Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 286, Issue 6 30-6, 2004, Pages

  Panduri, Vijayalakshmi ^a,b   Weitzman, Sigmund A ^a,b   Chandel, Navdeep S ^a,b   Kamp, David W ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

cells; DNA damage; Mitochondria; Oxidants; Pulmonary epithelium

Indexed keywords

ANION CHANNEL; ASBESTOS; BENZOIC ACID; CASPASE 9; CITRININ; DEFEROXAMINE; DICHLOROFLUORESCEIN; DNA FRAGMENT; FREE RADICAL; GLUTATHIONE; IRON CHELATING AGENT; MITOCHONDRIAL DNA; PHYTIC ACID; REACTIVE OXYGEN METABOLITE; SCAVENGER; UBIQUINOL CYTOCHROME C REDUCTASE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ELECTRON TRANSPORT; ENZYME ACTIVATION; EXPOSURE; FLUORESCENCE; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG TOXICITY; MITOCHONDRION; NICK END LABELING; OXIDATIVE STRESS; PRIORITY JOURNAL;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; APOPTOSIS; ASBESTOS; CARCINOGENS; CASPASE 9; CASPASES; CELL LINE, TUMOR; FREE RADICALS; GLUTATHIONE; HUMANS; LUNG NEOPLASMS; MITOCHONDRIA; OXIDATIVE STRESS; PULMONARY ALVEOLI; REACTIVE OXYGEN SPECIES;

EID: 2442656662     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00371.2003     Document Type: Article

References (43)

