메뉴 건너뛰기




Volumn 41, Issue 8-9, 2009, Pages 1708-1718

Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis

Author keywords

Cell traffic; Chemokines; Lung; Signal transduction; Stem cells

Indexed keywords

BLEOMYCIN; CHEMOKINE RECEPTOR CXCR4; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; RAPAMYCIN;

EID: 67349261972     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.02.020     Document Type: Article
Times cited : (154)

References (59)
  • 1
    • 20244364391 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis
    • Abdollahi A., Li M., Ping G., Plathow C., Domhan S., Kiessling F., et al. Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med 201 (2005) 925-935
    • (2005) J Exp Med , vol.201 , pp. 925-935
    • Abdollahi, A.1    Li, M.2    Ping, G.3    Plathow, C.4    Domhan, S.5    Kiessling, F.6
  • 2
    • 0035877019 scopus 로고    scopus 로고
    • Peripheral blood fibrocytes: differentiation pathway and migration to wound sites
    • Abe R., Donnelly S.C., Peng T., Bucala R., and Metz C.N. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 166 (2001) 7556-7562
    • (2001) J Immunol , vol.166 , pp. 7556-7562
    • Abe, R.1    Donnelly, S.C.2    Peng, T.3    Bucala, R.4    Metz, C.N.5
  • 6
    • 0030272487 scopus 로고    scopus 로고
    • Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide
    • Brazelton T.R., and Morris R.E. Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. Curr Opin Immunol 8 (1996) 710-720
    • (1996) Curr Opin Immunol , vol.8 , pp. 710-720
    • Brazelton, T.R.1    Morris, R.E.2
  • 7
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger J.A., and Kipps T.J. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107 (2006) 1761-1767
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 8
    • 34248369837 scopus 로고    scopus 로고
    • Mobilizing stem cells from normal donors: is it possible to improve upon G-CSF?
    • Cashen A.F., Lazarus H.M., and Devine S.M. Mobilizing stem cells from normal donors: is it possible to improve upon G-CSF?. Bone Marrow Transplant 39 (2007) 577-588
    • (2007) Bone Marrow Transplant , vol.39 , pp. 577-588
    • Cashen, A.F.1    Lazarus, H.M.2    Devine, S.M.3
  • 9
    • 4043184065 scopus 로고    scopus 로고
    • Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    • Ceradini D.J., Kulkarni A.R., Callaghan M.J., Tepper O.M., Bastidas N., Kleinman M.E., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10 (2004) 858-864
    • (2004) Nat Med , vol.10 , pp. 858-864
    • Ceradini, D.J.1    Kulkarni, A.R.2    Callaghan, M.J.3    Tepper, O.M.4    Bastidas, N.5    Kleinman, M.E.6
  • 10
    • 65549165761 scopus 로고    scopus 로고
    • Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
    • Christopher M.J., Liu F., Hilton M.J., Long F., and Link D.C. Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood (2009)
    • (2009) Blood
    • Christopher, M.J.1    Liu, F.2    Hilton, M.J.3    Long, F.4    Link, D.C.5
  • 11
    • 34347378496 scopus 로고    scopus 로고
    • HIV entry inhibitors
    • Este J.A., and Telenti A. HIV entry inhibitors. Lancet 370 (2007) 81-88
    • (2007) Lancet , vol.370 , pp. 81-88
    • Este, J.A.1    Telenti, A.2
  • 12
    • 54949144410 scopus 로고    scopus 로고
    • mTOR inhibitors in the treatment of cancer
    • Fasolo A., and Sessa C. mTOR inhibitors in the treatment of cancer. Expert Opin Investig Drugs 17 (2008) 1717-1734
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1717-1734
    • Fasolo, A.1    Sessa, C.2
  • 13
    • 31144435893 scopus 로고    scopus 로고
    • Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury
    • Gomperts B.N., Belperio J.A., Rao P.N., Randell S.H., Fishbein M.C., Burdick M.D., et al. Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J Immunol 176 (2006) 1916-1927
    • (2006) J Immunol , vol.176 , pp. 1916-1927
    • Gomperts, B.N.1    Belperio, J.A.2    Rao, P.N.3    Randell, S.H.4    Fishbein, M.C.5    Burdick, M.D.6
  • 14
    • 34447616779 scopus 로고    scopus 로고
    • Oxygen saturation in the bone marrow of healthy volunteers
