D.9
Tam, Y.Y.10
-
18
-
-
58149463957
-
Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: Impact of TNF-α
-
3 receptor and enhanced the secretion of inflammatory cytokines/chemokines in response to S1P. This study demonstrated that S1P protects synoviocytes firom apoptosis
-
3 receptor and enhanced the secretion of inflammatory cytokines/chemokines in response to S1P. This study demonstrated that S1P protects synoviocytes firom apoptosis.
-
(2008)
J. Lipid Res.
, vol.49
, Issue.11
, pp. 2323-2337
-
-
Zhao, C.1
Fernandes, M.J.2
Turgeon, M.3
Tancrède, S.4
Battista, J.D.5
Poubelle, P.E.6
Bourgoin, S.G.7
-
19
-
-
0030956854
-
Expression and transcriptional regulation of the PD-Iα/autotaxin gene in neuroblastoma
-
Kawagoe H, Stracke ML, Nakamura H, Sano K: Expression and transcriptional regulation of the PD-Iα/autotaxin gene in neuroblastoma. Cancer Res (1997) 57(12):2516-2521. (Pubitemid 27255915)
-
(1997)
Cancer Research
, vol.57
, Issue.12
, pp. 2516-2521
-
-
Kawagoe, H.1
Stracke, M.L.2
Nakamura, H.3
Sano, K.4
-
20
-
-
0036456916
-
Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells
-
Yang SY, Lee J, Park CG, Kim S, Hong S, Chung HC, Min SK, Han JW, Lee HW, Lee HY: Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin Exp Metastasis (2002) 19(7):603-608.
-
(2002)
Clin. Exp. Metastasis
, vol.19
, Issue.7
, pp. 603-608
-
-
Yang, S.Y.1
Lee, J.2
Park, C.G.3
Kim, S.4
Hong, S.5
Chung, H.C.6
Min, S.K.7
Han, J.W.8
Lee, H.W.9
Lee, H.Y.10
-
21
-
-
33745221886
-
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid
-
Kishi Y, Okudaira S, Tanaka M, Hama K, Shida D, Kitayama J, Yamori T, Aoki J, Fujimaki T, Arai H: Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem (2006) 281(25):17492-17500.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.25
, pp. 17492-17500
-
-
Kishi, Y.1
Okudaira, S.2
Tanaka, M.3
Hama, K.4
Shida, D.5
Kitayama, J.6
Yamori, T.7
Aoki, J.8
Fujimaki, T.9
Arai, H.10
-
22
-
-
0036244390
-
Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines
-
Euer N, Schwirzke M, Evtimova V, Burtscher H, Jarsch M, Tarin D, Weidle UH: Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines. Anticancer Res (2002) 22 (2A) : 733-740.
-
(2002)
Anticancer Res.
, vol.22
, Issue.2 A
, pp. 733-740
-
-
Euer, N.1
Schwirzke, M.2
Evtimova, V.3
Burtscher, H.4
Jarsch, M.5
Tarin, D.6
Weidle, U.H.7
-
23
-
-
0035310611
-
Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: A possible role in regulating cardiac function via sphingolipid receptors
-
Liliom K, Sun G, Bünemann M, Virág T, Nusser N, Baker DL, Wang DA, Fabian MJ, Brandts B, Bender K, Eickel A et al: Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: A possible role in regulating cardiac function via sphingolipid receptors. Biochem J (2001) 355 (Pt 1) : 189-197.
-
(2001)
Biochem. J.
, vol.355
, Issue.1 PT.
, pp. 189-197
-
-
Liliom, K.1
Sun, G.2
Bünemann, M.3
Virág, T.4
Nusser, N.5
Baker, D.L.6
Wang, D.A.7
Fabian, M.J.8
Brandts, B.9
Bender, K.10
Eickel, A.11
-
24
-
-
33748757239
-
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid
-
Tanaka M, Okudaira S, Kishi Y, Ohkawa R, Iseki S, Ota M, Noji S, Yatomi Y, Aoki J, Arai H: Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem (2006) 281(35):25822-25830.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.35
, pp. 25822-25830
-
-
Tanaka, M.1
Okudaira, S.2
Kishi, Y.3
Ohkawa, R.4
Iseki, S.5
Ota, M.6
Noji, S.7
Yatomi, Y.8
Aoki, J.9
Arai, H.10
-
25
-
-
33745466418
-
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
-
•• Decribes a gene-targeting study that determined an essential role for ATX in stabilizing blood vessels during embryonic development. ATX was demonstrated to be the major source of plasma LPA, but not S1P, levels in vivo
-
van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradère JP, Pettit TR, Wakelam MJ, Saulnier-Blache JS, Mummery CL, Moolenaar WH et al: Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol (2006) 26(13):5015-5022. •• Decribes a gene-targeting study that determined an essential role for ATX in stabilizing blood vessels during embryonic development. ATX was demonstrated to be the major source of plasma LPA, but not S1P, levels in vivo.
-
(2006)
Mol. Cell. Biol.
, vol.26
, Issue.13
, pp. 5015-5022
-
-
Van Meeteren, L.A.1
Ruurs, P.2
Stortelers, C.3
Bouwman, P.4
Van Rooijen, M.A.5
Pradère, J.P.6
Pettit, T.R.7
Wakelam, M.J.8
Saulnier-Blache, J.S.9
Mummery, C.L.10
Moolenaar, W.H.11
-
26
-
-
0032478615
-
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
-
DOI 10.1074/jbc.273.14.7906
-
An S, Bleu T, Hallmark OG, Goetzl EJ: Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem (1998) 273(14):7906-7910. (Pubitemid 28168837)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.14
, pp. 7906-7910
-
-
An, S.1
Bleu, T.2
Hallmark, O.G.3
Goetzl, E.J.4
-
27
-
-
0033600761
-
Molecular cloning and characterization of a novel human G-proteincoupled receptor, EDG7, for lysophosphatidic acid
-
Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K: Molecular cloning and characterization of a novel human G-proteincoupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem (1999) 274(39):27776-27785.
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.39
, pp. 27776-27785
-
-
Bandoh, K.1
Aoki, J.2
Hosono, H.3
Kobayashi, S.4
Kobayashi, T.5
Murakami-Murofushi, K.6
Tsujimoto, M.7
Arai, H.8
Inoue, K.9
-
28
-
-
0029836932
-
Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
-
Hecht JH, Weiner JA, Post SR, Chun J: Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol (1996) 135(4):1071-1083.