1. Aljandali A, Pollack H, Yeldandi A, Li Y, Weitzman SA, and Kamp DW. Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals. J Lab Clin Med 137: 330-339, 2001.
2. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Standen R, and Young IG. Sequence and organization of the human mitochondrial genome. Nature 290: 457-465, 1981.
3. Arnold RS, Shi J, Murad E, Whalen AM, Sun CQ, Polavarapu R, Parthasarathy S, Petros JA, and Lambeth JD. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci USA 98: 5550-5555, 2001.
4. Aust A and Eveleigh J. Mechanisms of DNA oxidation. Proc Soc Exp Biol Med 222: 246-252, 1999.
5. Bortner CD and Cidlowski JA. Cellular mechanisms for the repression of apoptosis. Annu Rev Pharmacol Toxicol 42: 259-281, 2002.
6. Brandt U. Bifurcated ubihydroquinone oxidation in the cytochrome bcl complex by proton-gated charge transfer. FEBS Lett 387: 1-6, 1996.
7. Brody AR and Overby LH. Incorporation of tritiated thymidine by epithelial and interstitial cells in bronchiolar-alveolar regions of asbestos-exposed rats. Am J Pathol 134: 133-140, 1989.
8. Buchet K and Godinot C. Functional F1-ATPase essential in maintaining growth and membrane potential of human mitochondrial DNA-depleted ρ0 cells. J Biol Chem 273: 22983-22989, 1998.
9. Bunnell E and Pacht ER. Oxidized glutathione is increased in the alveolar fluid of patients with the adult respiratory distress syndrome. Am Rev Respir Dis 148: 1174-1178, 1993.
10. Cantin AM, Hubbard RC, and Crystal RG. Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis. Am Rev Respir Dis 139: 370-372, 1989.
11. Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, and Schumacker PT. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1 α during hypoxia. J Biol Chem 275: 25130-25138, 2000.
12. Chandel NS and Schumacker PT. Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms. FEBS Lett 454: 173-176, 1999.
13. Dobson AW, Grishko V, LeDoux SP, Kelley MR, Wilson GL, and Gillespie MN. Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death. Am J Physiol Lung Cell Mol Physiol 283: L205-L210, 2002.
14. Dobson AW, Xu Y, Kelley MR, LeDoux SP, and Wilson GL. Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria. J Biol Chem 275: 37518-37523, 2000.
15. Fernandez-Checa JC, Kaplowitz N, Garcia-Ruiz C, Colell A, Miranda M, Mari M, Ardite E, and Morales A. GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol Gastrointest Liver Physiol 273: G7-G17, 1997.
16. Ferri KF and Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 3: E255-E263, 2001.
17. Fliss MS, Usadel H, Cabellero OL, Wu L, Buta MR, Eleff SM, Jen J, and Sidransky D. Facile detection of mitochondrial DNA mutation in tumors and bodily fluids. Science 287: 2017-2019, 2000.
18. 2 induces translocation of APE/REF-1 to mitochondria in the Raji B-cell line. J Cell Physiol 93: 180-186, 2002.
19. Fung H, Kow Y, Van Houten B, Taatjes D, Hatahet Z, Janssen Y, Vacek P, Faux S, and Mossman B. Asbestos increases mammalian major AP-endonuclease (APE) gene expression, protein levels and enzyme activity in rat pleural mesothelial cells. Cancer Res 58: 189-194, 1998.
20. Green DR and Reed JC. Mitochondria and apoptosis. Science 281: 1309-1312, 1998.
21. Grishko V, Solomon M, Wilson GL, LeDoux SP, and Gillespie MN. Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes. Am J Physiol Lung Cell Mol Physiol 280: L1300-L1308, 2001.
22. Han D, Antunes F, Canali R, Rettori D, and Cadenas E. Voltage-dependent anion channels control the release of superoxide anion from mitochondria to cytosol. J Biol Chem 278: 5557-5563, 2003.
23. Han D, Williams E, and Cadenas E. Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space. Biochem J 353: 411-416, 2001.
24. Hoidal JR. Reactive oxygen species and cell signaling. Am J Respir Cell Mol Biol 25: 661-663, 2001.
25. Kamp DW, Israbian VA, Preusen SE, Zhang CX, and Wietzman SA. Asbestos causes DNA strand breaks in cultured pulmonary epithelial cells: role of iron-catalyzed free radicals. Am J Physiol Lung Cell Mol Physiol 268: L471-L480, 1995.
26. Kamp DW and Mossman BT. Asbestos-associated cancers: clinical spectrum and pathogenic mechanisms. In: Clinical Occupational Environmental Medicine: Carcinogens in the Workplace, edited by Whysner J and Shields PG. Philadelphia, PA: Saunders, 2002, p. 753-778.
27. Kamp DW and Weitzman SA. The molecular basis of asbestos induced lung injury. Thorax 54: 638-652, 1999.
28. King MP and Attadi G. Mitochondria-mediated transformation of human rho(0) cells. Methods Enzymol 264: 313-334, 1996.
29. Lavrentiadou SN, Chan C, Kawcak T, Ravid T, Tsaba A, van der Vliet A, Rasooly R, and Goldkom T. Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione. Am J Respir Cell Mol Biol 25: 676-684, 2001.
30. Mambo E, Gao X, Cohen Y, Guo Z, Talalay P, and Sidransky D. Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. Proc Natl Acad Sci USA 100: 1838-1843, 2003.
31. Mossman BT and Churg A. Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med 157: 1666-1680, 1998.
32. Panduri V, Weitzman SA, Chandel N, and Kamp DW. The mitochondria-regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis. Am J Respir Cell Mol Biol 28: 241-248, 2003.
33. Park SY, Chang I, Kim JY, Kang SW, Park SH, Singh K, and Lee MS. Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase. J Biol Chem 279: 7512-7520, 2004.
34. Rahman I, Li XY, Donaldson K, Harrison DJ, and MacNee W. Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress. Am J Physiol Lung Cell Mol Physiol 269: L285-L292, 1995.
35. Ricci JE, Waterhouse N, and Green DR. Mitochondrial functions during cell death, a complex (I-V) dilemma. Cell Death Differ 10: 488-492, 2003.
36. Rudin CM, Yang Z, Schumaker LM, VanderWeele DJ, Newkirk K, Egorin MJ, Zuhowski EG, and Cullen KJ. Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance. Cancer Res 63: 312-318, 2003.
37. Santos JH, Hunakova L, Chen Y, Bortner C, and Van Houten B. Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death. J Biol Chem 278: 1728-1734, 2003.
38. Sawyer DE and Van Houten B. Repair of DNA damage in mitochondria. Mutat Res 434: 161-176, 1999.
39. Shukla A, Gulumian M, Hei T, Kamp DW, Rahman Q, Aust AE, and Mossman BT. Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases. Free Radic Biol Med 34: 1117-1129, 2003.
40. Timbrell V. Characteristics of the International Union Against Cancer standard reference samples of asbestos. In: Pneumonconiosis, Proceedings of the International Conference, Johannesburg, edited by Shapiro HA. London: Oxford Univ. Press, 1970, p. 28-36.
41. Uhal BD. Cell cycle kinetics in the alveolar epithelium. Am J Physiol Lung Cell Mol Physiol 272: L1031-L1045, 1997.
42. Van der Vliet A, O'Neill CA, Cross CE, Koostra JM, Volz WG, Halliwell B, and Louie S. Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids. Am J Physiol Lung Cell Mol Physiol 276: L289-L296, 1999.
43. Weitzman SA and Graceffa P. Asbestos catalyzes hydroxyl radical and superoxide radical generation from hydrogen peroxide. Arch Biochem Biophys 228: 373-376, 1984.