Zymomonas mobilis: A novel platform for future biorefineries

Biotechnology for Biofuels

Volumn 7, Issue 1, 2014, Pages

  He, Ming Xiong ^a   Wu, Bo ^a   Qin, Han ^a   Ruan, Zhi Yong ^b   Tan, Fu Rong ^a   Wang, Jing Li ^a   Shui, Zong Xia ^a   Dai, Li Chun ^a   Zhu, Qi Li ^a   Pan, Ke ^a   Tang, Xiao Yu ^a   Wang, Wen Guo ^a   Hu, Qi Chun ^a  

^a AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

biofuel; biorefinery; building block chemical; platform; Zymomonas mobilis

Indexed keywords

BIOCHEMISTRY; BIOFUELS; BIOMASS; ESCHERICHIA COLI; METABOLIC ENGINEERING; YEAST;

BIO-ETHANOL PRODUCTION; BIOREFINERIES; BUILDING BLOCKES; COMMERCIAL-SCALE PRODUCTION; ENTNER-DOUDOROFF PATHWAYS; INDUSTRIAL BIOTECHNOLOGY; PLATFORM; ZYMOMONAS MOBILIS;

REFINING;

BIOFUEL; BIOMASS; BIOTECHNOLOGY; COLIFORM BACTERIUM; METABOLITE; MICROORGANISM;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE; ZYMOMONAS MOBILIS;

EID: 84903421930     PISSN: 17546834     EISSN: None     Source Type: Journal    
DOI: 10.1186/1754-6834-7-101     Document Type: Review

References (167)

1. Systems metabolic engineering of microorganisms for natural and non-natural chemicals. Lee JW, Na D, Park JM, Lee J, Choi S, Lee SY, Nat Chem Biol 2012 8 536 546
2. Microbial engineering for the production of advanced biofuels. Peralta-Yahya PP, Zhang F, Del Cardayre SB, Keasling JD, Nature 2012 488 320 328
3. Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production. Chen XZ, Zhou L, Kangming T, Kumar A, Singh S, Prior BA, Wang ZX, Biotechnol Adv 2013 31 1200 1223
4. Metabolic engineering of yeast for production of fuels and chemicals. Nielsen J, Larsson C, van Maris A, Pronk J, Curr Opin Biotechnol 2013 24 398 404
5. Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries. Hong K-K, Nielsen J, Cell Mol Life Sci 2012 69 2671 2690
6. Biomass for energy in the European Union-a review of bioenergy resource assessments. Bentsen NS, Felby C, Biotechnol Biofuels 2012 5 1 10
7. Assessment of sustainable biomass resource for energy use in China. Zhou X, Wang F, Hu H, Yang L, Guo P, Xiao B, Biomass Bioenergy 2011 35 1 11
8. Zymomonas mobilis: an alternative ethanol producer. Panesar PS, Marwaha SS, Kennedy JF, J Chem Technol Biotechnol 2006 81 623 635
9. The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4. Seo JS, Chong H, Park HS, Yoon KO, Jung C, Kim JJ, Hong JH, Kim H, Kim JH, Kil JI, Park CJ, Oh HM, Lee JS, Jin SJ, Um HW, Lee HJ, Oh SJ, Kim JY, Kang HL, Lee SY, Lee KJ, Kang HS, Nat Biotechnol 2005 23 63 68
10. Zymomonas mobilis: science and industrial application. Doelle H, Kirk L, Crittenden R, Toh H, Doelle M, Crit Rev Biotechnol 1993 13 57 98
11. The Genus Zymomonas. Sahm H, Bringer-Meyer S, Sprenger G, Proc Natl Acad Sci U S A 2006 5 201 221
12. Ethanol fermentation from biomass resources: current state and prospects. Lin Y, Tanaka S, Appl Microbiol Biotechnol 2006 69 627 642
13. Zymomonas mobilis for fuel ethanol and higher value products. Rogers PL, Jeon YJ, Lee KJ, Lawford HG, Adv Biochem Eng Biotechnol 2007 108 263 288
14. Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches. Jang Y-S, Park JM, Choi S, Choi YJ, Seung DY, Cho JH, Lee SY, Biotechnol Adv 2012 30 989 1000
15. Zymomonas mobilis subspecies identification by amplified ribosomal DNA restriction analysis. Coton M, Laplace JM, Coton E, Lett Appl Microbiol 2005 40 152 157
16. "Framboisé" spoilage in French ciders: Zymomonas mobilis implication and characterization. Coton M, Laplace JM, Auffray Y, Coton E, LWT-Food Sci Technol 2006 39 972 979
17. Polyphasic study of Zymomonas mobilis strains revealing the existence of a novel subspecies Z. mobilis subsp. francensissubsp. nov., isolated from French cider. Coton M, Laplace J-M, Auffray Y, Coton E, Int J Syst Evol Microbiol 2006 56 121 125
18. Duplex PCR method for rapid detection of Zymomonas mobilis in cider. Coton M, Laplace J, Auffray Y, Coton E, J Inst Brew 2005 111 299 303
