메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages

Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease

Author keywords

Adult neurogenesis; Alzheimer's disease; DNA methylation; Epigenetics; Histone modifications; Induced pluripotent stem cell; MicroRNAs; Stem cell

Indexed keywords

BROXURIDINE; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HISTONE DEACETYLASE 2; MICRORNA 124; MICRORNA 125B; MICRORNA 132; MICRORNA 9;

EID: 84902892701     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-9-25     Document Type: Review
Times cited : (51)

References (206)
  • 1
    • 33846640175 scopus 로고    scopus 로고
    • The adult neural stem cell niche: Lessons for future neural cell replacement strategies
    • The adult neural stem cell niche: lessons for future neural cell replacement strategies. Lim DA, Huang YC, Alvarez-Buylla A, Neurosurg Clin N Am 2007 18 81 92
    • (2007) Neurosurg Clin N Am , vol.18 , pp. 81-92
    • Lim, D.A.1    Huang, Y.C.2    Alvarez-Buylla, A.3
  • 3
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • Mammalian neural stem cells. Gage FH, Science (80-) 2000 287 1433 1438
    • (2000) Science (80-) , vol.287 , pp. 1433-1438
    • Gage, F.H.1
  • 4
    • 77955738876 scopus 로고    scopus 로고
    • Neural stem cell niches and homing: Recruitment and integration into functional tissues
    • Neural stem cell niches and homing: recruitment and integration into functional tissues. Garzón-Muvdi T, Quiñones-Hinojosa A, ILAR J 2009 51 3 23
    • (2009) ILAR J , vol.51 , pp. 3-23
    • Garzón-Muvdi, T.1    Quiñones-Hinojosa, A.2
  • 5
    • 84901598383 scopus 로고    scopus 로고
    • Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: A role for miRNAs?
    • Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: A role for miRNAs? Van den Driesche S, Sharpe RM, Saunders PTK, Mitchell RT, Semin Cell Dev Biol 2014 29 76 83
    • (2014) Semin Cell Dev Biol , vol.29 , pp. 76-83
    • Van Den Driesche, S.1    Sharpe, R.M.2    Saunders, P.T.K.3    Mitchell, R.T.4
  • 6
    • 84904067164 scopus 로고    scopus 로고
    • Stem cell decisions: A twist of fate or a niche market?
    • in press
    • Stem cell decisions: A twist of fate or a niche market? Januschke J, Näthke I, Semin Cell Dev Biol in press
    • Semin Cell Dev Biol
    • Januschke, J.1    Näthke, I.2
  • 7
    • 0034548865 scopus 로고    scopus 로고
    • Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus
    • Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. Shihabuddin LS, Horner PJ, Ray J, Gage FH, J Neurosci 2000 20 8727 8735
    • (2000) J Neurosci , vol.20 , pp. 8727-8735
    • Shihabuddin, L.S.1    Horner, P.J.2    Ray, J.3    Gage, F.H.4
  • 8
    • 33644960523 scopus 로고    scopus 로고
    • Neurogenic niche modulation by activated microglia: Transforming growth factor beta increases neurogenesis in the adult dentate gyrus
    • Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Battista D, Ferrari CC, Gage FH, Pitossi FJ, Eur J Neurosci 2006 23 83 93
    • (2006) Eur J Neurosci , vol.23 , pp. 83-93
    • Battista, D.1    Ferrari, C.C.2    Gage, F.H.3    Pitossi, F.J.4
  • 9
    • 2542591096 scopus 로고    scopus 로고
    • Cellular interactions in the stem cell niche
    • Cellular interactions in the stem cell niche. Wurmser AE, Palmer TD, Gage FH, Science 2004 304 1253 1255
    • (2004) Science , vol.304 , pp. 1253-1255
    • Wurmser, A.E.1    Palmer, T.D.2    Gage, F.H.3
  • 10
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • Vascular niche for adult hippocampal neurogenesis. Palmer TD, Willhoite AR, Gage FH, J Comp Neurol 2000 425 479 494
    • (2000) J Comp Neurol , vol.425 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 11
    • 84904067165 scopus 로고    scopus 로고
    • From greenhouse to garden: The changing soil of the hematopoietic stem cell microenvironment during development
    • in press
    • From greenhouse to garden: The changing soil of the hematopoietic stem cell microenvironment during development. Mirshekar-Syahkal B, Fitch SR, Ottersbach K, Stem Cells in press
    • Stem Cells
    • Mirshekar-Syahkal, B.1    Fitch, S.R.2    Ottersbach, K.3
  • 12
    • 84885071003 scopus 로고    scopus 로고
    • Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling
    • Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling. Ghiaur G, Yegnasubramanian S, Perkins B, Gucwa JL, Gerber JM, Jones RJ, Proc Natl Acad Sci U S A 2013 110 16121 16126
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 16121-16126
    • Ghiaur, G.1    Yegnasubramanian, S.2    Perkins, B.3    Gucwa, J.L.4    Gerber, J.M.5    Jones, R.J.6
  • 13
    • 84871603152 scopus 로고    scopus 로고
    • Adhesion in the stem cell niche: Biological roles and regulation
    • Adhesion in the stem cell niche: biological roles and regulation. Chen S, Lewallen M, Xie T, Development 2013 140 255 265
    • (2013) Development , vol.140 , pp. 255-265
    • Chen, S.1    Lewallen, M.2    Xie, T.3
  • 14
    • 84860131560 scopus 로고    scopus 로고
    • The germline stem cell niche unit in mammalian testes
    • The germline stem cell niche unit in mammalian testes. Oatley JM, Brinster RL, Physiol Rev 2012 92 577 595
    • (2012) Physiol Rev , vol.92 , pp. 577-595
    • Oatley, J.M.1    Brinster, R.L.2
  • 15
    • 39149107803 scopus 로고    scopus 로고
    • Mechanisms and functional implications of adult neurogenesis
    • Mechanisms and functional implications of adult neurogenesis. Zhao C, Deng W, Gage FH, Cell 2008 132 645 660