    • Harrison J.S., Rameshwar P., Chang V., and Bandari P. Oxygen saturation in the bone marrow of healthy volunteers. Blood 99 (2002) 394
    • (2002) Blood , vol.99 , pp. 394
    • Harrison, J.S.1    Rameshwar, P.2    Chang, V.3    Bandari, P.4
  • 15
    • 1342268310 scopus 로고    scopus 로고
    • Bone marrow-derived progenitor cells in pulmonary fibrosis
    • Hashimoto N., Jin H., Liu T., Chensue S.W., and Phan S.H. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 113 (2004) 243-252
    • (2004) J Clin Invest , vol.113 , pp. 243-252
    • Hashimoto, N.1    Jin, H.2    Liu, T.3    Chensue, S.W.4    Phan, S.H.5
  • 16
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Heldin C.H., and Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79 (1999) 1283-1316
    • (1999) Physiol Rev , vol.79 , pp. 1283-1316
    • Heldin, C.H.1    Westermark, B.2
  • 17
    • 34247877918 scopus 로고    scopus 로고
    • Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration
    • Ishida Y., Kimura A., Kondo T., Hayashi T., Ueno M., Takakura N., et al. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am J Pathol 170 (2007) 843-854
    • (2007) Am J Pathol , vol.170 , pp. 843-854
    • Ishida, Y.1    Kimura, A.2    Kondo, T.3    Hayashi, T.4    Ueno, M.5    Takakura, N.6
  • 18
    • 33748304169 scopus 로고    scopus 로고
    • Gefitinib prevents bleomycin-induced lung fibrosis in mice
    • Ishii Y., Fujimoto S., and Fukuda T. Gefitinib prevents bleomycin-induced lung fibrosis in mice. Am J Respir Crit Care Med 174 (2006) 550-556
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 550-556
    • Ishii, Y.1    Fujimoto, S.2    Fukuda, T.3
  • 19
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • Kim K.K., Kugler M.C., Wolters P.J., Robillard L., Galvez M.G., Brumwell A.N., et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A 103 (2006) 13180-13185
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3    Robillard, L.4    Galvez, M.G.5    Brumwell, A.N.6
  • 20
    • 61749102618 scopus 로고    scopus 로고
    • Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
    • Kim K.K., Wei Y., Szekeres C., Kugler M.C., Wolters P.J., Hill M.L., et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119 (2009) 213-224
    • (2009) J Clin Invest , vol.119 , pp. 213-224
    • Kim, K.K.1    Wei, Y.2    Szekeres, C.3    Kugler, M.C.4    Wolters, P.J.5    Hill, M.L.6
  • 21
    • 0029831486 scopus 로고    scopus 로고
    • Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity
    • Klinghoffer R.A., Duckworth B., Valius M., Cantley L., and Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol 16 (1996) 5905-5914
    • (1996) Mol Cell Biol , vol.16 , pp. 5905-5914
    • Klinghoffer, R.A.1    Duckworth, B.2    Valius, M.3    Cantley, L.4    Kazlauskas, A.5
  • 23
    • 0023266217 scopus 로고
    • Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis
    • Martinet Y., Rom W.N., Grotendorst G.R., Martin G.R., and Crystal R.G. Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. N Engl J Med 317 (1987) 202-209
    • (1987) N Engl J Med , vol.317 , pp. 202-209
    • Martinet, Y.1    Rom, W.N.2    Grotendorst, G.R.3    Martin, G.R.4    Crystal, R.G.5
  • 25
    • 39149103740 scopus 로고    scopus 로고
    • The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
    • Moeller A., Ask K., Warburton D., Gauldie J., and Kolb M. The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?. Int J Biochem Cell Biol 40 (2008) 362-382
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 362-382
    • Moeller, A.1    Ask, K.2    Warburton, D.3    Gauldie, J.4    Kolb, M.5
  • 29
    • 0033646431 scopus 로고    scopus 로고
    • CXCR4: chemokine receptor extraordinaire
    • Murdoch C. CXCR4: chemokine receptor extraordinaire. Immunol Rev 177 (2000) 175-184
    • (2000) Immunol Rev , vol.177 , pp. 175-184
    • Murdoch, C.1
  • 30
    • 33751319000 scopus 로고    scopus 로고
    • Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
    • Pan J., Mestas J., Burdick M.D., Phillips R.J., Thomas G.V., Reckamp K., et al. Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer 5 (2006) 56