19. Biology of Zymomonas. Swings J, Deley J, Bacterial Rev 1977 41 1 46
20. Disruption of the Zymomonas mobilis extracellular sucrase gene (SacC) improves levan production. Senthilkumar V, Rameshkumar N, Busby S, Gunasekaran P, J Appl Microbiol 2004 96 671 676
21. DNA restriction-modification systems in the ethanologen, Zymomonas mobilis ZM4. Kerr AL, Jeon YJ, Svenson CJ, Rogers PL, Neilan BA, Appl Microbiol Biotechnol 2011 89 761 769
22. Construction and characterization of restriction-modification deficient mutants in Zymomonas mobilis ZM4. Wu B, He MX, Luo AJ, Zhang Y, Feng H, Hu QC, Zhang YZ, Chin J Appl Environ Biol 2013 19 2 189 197
23. Method for mass production of primary metabolites, strain for mass production of primary metabolites, and method for preparation thereof. Seo JS, Chong HY, Kim JH, Kim JY, US: Patent 2007 20090162910 A1
24. Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate. Viitanen PV, Tao L, Knoke K, Zhang Y, Caimi PG, Zhang M, Chou Y-c, Franden MA, EP: Patent 2012 2209899 B1
25. Process for the production of ethanol from a medium comprising xylose, employing a recombinant Zymomonas strain having a reduced himA expression. Viitanen PV, Tao L, Knoke K, Zhang Y, Caimi PG, Zhang M, Chou Y, Franden MA, WO: Patent 2009 2009058938
26. Respiration-deficient mutants of Zymomonas mobilis show improved growth and ethanol fermentation under aerobic and high temperature conditions. Hayashi T, Furuta Y, Furukawa K, J Biosci Bioeng 2011 111 414 419
27. NADH dehydrogenase deficiency results in low respiration rate and improved aerobic growth of Zymomonas mobilis. Kalnenieks U, Galinina N, Strazdina I, Kravale Z, Pickford JL, Rutkis R, Poole RK, Microbiology 2008 154 989 994
28. The Zymomonas mobilis regulator hfq contributes to tolerance against multiple lignocellulosic pretreatment inhibitors. Yang S, Pelletier DA, Lu TY, Brown SD, BMC Microbiol 2010 10 135
29. Paradigm for industrial strain improvement identifies sodium acetate tolerance loci in Zymomonas mobilis and Saccharomyces cerevisiae. Yang S, Land ML, Klingeman DM, Pelletier DA, Lu TY, Martin SL, Guo HB, Smith JC, Brown SD, Proc Natl Acad Sci U S A 2010 107 10395 10400
30. Engineering efficient xylose metabolism into an acetic acid-tolerant Zymomonas mobilis strain by introducing adaptation-induced mutations. Agrawal M, Wang Y, Chen RR, Biotechnol Lett 2012 34 1825 1832
31. Unmarked insertional inactivation in thegfogene improves growth and ethanol production by Zymomonas mobilis ZM4 in sucrose without formation of sorbitol as a by-product, but yields opposite effects in high glucose. Wang C, Liu C, Hong J, Zhang K, Ma Y, Zou S, Zhang M, Biochem Eng J 2013 72 61 69
32. Sorbitol required for cell growth and ethanol production by Zymomonas mobilis under heat, ethanol, and osmotic stresses. Sootsuwan K, Thanonkeo P, Keeratirakha N, Thanonkeo S, Jaisil P, Yamada M, Biotechnol Biofuels 2013 6 180
33. Physiological importance of cytochrome c peroxidase in ethanologenic thermotolerant Zymomonas mobilis. Charoensuk K, Irie A, Lertwattanasakul N, Sootsuwan K, Thanonkeo P, Yamada M, J Mol Microbiol Biotechnol 2011 20 70 82
34. Electron transport and oxidative stress in Zymomonas mobilis respiratory mutants. Strazdina I, Kravale Z, Galinina N, Rutkis R, Poole R, Kalnenieks U, Arch Microbiol 2012 194 461 471
35. Ethanol fermentation on the move. Jeffries TW, Nat Biotechnol 2005 23 40 41
36. Complete genome sequence of the ethanol producer Zymomonas mobilis NCIMB 11163. Kouvelis VN, Saunders E, Brettin TS, Bruce D, Detter C, Han C, Typas MA, Pappas KM, J Bacteriol 2009 191 7140 7141
37. Complete genome sequence of the ethanol-producing Zymomonas mobilis subsp. mobilis centrotype ATCC 29191. Desiniotis A, Kouvelis VN, Davenport K, Bruce D, Detter C, Tapia R, Han C, Goodwin LA, Woyke T, Kyrpides NC, J Bacteriol 2012 194 5966 5967