    • (2008) Cell , vol.132 , pp. 645-660
    • Zhao, C.1    Deng, W.2    Gage, F.H.3
  • 16
  • 17
    • 84879446488 scopus 로고    scopus 로고
    • Modulation of neural stem/progenitor cell proliferation during experimental Herpes Simplex encephalitis is mediated by differential FGF-2 expression in the adult brain
    • Modulation of neural stem/progenitor cell proliferation during experimental Herpes Simplex encephalitis is mediated by differential FGF-2 expression in the adult brain. Rotschafer JH, Hu S, Little M, Erickson M, Low WC, Cheeran MCJ, Neurobiol Dis 2013 58 144 155
    • (2013) Neurobiol Dis , vol.58 , pp. 144-155
    • Rotschafer, J.H.1    Hu, S.2    Little, M.3    Erickson, M.4    Low, W.C.5    Cheeran, M.C.J.6
  • 18
    • 78650016970 scopus 로고    scopus 로고
    • NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat
    • NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Acosta S, Jernberg J, Sanberg CD, Sanberg PR, Small BJ, Gemma C, Bickford PC, Rejuvenation Res 2010 13 581 588
    • (2010) Rejuvenation Res , vol.13 , pp. 581-588
    • Acosta, S.1    Jernberg, J.2    Sanberg, C.D.3    Sanberg, P.R.4    Small, B.J.5    Gemma, C.6    Bickford, P.C.7
  • 19
    • 77952543738 scopus 로고    scopus 로고
    • Neurogenesis and Alzheimer's disease: At the crossroads
    • Neurogenesis and Alzheimer's disease: at the crossroads. Lazarov O, Marr RA, Exp Neurol 2010 223 267 281
    • (2010) Exp Neurol , vol.223 , pp. 267-281
    • Lazarov, O.1    Marr, R.A.2
  • 20
    • 33845656103 scopus 로고    scopus 로고
    • A neurovascular niche for neurogenesis after stroke
    • A neurovascular niche for neurogenesis after stroke. Ohab J, Fleming S, J Neurosci 2006 26 13007 13016
    • (2006) J Neurosci , vol.26 , pp. 13007-13016
    • Ohab, J.1    Fleming, S.2
  • 21
    • 84055213663 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis and its role in Alzheimer's disease
    • Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mu Y, Gage FH, Mol Neurodegener 2011 6 85
    • (2011) Mol Neurodegener , vol.6 , pp. 85
    • Mu, Y.1    Gage, F.H.2
  • 22
    • 79952579942 scopus 로고    scopus 로고
    • Neurodegenerative disease and adult neurogenesis
    • Neurodegenerative disease and adult neurogenesis. Winner B, Kohl Z, Gage FH, Eur J Neurosci 2011 33 1139 1151
    • (2011) Eur J Neurosci , vol.33 , pp. 1139-1151
    • Winner, B.1    Kohl, Z.2    Gage, F.H.3
  • 23
    • 60049093577 scopus 로고    scopus 로고
    • Adult neurogenesis and its alteration under pathological conditions
    • Adult neurogenesis and its alteration under pathological conditions. Kaneko N, Sawamoto K, Neurosci Res 2009 63 155 164
    • (2009) Neurosci Res , vol.63 , pp. 155-164
    • Kaneko, N.1    Sawamoto, K.2
  • 24
    • 79956209852 scopus 로고    scopus 로고
    • Adult neurogenesis in the mammalian brain: Significant answers and significant questions
    • Adult neurogenesis in the mammalian brain: significant answers and significant questions. Ming G-L, Song H, Neuron 2011 70 687 702
    • (2011) Neuron , vol.70 , pp. 687-702
    • Ming, G.-L.1    Song, H.2
  • 26
    • 1542268981 scopus 로고    scopus 로고
    • For the long run: Maintaining germinal niches in the adult brain
    • For the long run: maintaining germinal niches in the adult brain. Alvarez-Buylla A, Lim DA, Neuron 2004 41 683 686
    • (2004) Neuron , vol.41 , pp. 683-686
    • Alvarez-Buylla, A.1    Lim, D.A.2
  • 27
    • 25844458514 scopus 로고    scopus 로고
    • Glial influences on neural stem cell development: Cellular niches for adult neurogenesis
    • Glial influences on neural stem cell development: cellular niches for adult neurogenesis. Ma DK, Ming G-L, Song H, Curr Opin Neurobiol 2005 15 514 520
    • (2005) Curr Opin Neurobiol , vol.15 , pp. 514-520
    • Ma, D.K.1    Ming, G.-L.2    Song, H.3
  • 28
    • 0033040497 scopus 로고    scopus 로고
    • Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
    • Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A, Cell 1999 97 703 716
    • (1999) Cell , vol.97 , pp. 703-716
    • Doetsch, F.1    Caillé, I.2    Lim, D.A.3    García-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 29
    • 0033594892 scopus 로고    scopus 로고
    • Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis
    • Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis. Lim DA, Alvarez-Buylla A, Proc Natl Acad Sci U S A 1999 96 7526 7531
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7526-7531
    • Lim, D.A.1    Alvarez-Buylla, A.2
  • 32
    • 33744999832 scopus 로고    scopus 로고
    • Glial conversion of SVZ-derived committed neuronal precursors after ectopic grafting into the adult brain
    • Glial conversion of SVZ-derived committed neuronal precursors after ectopic grafting into the adult brain. Seidenfaden R, Desoeuvre A, Bosio A, Virard I, Cremer H, Mol Cell Neurosci 2006 32 187 198
    • (2006) Mol Cell Neurosci , vol.32 , pp. 187-198
    • Seidenfaden, R.1    Desoeuvre, A.2    Bosio, A.3    Virard, I.4    Cremer, H.5
  • 34
    • 53849122281 scopus 로고    scopus 로고
    • Both cell-autonomous and cell non-autonomous functions of GAP-43 are required for normal patterning of the cerebellum in vivo
    • Both cell-autonomous and cell non-autonomous functions of GAP-43 are required for normal patterning of the cerebellum in vivo. Shen Y, Mishra R, Mani S, Meiri, Karina F, Cerebellum 2008 7 451 466
    • (2008) Cerebellum , vol.7 , pp. 451-466
