OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin

Cellular and Molecular Life Sciences

Volumn 71, Issue 13, 2014, Pages 2561-2576

  Han, Jonghee ^a   Jung, Sunmin ^a   Jang, Jiyeon ^b   Kam, Tae In ^a   Choi, Hyunwoo ^a   Kim, Byung Ju ^c   Nah, Jihoon ^a   Jo, Dong Gyu ^b   Nakagawa, Toshiyuki ^d   Nishimura, Masaki ^e   Jung, Yong Keun ^a  

^a Seoul National University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Alzheimer's disease; Nicastrin; OCIAD2; secretase

Indexed keywords

AMYLOID BETA PROTEIN; COMPLEMENTARY DNA; GAMMA SECRETASE; NICASTRIN; NOTCH RECEPTOR; PROTEIN OCIAD2; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA LIBRARY; ENZYME ACTIVATION; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID RAFT; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM;

MUS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; FIBROBLASTS; GENE LIBRARY; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE MICRODOMAINS; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; RECEPTORS, NOTCH;

EID: 84903301881     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1515-x     Document Type: Article

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