38. Genome sequence of the ethanol-producing Zymomonas mobilis subsp.pomaceae lectotype ATCC 29192. Kouvelis VN, Davenport KW, Brettin TS, Bruce D, Detter C, Han CS, Nolan M, Tapia R, Damoulaki A, Kyrpides NC, Typas MA, Pappas KM, J Bacteriol 2011 193 5049 5050
39. Genome sequence of the ethanol-producing Zymomonas mobilis subsp. mobilis lectotype ATCC 10988. Pappas KM, Kouvelis VN, Saunders E, Brettin TS, Bruce D, Detter C, Balakireva M, Han CS, Savvakis G, Kyrpides NC, Typas MA, J Bacteriol 2011 193 5051 5052
40. Draft genome sequence of the flocculating Zymomonas mobilis Strain ZM401 (ATCC 31822). Zhao N, Bai Y, Zhao X-Q, Yang Z-Y, Bai F-W, J Bacteriol 2012 194 7008 7009
41. Finished genome of Zymomonas mobilis subsp. mobilis strain CP4, an applied ethanol producer. Kouvelis VN, Teshima H, Bruce D, Detter C, Tapia R, Han C, Tampakopoulou VO, Goodwin L, Woyke T, Kyrpides NC, Typas MA, Pappas KM, Genome Announce 2014 2 00813 e00845
42. Transcriptomic and metabolomic profiling of Zymomonas mobilis during aerobic and anaerobic fermentations. Yang S, Tschaplinski TJ, Engle NL, Carroll SL, Martin SL, Davison BH, Palumbo AV, Rodriguez M Jr, Brown SD, BMC Genomics 2009 10 34
43. Transcriptome profiling of Zymomonas mobilis under furfural stress. He MX, Wu B, Shui ZX, Hu QC, Wang WG, Tan FR, Tang XY, Zhu QL, Pan K, Li Q, Su XH, Appl Microbiol Biotechnol 2012 95 189 199
44. Transcriptome profiling of Zymomonas mobilis under ethanol stress. He MX, Wu B, Shui ZX, Hu QC, Wang WG, Tan FR, Tang XY, Zhu QL, Pan K, Li Q, Su XH, Biotechnol Biofuels 2012 5 75
45. Systems biology analysis of Zymomonas mobilis ZM4 ethanol stress responses. Yang S, Pan C, Tschaplinski TJ, Hurst GB, Engle NL, Zhou W, Dam P, Xu Y, Rodriguez M Jr, Dice L, PLoS One 2013 8 68886
46. Genome-wide transcriptomic analysis of a flocculent strain of Zymomonas mobilis. Jeon YJ, Xun Z, Su P, Rogers PL, Appl Microbiol Biotechnol 2012 93 2513 2518
47. A mutant of Zymomonas mobilisZM4 capable of ethanol production from glucose in the presence of high acetate concentrations. Joachimsthal E, Haggett KD, Jang J-H, Rogers PL, Biotechnol Lett 1998 20 137 142
48. Kinetic analysis of ethanol production by an acetate-resistant strain of recombinant Zymomonas mobilis. Jeon YJ, Svenson CJ, Joachimsthal EL, Rogers PL, Biotechnol Lett 2002 24 819 824
49. Performance of a newly developed integrant of Zymomonas mobilis for ethanol production on corn stover hydrolysate. Mohagheghi A, Dowe N, Schell D, Chou YC, Eddy C, Zhang M, Biotechnol Lett 2004 26 321 325
50. Performance of immobilized Zymomonas mobilis31821 (pZB5) on actual hydrolysates produced by arkenol technology. Yamada T, Fatigati M, Zhang M, Biotechnology for Fuels and Chemicals Springer; Appl Biochem Biotechnol, Finkelstein M, McMillan J, Davison B, 2002 98 100 899-907
51. Genetic alteration of Zymomonas mobilis for ethanol production. Skotnicki ML, Lee K, Tribe D, Rogers P, Genetic Engineering of Microorganisms for Chemicals New York: Plenum Press, Hollaende A, DeMoss RD, Kaplan S, Konisky J, Savage D, Wolfe RS, 1982 271 290
52. Expression of a lactose transposon (Tn951) in Zymomonas mobilis. Carey V, Walia S, Ingram L, Appl Environ Microbiol 1983 46 1163 1168
53. Genetic modification of Zymomonas mobilis. Buchholz SE, Eveleigh DE, Biotechnol Adv 1990 8 547 581
54. Transposon mutagenesis and strain construction in Zymomonas mobilis. Pappas KM, Galani I, Typas MA, J Appl Microbiol 1997 82 379 388
55. Mini-Mu Transposon Mutagenesis of Ethanologenic Zymomonas mobilis. Pappas KM, Strain Engineering Springer; Methods Mol Biol, Williams JA, 2011 765 419-434
56. Use of a Tn5-based transposon system to create a cost-effective Zymomonas mobilis for ethanol production from lignocelluloses. Zhang X, Wang T, Zhou W, Jia X, Wang H, Microb Cell Fact 2013 12 41
57. ISZm1068: an IS5-like insertion element from Zymomonas mobilis. Galeros M, Pappas K-M, Beletsiotis E, Typas MA, Arch Microbiol 2001 175 323 333
58. Directed evolution of metabolic pathways. Chatterjee R, Yuan L, Trends Biotechnol 2006 24 28 38