    • Shen, Y.1    Mishra, R.2    Mani, S.3    Meiri4    Karina, F.5
  • 37
    • 84872132572 scopus 로고    scopus 로고
    • A specialized microvascular domain in the mouse neural stem cell niche
    • A specialized microvascular domain in the mouse neural stem cell niche. Culver JC, Vadakkan TJ, Dickinson ME, PLoS One 2013 8 53546
    • (2013) PLoS One , vol.8 , pp. 553546
    • Culver, J.C.1    Vadakkan, T.J.2    Dickinson, M.E.3
  • 38
    • 75649144081 scopus 로고    scopus 로고
    • Diverse roles of the vasculature within the neural stem cell niche
    • Diverse roles of the vasculature within the neural stem cell niche. Goldberg JS, Hirschi KK, Regen Med 2009 4 879 897
    • (2009) Regen Med , vol.4 , pp. 879-897
    • Goldberg, J.S.1    Hirschi, K.K.2
  • 41
    • 50849113768 scopus 로고    scopus 로고
    • Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain
    • Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Mirzadeh Z, Merkle FT, Soriano-Navarro M, Garcia-Verdugo JM, Alvarez-Buylla A, Cell Stem Cell 2008 3 265 278
    • (2008) Cell Stem Cell , vol.3 , pp. 265-278
    • Mirzadeh, Z.1    Merkle, F.T.2    Soriano-Navarro, M.3    Garcia-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 42
    • 0029855989 scopus 로고    scopus 로고
    • Network of tangential pathways for neuronal migration in adult mammalian brain
    • Network of tangential pathways for neuronal migration in adult mammalian brain. Doetsch F, Alvarez-Buylla A, Proc Natl Acad Sci U S A 1996 93 14895 14900
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14895-14900
    • Doetsch, F.1    Alvarez-Buylla, A.2
  • 45
    • 84857136514 scopus 로고    scopus 로고
    • S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone
    • S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone. Lacar B, Herman P, Hartman NW, Hyder F, Bordey A, PLoS One 2012 7 31960
    • (2012) PLoS One , vol.7 , pp. 531960
    • Lacar, B.1    Herman, P.2    Hartman, N.W.3    Hyder, F.4    Bordey, A.5
  • 46
    • 67649380339 scopus 로고    scopus 로고
    • Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion
    • Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion. Miyamoto N, Tanaka R, Zhang N, Shimura H, Onodera M, Mochizuki H, Hattori N, Urabe T, Neuroscience 2009 162 525 536
    • (2009) Neuroscience , vol.162 , pp. 525-536
    • Miyamoto, N.1    Tanaka, R.2    Zhang, N.3    Shimura, H.4    Onodera, M.5    Mochizuki, H.6    Hattori, N.7    Urabe, T.8
  • 48
    • 84888359215 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging
    • Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging. Gebara E, Sultan S, Kocher-Braissant J, Toni N, Front Neurosci 2013 7 145
    • (2013) Front Neurosci , vol.7 , pp. 145
    • Gebara, E.1    Sultan, S.2    Kocher-Braissant, J.3    Toni, N.4
  • 49
    • 84902074669 scopus 로고    scopus 로고
    • Epigenetics and memigenetics
    • Epigenetics and memigenetics. Mann JR, Cell Mol Life Sci 2014 71 1117 1122
    • (2014) Cell Mol Life Sci , vol.71 , pp. 1117-1122
    • Mann, J.R.1
  • 50
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Perceptions of epigenetics. Bird A, Nature 2007 447 396 398
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1
  • 51
    • 77952887349 scopus 로고    scopus 로고
    • Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: Unraveling the genome to understand the mind
    • Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Hsieh J, Eisch AJ, Neurobiol Dis 2010 39 73 84
    • (2010) Neurobiol Dis , vol.39 , pp. 73-84
    • Hsieh, J.1    Eisch, A.J.2
  • 52
    • 73649107635 scopus 로고    scopus 로고
    • Epigenetics: Molecular mechanisms and implications for disease
    • Epigenetics: molecular mechanisms and implications for disease. Handel AE, Ebers GC, Ramagopalan SV, Trends Mol Med 2010 16 7 16
    • (2010) Trends Mol Med , vol.16 , pp. 7-16
    • Handel, A.E.1    Ebers, G.C.2    Ramagopalan, S.V.3
  • 53
    • 84862850415 scopus 로고    scopus 로고
    • Epigenetic control on cell fate choice in neural stem cells
    • Epigenetic control on cell fate choice in neural stem cells. Hu X-L, Wang Y, Shen Q, Protein Cell 2012 3 278 290
    • (2012) Protein Cell , vol.3 , pp. 278-290
    • Hu, X.-L.1    Wang, Y.2    Shen, Q.3
  • 54
    • 84855867526 scopus 로고    scopus 로고
    • Epigenetic regulation of self-renewal and fate determination in neural stem cells
    • Epigenetic regulation of self-renewal and fate determination in neural stem cells. Ariff IM, Mitra A, Basu A, J Neurosci Res 2012 90 529 539
    • (2012) J Neurosci Res , vol.90 , pp. 529-539
    • Ariff, I.M.1    Mitra, A.2    Basu, A.3
  • 55
    • 0042132027 scopus 로고    scopus 로고
    • Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by dnmt3a and dnmt3b
    • Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b. Chen T, Ueda Y, Dodge JE, Wang Z, Li E, Mol Cell Biol 2003 23 5594 5605
    • (2003) Mol Cell Biol , vol.23 , pp. 5594-5605
    • Chen, T.1    Ueda, Y.2    Dodge, J.E.3    Wang, Z.4    Li, E.5
  • 56
    • 70350046301 scopus 로고    scopus 로고
    • Rethinking how DNA methylation patterns are maintained
    • Rethinking how DNA methylation patterns are maintained. Jones P a, Liang G, Nat Rev Genet 2009 10 805 811
    • (2009) Nat Rev Genet , vol.10 , pp. 805-811
    • Jones, P.A.1    Liang, G.2
  • 58
    • 84855956247 scopus 로고    scopus 로고
    • Epigenetics and the environment: Emerging patterns and implications
    • Epigenetics and the environment: emerging patterns and implications. Feil R, Fraga MF, Nat Rev Genet 2011 13 97 109
