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Volumn 521, Issue 16, 2013, Pages 3817-3831

Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants

Author keywords

Brain; Genotype; Hamartin; Phenotype; Tuberin

Indexed keywords

HAMARTIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE B; TUBERIN;

EID: 84892895777     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.23380     Document Type: Article
Times cited : (19)

References (43)
  • 1
    • 0033358523 scopus 로고    scopus 로고
    • Complete inactivation of the TSC2 gene leads to formation of hamartomas
    • Au K, Hebert A, Roach E, Northrup H. 1999. Complete inactivation of the TSC2 gene leads to formation of hamartomas. Am J Hum Genet 65:1790-1795.
    • (1999) Am J Hum Genet , vol.65 , pp. 1790-1795
    • Au, K.1    Hebert, A.2    Roach, E.3    Northrup, H.4
  • 4
    • 81955164876 scopus 로고    scopus 로고
    • Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin
    • Carson R, Van Nielen D, Winzenburger P, Ess K. 2012. Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin. Neurobiol Dis 45:369-380.
    • (2012) Neurobiol Dis , vol.45 , pp. 369-380
    • Carson, R.1    Van Nielen, D.2    Winzenburger, P.3    Ess, K.4
  • 6
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • Consortium.
    • Consortium. 1993. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75: 1305-1315.
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 7
    • 8844224854 scopus 로고    scopus 로고
    • Molecular pathogenesis of tuber formation in tuberous sclerosis complex
    • Crino PB. 2004. Molecular pathogenesis of tuber formation in tuberous sclerosis complex. J Child Neurol 19:716-725.
    • (2004) J Child Neurol , vol.19 , pp. 716-725
    • Crino, P.B.1
  • 10
    • 70350545722 scopus 로고    scopus 로고
    • Characterization of rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
    • Dibble C, Asara J, Manning B. 2009. Characterization of rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 29:5657-5670.
    • (2009) Mol Cell Biol , vol.29 , pp. 5657-5670
    • Dibble, C.1    Asara, J.2    Manning, B.3
  • 11
    • 8844247121 scopus 로고    scopus 로고
    • Brain abnormalities in tuberous sclerosis complex
    • DiMario FJ Jr. 2004. Brain abnormalities in tuberous sclerosis complex. J Child Neurol 19:650-657.
    • (2004) J Child Neurol , vol.19 , pp. 650-657
    • DiMario, F.J.1
  • 12
    • 65949106140 scopus 로고    scopus 로고
    • Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner
    • DiNardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski D, Sahin M. 2009. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J Neurosci 29:5926-5937.
    • (2009) J Neurosci , vol.29 , pp. 5926-5937
    • DiNardo, A.1    Kramvis, I.2    Cho, N.3    Sadowski, A.4    Meikle, L.5    Kwiatkowski, D.6    Sahin, M.7
  • 13
    • 0037454409 scopus 로고    scopus 로고
    • Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma
    • El-Hashemite N, Zhang H, Henske E, Kwiatkowski D. 2003. Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet 361:1348-1349.
    • (2003) Lancet , vol.361 , pp. 1348-1349
    • El-Hashemite, N.1    Zhang, H.2    Henske, E.3    Kwiatkowski, D.4
  • 14
    • 79961011264 scopus 로고    scopus 로고
    • Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signalregulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters
    • Fonseca BD, Alain T, Finestone LK, Huang BP, Rolfe M, Jiang T, Yao Z, Hernandez G, Bennett CF, Proud CG. 2011. Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signalregulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters. J Biol Chem 286:27111-27122.
    • (2011) J Biol Chem , vol.286 , pp. 27111-27122
    • Fonseca, B.D.1    Alain, T.2    Finestone, L.K.3    Huang, B.P.4    Rolfe, M.5    Jiang, T.6    Yao, Z.7    Hernandez, G.8    Bennett, C.F.9    Proud, C.G.10