59. Adaptive evolution of bacterial metabolic networks by horizontal gene transfer. Pál C, Papp B, Lercher MJ, Nat Genet 2005 37 1372 1375
60. Adaptive laboratory evolution-harnessing the power of biology for metabolic engineering. Portnoy VA, Bezdan D, Zengler K, Curr Opin Biotechnol 2011 22 590 594
61. Microbial laboratory evolution in the era of genome-scale science. Conrad TM, Lewis NE, Palsson BØ Mol Syst Biol 2011 7 509
62. Adaptive laboratory evolution-principles and applications for biotechnology. Dragosits M, Mattanovich D, Microb Cell Fact 2013 12 64
63. Metabolic characterization of Escherichia colistrains adapted to growth on lactate. Hua Q, Joyce AR, Palsson BØ Fong SS, Appl Environ Microbiol 2007 73 4639 4647
64. Adaptive evolution of Escherichia coli K-12 MG1655 during growth on a nonnative carbon source, L-1, 2-propanediol. Lee D-H, Palsson BØ Appl Environ Microbiol 2010 76 4158 4168
65. Adaptive evolution of an industrial strain of Saccharomyces cerevisiaefor combined tolerance to inhibitors and temperature. Wallace-Salinas V, Gorwa-Grauslund MF, Biotechnol Biofuels 2013 6 151
66. Evolutionary engineering of Saccharomyces cerevisiaefor improved industrially important properties. Cakar ZP, TuranliYildiz B, Alkim C, Yilmaz U, FEMS Yeast Res 2012 12 171 182
67. Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiaestrain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering. Demeke MM, Dietz H, Li Y, Foulquié-Moreno MR, Mutturi S, Deprez S, Den Abt T, Bonini BM, Liden G, Dumortier F, Biotechnol Biofuels 2013 6 89
68. Adaptation of Saccharomyces cerevisiaeto saline stress through laboratory evolution. Dhar R, Sägesser R, Weikert C, Yuan J, Wagner A, J Evol Biol 2011 24 1135 1153
69. Development of acetic-acid tolerant Zymomonas mobilis strains through adaptation. Wang Y, Master Thesis: Georgia Institute of Technology, Chemical Engineering 2008 URI: http://hdl.handle.net/1853/29747
70. Adaptation yields a highly efficient xylose fermenting Zymomonas mobilis strain. Agrawal M, Mao Z, Chen RR, Biotechnol Bioeng 2011 108 777 785
71. Direct production of ethanol from raw sweet potato starch using genetically engineered Zymomonas mobilis. He M-X, Feng H, Li Y, Bai F, Liu X, Zhang Y-Z, Afr J Microbiol Res 2009 3 721 726
72. Ethanol production by mixed-cultures of Paenibacillus sp and Zymomonas mobilis using the raw starchy material from sweet potato. He M-X, Li Y, Liu X, Bai F, Feng H, Zhang Y-Z, Ann Microbiol 2009 59 749 754
73. Net energy of cellulosic ethanol from switchgrass. Schmer KPV MR, Mitchell RB, Perrin RK, Proc Natl Acad Sci U S A 2008 105 464 469
74. Ethanol production using corn, switchgrass, and wood; biodiesel production using soybean and sunflower. Pimentel D, Patzek T, Nat Resour Res 2005 14 65 76
75. Recent trends in global production and utilization of bio-ethanol fuel. Balat M, Balat H, Appl Energy 2009 86 2273 2282
76. Metabolic engineering of a pentose metabolism pathway in ethanologenic Zymomonas mobilis. Zhang M, Eddy C, Deanda K, Finkelstein M, Picataggio S, Science 1995 267 240 243
77. Development of an arabinose-fermenting Zymomonas mobilisstrain by metabolic pathway engineering. Deanda K, Zhang M, Eddy C, Picataggio S, Appl Env Microbiol 1996 62 4465 4470
78. Cofermentation of glucose, xylose, and arabinose by mixed cultures of two genetically engineered Zymomonas mobilis strains. Mohagheghi A, Evans K, Finkelstein M, Zhang M, Appl Biochem Biotechnol 1998 70-72 285 299
79. Single Zymomonas mobilis strain for xylose and arabinose fermentation. Zhang M, Chou Y-C, Picataggio SK, Finkelstein M, US: Patent 1998 5843760
80. Cofermentation of glucose, xylose, and arabinose by genomic DNA-integrated xylose/arabinose fermenting strain of Zymomonas mobilis AX101. Mohagheghi A, Evans K, Chou Y-C, Zhang M, Appl Biochem Biotechnol 2002 98-100 885 898