    • (2011) Nat Rev Genet , vol.13 , pp. 97-109
    • Feil, R.1    Fraga, M.F.2
  • 59
    • 84886947411 scopus 로고    scopus 로고
    • Perinatal programming of adult hippocampal structure and function; Emerging roles of stress, nutrition and epigenetics
    • Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics. Lucassen PJ, Naninck EFG, van Goudoever JB, Fitzsimons C, Joels M, Korosi A, Trends Neurosci 2013 36 621 631
    • (2013) Trends Neurosci , vol.36 , pp. 621-631
    • Lucassen, P.J.1    Naninck, E.F.G.2    Van Goudoever, J.B.3    Fitzsimons, C.4    Joels, M.5    Korosi, A.6
  • 60
    • 77953807249 scopus 로고    scopus 로고
    • Epigenetic regulation of neurogenesis in the adult hippocampus
    • Epigenetic regulation of neurogenesis in the adult hippocampus. Covic M, Karaca E, Lie DC, Heredity (Edinb) 2010 105 122 134
    • (2010) Heredity (Edinb) , vol.105 , pp. 122-134
    • Covic, M.1    Karaca, E.2    Lie, D.C.3
  • 61
    • 75149177271 scopus 로고    scopus 로고
    • Cellular epigenetic modifications of neural stem cell differentiation
    • Cellular epigenetic modifications of neural stem cell differentiation. Singh R, Shiue K, Schomberg D, Zhou F, Cell Transplant 2009 18 1197 1211
    • (2009) Cell Transplant , vol.18 , pp. 1197-1211
    • Singh, R.1    Shiue, K.2    Schomberg, D.3    Zhou, F.4
  • 66
    • 17444371643 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone
    • Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone. Zheng W, Nowakowski RS, Vaccarino FM, Dev Neurosci 2004 26 181 196
    • (2004) Dev Neurosci , vol.26 , pp. 181-196
    • Zheng, W.1    Nowakowski, R.S.2    Vaccarino, F.M.3
  • 68
    • 56649117538 scopus 로고    scopus 로고
    • Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain
    • Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Kohyama J, Kojima T, Takatsuka E, Yamashita T, Namiki J, Hsieh J, Gage FH, PLoS One 2008 105 18012 18017
    • (2008) PLoS One , vol.105 , pp. 18012-18017
    • Kohyama, J.1    Kojima, T.2    Takatsuka, E.3    Yamashita, T.4    Namiki, J.5    Hsieh, J.6    Gage, F.H.7
  • 69
    • 68549087008 scopus 로고    scopus 로고
    • Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2
    • Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2. Tsujimura K, Abematsu M, Kohyama J, Namihira M, Nakashima K, Exp Neurol 2009 219 104 111
    • (2009) Exp Neurol , vol.219 , pp. 104-111
    • Tsujimura, K.1    Abematsu, M.2    Kohyama, J.3    Namihira, M.4    Nakashima, K.5
  • 70
    • 84904067157 scopus 로고    scopus 로고
    • MeCP2: The long trip from a chromatin protein to neurological disorders
    • in press
    • MeCP2: the long trip from a chromatin protein to neurological disorders. Ausió J, Paz AM D, Esteller M, Trends Mol Med in press
    • Trends Mol Med
    • Ausió, J.1    Paz Am, D.2    Esteller, M.3
  • 73
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Guo JU, Su Y, Zhong C, Ming G, Song H, Cell 2011 145 423 434
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.4    Song, H.5
  • 74
    • 84861118285 scopus 로고    scopus 로고
    • The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: Current status and prospects for future studies
    • The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies. Van den Hove DLA, Chouliaras L, Rutten BPF, Curr Alzheimer Res 2012 9 545 549
    • (2012) Curr Alzheimer Res , vol.9 , pp. 545-549
    • Van Den Hove, D.L.A.1    Chouliaras, L.2    Rutten, B.P.F.3
  • 76
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y, Science 2011 333 1300 1303
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6    He, C.7    Zhang, Y.8
  • 79
    • 5144220241 scopus 로고    scopus 로고
    • Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase
    • Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. Matsubara M, Tanaka T, Terato H, Ohmae E, Izumi S, Katayanagi K, Ide H, Nucleic Acids Res 2004 32 5291 5302
    • (2004) Nucleic Acids Res , vol.32 , pp. 5291-5302
    • Matsubara, M.1    Tanaka, T.2    Terato, H.3    Ohmae, E.4    Izumi, S.5    Katayanagi, K.6    Ide, H.7
  • 82
    • 57649196594 scopus 로고    scopus 로고
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR, Cell 2008 135 1201 1212
    • (2008) Cell , vol.135 , pp. 1201-1212
    • Rai, K.1    Huggins, I.J.2    James, S.R.3    Karpf, A.R.4    Jones, D.A.5    Cairns, B.R.6
  • 83
    • 59849090498 scopus 로고    scopus 로고
    • TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation
    • TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Schmitz K-M, Schmitt N, Hoffmann-Rohrer U, Schäfer A, Grummt I, Mayer C, Mol Cell 2009 33 344 353
    • (2009) Mol Cell , vol.33 , pp. 344-353
    • Schmitz, K.-M.1    Schmitt, N.2    Hoffmann-Rohrer, U.3    Schäfer, A.4    Grummt, I.5    Mayer, C.6
  • 84
    • 84876580885 scopus 로고    scopus 로고
    • Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method
    • Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method. Tan L, Xiong L, Xu W, Wu F, Huang N, Xu Y, Kong L, Zheng L, Schwartz L, Shi Y, Shi YG, Nucleic Acids Res 2013 41 84
    • (2013) Nucleic Acids Res , vol.41 , pp. 584
    • Tan, L.1    Xiong, L.2    Xu, W.3    Wu, F.4    Huang, N.5    Xu, Y.6    Kong, L.7    Zheng, L.8    Schwartz, L.9    Shi, Y.10    Shi, Y.G.11
  • 87
    • 84883789401 scopus 로고    scopus 로고
    • Active DNA demethylation in post-mitotic neurons: A reason for optimism
    • Active DNA demethylation in post-mitotic neurons: A reason for optimism. Gavin DP, Chase KA, Sharma RP, Neuropharmacology 2013 75 233 245
