메뉴 건너뛰기




Volumn 58, Issue 12, 2008, Pages 3913-3923

Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CHEMOKINE; CXCL1 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEASOME; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6;

EID: 57349109321     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24049     Document Type: Article
Times cited : (74)

References (50)
  • 1
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: A prototypic multisystem fibrotic disorder
    • Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007;117:557-67.
    • (2007) J Clin Invest , vol.117 , pp. 557-567
    • Varga, J.1    Abraham, D.2
  • 2
    • 33847119836 scopus 로고    scopus 로고
    • Update on pathophysiology of scleroderma with special reference to immunoinflammatory events
    • Chizzolini C. Update on pathophysiology of scleroderma with special reference to immunoinflammatory events. Ann Med 2007;39:42-53.
    • (2007) Ann Med , vol.39 , pp. 42-53
    • Chizzolini, C.1
  • 3
    • 70350523842 scopus 로고    scopus 로고
    • Polarized subsets of human T-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts
    • Chizzolini C, Parel Y, Scheja A, Dayer JM. Polarized subsets of human T-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts. Arthritis Res Ther 2006;8:R10.
    • (2006) Arthritis Res Ther , vol.8
    • Chizzolini, C.1    Parel, Y.2    Scheja, A.3    Dayer, J.M.4
  • 4
    • 33746350138 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in scleroderma
    • Yamamoto T. Chemokines and chemokine receptors in scleroderma. Int Arch Allergy Immunol 2006;140:345-56.
    • (2006) Int Arch Allergy Immunol , vol.140 , pp. 345-356
    • Yamamoto, T.1
  • 5
    • 33847364936 scopus 로고    scopus 로고
    • The role of CXC chemokines in pulmonary fibrosis
    • Strieter RM, Gomperts BN, Keane MP. The role of CXC chemokines in pulmonary fibrosis. J Clin Invest 2007;117:549-56.
    • (2007) J Clin Invest , vol.117 , pp. 549-556
    • Strieter, R.M.1    Gomperts, B.N.2    Keane, M.P.3
  • 6
    • 0033137106 scopus 로고    scopus 로고
    • Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis
    • Keane MP, Belperio JA, Moore TA, Moore BB, Arenberg DA, Smith RE, et al. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis. J Immunol 1999;162:5511-8.
    • (1999) J Immunol , vol.162 , pp. 5511-5518
    • Keane, M.P.1    Belperio, J.A.2    Moore, T.A.3    Moore, B.B.4    Arenberg, D.A.5    Smith, R.E.6
  • 7
    • 0035149215 scopus 로고    scopus 로고
    • Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: Role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis
    • Distler O, Pap T, Kowal-Bielecka O, Meyringer R, Guiducci S, Landthaler M, et al. Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis. Arthritis Rheum 2001;44:2665-78.
    • (2001) Arthritis Rheum , vol.44 , pp. 2665-2678
    • Distler, O.1    Pap, T.2    Kowal-Bielecka, O.3    Meyringer, R.4    Guiducci, S.5    Landthaler, M.6
  • 8
    • 0034966873 scopus 로고    scopus 로고
    • Chemokine expression by systemic sclerosis fibroblasts: Abnormal regulation of monocyte chemoattractant protein 1 expression
    • Galindo M, Santiago B, Rivero M, Rullas J, Alcami J, Pablos JL. Chemokine expression by systemic sclerosis fibroblasts: abnormal regulation of monocyte chemoattractant protein 1 expression. Arthritis Rheum 2001;44:1382-6.
    • (2001) Arthritis Rheum , vol.44 , pp. 1382-1386
    • Galindo, M.1    Santiago, B.2    Rivero, M.3    Rullas, J.4    Alcami, J.5    Pablos, J.L.6
  • 9
    • 0034777651 scopus 로고    scopus 로고
    • High expression and autoinduction of monocyte chemoattractant protein-1 in scleroderma fibroblasts
    • Yamamoto T, Eckes B, Krieg T. High expression and autoinduction of monocyte chemoattractant protein-1 in scleroderma fibroblasts. Eur J Immunol 2001;31:2936-41.
    • (2001) Eur J Immunol , vol.31 , pp. 2936-2941
    • Yamamoto, T.1    Eckes, B.2    Krieg, T.3
  • 11
    • 29144443977 scopus 로고    scopus 로고
    • Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: Evidence for autocrine regulation of myofibroblast differentiation
    • Carulli MT, Ong VH, Ponticos M, Shiwen X, Abraham DJ, Black CM, et al. Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation. Arthritis Rheum 2005;52:3772-82.