81. Nuclear magnetic resonance studies of acetic acid inhibition of rec Zymomonas mobilis ZM4 (pZB5). Kim IS, Barrow KD, Rogers PL, Appl Biochem Biotechnol 2000 84 357 370
82. Improving fermentation performance of recombinant Zymomonas in acetic acid-containing media. Lawford HG, Rousseau JD, Appl Biochem Biotechnol 1998 70-72 161 172
83. Over-expression of xylulokinase in a xylose-metabolising recombinant strain of Zymomonas mobilis. Jeon YJ, Svenson CJ, Rogers PL, FEMS Microbiol Lett 2005 244 85 92
84. Isolation and preliminary characterization of a Zymomonas mobilis mutant with an altered preference for xylose and glucose utilization. Supple SG, Joachimsthal EL, Dunn NW, Rogers PL, Biotechnol Lett 2000 22 157 164
85. Improving xylose utilization by recombinant Zymomonas mobilis strain 8b through adaptation using 2-deoxyglucose. Mohagheghi A, Linger J, Smith H, Yang S, Dowe N, Pienkos PT, Biotechnol Biofuels 2014 7 19
86. Discovery and characterization of a xylose reductase from Zymomonas mobilis ZM4. Agrawal M, Chen RR, Biotechnol Lett 2011 33 2127 2133
87. Kinetic and nuclear magnetic resonance studies of xylose metabolism by recombinant Zymomonas mobilis ZM4(pZB5). Kim IS, Barrow KD, Rogers PL, Appl Environ Microbiol 2000 66 186 193
88. Comparing the fermentation performance ofEscherichia coliKO11, Saccharomyces cerevisiae424A(LNH-ST) and Zymomonas mobilis AX101 for cellulosic ethanol production. Lau MW, Gunawan C, Balan V, Dale BE, Biotechnol Biofuels 2010 3 11
89. Construction of a novel cell-surface display system for heterologous gene expression in Escherichia coli by using an outer membrane protein of Zymomonas mobilis as anchor motif. He MX, Feng H, Zhang YZ, Biotechnol Lett 2008 30 2111 2117
90. Evaluation of Thai agro-industrial wastes for bio-ethanol production by Zymomonas mobilis. Ruanglek V, Maneewatthana D, Tripetchkul S, Process Biochem 2006 41 1432 1437
91. Ethanol production from sugarcane bagasse by Zymomonas mobilis using simultaneous saccharification and fermentation (SSF) process. dos Santos DS, Camelo AC, Rodrigues KC, Carlos LC, Pereira N Jr, Appl Biochem Biotechnol 2010 161 93 105
92. Comparative ethanol productivities of different Zymomonas recombinants fermenting oat hull hydrolysate. Lawford HG, Rousseau JD, Tolan JS, Appl Biochem Biotechnol 2001 91 133 146
93. Ethanol production from high-solid SSCF of alkaline-pretreated corncob using recombinant Zymomonas mobilis CP4. Su R, Ma Y, Qi W, Zhang M, Wang F, Du R, Yang J, Zhang M, He Z, Bioenergy Res 2013 6 292 299
94. Bio-ethanol production from bamboo residues with lignocellulose fractionation technology (LFT) and separate hydrolysis fermentation (SHF) by Zymomonas mobilis. He MX, Li Q, Liu XY, Hu QC, Hu GQ, Pan K, Zhu QL, Wu J, Am J Biomass Bioenergy 2013 1 1 10
95. Consolidated Bioprocessing. Linger JG, Darzins A, Advanced Biofuels and Bioproducts Springer, Lee JW, 2013 267 280
96. Consolidated bioprocessing of cellulosic biomass: an update. Lynd LR, Zyl WH, McBRIDE JE, Laser M, Curr Opin Biotechnol 2005 16 577 583
97. Heterologous expression and extracellular secretion of cellulolytic enzymes by Zymomonas mobilis. Linger JG, Adney WS, Darzins A, Appl Environ Microbiol 2010 76 6360 6369
98. Cloning of bacterial cellulose gene into Zymomonas mobilis for cellulosic ethanol production. Thirumalai Vasan P, PhD Thesis of Bharathidasan University 2012 URI: http://hdl.handle.net/10603/4784
99. Direct ethanol production from cellulosic materials byZymobacter palmaecarrying Cellulomonas endoglucanase and Ruminococcus β-glucosidase genes. Kojima M, Okamoto K, Yanase H, Appl Microbiol Biotechnol 2013 97 5137 5147
100. Top Value Added Chemicals from Biomass. Volume I-Results of Screening for Potential Candidates from Sugars and Synthesis Gas. Werpy T, Petersen G, DOE Report by PNNL, NREL, EERE 2013 website: http://ascension-publishingcom/BIZ/ HD49pdf
101. Sorbitol production by Zymomonas mobilis. Barrow KD, Collins JG, Leight DA, Rogers PL, Warr RG, Appl Microbiol Biotechnol 1984 20 225 232