-
(1996)
J. Cell. Biol.
, vol.135
, Issue.4
, pp. 1071-1083
-
-
Hecht, J.H.1
Weiner, J.A.2
Post, S.R.3
Chun, J.4
-
29
-
-
0038152846
-
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
-
Noguchi K, Ishii S, Shimizu T: Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem (2003) 278(28):25600-25606.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.28
, pp. 25600-25606
-
-
Noguchi, K.1
Ishii, S.2
Shimizu, T.3
-
31
-
-
39749127777
-
5 and its ligand LPA are involved in maintenance of human hair growth
-
5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet (2008) 40(3):329-334.
-
(2008)
Nat. Genet.
, vol.40
, Issue.3
, pp. 329-334
-
-
Pasternack, S.M.1
Von Kügelgen, I.2
Aboud, K.A.3
Lee, Y.A.4
Rüschendorf, F.5
Voss, K.6
Hillmer, A.M.7
Molderings, G.J.8
Franz, T.9
Ramirez, A.10
Nürnberg, P.11
-
32
-
-
39749127117
-
5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair
-
5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nat Genet (2008) 40(3):335-339.
-
(2008)
Nat. Genet.
, vol.40
, Issue.3
, pp. 335-339
-
-
Shimomura, Y.1
Wajid, M.2
Ishii, Y.3
Shapiro, L.4
Petukhova, L.5
Gordon, D.6
Christiano, A.M.7
-
33
-
-
34948889998
-
The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor
-
Tabata K, Baba K, Shiraishi A, Ito M, Fujita N: The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun (2007) 363(3):861-866.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.363
, Issue.3
, pp. 861-866
-
-
Tabata, K.1
Baba, K.2
Shiraishi, A.3
Ito, M.4
Fujita, N.5
-
35
-
-
0035895989
-
Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent
-
Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR: Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. J Biol Chem (2001) 276(7):4611-4621.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.7
, pp. 4611-4621
-
-
Hooks, S.B.1
Santos, W.L.2
Im, D.S.3
Heise, C.E.4
Macdonald, T.L.5
Lynch, K.R.6
-
36
-
-
0037422595
-
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist
-
DOI 10.1073/pnas.0135855100
-
McIntyre TM, Pontsler AV, Silva AR, St Hilaire A, Xu Y, Hinshaw JC, Zimmerman GA, Hama K, Aoki J, Arai H, Prestwich GD: Identification of an intracellular receptor for lysophosphatidic acid (LPA) : LPA is a transcellular PPARγ agonist. Proc Natl Acad Sci USA (2003) 100(1):131-136. (Pubitemid 36078041)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.1
, pp. 131-136
-
-
McIntyre, T.M.1
Pontsler, A.V.2
Silva, A.R.3
St. Hilaire, A.4
Xu, Y.5
Hinshaw, J.C.6
Zimmerman, G.A.7
Hama, K.8
Aoki, J.9
Arai, H.10
Prestwich, G.D.11
-
38
-
-
0031014301
-
Signalling properties of lysophosphatidic acid in primary human skin fibroblasts: Role of pertussis toxin-sensitive GTP-binding proteins
-
Pietruck F, Busch S, Virchow S, Brockmeyer N, Siffert W: Signalling properties of lysophosphatidic acid in primary human skin fibroblasts: Role of pertussis toxin-sensitive GTP-binding proteins. Naunyn Schmiedebergs Arch Pharmacol (1997) 355(1):1-7.
-
(1997)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.355
, Issue.1
, pp. 1-7
-
-
Pietruck, F.1
Busch, S.2
Virchow, S.3
Brockmeyer, N.4
Siffert, W.5
-
39
-
-
0036291608
-
Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells
-
Thoreson WB, Ryan JS, Shi C, Kelly ME, Bryson EJ, Toews ML, Ediger TL, Chacko DM: Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2002) 43(7):2450-2461.
-
(2002)
Invest. Ophthalmol. Vis. Sci.
, vol.43
, Issue.7
, pp. 2450-2461
-
-
Thoreson, W.B.1
Ryan, J.S.2
Shi, C.3
Kelly, M.E.4
Bryson, E.J.5
Toews, M.L.6
Ediger, T.L.7
Chacko, D.M.8
-
41
-
-
17044448378
-
Mechanisms in LPA-induced tumor cell migration: Critical role of phosphorylated ERK
-
Stahle M, Veit C, Bachfscher U, Schierling K, Skripczynski B, Hall A, Gierschik P, Giehl K: Mechanisms in LPA-induced tumor cell migration: Critical role of phosphorylated ERK. J Cell Sci (2003) 116 (Pt 18) : 3835-3846.
-
(2003)
J. Cell. Sci.
, vol.116
, Issue.18 PT.
, pp. 3835-3846
-
-
Stahle, M.1
Veit, C.2
Bachfscher, U.3
Schierling, K.4
Skripczynski, B.5
Hall, A.6
Gierschik, P.7
Giehl, K.8
-
42
-
-
0037448449
-
Modulation of phosphoinositide 3-kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling
-
Peres C, Yart A, Perret B, Salles JP, Raynal P: Modulation of phosphoinositide 3-kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling. FEBS Lett (2003) 534 (1-3) : 164-168.
-
(2003)
FEBS Lett.
, vol.534
, Issue.1-3
, pp. 164-168
-
-
Peres, C.1
Yart, A.2
Perret, B.3
Salles, J.P.4
Raynal, P.5
-
43
-
-
0037162032
-
Phosphoinositide 3-kinases in lysophosphatidic acid signaling: Regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway
-
Yart A, Chap H, Raynal P: Phosphoinositide 3-kinases in lysophosphatidic acid signaling: Regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway. Biochim Biophys Acta (2002) 1582 (1-3) : 107-111.
-
(2002)
Biochim. Biophys. Acta
, vol.1582
, Issue.1-3
, pp. 107-111
-
-
Yart, A.1
Chap, H.2
Raynal, P.3
-
45
-
-
0037084077
-
Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression
-
Hahn A, Barth H, Kress M, Mertens PR, Goppelt-Struebe M: Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression. Biochem J (2002) 362 (Pt 1) : 33-40.
-
(2002)
Biochem. J.
, vol.362
, Issue.1 PT.