    • (2013) Neuropharmacology , vol.75 , pp. 233-245
    • Gavin, D.P.1    Chase, K.A.2    Sharma, R.P.3
  • 88
    • 80053519269 scopus 로고    scopus 로고
    • Histone deacetylases in neural stem cells and induced pluripotent stem cells
    • Histone deacetylases in neural stem cells and induced pluripotent stem cells. Sun G, Fu C, Shen C, Shi Y, J Biomed Biotechnol 2011 2011 1 6
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 1-6
    • Sun, G.1    Fu, C.2    Shen, C.3    Shi, Y.4
  • 89
    • 34848818037 scopus 로고    scopus 로고
    • Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation
    • Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Sun G, Yu RT, Evans RM, Shi Y, Proc Natl Acad Sci U S A 2007 104 15282 15287
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15282-15287
    • Sun, G.1    Yu, R.T.2    Evans, R.M.3    Shi, Y.4
  • 90
    • 79957464366 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells
    • Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells. Zhou Q, Dalgard CL, Wynder C, Doughty ML, BMC Neurosci 2011 12 50
    • (2011) BMC Neurosci , vol.12 , pp. 50
    • Zhou, Q.1    Dalgard, C.L.2    Wynder, C.3    Doughty, M.L.4
  • 91
    • 9344252804 scopus 로고    scopus 로고
    • Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells
    • Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage FH, Proc Natl Acad Sci U S A 2004 101 16659 16664
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16659-16664
    • Hsieh, J.1    Nakashima, K.2    Kuwabara, T.3    Mejia, E.4    Gage, F.H.5
  • 92
    • 33846632355 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    • Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells. Siebzehnrubl F a, Buslei R, Eyupoglu IY, Seufert S, Hahnen E, Blumcke I, Exp Brain Res 2007 176 672 678
    • (2007) Exp Brain Res , vol.176 , pp. 672-678
    • Siebzehnrubl, F.A.1    Buslei, R.2    Eyupoglu, I.Y.3    Seufert, S.4    Hahnen, E.5    Blumcke, I.6
  • 95
    • 79952596383 scopus 로고    scopus 로고
    • The emerging role of epigenetics in stroke
    • The emerging role of epigenetics in stroke. Qureshi IA, Mehler MF, Arch Neurol 2011 68 294 302
    • (2011) Arch Neurol , vol.68 , pp. 294-302
    • Qureshi, I.A.1    Mehler, M.F.2
  • 101
    • 84891818318 scopus 로고    scopus 로고
    • MiRBase: Annotating high confidence microRNAs using deep sequencing data
    • miRBase: annotating high confidence microRNAs using deep sequencing data. Kozomara A, Griffiths-Jones S, Nucleic Acids Res 2014 42 68 D73
    • (2014) Nucleic Acids Res , vol.42
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 104
    • 84862173056 scopus 로고    scopus 로고
    • MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation
    • MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation. Fineberg SK, Datta P, Stein CS, Davidson BL, PLoS One 2012 7 38562
    • (2012) PLoS One , vol.7 , pp. 538562
    • Fineberg, S.K.1    Datta, P.2    Stein, C.S.3    Davidson, B.L.4
  • 107
    • 33847203593 scopus 로고    scopus 로고
    • Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
    • Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Lukiw WJ, Neuroreport 2007 18 297 300
    • (2007) Neuroreport , vol.18 , pp. 297-300
    • Lukiw, W.J.1
  • 110
    • 20444440706 scopus 로고    scopus 로고
    • Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation
    • Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. Lee YS, Kim HK, Chung S, Kim K-S, Dutta A, J Biol Chem 2005 280 16635 16641
    • (2005) J Biol Chem , vol.280 , pp. 16635-16641
    • Lee, Y.S.1    Kim, H.K.2    Chung, S.3    Kim, K.-S.4    Dutta, A.5
  • 112
    • 84866697075 scopus 로고    scopus 로고
    • MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin
    • MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin. Cui Y, Xiao Z, Han J, Sun J, Ding W, Zhao Y, Chen B, Li X, Dai J, BMC Neurosci 2012 13 116
    • (2012) BMC Neurosci , vol.13 , pp. 116
    • Cui, Y.1    Xiao, Z.2    Han, J.3    Sun, J.4    Ding, W.5    Zhao, Y.6    Chen, B.7    Li, X.8    Dai, J.9
  • 116
    • 78649739197 scopus 로고    scopus 로고
    • Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory
    • Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory. Hansen KF, Sakamoto K, Wayman GA, Impey S, Obrietan K, PLoS One 2010 5 15497
    • (2010) PLoS One , vol.5 , pp. 515497
    • Hansen, K.F.1    Sakamoto, K.2    Wayman, G.A.3    Impey, S.4    Obrietan, K.5
  • 117
    • 84863102115 scopus 로고    scopus 로고
    • MiR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression
    • miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression. Yang D, Li T, Wang Y, Tang Y, Cui H, Tang Y, Zhang X, Chen D, Shen N, Le W, J Cell Sci 2012 125 Pt 7 1673 1682
    • (2012) J Cell Sci , vol.125 , Issue.PT 7 , pp. 1673-1682
    • Yang, D.1    Li, T.2    Wang, Y.3    Tang, Y.4    Cui, H.5    Tang, Y.6    Zhang, X.7    Chen, D.8    Shen, N.9    Le, W.10
  • 119
    • 39749193120 scopus 로고    scopus 로고
    • MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production
    • MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production. Abuhatzira L, Makedonski K, Kaufman Y, Razin A, Shemer R, Epigenetics 2007 2 214 222
    • (2007) Epigenetics , vol.2 , pp. 214-222
    • Abuhatzira, L.1    Makedonski, K.2    Kaufman, Y.3    Razin, A.4    Shemer, R.5
  • 121
    • 63649138643 scopus 로고    scopus 로고
    • MiR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
    • miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Cheng L-C, Pastrana E, Tavazoie M, Doetsch F, Nat Neurosci 2009 12 399 408
    • (2009) Nat Neurosci , vol.12 , pp. 399-408
    • Cheng, L.-C.1    Pastrana, E.2    Tavazoie, M.3    Doetsch, F.4
  • 122
    • 64049095014 scopus 로고    scopus 로고
    • A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
    • A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Zhao C, Sun G, Li S, Shi Y, Nat Struct Mol Biol 2009 16 365 371
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 365-371
    • Zhao, C.1    Sun, G.2    Li, S.3    Shi, Y.4
  • 123
    • 76649088031 scopus 로고    scopus 로고
    • MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling
    • MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling. Zhao C, Sun G, Li S, Lang M-F, Yang S, Li W, Shi Y, Proc Natl Acad Sci U S A 2010 107 1876 1881
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1876-1881
    • Zhao, C.1    Sun, G.2    Li, S.3    Lang, M.-F.4    Yang, S.5    Li, W.6    Shi, Y.7
  • 128
    • 77956099873 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation
    • Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Liu C, Teng Z, Santistevan N, Szulwach K, Cell Stem Cell 2010 6 433 444
    • (2010) Cell Stem Cell , vol.6 , pp. 433-444
    • Liu, C.1    Teng, Z.2    Santistevan, N.3    Szulwach, K.4
  • 130
    • 0034829801 scopus 로고    scopus 로고
    • The molecular bases of Alzheimer's disease and other neurodegenerative disorders
    • The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Maccioni RB, Muñoz JP, Barbeito L, Arch Med Res 2001 32 367 381
    • (2001) Arch Med Res , vol.32 , pp. 367-381
    • MacCioni, R.B.1    Muñoz, J.P.2    Barbeito, L.3
  • 131
    • 84877285151 scopus 로고    scopus 로고
    • Role of neuroinflammation in adult neurogenesis and Alzheimer disease: Therapeutic approaches
    • Role of neuroinflammation in adult neurogenesis and Alzheimer disease: therapeutic approaches. Fuster-Matanzo A, Llorens-Martín M, Hernández F, Avila J, Mediators Inflamm 2013 2013 1 9
    • (2013) Mediators Inflamm , vol.2013 , pp. 1-9
    • Fuster-Matanzo, A.1    Llorens-Martín, M.2    Hernández, F.3    Avila, J.4
  • 133
    • 33748790666 scopus 로고    scopus 로고
    • Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus
    • Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Boekhoorn K, Joels M, Lucassen PJ, Neurobiol Dis 2006 24 1 14
    • (2006) Neurobiol Dis , vol.24 , pp. 1-14
    • Boekhoorn, K.1    Joels, M.2    Lucassen, P.J.3
  • 134
    • 84861691381 scopus 로고    scopus 로고
    • Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology
    • Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology. Perry EK, Johnson M, Ekonomou A, Perry RH, Ballard C, Attems J, Neurobiol Dis 2012 47 155 162
    • (2012) Neurobiol Dis , vol.47 , pp. 155-162
    • Perry, E.K.1    Johnson, M.2    Ekonomou, A.3    Perry, R.H.4    Ballard, C.5    Attems, J.6
  • 135
    • 77956843852 scopus 로고    scopus 로고
    • Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis
    • Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis. Crews L, Adame A, Patrick C, Delaney A, Pham E, Rockenstein E, Hansen L, Masliah E, J Neurosci 2010 30 12252 12262
    • (2010) J Neurosci , vol.30 , pp. 12252-12262
    • Crews, L.1    Adame, A.2    Patrick, C.3    Delaney, A.4    Pham, E.5    Rockenstein, E.6    Hansen, L.7    Masliah, E.8
  • 137
    • 49249116020 scopus 로고    scopus 로고
    • Behavior of neural stem cells in the Alzheimer brain
    • Behavior of neural stem cells in the Alzheimer brain. Waldau B, Shetty AK, Cell Mol Life Sci 2008 65 2372 2384
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2372-2384
    • Waldau, B.1    Shetty, A.K.2
  • 138
    • 73949086520 scopus 로고    scopus 로고
    • Adult neurogenesis, neural stem cells and Alzheimer's disease:developments, limitations, problems and promises
    • Adult neurogenesis, neural stem cells and Alzheimer's disease:developments, limitations, problems and promises. Taupin P, Curr Alzheimer Res 2009 6 461 470
    • (2009) Curr Alzheimer Res , vol.6 , pp. 461-470
    • Taupin, P.1
  • 139
    • 33745591621 scopus 로고    scopus 로고
    • Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: Allopregnanolone as a proof of concept neurogenic agent
    • Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent. Brinton RD, Wang JM, Curr Alzheimer Res 2006 3 185 190
    • (2006) Curr Alzheimer Res , vol.3 , pp. 185-190
    • Brinton, R.D.1    Wang, J.M.2
  • 145
    • 84881115847 scopus 로고    scopus 로고
    • Delayed dendritic development in newly generated dentate granule cells by cell-autonomous expression of the amyloid precursor protein
    • Delayed dendritic development in newly generated dentate granule cells by cell-autonomous expression of the amyloid precursor protein. Morgenstern NA, Giacomini D, Lombardi G, Castaño EM, Schinder AF, Mol Cell Neurosci 2013 56 298 306
    • (2013) Mol Cell Neurosci , vol.56 , pp. 298-306
    • Morgenstern, N.A.1    Giacomini, D.2    Lombardi, G.3    Castaño, E.M.4    Schinder, A.F.5
  • 146
    • 30644474606 scopus 로고    scopus 로고
    • Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    • Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. Zhao C, Teng EM, Summers RG, Ming G-L, Gage FH, J Neurosci 2006 26 3 11
    • (2006) J Neurosci , vol.26 , pp. 3-11
    • Zhao, C.1    Teng, E.M.2    Summers, R.G.3    Ming, G.-L.4    Gage, F.H.5
