Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers

International Journal of Cancer

Volumn 107, Issue 4, 2003, Pages 612-616

  Zöchbauer Müller, Sabine ^a,b,f   Lam, Stephen ^c   Toyooka, Shinichi ^a   Virmani, Arvind K ^a,d   Toyooka, Kiyomi O ^a   Seidl, Sonja ^b   Minna, John D ^a,d,e   Gazdar, Adi F ^a,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY OF TEXAS AT DALLAS   (United States)

^f UNIVERSITY OF VIENNA   (Austria)

Author keywords

Aberrant methylation; Cigarette smoking; Lung cancer; Methylation specific PCR; Preneoplastic lesion

Indexed keywords

CADHERIN; H CADHERIN; PROTEIN P16; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR BETA 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BRONCHUS SECRETION; CANCER RISK; CHEMOPROPHYLAXIS; CIGARETTE SMOKING; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE EPITHELIUM; LUNG CARCINOMA; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; ONCOGENE RAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; RISK ASSESSMENT; SMOKING HABIT; SPUTUM ANALYSIS; THROAT CULTURE; TUMOR SUPPRESSOR GENE; UPPER GASTROINTESTINAL TRACT;

ADULT; AGED; BRONCHOALVEOLAR LAVAGE; CADHERINS; CASE-CONTROL STUDIES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PRECANCEROUS CONDITIONS; PROMOTER REGIONS (GENETICS); RECEPTORS, RETINOIC ACID; RESPIRATORY MUCOSA; SMOKING; TUMOR SUPPRESSOR PROTEINS;

EID: 0142053910     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11458     Document Type: Article

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