, pp. 33-40
-
-
Hahn, A.1
Barth, H.2
Kress, M.3
Mertens, P.R.4
Goppelt-Struebe, M.5
-
46
-
-
2442658976
-
Lysophospholipid G protein-coupled receptors
-
Anliker B, Chun J: Lysophospholipid G protein-coupled receptors. J Biol Chem (2004) 279(20):20555-20558.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.20
, pp. 20555-20558
-
-
Anliker, B.1
Chun, J.2
-
48
-
-
12544253058
-
Structural and functional characteristics of S1P receptors
-
Sanchez T, Hla T: Structural and functional characteristics of S1P receptors. J Cell Biochem (2004) 92(5):913-922.
-
(2004)
J. Cell. Biochem.
, vol.92
, Issue.5
, pp. 913-922
-
-
Sanchez, T.1
Hla, T.2
-
49
-
-
0034799675
-
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
-
Garcia JG, Liu F, Verin AD, Birukova A, Dechert MA, Gerthoffer WT, Bamberg JR, English D: Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest (2001) 108(5):689-701.
-
(2001)
J. Clin. Invest.
, vol.108
, Issue.5
, pp. 689-701
-
-
Garcia, J.G.1
Liu, F.2
Verin, A.D.3
Birukova, A.4
Dechert, M.A.5
Gerthoffer, W.T.6
Bamberg, J.R.7
English, D.8
-
50
-
-
0033615537
-
Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
-
Lee MJ, Thangada S, Claffey KP, Ancellin N, Liu CH, Kluk M, Volpi M, Sha'af RI, Hla T: Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell (1999) 99(3):301-312.
-
(1999)
Cell.
, vol.99
, Issue.3
, pp. 301-312
-
-
Lee, M.J.1
Thangada, S.2
Claffey, K.P.3
Ancellin, N.4
Liu, C.H.5
Kluk, M.6
Volpi, M.7
Sha'af, R.I.8
Hla, T.9
-
51
-
-
17944363486
-
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
-
Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, Hla T: Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol Cell (2001) 8(3):693-704.
-
(2001)
Mol. Cell.
, vol.8
, Issue.3
, pp. 693-704
-
-
Lee, M.J.1
Thangada, S.2
Paik, J.H.3
Sapkota, G.P.4
Ancellin, N.5
Chae, S.S.6
Wu, M.7
Morales-Ruiz, M.8
Sessa, W.C.9
Alessi, D.R.10
Hla, T.11
-
52
-
-
0033516586
-
Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5
-
Ancellin N, Hla T: Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J Biol Chem (1999) 274(27):18997-19002.
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.27
, pp. 18997-19002
-
-
Ancellin, N.1
Hla, T.2
-
53
-
-
0037370012
-
i pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform
-
i pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol (2003) 23(5):1534-1545.
-
(2003)
Mol. Cell. Biol.
, vol.23
, Issue.5
, pp. 1534-1545
-
-
Sugimoto, N.1
Takuwa, N.2
Okamoto, H.3
Sakurada, S.4
Takuwa, Y.5
-
55
-
-
49949116576
-
Biological roles of lysophospholipid receptors revealed by genetic null mice: An update
-
Choi JW, Lee CW, Chun J: Biological roles of lysophospholipid receptors revealed by genetic null mice: An update. Biochim Biophys Acta (2008) 1781(9):531-539.
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, Issue.9
, pp. 531-539
-
-
Choi, J.W.1
Lee, C.W.2
Chun, J.3
-
56
-
-
0030582689
-
Treatment of fibroblast-like synoviocytes with IFN-γ results in the down-regulation of autotaxin mRNA
-
Santos AN, Riemann D, Santos AN, Kehlen A, Thiele K, Langner J: Treatment of fibroblast-like synoviocytes with IFN-γ results in the down-regulation of autotaxin mRNA. Biochem Biophys Res Commun (1996) 229(2):419-424.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.229
, Issue.2
, pp. 419-424
-
-
Santos, A.N.1
Riemann, D.2
Santos, A.N.3
Kehlen, A.4
Thiele, K.5
Langner, J.6
-
57
-
-
0035145794
-
IL-1 β-and IL-4-induced downregulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA)
-
Kehlen A, Lauterbach R, Santos AN, Thiele K, Kabisch U, Weber E, Riemann D, Langner J: IL-1 β-and IL-4-induced downregulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA). Clin Exp Immunol (2001) 123(1):147-154.
-
(2001)
Clin. Exp. Immunol.
, vol.123
, Issue.1
, pp. 147-154
-
-
Kehlen, A.1
Lauterbach, R.2
Santos, A.N.3
Thiele, K.4
Kabisch, U.5
Weber, E.6
Riemann, D.7
Langner, J.8
-
58
-
-
0028986238
-
2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells
-
2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell (1995) 80(6):919-927.
-
(1995)
Cell.
, vol.80
, Issue.6
, pp. 919-927
-
-
Fourcade, O.1
Simon, M.F.2
Viodé, C.3
Rugani, N.4
Leballe, F.5
Ragab, A.6
Fournie, B.7
Sarda, L.8
Chap, H.9
-
60
-
-
0037073806
-
Serum lysophosphatidic acid is produced through diverse phospholipase pathways
-
Aoki J, Taira A, Takanezawa Y, Kishi Y, Hama K, Kishimoto T, Mizuno K, Saku K, Taguchi R, Arai H: Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J Biol Chem (2002) 277(50):48737-48744.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.50
, pp. 48737-48744
-
-
Aoki, J.1
Taira, A.2
Takanezawa, Y.3
Kishi, Y.4
Hama, K.5
Kishimoto, T.6
Mizuno, K.7
Saku, K.8
Taguchi, R.9
Arai, H.10
-
61
-
-
71849087397
-
Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis
-
Lai WQ, Irwan AW, Goh HH, Howe HS, Yu DT, Valle-Onate R, McInnes IB, Melendez AJ, Leung BP: Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. J Immunol (2008) 181(11):8010-8017.
-
(2008)
J. Immunol.
, vol.181
, Issue.11
, pp. 8010-8017
-
-
Lai, W.Q.1
Irwan, A.W.2
Goh, H.H.3
Howe, H.S.4
Yu, D.T.5
Valle-Onate, R.6
McInnes, I.B.7
Melendez, A.J.8
Leung, B.P.9
-
62
-
-
52049086486
-
Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling
-
Stortelers C, Kerkhoven R, Moolenaar WH: Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling. BMC Genomics (2008) 9:387.
-
(2008)
BMC Genomics
, vol.9
, pp. 387
-
-
Stortelers, C.1
Kerkhoven, R.2
Moolenaar, W.H.3
-
63
-
-
0020628182
-
Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus
-
Shiozawa S, Shiozawa K, Fujita T: Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus. Arthritis Rheum (1983) 26(4):472-478.