  • 147
    • 0029440466 scopus 로고
    • Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
    • Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient. West RL, Lee JM, Maroun LE, J Mol Neurosci 1995 6 141 146
    • (1995) J Mol Neurosci , vol.6 , pp. 141-146
    • West, R.L.1    Lee, J.M.2    Maroun, L.E.3
  • 148
    • 69449086451 scopus 로고    scopus 로고
    • DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
    • DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. Barrachina M, Ferrer I, J Neuropathol Exp Neurol 2009 68 880 891
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 880-891
    • Barrachina, M.1    Ferrer, I.2
  • 149
    • 78649381716 scopus 로고    scopus 로고
    • A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease
    • A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease. Brohede J, Rinde M, Winblad B, Graff C, J Neurogenet 2010 24 179 181
    • (2010) J Neurogenet , vol.24 , pp. 179-181
    • Brohede, J.1    Rinde, M.2    Winblad, B.3    Graff, C.4
  • 150
    • 0033052929 scopus 로고    scopus 로고
    • Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex
    • Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex. Tohgi H, Utsugisawa K, Nagane Y, Yoshimura M, Genda Y, Ukitsu M, Brain Res Mol Brain Res 1999 70 288 292
    • (1999) Brain Res Mol Brain Res , vol.70 , pp. 288-292
    • Tohgi, H.1    Utsugisawa, K.2    Nagane, Y.3    Yoshimura, M.4    Genda, Y.5    Ukitsu, M.6
  • 151
    • 0032716797 scopus 로고    scopus 로고
    • The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex
    • The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex. Tohgi H, Utsugisawa K, Nagane Y, Yoshimura M, Ukitsu M, Genda Y, Neurosci Lett 1999 275 89 92
    • (1999) Neurosci Lett , vol.275 , pp. 89-92
    • Tohgi, H.1    Utsugisawa, K.2    Nagane, Y.3    Yoshimura, M.4    Ukitsu, M.5    Genda, Y.6
  • 152
    • 0029799427 scopus 로고    scopus 로고
    • Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease
    • Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. Morrison LD, Smith DD, Kish SJ, J Neurochem 1996 67 1328 1331
    • (1996) J Neurochem , vol.67 , pp. 1328-1331
    • Morrison, L.D.1    Smith, D.D.2    Kish, S.J.3
  • 153
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD, PLoS One 2009 4 6617
    • (2009) PLoS One , vol.4 , pp. 56617
    • Mastroeni, D.1    McKee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.D.5
  • 158
    • 56949102195 scopus 로고    scopus 로고
    • The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells
    • The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. Chen K-L, Wang SS-S, Yang Y-Y, Yuan R-Y, Chen R-M, Hu C-J, Biochem Biophys Res Commun 2009 378 57 61
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 57-61
    • Chen, K.-L.1    Wang, S.-S.2    Yang, Y.-Y.3    Yuan, R.-Y.4    Chen, R.-M.5    Hu, C.-J.6
  • 160
    • 70449725209 scopus 로고    scopus 로고
    • Epigenetic mechanisms in neurological diseases: Genes, syndromes, and therapies
    • Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Urdinguio RG, Sanchez-Mut JV, Esteller M, Lancet Neurol 2009 8 1056 1072
    • (2009) Lancet Neurol , vol.8 , pp. 1056-1072
    • Urdinguio, R.G.1    Sanchez-Mut, J.V.2    Esteller, M.3
  • 162
    • 0037464488 scopus 로고    scopus 로고
    • Presenilin 1 gene silencing by S-adenosylmethionine: A treatment for Alzheimer disease?
    • Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? Scarpa S, Fuso A, D'Anselmi F, Cavallaro RA, FEBS Lett 2003 541 145 148
    • (2003) FEBS Lett , vol.541 , pp. 145-148
    • Scarpa, S.1    Fuso, A.2    D'Anselmi, F.3    Cavallaro, R.A.4
  • 167
    • 84860863375 scopus 로고    scopus 로고
    • Targeted proteomics for quantification of histone acetylation in Alzheimer's disease
    • Targeted proteomics for quantification of histone acetylation in Alzheimer's disease. Zhang K, Schrag M, Crofton A, Trivedi R, Vinters H, Kirsch W, Proteomics 2012 12 1261 1268
    • (2012) Proteomics , vol.12 , pp. 1261-1268
    • Zhang, K.1    Schrag, M.2    Crofton, A.3    Trivedi, R.4    Vinters, H.5    Kirsch, W.6
  • 169
    • 79955622702 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in physiological and pathological brain processes
    • Epigenetic regulation of gene expression in physiological and pathological brain processes. Gräff J, Kim D, Dobbin MM, Tsai L-H, Physiol Rev 2011 91 603 649
    • (2011) Physiol Rev , vol.91 , pp. 603-649
    • Gräff, J.1    Kim, D.2    Dobbin, M.M.3    Tsai, L.-H.4
  • 176
    • 84855806746 scopus 로고    scopus 로고
    • MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
    • MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y, Qiang B, Yuan J, Peng X, Neurobiol Aging 2012 33 522 534
    • (2012) Neurobiol Aging , vol.33 , pp. 522-534
    • Liu, W.1    Liu, C.2    Zhu, J.3    Shu, P.4    Yin, B.5    Gong, Y.6    Qiang, B.7    Yuan, J.8    Peng, X.9
  • 177
    • 62349123068 scopus 로고    scopus 로고
    • Senescence-accelerated mouse (SAM) with special references to neurodegeneration models, SAMP8 and SAMP10 mice
    • Senescence-accelerated mouse (SAM) with special references to neurodegeneration models, SAMP8 and SAMP10 mice. Takeda T, Neurochem Res 2009 34 639 659
    • (2009) Neurochem Res , vol.34 , pp. 639-659
    • Takeda, T.1
  • 179
    • 84866134171 scopus 로고    scopus 로고
    • MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients
    • MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients. Long JM, Ray B, Lahiri DK, J Biol Chem 2012 287 31298 31310