    • (2005) Arthritis Rheum , vol.52 , pp. 3772-3782
    • Carulli, M.T.1    Ong, V.H.2    Ponticos, M.3    Shiwen, X.4    Abraham, D.J.5    Black, C.M.6
  • 13
    • 0037829128 scopus 로고    scopus 로고
    • Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-α are elevated in patients with systemic sclerosis
    • Furuse S, Fujii H, Kaburagi Y, Fujimoto M, Hasegawa M, Takehara K, et al. Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-α are elevated in patients with systemic sclerosis. J Rheumatol 2003;30:1524-8.
    • (2003) J Rheumatol , vol.30 , pp. 1524-1528
    • Furuse, S.1    Fujii, H.2    Kaburagi, Y.3    Fujimoto, M.4    Hasegawa, M.5    Takehara, K.6
  • 14
    • 0031935542 scopus 로고    scopus 로고
    • Increased production of interleukin 6 and interleukin 8 in scleroderma fibroblasts
    • Kadono T, Kikuchi K, Ihn H, Takehara K, Tamaki K. Increased production of interleukin 6 and interleukin 8 in scleroderma fibroblasts. J Rheumatol 1998;25:296-301.
    • (1998) J Rheumatol , vol.25 , pp. 296-301
    • Kadono, T.1    Kikuchi, K.2    Ihn, H.3    Takehara, K.4    Tamaki, K.5
  • 15
    • 0027397988 scopus 로고
    • Demonstration of interleukin 8 and autoantibodies to interleukin 8 in the serum of patients with systemic sclerosis and related disorders
    • Reitamo S, Remitz A, Varga J, Ceska M, Effenberger F, Jimenez S, et al. Demonstration of interleukin 8 and autoantibodies to interleukin 8 in the serum of patients with systemic sclerosis and related disorders. Arch Dermatol 1993;129:189-93.
    • (1993) Arch Dermatol , vol.129 , pp. 189-193
    • Reitamo, S.1    Remitz, A.2    Varga, J.3    Ceska, M.4    Effenberger, F.5    Jimenez, S.6
  • 16
  • 17
    • 2942517919 scopus 로고    scopus 로고
    • Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants, TARC and MDC, are elevated in patients with systemic sclerosis
    • Fujii H, Shimada Y, Hasegawa M, Takehara K, Sato S. Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants, TARC and MDC, are elevated in patients with systemic sclerosis. J Dermatol Sci 2004;35:43-51.
    • (2004) J Dermatol Sci , vol.35 , pp. 43-51
    • Fujii, H.1    Shimada, Y.2    Hasegawa, M.3    Takehara, K.4    Sato, S.5
  • 18
    • 0033571117 scopus 로고    scopus 로고
    • IFN-γ-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis
    • Keane MP, Belperio JA, Arenberg DA, Burdick MD, Xu ZJ, Xue YY, et al. IFN-γ-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis. J Immunol 1999;163:5686-92.
    • (1999) J Immunol , vol.163 , pp. 5686-5692
    • Keane, M.P.1    Belperio, J.A.2    Arenberg, D.A.3    Burdick, M.D.4    Xu, Z.J.5    Xue, Y.Y.6
  • 20
    • 4043049618 scopus 로고    scopus 로고
    • Regulation of pulmonary fibrosis by chemokine receptor CXCR3
    • Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, et al. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest 2004;114:291-9.
    • (2004) J Clin Invest , vol.114 , pp. 291-299
    • Jiang, D.1    Liang, J.2    Hodge, J.3    Lu, B.4    Zhu, Z.5    Yu, S.6
  • 21
    • 0036269002 scopus 로고    scopus 로고
    • Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis
    • Chizzolini C, Raschi E, Rezzonico R, Testoni C, Mallone R, Gabrielli A, et al. Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis. Arthritis Rheum 2002;46:1602-13.
    • (2002) Arthritis Rheum , vol.46 , pp. 1602-1613
    • Chizzolini, C.1    Raschi, E.2    Rezzonico, R.3    Testoni, C.4    Mallone, R.5    Gabrielli, A.6
  • 22
    • 36448974512 scopus 로고    scopus 로고
    • Anti-fibroblast antibodies detected by cell-based ELISA in systemic sclerosis enhance the collagenolytic activity and matrix metalloproteinase-1 production in dermal fibroblasts
    • Fineschi S, Cozzi F, Burger D, Dayer JM, Meroni PL, Chizzolini C. Anti-fibroblast antibodies detected by cell-based ELISA in systemic sclerosis enhance the collagenolytic activity and matrix metalloproteinase-1 production in dermal fibroblasts. Rheumatology (Oxford) 2007;46:1779-85.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 1779-1785
    • Fineschi, S.1    Cozzi, F.2    Burger, D.3    Dayer, J.M.4    Meroni, P.L.5    Chizzolini, C.6
  • 23
    • 5644247451 scopus 로고    scopus 로고
    • Direct binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis
    • Henault J, Tremblay M, Clement I, Raymond Y, Senecal JL. Direct binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis. Arthritis Rheum 2004;50:3265-74.