-
(1983)
Arthritis Rheum.
, vol.26
, Issue.4
, pp. 472-478
-
-
Shiozawa, S.1
Shiozawa, K.2
Fujita, T.3
-
64
-
-
14944377754
-
Chemokines and their receptors in rheumatoid arthritis: Future targets?
-
Koch AE: Chemokines and their receptors in rheumatoid arthritis: Future targets? Arthritis Rheum (2005) 52(3):710-721.
-
(2005)
Arthritis Rheum.
, vol.52
, Issue.3
, pp. 710-721
-
-
Koch, A.E.1
-
66
-
-
21744459701
-
Participation of prostacyclin in endothelial dysfunction induced by aldosterone in normotensive and hypertensive rats
-
Blanco-Rivero J, Cachofeiro V, Lahera V, Aras-Lopez R, Márquez-Rodas I, Salaices M, Xavier FE, Ferrer M, Balfagón G: Participation of prostacyclin in endothelial dysfunction induced by aldosterone in normotensive and hypertensive rats. Hypertension (2005) 46(1):107-112.
-
(2005)
Hypertension
, vol.46
, Issue.1
, pp. 107-112
-
-
Blanco-Rivero, J.1
Cachofeiro, V.2
Lahera, V.3
Aras-Lopez, R.4
Márquez-Rodas, I.5
Salaices, M.6
Xavier, F.E.7
Ferrer, M.8
Balfagón, G.9
-
67
-
-
0034994651
-
Cyclooxygenase-2: A novel target for cancer chemotherapy?
-
Dempke W, Rie C, Grothey A, Schmoll HJ: Cyclooxygenase-2: A novel target for cancer chemotherapy? J Cancer Res Clin Oncol (2001) 127(7):411-417.
-
(2001)
J. Cancer Res. Clin. Oncol.
, vol.127
, Issue.7
, pp. 411-417
-
-
Dempke, W.1
Rie, C.2
Grothey, A.3
Schmoll, H.J.4
-
68
-
-
33744471666
-
The potential and rationale for COX-2 inhibitors in lung cancer
-
Krysan K, Reckamp KL, Sharma S, Dubinett SM: The potential and rationale for COX-2 inhibitors in lung cancer. Anticancer Agents Med Chem (2006) 6(3):209-220.
-
(2006)
Anticancer Agents Med. Chem.
, vol.6
, Issue.3
, pp. 209-220
-
-
Krysan, K.1
Reckamp, K.L.2
Sharma, S.3
Dubinett, S.M.4
-
70
-
-
0034926637
-
Dynamic changes in cytokine levels in serum and synovial fuid following filtration leukocytapheresis therapy in patients with rheumatoid arthritis
-
Hidaka T, Suzuki K, Kawakami M, Okada M, Kataharada K, Shinohara T, Takamizawa-Matsumoto M, Ohsuzu F: Dynamic changes in cytokine levels in serum and synovial fuid following filtration leukocytapheresis therapy in patients with rheumatoid arthritis. J Clin Apher (2001) 16(2):74-81.
-
(2001)
J. Clin. Apher
, vol.16
, Issue.2
, pp. 74-81
-
-
Hidaka, T.1
Suzuki, K.2
Kawakami, M.3
Okada, M.4
Kataharada, K.5
Shinohara, T.6
Takamizawa-Matsumoto, M.7
Ohsuzu, F.8
-
71
-
-
0031667896
-
Synovial fluid cytokines in patients with rheumatoid arthritis or other arthritic lesions
-
DOI 10.1046/j.1365-3083.1998.00399.x
-
Lettesjo H, Nordström E, Strom H, Nilsson B, Glinghammar B, Dahlstedt L, Möller E: Synovial fuid cytokines in patients with rheumatoid arthritis or other arthritic lesions. Scand J Immunol (1998) 48(3):286-292. (Pubitemid 28416972)
-
(1998)
Scandinavian Journal of Immunology
, vol.48
, Issue.3
, pp. 286-292
-
-
Lettesjo, H.1
Nordstrom, E.2
Strom, H.3
Nilsson, B.4
Glinghammar, B.5
Dahlstedt, L.6
Moller, E.7
-
74
-
-
33644885430
-
Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells
-
Pi X, Tan SY, Hayes M, Xiao L, Shayman JA, Ling S, Holoshitz J: Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells. Arthritis Rheum (2006) 54(3):754-764.
-
(2006)
Arthritis Rheum.
, vol.54
, Issue.3
, pp. 754-764
-
-
Pi, X.1
Tan, S.Y.2
Hayes, M.3
Xiao, L.4
Shayman, J.A.5
Ling, S.6
Holoshitz, J.7
-
76
-
-
0038011833
-
Evolving concepts of rheumatoid arthritis
-
Firestein GS: Evolving concepts of rheumatoid arthritis. Nature (2003) 423(6937):356-361.
-
(2003)
Nature
, vol.423
, Issue.6937
, pp. 356-361
-
-
Firestein, G.S.1
-
77
-
-
0024582869
-
Changes in the viscosity of hyaluronic acid after exposure to a myeloperoxidase-derived oxidant
-
Baker MS, Green SP, Lowther DA: Changes in the viscosity of hyaluronic acid after exposure to a myeloperoxidase-derived oxidant. Arthritis Rheum (1989) 32(4):461-467.
-
(1989)
Arthritis Rheum.
, vol.32
, Issue.4
, pp. 461-467
-
-
Baker, M.S.1
Green, S.P.2
Lowther, D.A.3
-
78
-
-
0034545158
-
The pathogenesis and prevention of joint damage in rheumatoid arthritis: Advances from synovial biopsy and tissue analysis
-
Tak PP, Bresnihan B: The pathogenesis and prevention of joint damage in rheumatoid arthritis: Advances from synovial biopsy and tissue analysis. Arthritis Rheum (2000) 43(12):2619-2633.
-
(2000)
Arthritis Rheum.
, vol.43
, Issue.12
, pp. 2619-2633
-
-
Tak, P.P.1
Bresnihan, B.2
-
79
-
-
25444499133
-
Neutrophil gene expression in rheumatoid arthritis
-
Cross A, Bakstad D, Allen JC, Thomas L, Moots RJ, Edwards SW: Neutrophil gene expression in rheumatoid arthritis. Pathophysiology (2005) 12(3):191-202.