102. A proposed pathway for sorbitol production by Zymomonas mobilis. Leigh D, Scopes R, Rogers P, Appl Microbiol Biotechnol 1984 20 413 415
103. Glucose-fructose oxidoreductase, a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production. Zachariou M, Scopes RK, J Bacteriol 1986 167 863 869
104. The simultaneous production of sorbitol from fructose and gluconic acid from glucose using an oxidoreductase of Zymomonas mobilis. Chun U, Rogers P, Appl Microbiol Biotechnol 1988 29 19 24
105. Production of sorbitol and gluconic acid by permeabilized cells of Zymomonas mobilis. Rehr B, Wilhelm C, Sahm H, Appl Microbiol Biotechnol 1991 35 144 148
106. Formation and degradation of gluconate by Zymomonas mobilis. Strohdeicher M, Schmitz B, Bringer-Meyer S, Sahm H, Appl Microbiol Biotechnol 1988 27 378 382
107. Bioconversion of glucose and fructose to sorbitol and gluconic acid by untreated cells of Zymomonas mobilis. Silveira MM, Wisbeck E, Lemmel C, Erzinger G, da Costa JP, Bertasso M, Jonas R, J Biol Chem 1999 75 99 103
108. Optimization study for sorbitol production by Zymomonas mobilis in sugar cane molasses. Cazetta ML, Celligoi MAPC, Buzato JB, Scarmino IS, da Silva RSF, Process Biochem 2005 40 747 751
109. Sorbitol production using recombinant Zymomonas mobilis strain. Liu C, Dong HW, Zhong J, Ryu DD, Bao J, J Biotechnol 2010 148 105 112
110. Sorbitol production from lactose by engineered Lactobacillus casei deficient in sorbitol transport system and mannitol-1-phosphate dehydrogenase. De Boeck R, Sarmiento-Rubiano LA, Nadal I, Monedero V, Pérez- Martínez G, Yebra MJ, Appl Microbiol Biotechnol 2010 85 1915 1922
111. High-level production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metabolic engineering. Ladero V, Ramos A, Wiersma A, Goffin P, Schanck A, Kleerebezem M, Hugenholtz J, Smid EJ, Hols P, Appl Environ Microbiol 2007 73 1864 1872
112. Metabolic engineering for bioproduction of sugar alcohols. Akinterinwa O, Khankal R, Cirino PC, Curr Opin Biotechnol 2008 19 461 467
113. Bio-production of lactobionic acid: current status, applications and future prospects. Alonso S, Rendueles M, Díaz M, Biotechnol Adv 2013 31 1275 1291
114. Sorbitol promotes growth of Zymomonas mobilis in environments with high concentrations of sugar: evidence for a physiological function of glucose-fructose oxidoreductase in osmoprotection. Loos H, Krämer R, Sahm H, Sprenger GA, J Bacteriol 1994 176 7688 7693
115. Continuous enzymatic production of lactobionic acid using glucose-fructose oxidoreductase in an ultrafiltration membrane reactor. Satory M, Fürlinger M, Haltrich D, Kulbe K, Pittner F, Nidetzky B, Biotechnol Lett 1997 19 1205 1208
116. Production of lactobionic acid and sorbitol from lactose/fructose substrate using GFOR/GL enzymes from Zymomonas mobilis cells: a kinetic study. Pedruzzi I, da Silva EAB, Rodrigues AE, Enzyme Microb Technol 2011 49 183 191
117. Production of organic acids by periplasmic enzymes present in free and immobilized cells of Zymomonas mobilis. Malvessi E, Carra S, Pasquali FC, Kern DB, da Silveira MM, Ayub MAZ, J Ind Microbiol Biotechnol 2013 40 1 10
118. Levan-ethanol biosynthesis using Zymomonas mobilis cells immobilized by attachment and entrapment. Bekers M, Laukevics J, Karsakevich A, Ventina E, Kaminska E, Upite D, Vna I, Linde R, Scherbaka R, Process Biochem 2001 36 979 986
119. Sucrose utilization by Zymomonas mobilis: formation of a levan. Dawes E, Ribbons D, Biochem J 1966 98 804 812
120. Formation of levan and sorbitol from sucrose by Zymomonas mobilis. Viikari L, Appl Microbiol Biotechnol 1984 19 252 255
121. A simultaneous sucrose bioconversion into ethanol and levan by Zymomonas mobilis. Beker M, Shvinka J, Pankova L, Laivenieks M, Mezhbarde I, Appl Biochem Biotechnol 1990 24 265 274
122. Production of levan by a Zymomonas sp. Yoshida Y, Suzuki R, Yagi Y, J Ferment Bioeng 1990 70 269 271