  • 15
    • 0004102014 scopus 로고    scopus 로고
    • 3rd ed. New York: Oxford University Press.
    • Gomez MR (ed.). 1999. Tuberous sclerosis complex, 3rd ed. New York: Oxford University Press.
    • (1999) Tuberous sclerosis complex
    • Gomez, M.R.1
  • 17
    • 79953251423 scopus 로고    scopus 로고
    • TSC1/TSC2 signaling in the CNS
    • Han J, Sahin M. 2011. TSC1/TSC2 signaling in the CNS. FEBS Lett 585:973-980.
    • (2011) FEBS Lett , vol.585 , pp. 973-980
    • Han, J.1    Sahin, M.2
  • 18
    • 0030725540 scopus 로고    scopus 로고
    • Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors
    • Henske E, Wessner L, Golden J, Scheithauser b, Vortmeyer A, Zhuang Z, Klein-Szanto A, Kwiatkowski D, Yueng R. 1997. Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am J Pathol 151:1639-1647.
    • (1997) Am J Pathol , vol.151 , pp. 1639-1647
    • Henske, E.1    Wessner, L.2    Golden, J.3    Scheithauser, B.4    Vortmeyer, A.5    Zhuang, Z.6    Klein-Szanto, A.7    Kwiatkowski, D.8    Yueng, R.9
  • 19
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang J, Manning B. 2009. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37:217-222.
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.2
  • 20
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang J, Dibble C, Matsuzaki M, Manning B. 2008. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 28:4101-4115.
    • (2008) Mol Cell Biol , vol.28 , pp. 4101-4115
    • Huang, J.1    Dibble, C.2    Matsuzaki, M.3    Manning, B.4
  • 21
    • 0030696314 scopus 로고    scopus 로고
    • Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis
    • Jones A, Daniells C, Snell R, Tachataki M, Idziaszczyk S, Krawczak M, Sampson J, Cheadle J. 1997. Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis. Hum Mol Genet 6:2155-2161.
    • (1997) Hum Mol Genet , vol.6 , pp. 2155-2161
    • Jones, A.1    Daniells, C.2    Snell, R.3    Tachataki, M.4    Idziaszczyk, S.5    Krawczak, M.6    Sampson, J.7    Cheadle, J.8
  • 23
    • 1542407036 scopus 로고    scopus 로고
    • Genotype and psychological phenotype in tuberous sclerosis
    • Lewis J, Thomas H, Murphy K, Sampson J. 2004. Genotype and psychological phenotype in tuberous sclerosis. J Med Genet 41:203-207.
    • (2004) J Med Genet , vol.41 , pp. 203-207
    • Lewis, J.1    Thomas, H.2    Murphy, K.3    Sampson, J.4
  • 24
    • 79959990517 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45
    • Li H, Adachi Y, Yamamoto H, Min Y, Ohashi H, Ii M, Arimura Y, Endo T, Lee CT, Carbone DP, Imai K, Shinomura Y. 2011. Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45. Cancer 117:3135-3147.
    • (2011) Cancer , vol.117 , pp. 3135-3147
    • Li, H.1    Adachi, Y.2    Yamamoto, H.3    Min, Y.4    Ohashi, H.5    Ii, M.6    Arimura, Y.7    Endo, T.8    Lee, C.T.9    Carbone, D.P.10    Imai, K.11    Shinomura, Y.12
  • 25
    • 35348930475 scopus 로고    scopus 로고
    • Characteristics of abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MR imaging in tuberous sclerosis comnplex
    • Makki M, Chugani D, Janisse J, Chugani H. 2007. Characteristics of abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MR imaging in tuberous sclerosis comnplex. Am J Neuroradiol 28:1662-1667.
    • (2007) Am J Neuroradiol , vol.28 , pp. 1662-1667
    • Makki, M.1    Chugani, D.2    Janisse, J.3    Chugani, H.4
  • 27
    • 34250626014 scopus 로고    scopus 로고
    • A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival
    • Meikle L, Talos DM, Onda H, Pollizzi K, Rotenberg A, Sahin M, Jensen FE, Kwiatkowski DJ. 2007. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci 27:5546-5558.
    • (2007) J Neurosci , vol.27 , pp. 5546-5558