-
(2005)
Pathophysiology
, vol.12
, Issue.3
, pp. 191-202
-
-
Cross, A.1
Bakstad, D.2
Allen, J.C.3
Thomas, L.4
Moots, R.J.5
Edwards, S.W.6
-
80
-
-
0025823186
-
Quantitation and kinetics of polymorphonuclear leukocyte and lymphocyte accumulation in joints during adjuvant arthritis in the rat
-
Issekutz AC, Issekutz TB: Quantitation and kinetics of polymorphonuclear leukocyte and lymphocyte accumulation in joints during adjuvant arthritis in the rat. Lab Invest (1991) 64(5):656-663.
-
(1991)
Lab. Invest.
, vol.64
, Issue.5
, pp. 656-663
-
-
Issekutz, A.C.1
Issekutz, T.B.2
-
81
-
-
0035423403
-
Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis
-
Wipke BT, Allen PM: Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol (2001) 167(3):1601-1608.
-
(2001)
J. Immunol.
, vol.167
, Issue.3
, pp. 1601-1608
-
-
Wipke, B.T.1
Allen, P.M.2
-
82
-
-
40949164579
-
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs
-
Kanda H, Newton R, Klein R, Morita Y, Gunn MD, Rosen SD: Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol (2008) 9(4):415-423.
-
(2008)
Nat. Immunol.
, vol.9
, Issue.4
, pp. 415-423
-
-
Kanda, H.1
Newton, R.2
Klein, R.3
Morita, Y.4
Gunn, M.D.5
Rosen, S.D.6
-
83
-
-
55349095818
-
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions
-
Nakasaki T, Tanaka T, Okudaira S, Hirosawa M, Umemoto E, Otani K, Jin S, Bai Z, Hayasaka H, Fukui Y, Aozasa K et al: Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions. Am J Pathol (2008) 173(5):1566-1576.
-
(2008)
Am. J. Pathol.
, vol.173
, Issue.5
, pp. 1566-1576
-
-
Nakasaki, T.1
Tanaka, T.2
Okudaira, S.3
Hirosawa, M.4
Umemoto, E.5
Otani, K.6
Jin, S.7
Bai, Z.8
Hayasaka, H.9
Fukui, Y.10
Aozasa, K.11
-
84
-
-
2442590862
-
New drugs for rheumatoid arthritis
-
Olsen NJ, Stein CM: New drugs for rheumatoid arthritis. N Engl J Med (2004) 350(21):2167-2179.
-
(2004)
N. Engl. J. Med.
, vol.350
, Issue.21
, pp. 2167-2179
-
-
Olsen, N.J.1
Stein, C.M.2
-
85
-
-
0035399943
-
TNF-α-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes
-
Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S, Moriwaki H: TNF-α-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol (2001) 167(1):173-180.
-
(2001)
J. Immunol.
, vol.167
, Issue.1
, pp. 173-180
-
-
Osawa, Y.1
Banno, Y.2
Nagaki, M.3
Brenner, D.A.4
Naiki, T.5
Nozawa, Y.6
Nakashima, S.7
Moriwaki, H.8
-
86
-
-
0033544651
-
Tumor necrosis factor-α-mediated signal transduction in human neutrophils: Involvement of sphingomyelin metabolites in the priming effect of TNF-α on the fMLP-stimulated superoxide production
-
Niwa M, Kozawa O, Matsuno H, Kanamori Y, Hara A, Uematsu T: Tumor necrosis factor-α-mediated signal transduction in human neutrophils: Involvement of sphingomyelin metabolites in the priming effect of TNF-α on the fMLP-stimulated superoxide production. Life Sci (2000) 66(3):245-256.
-
(2000)
Life Sci.
, vol.66
, Issue.3
, pp. 245-256
-
-
Niwa, M.1
Kozawa, O.2
Matsuno, H.3
Kanamori, Y.4
Hara, A.5
Uematsu, T.6
-
87
-
-
22744456880
-
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARγ, and inhibitors of autotaxin
-
Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G et al: Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARγ, and inhibitors of autotaxin. J Med Chem (2005) 48(15):4919-4930.
-
(2005)
J. Med. Chem.
, vol.48
, Issue.15
, pp. 4919-4930
-
-
Durgam, G.G.1
Virag, T.2
Walker, M.D.3
Tsukahara, R.4
Yasuda, S.5
Liliom, K.6
Van Meeteren, L.A.7
Moolenaar, W.H.8
Wilke, N.9
Siess, W.10
Tigyi, G.11
-
89
-
-
0035206909
-
3 receptor antagonist
-
3 receptor antagonist. Mol Pharmacol (2001) 60(6):1173-1180.
-
(2001)
Mol. Pharmacol.
, vol.60
, Issue.6
, pp. 1173-1180
-
-
Heise, C.E.1
Santos, W.L.2
Schreihofer, A.M.3
Heasley, B.H.4
Mukhin, Y.V.5
Macdonald, T.L.6
Lynch, K.R.7
-
90
-
-
35448975763
-
α-Substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA
-
Jiang G, Xu Y, Fujiwara Y, Tsukahara T, Tsukahara R, Gajewiak J, Tigyi G, Prestwich GD: α-Substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA. ChemMedChem (2007) 2(5):679-690.
-
(2007)
ChemMedChem
, vol.2
, Issue.5
, pp. 679-690
-
-
Jiang, G.1
Xu, Y.2
Fujiwara, Y.3
Tsukahara, T.4
Tsukahara, R.5
Gajewiak, J.6
Tigyi, G.7
Prestwich, G.D.8
-
91
-
-
0141629758
-
Synthesis of α-fuorinated phosphonates from α- fuorovinylphosphonates: A new route to analogues of lysophosphatidic acid
-
Xu Y, Qian L, Prestwich GD: Synthesis of α-fuorinated phosphonates from α-fuorovinylphosphonates: A new route to analogues of lysophosphatidic acid. Org Lett (2003) 5(13):2267-2270.
-
(2003)
Org. Lett.
, vol.5
, Issue.13
, pp. 2267-2270
-
-
Xu, Y.1
Qian, L.2
Prestwich, G.D.3
-
92
-
-
2942532893
-
Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid
-
Santos WL, Heasley BH, Jarosz R, Carter KM, Lynch KR, Macdonald TL: Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorg Med Chem Lett (2004) 14(13):3473-3476.
-
(2004)
Bioorg Med. Chem. Lett.
