Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons

Cell

Volumn 146, Issue 3, 2011, Pages 359-371

  Qiang, Liang ^a   Fujita, Ryousuke ^a   Yamashita, Toru ^a   Angulo, Sergio ^b   Rhinn, Herve ^a   Rhee, David ^a   Doege, Claudia ^a   Chau, Lily ^a   Aubry, Laetitia ^a   Vanti, William B ^a   Moreno, Herman ^b   Abeliovich, Asa ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b SUNY Downstate Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

ADULT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL SPECIFICITY; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; FAMILIAL DISEASE; FOREBRAIN; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SKIN FIBROBLAST;

RODENTIA;

EID: 79961131135     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2011.07.007     Document Type: Article

References (39)

1. A. Abeliovich, and C.A. Doege Reprogramming therapeutics: iPS cell prospects for neurodegenerative disease Neuron 61 2009 337 339
2. A. Alzheimer Uber eine eigenartige Erkrankung der Hirnrinde Allg Z Psychiat Psych-Gerichtl Med 64 1907 146 148
3. M. Bentahir, O. Nyabi, J. Verhamme, A. Tolia, K. Horré, J. Wiltfang, H. Esselmann, and B. De Strooper Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms J. Neurochem. 96 2006 732 742
4. O. Brüstle, A.C. Spiro, K. Karram, K. Choudhary, S. Okabe, and R.D. McKay in vitro-generated neural precursors participate in mammalian brain development Proc. Natl. Acad. Sci. USA 94 1997 14809 14814 (Pubitemid 28041456)
5. A.M. Cataldo, J.L. Barnett, C. Pieroni, and R.A. Nixon Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis J. Neurosci. 17 1997 6142 6151 (Pubitemid 27329890)
6. A.M. Cataldo, D.J. Hamilton, J.L. Barnett, P.A. Paskevich, and R.A. Nixon Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease J. Neurosci. 16 1996 186 199 (Pubitemid 26010711)
7. J.R. Cirrito, P.C. May, M.A. O'Dell, J.W. Taylor, M. Parsadanian, J.W. Cramer, J.E. Audia, J.S. Nissen, K.R. Bales, and S.M. Paul in vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life J. Neurosci. 23 2003 8844 8853 (Pubitemid 37210896)
8. R.L. Davis, H. Weintraub, and A.B. Lassar Expression of a single transfected cDNA converts fibroblasts to myoblasts Cell 51 1987 987 1000
9. B. De Strooper, and W. Annaert Novel research horizons for presenilins and γ-secretases in cell biology and disease Annu. Rev. Cell Dev. Biol. 26 2010 235 260
10. C. Eroglu, and B.A. Barres Regulation of synaptic connectivity by glia Nature 468 2010 223 231
11. L. Forti, C. Pouzat, and I. Llano Action potential-evoked Ca2+ signals and calcium channels in axons of developing rat cerebellar interneurones J. Physiol. 527 2000 33 48 (Pubitemid 30649582)
12. A.V. Gilyarov Nestin in central nervous system cells Neurosci. Behav. Physiol. 38 2008 165 169
13. J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356 (Pubitemid 34790756)
14. I. Llano, and F. Bezanilla Current recorded from a cut-open giant axon under voltage clamp Proc. Natl. Acad. Sci. USA 77 1980 7484 7486 (Pubitemid 11131155)
15. D. MacLeod, J. Dowman, R. Hammond, T. Leete, K. Inoue, and A. Abeliovich The familial Parkinsonism gene LRRK2 regulates neurite process morphology Neuron 52 2006 587 593 (Pubitemid 44781171)
16. M.D. Muzumdar, B. Tasic, K. Miyamichi, L. Li, and L. Luo A global double-fluorescent Cre reporter mouse Genesis 45 2007 593 605 (Pubitemid 350013057)
17. R.A. Nixon, and A.M. Cataldo Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease J. Alzheimers Dis. 9 3, Suppl 2006 277 289 (Pubitemid 44253321)
18. M.F. Pera Stem cells: The dark side of induced pluripotency Nature 471 2011 46 47
