Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus

Journal of Neuroscience

Volumn 20, Issue 23, 2000, Pages 8727-8735

  Shihabuddin, L S ^a   Horner, P J ^a   Ray, J ^a   Gage, F H ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Adult; FGF; Neuroplasticity; Spinal cord; Stem cells; Transplantation

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; DENTATE GYRUS; MACROGLIA; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; SPINAL CORD; STEM CELL TRANSPLANTATION;

EID: 0034548865     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-23-08727.2000     Document Type: Article

References (50)

1. 3H by cells in normal and injured mouse spinal cord
2. The development of the rat spinal cord
3. Immunohistochemical localization of calcium-binding protein in the cerebellum, hippocampal formation and olfactory bulb of the rat
4. Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life
5. Expression of the APC tumor suppressor protein in oligodendroglia
6. Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo
7. In vitro-generated neural precursors participate in mammalian brain development
8. Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats
9. Regulation of neurogenesis by growth factors and neurotransmitters
10. Calbindin D-28k and parvalbumin in the rat nervous system
11. Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF) responsiveness in mouse striatal precursor cells: Identification of neural precursors responding to both EGF and FGF-2
12. In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain
13. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes
14. In situ demonstration of mature oligodendrocytes and their processes: An immunocytochemical study with a new monoclonal antibody, rip
15. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain
16. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor
17. Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain
18. Stem cells: The generation and renewal of cellular diversity
19. Myelination following transplantation of EGF-responsive neural stem cells into a myelin-deficient environment
20. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
21. Identification of a neural stem cell in the adult mammalian central nervous system
22. Neuroepithelial stem cells from the embryonic spinal cord: Isolation, characterization, and clonal analysis
23. Neurogenesis in the adult rat: Electron microscopy analysis of light radioautographs
24. Gliogenesis of astrocytes and oligodendrocytes in the neocortical grey and white matter of the adult
25. Neurogenesis in postnatal rat spinal cord: A study in primary culture
26. Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF
27. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation
28. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain
29. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia
30. Long-distance neuronal migration in the adult mammalian brain
31. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
32. Improved retroviral vectors for gene transfer and expression
33. Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells
34. A common progenitor for the CNS and PNS
35. Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro
36. Temporal pattern of neurogenesis in spinal cord of rat. I. An autoradiographic study - Time and sites of origin and migration and settling patterns of neuroblasts
37. FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain
38. The adult rat hippocampus contains primordial neural stem cells
39. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS
40. Limits of neurogenesis in primates
41. Proliferation, differentiation, and long-term culture of primary hippocampal neurons
42. The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins
43. FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord
44. Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan
45. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
46. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system
47. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina
48. Stem cells in the adult mammalian central nervous system
49. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis
50. Incorporation and glial differentiation of mouse EGF-responslve neural progenitor cells after transplantation into the embryonic rat brain