    • (2004) Arthritis Rheum , vol.50 , pp. 3265-3274
    • Henault, J.1    Tremblay, M.2    Clement, I.3    Raymond, Y.4    Senecal, J.L.5
  • 24
    • 33845510782 scopus 로고    scopus 로고
    • Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension
    • Tamby MC, Humbert M, Guilpain P, Servettaz A, Dupin N, Christner JJ, et al. Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension. Eur Respir J 2006;28:799-807.
    • (2006) Eur Respir J , vol.28 , pp. 799-807
    • Tamby, M.C.1    Humbert, M.2    Guilpain, P.3    Servettaz, A.4    Dupin, N.5    Christner, J.J.6
  • 25
    • 25444475774 scopus 로고    scopus 로고
    • Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-β pathway to recapitulate the scleroderma phenotype
    • Zhou X, Tan FK, Milewicz DM, Guo X, Bona CA, Arnett FC. Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-β pathway to recapitulate the "scleroderma phenotype." J Immunol 2005;175:4555-60.
    • (2005) J Immunol , vol.175 , pp. 4555-4560
    • Zhou, X.1    Tan, F.K.2    Milewicz, D.M.3    Guo, X.4    Bona, C.A.5    Arnett, F.C.6
  • 26
    • 0033790892 scopus 로고    scopus 로고
    • Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells
    • Lunardi C, Bason C, Navone R, Millo E, Damonte G, Corrocher R, et al. Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells. Nat Med 2000;6:1183-6.
    • (2000) Nat Med , vol.6 , pp. 1183-1186
    • Lunardi, C.1    Bason, C.2    Navone, R.3    Millo, E.4    Damonte, G.5    Corrocher, R.6
  • 27
    • 32044456248 scopus 로고    scopus 로고
    • Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: A gene array approach
    • Lunardi C, Dolcino M, Peterlana D, Bason C, Navone R, Tamassia N, et al. Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach. PLoS Med 2006;3:e2.
    • (2006) PLoS Med , vol.3
    • Lunardi, C.1    Dolcino, M.2    Peterlana, D.3    Bason, C.4    Navone, R.5    Tamassia, N.6
  • 30
    • 34247891509 scopus 로고    scopus 로고
    • Immunologically active autoantigens: The role of Toll-like receptors in the development of chronic inflammatory disease
    • Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of Toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol 2007;25:419-41.
    • (2007) Annu Rev Immunol , vol.25 , pp. 419-441
    • Marshak-Rothstein, A.1    Rifkin, I.R.2
  • 31
    • 0037528699 scopus 로고    scopus 로고
    • Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    • Raschi E, Testoni C, Bosisio D, Borghi MO, Koike T, Mantovani A, et al. Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 2003;101:3495-500.
    • (2003) Blood , vol.101 , pp. 3495-3500
    • Raschi, E.1    Testoni, C.2    Bosisio, D.3    Borghi, M.O.4    Koike, T.5    Mantovani, A.6
  • 33
    • 33846899419 scopus 로고    scopus 로고
    • The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies
    • Satta N, Dunoyer-Geindre S, Reber G, Fish RJ, Boehlen F, Kruithof EK, et al. The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies. Blood 2007;109:1507-14.
    • (2007) Blood , vol.109 , pp. 1507-1514
    • Satta, N.1    Dunoyer-Geindre, S.2    Reber, G.3    Fish, R.J.4    Boehlen, F.5    Kruithof, E.K.6
  • 34
    • 33749002571 scopus 로고    scopus 로고
    • In celiac disease, a subset of autoantibodies against transglutaminase binds Toll-like receptor 4 and induces activation of monocytes
    • Zanoni G, Navone R, Lunardi C, Tridente G, Bason C, Sivori S, et al. In celiac disease, a subset of autoantibodies against transglutaminase binds Toll-like receptor 4 and induces activation of monocytes. PLoS Med 2006;3:e358.
    • (2006) PLoS Med , vol.3
    • Zanoni, G.1    Navone, R.2    Lunardi, C.3    Tridente, G.4    Bason, C.5    Sivori, S.6
  • 35
    • 0018887574 scopus 로고    scopus 로고
    • Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis scleroderma, Arthritis Rheum 1980;23:581-90
    • Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980;23:581-90.
  • 36
    • 85047690873 scopus 로고    scopus 로고
    • Antagonistic antibody prevents Toll-like receptor 2-driven lethal shock-like syndromes
    • Meng G, Rutz M, Schiemann M, Metzger J, Grabiec A, Schwandner R, et al. Antagonistic antibody prevents Toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 2004;113:1473-81.