, vol.14
, Issue.13
, pp. 3473-3476
-
-
Santos, W.L.1
Heasley, B.H.2
Jarosz, R.3
Carter, K.M.4
Lynch, K.R.5
Macdonald, T.L.6
-
93
-
-
20944435206
-
Structure-activity relationships of fuorinated lysophosphatidic acid analogues
-
Xu Y, Aoki J, Shimizu K, Umezu-Goto M, Hama K, Takanezawa Y, Yu S, Mills GB, Arai H, Qian L, Prestwich DD: Structure-activity relationships of fuorinated lysophosphatidic acid analogues. J Med Chem (2005) 48(9):3319-3327.
-
(2005)
J. Med. Chem.
, vol.48
, Issue.9
, pp. 3319-3327
-
-
Xu, Y.1
Aoki, J.2
Shimizu, K.3
Umezu-Goto, M.4
Hama, K.5
Takanezawa, Y.6
Yu, S.7
Mills, G.B.8
Arai, H.9
Qian, L.10
Prestwich, D.D.11
-
94
-
-
0034812654
-
Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors
-
Fischer DJ, Nusser N, Virag T, Yokoyama K, Wang Da, Baker DL, Bautista D, Parrill AL, Tigyi G: Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors. Mol Pharmacol (2001) 60(4):776-784.
-
(2001)
Mol. Pharmacol.
, vol.60
, Issue.4
, pp. 776-784
-
-
Fischer, D.J.1
Nusser, N.2
Virag, T.3
Yokoyama, K.4
Da, W.5
Baker, D.L.6
Bautista, D.7
Parrill, A.L.8
Tigyi, G.9
-
95
-
-
0141570981
-
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors
-
Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J, Kimura T, Tobo M, Yamazaki Y, Watanabe T, Yagi M et al: Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol (2003) 64(4):994-1005.
-
(2003)
Mol. Pharmacol.
, vol.64
, Issue.4
, pp. 994-1005
-
-
Ohta, H.1
Sato, K.2
Murata, N.3
Damirin, A.4
Malchinkhuu, E.5
Kon, J.6
Kimura, T.7
Tobo, M.8
Yamazaki, Y.9
Watanabe, T.10
Yagi, M.11
-
96
-
-
15444373345
-
Sphingosine 1-phosphate analogs as receptor antagonists
-
Davis MD, Clemens JJ, Macdonald TL, Lynch KR: Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem (2005) 280(11):9833-9841.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.11
, pp. 9833-9841
-
-
Davis, M.D.1
Clemens, J.J.2
Macdonald, T.L.3
Lynch, K.R.4
-
97
-
-
0037057548
-
Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships
-
Koide Y, Hasegawa T, Takahashi A, Endo A, Mochizuki N, Nakagawa M, Nishida A: Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. J Med Chem (2002) 45(21):4629-4638.
-
(2002)
J. Med. Chem.
, vol.45
, Issue.21
, pp. 4629-4638
-
-
Koide, Y.1
Hasegawa, T.2
Takahashi, A.3
Endo, A.4
Mochizuki, N.5
Nakagawa, M.6
Nishida, A.7
-
98
-
-
0036434445
-
Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist
-
Osada M, Yatomi Y, Ohmori T, Ikeda H, Ozaki Y: Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem Biophys Res Commun (2002) 299(3):483-487.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, Issue.3
, pp. 483-487
-
-
Osada, M.1
Yatomi, Y.2
Ohmori, T.3
Ikeda, H.4
Ozaki, Y.5
-
99
-
-
67649807699
-
Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer
-
Peyruchaud O: Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer. Anticancer Agents Med Chem (2009) 9(4):381-391.
-
(2009)
Anticancer Agents Med. Chem.
, vol.9
, Issue.4
, pp. 381-391
-
-
Peyruchaud, O.1
-
100
-
-
65449156892
-
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis
-
Pamuklar Z, Federico L, Liu S, Umezu-Goto M, Dong A, Panchatcharam M, Fulerson Z, Berdyshev E, Natarajan V, Fang X, Van Meerteren LA et al: Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem (2009) 284(11):7385-7394.
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.11
, pp. 7385-7394
-
-
Pamuklar, Z.1
Federico, L.2
Liu, S.3
Umezu-Goto, M.4
Dong, A.5
Panchatcharam, M.6
Fulerson, Z.7
Berdyshev, E.8
Natarajan, V.9
Fang, X.10
Van Meerteren, L.A.11
-
101
-
-
20444386550
-
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate
-
•• Demonstrated that ATX is feedback inhibited by LPA, indicating that LPA can regulate its own synthesis. S1P was revealed as a potent physiological inhibitor of ATX
-
van Meeteren LA, Ruurs P, Christodoulou E, Goding JW, Takakusa H, Kikuchi K, Perrakis A, Nagano T, Moolenaar WH: Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. J Biol Chem (2005) 280(22):21155-21161. •• Demonstrated that ATX is feedback inhibited by LPA, indicating that LPA can regulate its own synthesis. S1P was revealed as a potent physiological inhibitor of ATX.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.22
, pp. 21155-21161
-
-
Van Meeteren, L.A.1
Ruurs, P.2
Christodoulou, E.3
Goding, J.W.4
Takakusa, H.5
Kikuchi, K.6
Perrakis, A.7
Nagano, T.8
Moolenaar, W.H.9
-
102
-
-
33847077525
-
Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors
-
Cui P, Tomsig JL, McCalmont WF, Lee S, Becker CJ, Lynch KR, Macdonald TL: Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors. Bioorg Med Chem Lett (2007) 17(6):1634-1640.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, Issue.6
, pp. 1634-1640
-
-
Cui, P.1
Tomsig, J.L.2
McCalmont, W.F.3
Lee, S.4
Becker, C.J.5
Lynch, K.R.6
Macdonald, T.L.7
-
103
-
-
57349197956
-
S32826, a nanomolar inhibitor of autotaxin: Discovery, synthesis and applications as a pharmacological tool
-
Ferry G, Moulharat N, Pradere JP, Desos P, Try A, Genton A, Giganti A, Beucher-Gaudin M, Lonchampt M, Bertrand M, Saulnier-Blache JS et al: S32826, a nanomolar inhibitor of autotaxin: Discovery, synthesis and applications as a pharmacological tool. J Pharmacol Exp Ther (2008) 327(3):809-819.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.327
, Issue.3
, pp. 809-819
-
-
Ferry, G.1
Moulharat, N.2
Pradere, J.P.3
Desos, P.4
Try, A.5
Genton, A.6
Giganti, A.7
Beucher-Gaudin, M.8
Lonchampt, M.9
Bertrand, M.10
Saulnier-Blache, J.S.11
-
104
-
-
40749104578
-
α-and β-substituted phosphonate analogs of LPA as autotaxin inhibitors
-
Cui P, McCalmont WF, Tomsig JL, Lynch KR, Macdonald TL: α-and β-substituted phosphonate analogs of LPA as autotaxin inhibitors. Bioorg Med Chem (2008) 16(5):2212-2225.
