Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Nature Communications

Volumn 4, Issue , 2013, Pages

  Liu, Baohua ^a,b   Wang, Zimei ^a   Zhang, Le ^a   Ghosh, Shrestha ^a   Zheng, Huiling ^a,c   Zhou, Zhongjun ^a,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (China)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIN; METHYLTRANSFERASE; METHYLTRANSFERASE SUV39H1; PRELAMIN A; PROTEASOME; UNCLASSIFIED DRUG;

CYTOLOGY; ENZYME ACTIVITY; MUTATION; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; CONTROLLED STUDY; DEGRADATION; DEPLETION; DNA REPAIR; ENZYME STABILITY; EPIGENETICS; GENOME; HETEROCHROMATIN; LAMINOPATHY; LIFESPAN; MALE; MOUSE; NONHUMAN; PREMATURE AGING; PROGERIA; SENESCENCE; WEIGHT REDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA REPAIR; ENZYME STABILITY; FIBROBLASTS; HEK293 CELLS; HETEROCHROMATIN; HISTONES; HUMANS; LAMIN TYPE A; LONGEVITY; LYSINE; METHYLATION; METHYLTRANSFERASES; MICE; NUCLEAR PROTEINS; PROGERIA; PROTEIN BINDING; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPRESSOR PROTEINS;

MUS;

EID: 84878738557     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2885     Document Type: Article

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