    • Meikle, L.1    Talos, D.M.2    Onda, H.3    Pollizzi, K.4    Rotenberg, A.5    Sahin, M.6    Jensen, F.E.7    Kwiatkowski, D.J.8
  • 28
    • 79959565622 scopus 로고    scopus 로고
    • Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of rapamycin pathway
    • Park JH, Arakawa-Takeuchi S, Jinno S, Okayama H. 2011. Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of rapamycin pathway. J Biol Chem 286:23132-23141.
    • (2011) J Biol Chem , vol.286 , pp. 23132-23141
    • Park, J.H.1    Arakawa-Takeuchi, S.2    Jinno, S.3    Okayama, H.4
  • 29
    • 0032213545 scopus 로고    scopus 로고
    • Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
    • Plank T, Yeung R, Henske E. 1998. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res 58:4766-4770.
    • (1998) Cancer Res , vol.58 , pp. 4766-4770
    • Plank, T.1    Yeung, R.2    Henske, E.3
  • 31
    • 0035805162 scopus 로고    scopus 로고
    • Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
    • Potter CJ, Huang H, Xu T. 2001. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105: 357-368.
    • (2001) Cell , vol.105 , pp. 357-368
    • Potter, C.J.1    Huang, H.2    Xu, T.3
  • 32
    • 78449298516 scopus 로고    scopus 로고
    • Analysis of TSC cortical tubers by deep sequencing ofr TSC1, TSC2 and KRAS demonstrates that small hit mutation in these genes are rare events
    • Qin W, Chan J, Vinters H, Mathern G, Franz D, Taillon B, Bouffard P, Kwiatkowski D. 2012. Analysis of TSC cortical tubers by deep sequencing ofr TSC1, TSC2 and KRAS demonstrates that small hit mutation in these genes are rare events. Brain Pathol 20:1096-1105.
    • (2012) Brain Pathol , vol.20 , pp. 1096-1105
    • Qin, W.1    Chan, J.2    Vinters, H.3    Mathern, G.4    Franz, D.5    Taillon, B.6    Bouffard, P.7    Kwiatkowski, D.8
  • 34
    • 43149101490 scopus 로고    scopus 로고
    • The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners
    • Rosner M, Hanneder M, Siegel N, Valli A, Hengstschlager M. 2008. The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners. Mutat Res 658:234-246.
    • (2008) Mutat Res , vol.658 , pp. 234-246
    • Rosner, M.1    Hanneder, M.2    Siegel, N.3    Valli, A.4    Hengstschlager, M.5
  • 37
    • 66049119030 scopus 로고    scopus 로고
    • Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation
    • Tyler W, Gangoli N, Gokina P, Kim H, Covey M, Levison S, Wood T. 2009. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci 29:6367-6378.
    • (2009) J Neurosci , vol.29 , pp. 6367-6378
    • Tyler, W.1    Gangoli, N.2    Gokina, P.3    Kim, H.4    Covey, M.5    Levison, S.6    Wood, T.7
  • 40
    • 63149114250 scopus 로고    scopus 로고
    • Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse
    • Way S, McKenna J, Mietzsch U, Reith R, Wu H, Gambello M. 2009. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum Mol Genet 18:1252-1265.
    • (2009) Hum Mol Genet , vol.18 , pp. 1252-1265
    • Way, S.1    McKenna, J.2    Mietzsch, U.3    Reith, R.4    Wu, H.5    Gambello, M.6
  • 42
    • 80054785459 scopus 로고    scopus 로고
    • A mechanism for synergy with combined mTOR and PI3 kinase inhibitors
    • Yang S, Xiao X, Meng X, Leslie KK. 2011. A mechanism for synergy with combined mTOR and PI3 kinase inhibitors. PloS One 6:e26343.
    • (2011) PloS One , vol.6
    • Yang, S.1    Xiao, X.2    Meng, X.3    Leslie, K.K.4
  • 43
    • 78651064535 scopus 로고    scopus 로고
    • Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex
    • Zeng L, Rensing N, Zhang B, Gutmann D, Gambello M, Wong M. 2011. Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. Hum Mol Genet 20:445-454.
    • (2011) Hum Mol Genet , vol.20 , pp. 445-454
    • Zeng, L.1    Rensing, N.2    Zhang, B.3    Gutmann, D.4    Gambello, M.5    Wong, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.