-
(2008)
Bioorg Med. Chem.
, vol.16
, Issue.5
, pp. 2212-2225
-
-
Cui, P.1
McCalmont, W.F.2
Tomsig, J.L.3
Lynch, K.R.4
Macdonald, T.L.5
-
105
-
-
33747354637
-
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis
-
•• Describes carba analogs of ccPA that are selective inhibitors of ATX and that were evaluated as anticancer drug therapy. Cancer cell invasion in vitro and melanoma cell metastasis in vivo were demonstrated to be inhibited by ccPA; the ATX-LPA axis was suggested to be an attractive target for anticancer and anti-angiogenesis therapy
-
Baker DL, Fujiwara Y, Pigg KR, Tsukahara R, Kobayashi S, Murofushi H, Uchiyama A, Murakami-Murofushi K, Koh E, Bandle RW, Byun HS et al: Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis. J Biol Chem (2006) 281(32):22786-22793. •• Describes carba analogs of ccPA that are selective inhibitors of ATX and that were evaluated as anticancer drug therapy. Cancer cell invasion in vitro and melanoma cell metastasis in vivo were demonstrated to be inhibited by ccPA; the ATX-LPA axis was suggested to be an attractive target for anticancer and anti-angiogenesis therapy.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.32
, pp. 22786-22793
-
-
Baker, D.L.1
Fujiwara, Y.2
Pigg, K.R.3
Tsukahara, R.4
Kobayashi, S.5
Murofushi, H.6
Uchiyama, A.7
Murakami-Murofushi, K.8
Koh, E.9
Bandle, R.W.10
Byun, H.S.11
-
106
-
-
33747593309
-
Phosphonothioate and fuoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors
-
Xu Y, Jiang G, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD: Phosphonothioate and fuoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors. J Med Chem (2006) 49(17):5309-5315.
-
(2006)
J. Med. Chem.
, vol.49
, Issue.17
, pp. 5309-5315
-
-
Xu, Y.1
Jiang, G.2
Tsukahara, R.3
Fujiwara, Y.4
Tigyi, G.5
Prestwich, G.D.6
-
107
-
-
45049086146
-
Anticancer activity of FTY720: Phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D
-
• Describes the inhibition of the ATX-LPA axis as an additional target of FTY-720-P, and demonstrated that the anti-inflammatory effect of FTY-720 in animal models of arthritis may relate to FTY-720-P inhibiting the ATX-LPA axis, in addition to sequestering lymphocytes in secondary lymphoid organs
-
Van Meeteren LA, Brinkmann V, Saulnier-Blache JS, Lynch KR, Moolenaar WH: Anticancer activity of FTY720: Phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Lett (2008) 266(2):203-208. • Describes the inhibition of the ATX-LPA axis as an additional target of FTY-720-P, and demonstrated that the anti-inflammatory effect of FTY-720 in animal models of arthritis may relate to FTY-720-P inhibiting the ATX-LPA axis, in addition to sequestering lymphocytes in secondary lymphoid organs.
-
(2008)
Cancer Lett.
, vol.266
, Issue.2
, pp. 203-208
-
-
Van Meeteren, L.A.1
Brinkmann, V.2
Saulnier-Blache, J.S.3
Lynch, K.R.4
Moolenaar, W.H.5
-
108
-
-
49949105271
-
Phosphatase-resistant analogues of lysophosphatidic acid: Agonists promote healing, antagonists and autotaxin inhibitors treat cancer
-
Prestwich GD, Gajewiak J, Zhang H, Xu X, Yang G, Serban M: Phosphatase-resistant analogues of lysophosphatidic acid: Agonists promote healing, antagonists and autotaxin inhibitors treat cancer. Biochim Biophys Acta (2008) 1781(9):588-594.
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, Issue.9
, pp. 588-594
-
-
Prestwich, G.D.1
Gajewiak, J.2
Zhang, H.3
Xu, X.4
Yang, G.5
Serban, M.6
-
109
-
-
67650458524
-
Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
-
Zhang H, Xu X, Gajewiak J, Tsukahara R, Fujiwara Y, Liu J, Fells JI, Perygin D, Parrill AL, Tigyi G, Prestwich GD: Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res (2009) 69(13):5441-5449.
-
(2009)
Cancer Res.
, vol.69
, Issue.13
, pp. 5441-5449
-
-
Zhang, H.1
Xu, X.2
Gajewiak, J.3
Tsukahara, R.4
Fujiwara, Y.5
Liu, J.6
Fells, J.I.7
Perygin, D.8
Parrill, A.L.9
Tigyi, G.10
Prestwich, G.D.11
-
110
-
-
49949109713
-
Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720
-
Kihara A, Igarashi Y: Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720. Biochim Biophys Acta (2008) 1781(9):496-502.
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, Issue.9
, pp. 496-502
-
-
Kihara, A.1
Igarashi, Y.2
-
111
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA et al: The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem (2002) 277(24):21453-21457.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.24
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
-
112
-
-
34247874512
-
Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
-
Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T: Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem (2007) 282(12):9082-9089.
-
(2007)
J. Biol. Chem.
, vol.282
, Issue.12
, pp. 9082-9089
-
-
Oo, M.L.1
Thangada, S.2
Wu, M.T.3
Liu, C.H.4
Macdonald, T.L.5
Lynch, K.R.6
Lin, C.Y.7
Hla, T.8
-
113
-
-
36248956701
-
Finding a way out: Lymphocyte egress from lymphoid organs
-
Schwab SR, Cyster JG: Finding a way out: Lymphocyte egress from lymphoid organs. Nat Immunol (2007) 8(12):1295-1301.
-
(2007)
Nat. Immunol.
, vol.8
, Issue.12
, pp. 1295-1301
-
-
Schwab, S.R.1
Cyster, J.G.2
-
114
-
-
0036494268
-
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models
-
Azuma H, Takahara S, Ichimaru N, Wang JD, Itoh Y, Otsuki Y, Morimoto J, Fukui R, Hoshiga M, Ishihara T, Nonomura N et al: Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res (2002) 62(5):1410-1419.
-
(2002)
Cancer Res.
