IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

Human Molecular Genetics

Volumn 21, Issue 1, 2012, Pages 101-114

  Lee, Huikyong ^a   Noh, Jee Yeon ^a   Oh, Yumin ^a   Kim, Youngdoo ^a   Chang, Jae Woong ^a   Chung, Chul Woong ^b   Lee, Soon Tae ^c   Kim, Manho ^c   Ryu, Hoon ^d   Jung, Yong Keun ^a  

^a Seoul National University   (South Korea)

^b LG Chemical Ltd   (South Korea)

^c Seoul National University Hospital   (South Korea)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; COMPLEMENTARY DNA; HUNTINGTIN; PROTEIN IRE1; THAPSIGARGIN; TUNICAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL LOSS; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE ACTIVATION; GENE ISOLATION; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; IMMUNOCYTOCHEMISTRY; MOUSE; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT; STRIATE CORTEX; UPREGULATION;

ANIMALS; AUTOPHAGY; CELL LINE; CELLS, CULTURED; DOWN-REGULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HUMANS; HUNTINGTON DISEASE; MEMBRANE PROTEINS; MICE; MUTATION; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RATS;

EID: 83455169115     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr445     Document Type: Article

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