19. E. Repetto, I.S. Yoon, H. Zheng, and D.E. Kang Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway J. Biol. Chem. 282 2007 31504 31516 (Pubitemid 350044898)
20. H. Rhinn, C. Marchand-Leroux, N. Croci, M. Plotkine, D. Scherman, and V. Escriou Housekeeping while brain's storming Validation of normalizing factors for gene expression studies in a murine model of traumatic brain injury BMC Mol. Biol. 9 2008 62
21. J. Shen, and R.J. Kelleher III The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism Proc. Natl. Acad. Sci. USA 104 2007 403 409 (Pubitemid 46123039)
22. K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676 (Pubitemid 44233629)
23. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, and S. Yamanaka Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872 (Pubitemid 350138099)
24. B.L. Tang Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors Cell Adh. Migr. 3 2009 118 128
25. G. Thinakaran, and E.H. Koo Amyloid precursor protein trafficking, processing, and function J. Biol. Chem. 283 2008 29615 29619
26. G. Thinakaran, C.L. Harris, T. Ratovitski, F. Davenport, H.H. Slunt, D.L. Price, D.R. Borchelt, and S.S. Sisodia Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors J. Biol. Chem. 272 1997 28415 28422 (Pubitemid 27517788)
27. R. Vassar, B.D. Bennett, S. Babu-Khan, S. Kahn, E.A. Mendiaz, P. Denis, D.B. Teplow, S. Ross, P. Amarante, and R. Loeloff Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 1999 735 741
28. T. Vierbuchen, A. Ostermeier, Z.P. Pang, Y. Kokubu, T.C. Südhof, and M. Wernig Direct conversion of fibroblasts to functional neurons by defined factors Nature 463 2010 1035 1041
29. E.S. Walker, M. Martinez, A.L. Brunkan, and A. Goate Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios J. Neurochem. 92 2005 294 301 (Pubitemid 40194020)
30. J. Yu, M.A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J.L. Frane, S. Tian, J. Nie, G.A. Jonsdottir, V. Ruotti, and R. Stewart Induced pluripotent stem cell lines derived from human somatic cells Science 318 2007 1917 1920
31. Baylor, S.M.; and Hollingworth, S. (1998). Model of sarcomeric Ca2+ movements, including ATP Ca2+ binding and diffusion, during activation of frog skeletal muscle. J. Gen. Physiol. 112, 297-316. (Pubitemid 28421738)
32. Bezanilla, F.; and Armstrong, C.M. (1977). Inactivation of the sodium channel. I. Sodium current experiments. J. Gen. Physiol. 70, 549-566. (Pubitemid 8239321)
33. Huang, W.; Sherman, B.T.; and Lempicki, R.A. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57.
34. Kaech, S.; and Banker, G. (2006). Culturing hippocampal neurons. Nat. Protoc. 1, 2406-2415.
35. Saeed, A.I.; Sharov, V.; White, J.; Li, J.; Liang, W.; Bhagabati, N.; Braisted, J.; Klapa, M.; Currier, T.; Thiagarajan, M.; et al. (2003). TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34, 374-378. (Pubitemid 36184095)
36. Smyth, G.K. (2004). Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, Article3.
37. Sommer, C.A.; Stadtfeld, M.; Murphy, G.J.; Hochedlinger, K.; Kotton, D.N.; and Mostoslavsky, G. (2009). Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells 27, 543-549.
38. Wernig, M.; Zhao, J.P.; Pruszak, J.; Hedlund, E.; Fu, D.; Soldner, F.; Broccoli, V.; Constantine-Paton, M.; Isacson, O.; and Jaenisch, R. (2008). Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc. Natl. Acad. Sci. USA 105, 5856-5861. (Pubitemid 351758462)
39. Yang, H.; Lu, P.; Wang, Y.; and Ma, H. (2011). The transcriptome landscape of Arabidopsis male meiocytes from high-throughput sequencing: the complexity and evolution of the meiotic process. Plant J. 65, 503-516.