123. Reiss M, Hartmeier W, Levan Production With a Flocculent Strain of Zymomonas Mobilis 1990
124. Isolation and characterization of mutants from levan-producing Zymomonas mobilis. Ananthalakshmy VK, Gunasekaran P, J Biosci Bioeng 1999 87 214 217
125. Antitumour activities of levans produced by Zymomonas mobilis strains. Calazans G, Lopes C, Lima R, De Franc F, Biotechnol Lett 1997 19 19 21
126. Molecular weight and antitumour activity of Zymomonas mobilis levans. Calazans GM, Lima RC, de França FP, Lopes CE, Int J Biol Macromol 2000 27 245 247
127. The sacB and sacC genes encoding levansucrase and sucrase form a gene cluster in Zymomonas mobilis. Gunasekaran P, Mukundan G, Kannan R, Velmurugan S, Ait-Abdelkader N, Alvarez-Macarie E, Baratti J, Biotechnol Lett 1995 17 635 642
128. Study of levan production by Zymomonas mobilis using regional low-cost carbohydrate sources. de Oliveira MR, da Silva RSSF, Buzato JB, Celligoi MAPC, Biochem Eng J 2007 37 177 183
129. Levan production by Zymomonas mobilis in batch and continuous fermentation systems. Silbir S, Dagbagli S, Yegin S, Baysal T, Goksungur Y, Carbohydr Polym 2014 99 454 461
130. Microbial succinic acid production: natural versus metabolic engineered producers. Beauprez JJ, De Mey M, Soetaert WK, Process Biochem 2010 45 1103 1114
131. Biotechnological production of succinic acid: current state and perspectives. Cheng KK, Zhao XB, Zeng J, Zhang JA, Biofuels Bioprod Biorefin 2012 6 302 318
132. Metabolic engineering of Escherichia colifor enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation. Lee SJ, Lee D-Y, Kim TY, Kim BH, Lee J, Lee SY, Appl Environ Microbiol 2005 71 7880 7887
133. Effect of growth phase feeding strategies on succinate production by metabolically engineered Escherichia coli. Jiang M, Liu SW, Ma J, Chen K, Yu L, Yue F, Xu B, Wei P, Appl Environ Microbiol 2010 76 1298 1300
134. Genome-scale modeling enables metabolic engineering of Saccharomyces cerevisiaefor succinic acid production. Agren R, Otero JM, Nielsen J, J Ind Microbiol Biotechnol 2013 40 735 747
135. Metabolic engineering of Saccharomyces cerevisiae for the biotechnological production of succinic acid. Raab AM, Gebhardt G, Bolotina N, Weuster-Botz D, Lang C, Metab Eng 2010 12 518 525
136. The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production strategies. Lee K, Park J, Kim T, Yun H, Lee S, Microb Cell Fact 2010 9 94
137. Genome-scale modeling and in silico analysis of ethanologenic bacteria Zymomonas mobilis. Widiastuti H, Kim JY, Selvarasu S, Karimi IA, Kim H, Seo JS, Lee DY, Biotechnol Bioeng 2011 108 655 665
138. Biotechnological potential of respiring Zymomonas mobilis: a stoichiometric analysis of its central metabolism. Pentjuss A, Odzina I, Kostromins A, Fell D, Stalidzans E, Kalnenieks U, J Biotechnol 2013 165 1 10
139. Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Atsumi S, Hanai T, Liao JC, Nature 2008 451 86 89
140. Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes. Atsumi S, Wu TY, Eckl EM, Hawkins SD, Buelter T, Liao JC, Appl Microbiol Biotechnol 2010 85 651 657
141. Metabolic engineering for advanced biofuels production from Escherichia coli. Atsumi S, Liao JC, Curr Opin Biotechnol 2008 19 414 419
142. Increased isobutanol production inSaccharomyces cerevisiaeby overexpression of genes in valine metabolism. Chen X, Nielsen KF, Borodina I, Kielland-Brandt MC, Karhumaa K, Biotechnol Biofuels 2011 4 2089 2090
143. Isobutanol production from D-ylose by recombinant Saccharomyces cerevisiae. Brat D, Boles E, FEMS Yeast Res 2013 3 241 244
144. A novel pathway to produce butanol and isobutanol in Saccharomyces cerevisiae. Branduardi P, Longo V, Berterame NM, Rossi G, Porro D, Biotechnol Biofuels 2013 6 1 12
145. Engineering Corynebacterium glutamicum for isobutanol production. Smith KM, Cho K-M, Liao JC, Appl Microbiol Biotechnol 2010 87 1045 1055