    • (2006) Mol Cancer , vol.5 , pp. 56
    • Pan, J.1    Mestas, J.2    Burdick, M.D.3    Phillips, R.J.4    Thomas, G.V.5    Reckamp, K.6
  • 31
    • 34248359065 scopus 로고    scopus 로고
    • Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    • Parmar K., Mauch P., Vergilio J.A., Sackstein R., and Down J.D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A 104 (2007) 5431-5436
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5431-5436
    • Parmar, K.1    Mauch, P.2    Vergilio, J.A.3    Sackstein, R.4    Down, J.D.5
  • 32
    • 4043055316 scopus 로고    scopus 로고
    • Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    • Phillips R.J., Burdick M.D., Hong K., Lutz M.A., Murray L.A., Xue Y.Y., et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Investig 114 (2004) 438-446
    • (2004) J Clin Investig , vol.114 , pp. 438-446
    • Phillips, R.J.1    Burdick, M.D.2    Hong, K.3    Lutz, M.A.4    Murray, L.A.5    Xue, Y.Y.6
  • 33
    • 0038206771 scopus 로고    scopus 로고
    • The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases
    • Phillips R.J., Burdick M.D., Lutz M., Belperio J.A., Keane M.P., and Strieter R.M. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 167 (2003) 1676-1686
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1676-1686
    • Phillips, R.J.1    Burdick, M.D.2    Lutz, M.3    Belperio, J.A.4    Keane, M.P.5    Strieter, R.M.6
  • 34
    • 20444445920 scopus 로고    scopus 로고
    • Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha
    • Phillips R.J., Mestas J., Gharaee-Kermani M., Burdick M.D., Sica A., Belperio J.A., et al. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J Biol Chem 280 (2005) 22473-22481
    • (2005) J Biol Chem , vol.280 , pp. 22473-22481
    • Phillips, R.J.1    Mestas, J.2    Gharaee-Kermani, M.3    Burdick, M.D.4    Sica, A.5    Belperio, J.A.6
  • 35
    • 13244254138 scopus 로고    scopus 로고
    • Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition
    • Pilewski J.M., Liu L., Henry A.C., Knauer A.V., and Feghali-Bostwick C.A. Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Am J Pathol 166 (2005) 399-407
    • (2005) Am J Pathol , vol.166 , pp. 399-407
    • Pilewski, J.M.1    Liu, L.2    Henry, A.C.3    Knauer, A.V.4    Feghali-Bostwick, C.A.5
  • 38
    • 0032986505 scopus 로고    scopus 로고
    • Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats
    • Rice A.B., Moomaw C.R., Morgan D.L., and Bonner J.C. Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats. Am J Pathol 155 (1999) 213-221
    • (1999) Am J Pathol , vol.155 , pp. 213-221
    • Rice, A.B.1    Moomaw, C.R.2    Morgan, D.L.3    Bonner, J.C.4
  • 39
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
    • Richard D.E., Berra E., and Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 275 (2000) 26765-26771
    • (2000) J Biol Chem , vol.275 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 40
    • 33749024991 scopus 로고    scopus 로고
    • Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis
    • Sakai N., Wada T., Yokoyama H., Lipp M., Ueha S., Matsushima K., et al. Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis. Proc Natl Acad Sci U S A 103 (2006) 14098-14103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14098-14103
    • Sakai, N.1    Wada, T.2    Yokoyama, H.3    Lipp, M.4    Ueha, S.5    Matsushima, K.6
  • 42
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103 (2000) 211-225
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 43
    • 67349144541 scopus 로고
    • Oxygen saturation of sternal marrow blood in polycythemia vera
    • Schwartz B.M., and Stats D. Oxygen saturation of sternal marrow blood in polycythemia vera. J Clin Invest 28 (1949) 736-740
    • (1949) J Clin Invest , vol.28 , pp. 736-740
    • Schwartz, B.M.1    Stats, D.2
  • 44
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15 (1999) 551-578
    • (1999) Annu Rev Cell Dev Biol , vol.15 , pp. 551-578
    • Semenza, G.L.1
  • 45
    • 0001572828 scopus 로고    scopus 로고