, vol.62
, Issue.5
, pp. 1410-1419
-
-
Azuma, H.1
Takahara, S.2
Ichimaru, N.3
Wang, J.D.4
Itoh, Y.5
Otsuki, Y.6
Morimoto, J.7
Fukui, R.8
Hoshiga, M.9
Ishihara, T.10
Nonomura, N.11
-
115
-
-
28044460091
-
FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer
-
Chua CW, Lee DT, Ling MT, Zhou C, Man K, Ho J, Chan FL, Wang X, Wong YC: FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. Int J Cancer (2005) 117(6):1039-1048.
-
(2005)
Int. J. Cancer
, vol.117
, Issue.6
, pp. 1039-1048
-
-
Chua, C.W.1
Lee, D.T.2
Ling, M.T.3
Zhou, C.4
Man, K.5
Ho, J.6
Chan, F.L.7
Wang, X.8
Wong, Y.C.9
-
116
-
-
0033829476
-
Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats
-
Matsuura M, Imayoshi T, Chiba K, Okumoto T: Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats. Inflamm Res (2000) 49(8):404-410.
-
(2000)
Inflamm Res.
, vol.49
, Issue.8
, pp. 404-410
-
-
Matsuura, M.1
Imayoshi, T.2
Chiba, K.3
Okumoto, T.4
-
117
-
-
34648854480
-
Reduction of CD4 positive T cells and improvement of pathological changes of collagen-induced arthritis by FTY720
-
Wang F, Tan W, Guo D, He S: Reduction of CD4 positive T cells and improvement of pathological changes of collagen-induced arthritis by FTY720. Eur J Pharmacol (2007) 573 (1-3) : 230-240.
-
(2007)
Eur. J. Pharmacol.
, vol.573
, Issue.1-3
, pp. 230-240
-
-
Wang, F.1
Tan, W.2
Guo, D.3
He, S.4
-
118
-
-
39449109861
-
Recent trials for FTY720 (fngolimod) : A new generation of immunomodulators structurally similar to sphingosine
-
Mansoor M, Melendez AJ: Recent trials for FTY720 (fngolimod) : A new generation of immunomodulators structurally similar to sphingosine. Rev Recent Clin Trials (2008) 3(1):62-69.
-
(2008)
Rev. Recent Clin. Trials
, vol.3
, Issue.1
, pp. 62-69
-
-
Mansoor, M.1
Melendez, A.J.2
-
119
-
-
38949186792
-
Virtual screening approaches for the identification of non-lipid autotaxin inhibitors
-
Parrill AL, Echols U, Nguyen T, Pham TC, Hoeglund A, Baker DL: Virtual screening approaches for the identification of non-lipid autotaxin inhibitors. Bioorg Med Chem (2008) 16(4):1784-1795.
-
(2008)
Bioorg Med. Chem.
, vol.16
, Issue.4
, pp. 1784-1795
-
-
Parrill, A.L.1
Echols, U.2
Nguyen, T.3
Pham, T.C.4
Hoeglund, A.5
Baker, D.L.6
-
120
-
-
55749092457
-
Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion
-
Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, De La Cruz EM, Braddock DT: Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Mol Cancer Ther (2008) 7(10):3352-3362.
-
(2008)
Mol. Cancer Ther.
, vol.7
, Issue.10
, pp. 3352-3362
-
-
Saunders, L.P.1
Ouellette, A.2
Bandle, R.3
Chang, W.C.4
Zhou, H.5
Misra, R.N.6
De La, C.E.M.7
Braddock, D.T.8
-
121
-
-
34250181673
-
Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists
-
Yamamoto T, Fujita K, Asari S, Chiba A, Kataba Y, Ohsumi K, Ohmuta N, Iida Y, Ijichi C, Iwayama S, Fukuchi N et al: Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists. Bioorg Med Chem Lett (2007) 17(13):3736-3740.
-
(2007)
Bioorg Med. Chem. Lett.
, vol.17
, Issue.13
, pp. 3736-3740
-
-
Yamamoto, T.1
Fujita, K.2
Asari, S.3
Chiba, A.4
Kataba, Y.5
Ohsumi, K.6
Ohmuta, N.7
Iida, Y.8
Ijichi, C.9
Iwayama, S.10
Fukuchi, N.11
-
122
-
-
0037809241
-
3 receptor
-
DOI 10.1074/jbc.M209168200
-
3 receptor. J Biol Chem (2003) 278(14):11962-11969. (Pubitemid 36800170)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.14
, pp. 11962-11969
-
-
Hasegawa, Y.1
Erickson, J.R.2
Goddard, G.J.3
Yu, S.4
Liu, S.5
Cheng, K.W.6
Eder, A.7
Bandoh, K.8
Aoki, J.9
Jarosz, R.10
Schrier, A.D.11
Lynch, K.R.12
Mills, G.B.13
Fang, X.14
-
123
-
-
0038069067
-
Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors
-
Virag T, Elrod DB, Liliom K, Sardar VM, Parrill AL, Yokoyama K, Durgam G, Deng W, Miller DD, Tigyi G: Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors. Mol Pharmacol (2003) 63(5):1032-1042.
-
(2003)
Mol. Pharmacol.
, vol.63
, Issue.5
, pp. 1032-1042
-
-
Virag, T.1
Elrod, D.B.2
Liliom, K.3
Sardar, V.M.4
Parrill, A.L.5
Yokoyama, K.6
Durgam, G.7
Deng, W.8
Miller, D.D.9
Tigyi, G.10
-
124
-
-
74049094039
-
Utilization of the Tango β-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation
-
Wetter JA, Revankar C, Hanson BJ: Utilization of the Tango β-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation. J Biomol Screen (2009) 14(9):1134-1141.
-
(2009)
J. Biomol. Screen
, vol.14
, Issue.9
, pp. 1134-1141
-
-
Wetter, J.A.1
Revankar, C.2
Hanson, B.J.3
-
125
-
-
24944535833
-
S1P1-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate
-
Jo E, Sanna MG, Gonzalez-Cabrera PJ, Thangada S, Tigyi G, Osborne DA, Hla T, Parrill AL, Rosen H: S1P1-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol (2005) 12(6):703-715.
-
(2005)
Chem. Biol.
, vol.12
, Issue.6
, pp. 703-715
-
-
Jo, E.1
Sanna, M.G.2
Gonzalez-Cabrera, P.J.3
Thangada, S.4
Tigyi, G.5
Osborne, D.A.6
Hla, T.7
Parrill, A.L.8
Rosen, H.9
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