146. Corynebacterium glutamicum tailored for efficient isobutanol production. Blombach B, Riester T, Wieschalka S, Ziert C, Youn J-W, Wendisch VF, Eikmanns BJ, Appl Environ Microbiol 2011 77 3300 3310
147. Strain optimization for efficient isobutanol production using Corynebacterium glutamicum under oxygen deprivation. Yamamoto S, Suda M, Niimi S, Inui M, Yukawa H, Biotechnol Bioeng 2013 110 2938 2948
148. Engineering Bacillus subtilis for isobutanol production by heterologous Ehrlich pathway construction and the biosynthetic 2-ketoisovalerate precursor pathway overexpression. Li SS, Wen JP, Jia XQ, Appl Microbiol Biotechnol 2011 91 577 589
149. Design and characterization of synthetic fungal-bacterial consortia for direct production of isobutanol from cellulosic biomass. Minty JJ, Singer ME, Scholz SA, Bae C-H, Ahn J-H, Foster CE, Liao JC, Lin XN, Proc Natl Acad Sci U S A 2013 110 14592 14597
150. Expression of an L-alanine dehydrogenase gene in Zymomonas mobilis and excretion of L-alanine. Uhlenbusch I, Sahm H, Sprenger GA, Appl Environ Microbiol 1991 57 1360 1366
151. Manufacturing molecules through metabolic engineering. Keasling JD, Science 2010 330 1355 1358
152. Microbial Isoprenoid Production: An Example of Green Chemistry through Metabolic Engineering. Maury J, Asadollahi M, Møller K, Clark A, Nielsen J, Biotechnology for the Future, Volume 100 Berlin Heidelberg: Springer, Nielsen J, 2005 19 51 Advances in Biochemical Engineering/Biotechnology
153. Content and composition of hopanoids in Zymomonas mobilisunder various growth conditions. Hermans MA, Neuss B, Sahm H, J Bacteriol 1991 173 5592 5595
154. Effect of alcohols and temperature on the hopanoid content of Zymomonas mobilis. Schmidt A, Bringer-Meyer S, Poralla K, Sahm H, Appl Microbiol Biotechnol 1986 25 32 36
155. On the reduction steps in the mevalonate independent 2-C-methyl-d- erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in the bacterium Zymomonas mobilis. Charon L, Pale-Grosdemange C, Rohmer M, Tetrahedron Lett 1999 40 7231 7234
156. Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicumthat function in the biosynthesis of hopanoid lipids. Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Elmar L, Biochim Biophys Acta (BBA)-Lipids Lipid Metabol 1998 1393 108 118
157. Isolation of the dxr gene of Zymomonas mobilisand characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Grolle S, Bringer-Meyer S, Sahm H, FEMS Microbiol Lett 2000 191 131 137
158. Composite hopanoid biosynthesis in Zymomonas mobilis: N-acetyl-D-glucosamine as precursor for the cyclopentane ring linked to bacteriohopanetetrol. Vincent SP, Sinay P, Rohmer M, Chem Commun 2003 6 782 783
159. Production of beta-carotene in Zymomonas mobilis and Agrobacterium tumefaciensby introduction of the biosynthesis genes from Erwinia uredovora. Misawa N, Yamano S, Ikenaga H, Appl Environ Microbiol 1991 57 1847 1849
160. Programming cells by multiplex genome engineering and accelerated evolution. Wang HH, Isaacs FJ, Carr PA, Sun ZZ, Xu G, Forest CR, Church GM, Nature 2009 460 894 898
161. Genome engineering. Carr PA, Church GM, Nat Biotechnol 2009 27 1151 1162
162. Multiplex genome engineering using CRISPR/Cas systems. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Science 2013 339 819 823
163. Genome engineering using site-specific recombinases. Kolb AF, Cloning Stem Cells 2002 4 65 80
164. Road to precision: recombinase-based targeting technologies for genome engineering. Wirth D, Gama-Norton L, Riemer P, Sandhu U, Schucht R, Hauser H, Curr Opin Biotechnol 2007 18 411 419
165. Genome shuffling leads to rapid phenotypic improvement in bacteria. Zhang Y-X, Perry K, Vinci VA, Powell K, Stemmer WP, del Cardayré SB, Nature 2002 415 644 646
166. Global transcription machinery engineering: a new approach for improving cellular phenotype. Alper H, Stephanopoulos G, Metab Eng 2007 9 258 267
167. Genome engineering with zinc-finger nucleases. Carroll D, Genetics 2011 188 773 782