    • Oxygen-regulated transcription factors and their role in pulmonary disease
    • Semenza G.L. Oxygen-regulated transcription factors and their role in pulmonary disease. Respir Res 1 (2000) 159-162
    • (2000) Respir Res , vol.1 , pp. 159-162
    • Semenza, G.L.1
  • 46
    • 27644517442 scopus 로고    scopus 로고
    • G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
    • Semerad C.L., Christopher M.J., Liu F., Short B., Simmons P.J., Winkler I., et al. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 106 (2005) 3020-3027
    • (2005) Blood , vol.106 , pp. 3020-3027
    • Semerad, C.L.1    Christopher, M.J.2    Liu, F.3    Short, B.4    Simmons, P.J.5    Winkler, I.6
  • 48
    • 0017259926 scopus 로고
    • Haematologic adaptation in patients with chronic bronchitis and pulmonary insufficiency
    • Skouby A.R. Haematologic adaptation in patients with chronic bronchitis and pulmonary insufficiency. Acta Med Scand 199 (1976) 185-190
    • (1976) Acta Med Scand , vol.199 , pp. 185-190
    • Skouby, A.R.1
  • 50
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P., Sulitkova J., Lisztwan J., Moch H., Oakeley E.J., and Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425 (2003) 307-311
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 51
    • 33845445939 scopus 로고    scopus 로고
    • Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    • Sugiyama T., Kohara H., Noda M., and Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25 (2006) 977-988
    • (2006) Immunity , vol.25 , pp. 977-988
    • Sugiyama, T.1    Kohara, H.2    Noda, M.3    Nagasawa, T.4
  • 52
    • 0031762979 scopus 로고    scopus 로고
    • Morphometric analysis of insulin-like growth factor-I localization in lung tissues of patients with idiopathic pulmonary fibrosis
    • Uh S.T., Inoue Y., King Jr. T.E., Chan E.D., Newman L.S., and Riches D.W. Morphometric analysis of insulin-like growth factor-I localization in lung tissues of patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 158 (1998) 1626-1635
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1626-1635
    • Uh, S.T.1    Inoue, Y.2    King Jr., T.E.3    Chan, E.D.4    Newman, L.S.5    Riches, D.W.6
  • 53
    • 0027960797 scopus 로고
    • Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity
    • Vanhee D., Gosset P., Wallaert B., Voisin C., and Tonnel A.B. Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity. Am J Respir Crit Care Med 150 (1994) 1049-1055
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 1049-1055
    • Vanhee, D.1    Gosset, P.2    Wallaert, B.3    Voisin, C.4    Tonnel, A.B.5
  • 55
    • 34347364932 scopus 로고    scopus 로고
    • Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse
    • Wu Z., Yang L., Cai L., Zhang M., Cheng X., Yang X., et al. Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res 8 (2007) 1
    • (2007) Respir Res , vol.8 , pp. 1
    • Wu, Z.1    Yang, L.2    Cai, L.3    Zhang, M.4    Cheng, X.5    Yang, X.6
  • 56
    • 41049086675 scopus 로고    scopus 로고
    • Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibrosis
    • Yamada M., Kuwano K., Maeyama T., Hamada N., Yoshimi M., Nakanishi Y., et al. Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibrosis. Histochem Cell Biol 129 (2008) 453-462
    • (2008) Histochem Cell Biol , vol.129 , pp. 453-462
    • Yamada, M.1    Kuwano, K.2    Maeyama, T.3    Hamada, N.4    Yoshimi, M.5    Nakanishi, Y.6
  • 57
    • 33947171101 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration
    • Yasuoka H., Zhou Z., Pilewski J.M., Oury T.D., Choi A.M., and Feghali-Bostwick C.A. Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. Am J Pathol 169 (2006) 1633-1642
    • (2006) Am J Pathol , vol.169 , pp. 1633-1642
    • Yasuoka, H.1    Zhou, Z.2    Pilewski, J.M.3    Oury, T.D.4    Choi, A.M.5    Feghali-Bostwick, C.A.6
  • 58
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
    • Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60 (2000) 1541-1545
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.