    • (2004) J Clin Invest , vol.113 , pp. 1473-1481
    • Meng, G.1    Rutz, M.2    Schiemann, M.3    Metzger, J.4    Grabiec, A.5    Schwandner, R.6
  • 38
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999;11:443-51.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6
  • 39
    • 33750207136 scopus 로고    scopus 로고
    • Is scleroderma an autoantibody mediated disease?
    • Arnett FC. Is scleroderma an autoantibody mediated disease? Curr Opin Rheumatol 2006;18:579-81.
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 579-581
    • Arnett, F.C.1
  • 40
    • 0027717313 scopus 로고
    • In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis: Their role in early and late disease
    • Koch AE, Kronfeld-Harrington LB, Szekanecz Z, Cho MM, Haines GK, Harlow LA, et al. In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis: their role in early and late disease. Pathobiology 1993;61:239-46.
    • (1993) Pathobiology , vol.61 , pp. 239-246
    • Koch, A.E.1    Kronfeld-Harrington, L.B.2    Szekanecz, Z.3    Cho, M.M.4    Haines, G.K.5    Harlow, L.A.6
  • 42
    • 4444364180 scopus 로고    scopus 로고
    • Chemokine-like factor 1, a novel cytokine, contributes to airway damage, remodeling and pulmonary fibrosis
    • Tan YX, Han WL, Chen YY, Ouyang NT, Tang Y, Li F, et al. Chemokine-like factor 1, a novel cytokine, contributes to airway damage, remodeling and pulmonary fibrosis. Chin Med J (Engl) 2004;117:1123-9.
    • (2004) Chin Med J (Engl) , vol.117 , pp. 1123-1129
    • Tan, Y.X.1    Han, W.L.2    Chen, Y.Y.3    Ouyang, N.T.4    Tang, Y.5    Li, F.6
  • 44
    • 3543134126 scopus 로고    scopus 로고
    • Matrix metalloproteinases as modulators of inflammation and innate immunity
    • Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 2004;4:617-29.
    • (2004) Nat Rev Immunol , vol.4 , pp. 617-629
    • Parks, W.C.1    Wilson, C.L.2    Lopez-Boado, Y.S.3
  • 45
    • 0141989767 scopus 로고    scopus 로고
    • Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair
    • Sandler NG, Mentink-Kane MM, Cheever AW, Wynn TA. Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. J Immunol 2003;171:3655-67.
    • (2003) J Immunol , vol.171 , pp. 3655-3667
    • Sandler, N.G.1    Mentink-Kane, M.M.2    Cheever, A.W.3    Wynn, T.A.4
  • 46
    • 0030685825 scopus 로고    scopus 로고
    • IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
    • Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, et al. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 1997;278:860-6.
    • (1997) Science , vol.278 , pp. 860-866
    • Mercurio, F.1    Zhu, H.2    Murray, B.W.3    Shevchenko, A.4    Bennett, B.L.5    Li, J.6
  • 47
    • 0031931132 scopus 로고    scopus 로고
    • Effect of proteasome inhibitors on monocytic IκB-α and -β depletion, NF-κB activation, and cytokine production
    • Haas M, Page S, Page M, Neumann FJ, Marx N, Adam M, et al. Effect of proteasome inhibitors on monocytic IκB-α and -β depletion, NF-κB activation, and cytokine production. J Leukoc Biol 1998;63:395-404.
    • (1998) J Leukoc Biol , vol.63 , pp. 395-404
    • Haas, M.1    Page, S.2    Page, M.3    Neumann, F.J.4    Marx, N.5    Adam, M.6
  • 48
    • 34548442991 scopus 로고    scopus 로고
    • Coordinating TLR-activated signaling pathways in cells of the immune system
    • Banerjee A, Gerondakis S. Coordinating TLR-activated signaling pathways in cells of the immune system. Immunol Cell Biol 2007;85:420-4.
    • (2007) Immunol Cell Biol , vol.85 , pp. 420-424
    • Banerjee, A.1    Gerondakis, S.2
  • 49
    • 7944232105 scopus 로고    scopus 로고
    • Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
    • Martinon F, Agostini L, Meylan E, Tschopp J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 2004;14:1929-34.
    • (2004) Curr Biol , vol.14 , pp. 1929-1934
    • Martinon, F.1    Agostini, L.2    Meylan, E.3    Tschopp, J.4
  • 50
    • 44849130732 scopus 로고    scopus 로고
    • CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma
    • Yoshizaki A, Iwata Y, Komura K, Ogawa F, Hara T, Muroi E, et al. CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. Am J Pathol 2008;172:1650-63.
    • (2008) Am J Pathol , vol.172 , pp. 1650-1663
    • Yoshizaki, A.1    Iwata, Y.2    Komura, K.3    Ogawa, F.4    Hara, T.5    Muroi, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.