    • (2012) J Biol Chem , vol.287 , pp. 31298-31310
    • Long, J.M.1    Ray, B.2    Lahiri, D.K.3
  • 180
  • 181
    • 84855177724 scopus 로고    scopus 로고
    • The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease
    • The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease. Fang M, Wang J, Zhang X, Geng Y, Hu Z, Rudd JA, Ling S, Chen W, Han S, Toxicol Lett 2012 209 94 105
    • (2012) Toxicol Lett , vol.209 , pp. 94-105
    • Fang, M.1    Wang, J.2    Zhang, X.3    Geng, Y.4    Hu, Z.5    Rudd, J.A.6    Ling, S.7    Chen, W.8    Han, S.9
  • 182
    • 80054025163 scopus 로고    scopus 로고
    • MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease
    • MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease. Geekiyanage H, Chan C, J Neurosci 2011 31 14820 14830
    • (2011) J Neurosci , vol.31 , pp. 14820-14830
    • Geekiyanage, H.1    Chan, C.2
  • 183
    • 77957265786 scopus 로고    scopus 로고
    • MiR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor
    • miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor. Wang H, Liu J, Zong Y, Xu Y, Deng W, Zhu H, Liu Y, Ma C, Huang L, Zhang L, Qin C, Brain Res 2010 1357 166 174
    • (2010) Brain Res , vol.1357 , pp. 166-174
    • Wang, H.1    Liu, J.2    Zong, Y.3    Xu, Y.4    Deng, W.5    Zhu, H.6    Liu, Y.7    Ma, C.8    Huang, L.9    Zhang, L.10    Qin, C.11
  • 184
    • 84864778051 scopus 로고    scopus 로고
    • Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β
    • Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β Schonrock N, Humphreys DT, Preiss T, Götz J, J Mol Neurosci 2012 46 324 335
    • (2012) J Mol Neurosci , vol.46 , pp. 324-335
    • Schonrock, N.1    Humphreys, D.T.2    Preiss, T.3    Götz, J.4
  • 190
    • 84872196941 scopus 로고    scopus 로고
    • Reduced RAN expression and disrupted transport between cytoplasm and nucleus; A key event in Alzheimer's disease pathophysiology
    • Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology. Mastroeni D, Chouliaras L, Grover A, Liang WS, Hauns K, Rogers J, Coleman PD, PLoS One 2013 8 53349
    • (2013) PLoS One , vol.8 , pp. 553349
    • Mastroeni, D.1    Chouliaras, L.2    Grover, A.3    Liang, W.S.4    Hauns, K.5    Rogers, J.6    Coleman, P.D.7
  • 191
    • 28944431913 scopus 로고    scopus 로고
    • Animal models of Alzheimer's disease: A road full of pitfalls
    • Animal models of Alzheimer's disease: a road full of pitfalls. Delacourte A, Buée L, Psychol Neuropsychiatr Vieil 2005 3 261 270
    • (2005) Psychol Neuropsychiatr Vieil , vol.3 , pp. 261-270
    • Delacourte, A.1    Buée, L.2
  • 192
    • 8844285984 scopus 로고    scopus 로고
    • Mouse models of Alzheimer's disease: Insight into treatment
    • Mouse models of Alzheimer's disease: insight into treatment. German DC, Eisch AJ, Rev Neurosci 2004 15 353 369
    • (2004) Rev Neurosci , vol.15 , pp. 353-369
    • German, D.C.1    Eisch, A.J.2
  • 195
    • 78149433116 scopus 로고    scopus 로고
    • Role of epigenetics in Alzheimer's and Parkinson's disease
    • Role of epigenetics in Alzheimer's and Parkinson's disease. Kwok JBJ, Epigenomics 2010 2 671 682
    • (2010) Epigenomics , vol.2 , pp. 671-682
    • Kwok, J.B.J.1
  • 196
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Takahashi K, Yamanaka S, Cell 2006 126 663 676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 198
    • 80053416868 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and promises of neuroregenerative medicine
    • Induced pluripotent stem cells and promises of neuroregenerative medicine. Verma A, Verma N, Neurol India 2011 59 555 557
    • (2011) Neurol India , vol.59 , pp. 555-557
    • Verma, A.1    Verma, N.2
  • 200
    • 84876391906 scopus 로고    scopus 로고
    • Alzheimer's disease modeling: Ups, downs, and perspectives for human induced pluripotent stem cells
    • Alzheimer's disease modeling: ups, downs, and perspectives for human induced pluripotent stem cells. Wojda U, Kuznicki J, J Alzheimers Dis 2013 34 563 588
    • (2013) J Alzheimers Dis , vol.34 , pp. 563-588
    • Wojda, U.1    Kuznicki, J.2
  • 202
    • 84885139912 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling
    • Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling. Pyko IV, Nakada M, Sabit H, Teng L, Furuyama N, Hayashi Y, Kawakami K, Minamoto T, Fedulau AS, Hamada J, Carcinogenesis 2013 34 2206 2217
    • (2013) Carcinogenesis , vol.34 , pp. 2206-2217
    • Pyko, I.V.1    Nakada, M.2    Sabit, H.3    Teng, L.4    Furuyama, N.5    Hayashi, Y.6    Kawakami, K.7    Minamoto, T.8    Fedulau, A.S.9    Hamada, J.10
  • 203
    • 79960656490 scopus 로고
    • O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry
    • O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry. Christmann M, Verbeek B, Roos WP, Kaina B, Biochim Biophys Acta 1816 2011 179 190
    • (1816) Biochim Biophys Acta , vol.2011 , pp. 179-190
    • Christmann, M.1    Verbeek, B.2    Roos, W.P.3    Kaina, B.4
  • 206
    • 0036395237 scopus 로고    scopus 로고
    • β-Amyloid plaques in a model for sporadic alzheimer's disease based on transgenic anti-nerve growth factor antibodies
    • β-Amyloid Plaques in a Model for Sporadic Alzheimer's Disease Based on Transgenic Anti-Nerve Growth Factor Antibodies. Capsoni S, Mol Cell Neurosci 2002 21 15 28
    • (2002) Mol Cell Neurosci , vol.21 , pp. 15-28
    • Capsoni, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.