Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model

Journal of Hepatology

Volumn 52, Issue 6, 2010, Pages 903-912

  Shindo, Nobuyasu ^a   Fujisawa, Tomomi ^a   Sugimoto, Ken ^a   Nojima, Koji ^a   Oze Fukai, Aya ^a   Yoshikawa, Yuki ^a   Wang, Xiang ^a   Yasuda, Osamu ^a   Ikegami, Hiroshi ^b   Rakugi, Hiromi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Glucose intolerance; Insulin resistance; Microsomal triglyceride transfer protein; Nonalcoholic steatohepatitis; Spontaneous model

Indexed keywords

APOLIPOPROTEIN B; CARNITINE PALMITOYLTRANSFERASE I; FAT DROPLET; GENE PRODUCT; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN EMR1; PROTEIN TGFB1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; GENE EXPRESSION; GLUCOSE INTOLERANCE; INFLAMMATION; INSULIN RESISTANCE; LIPID STORAGE; LIPOPROTEIN SECRETION; LIVER; LIVER FIBROSIS; LIVER HISTOLOGY; MALE; MOUSE; MOUSE STRAIN; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; CHOLESTEROL, VLDL; DISEASE MODELS, ANIMAL; FATTY LIVER; GENE EXPRESSION; GLUCOSE INTOLERANCE; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSOMES, LIVER; PHENOTYPE; TRANSFECTION; TRIGLYCERIDES;

EID: 77952425688     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.12.033     Document Type: Article

References (24)

1. Abe C., Ikeda S., Uchida T., Yamashita K., and Ichikawa T. Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. J Nutr 137 (2007) 345-350
2. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 346 (2002) 1221-1231
3. Anstee Q.M., and Goldin R.D. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int J Exp Pathol 87 (2006) 1-16
4. Browning J.D., and Horton J.D. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114 (2004) 147-152
5. Cuchel M., Bloedon L.T., Szapary P.O., Kolansky D.M., Wolfe M.L., Sarkis A., et al. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N Engl J Med 356 (2007) 148-156
6. Farrell G.C., and Larter C.Z. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43 (2006) S99-S112
7. Fujita K., Nozaki Y., Wada K., Yoneda M., Fujimoto Y., Fujitake M., et al. Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis. Hepatology 50 (2009) 772-780
8. Gambino R., Cassader M., Pagano G., Durazzo M., and Musso G. Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?. Hepatology 45 (2007) 1097-1107
9. Gastaldelli A., Kozakova M., Hojlund K., Flyvbjerg A., Favuzzi A., Mitrakou A., et al. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population. Hepatology 49 (2009) 1537-1544
10. Gordon D.A., and Jamil H. Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly. Biochim Biophys Acta 1486 (2000) 72-83
11. Hussain M.M., and Bakillah A. New approaches to target microsomal triglyceride transfer protein. Curr Opin Lipidol 19 (2008) 572-578
12. Kawaguchi K., Sakaida I., Tsuchiya M., Omori K., Takami T., and Okita K. Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient l-amino acid-defined diet. Biochem Biophys Res Commun 315 (2004) 187-195
13. Kleiner D.E., Brunt E.M., Van Natta M., Behling C., Contos M.J., Cummings O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005) 1313-1321
14. Lazo M., and Clark J.M. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis 28 (2008) 339-350
15. Lin M.C., Gordon D., and Wetterau J.R. Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J Lipid Res 36 (1995) 1073-1081
16. Ludwig J., Viggiano T.R., McGill D.B., and Oh B.J. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55 (1980) 434-438
17. Oze-Fukai A., Fujisawa T., Sugimoto K., Nojima K., Shindo N., Shimoyoshi S., et al. A novel mouse model for type 2 diabetes and non-alcoholic fatty liver disease: spontaneous amelioration of diabetes by augmented beta cell mass. Endocr J 56 (2009) 227-234
18. Petersen K.F., Dufour S., Feng J., Befroy D., Dziura J., Dalla Man C., et al. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci USA 103 (2006) 18273-18277
19. Soga M., Kishimoto Y., Kawaguchi J., Nakai Y., Kawamura Y., Inagaki S., et al. The FLS mouse: a new inbred strain with spontaneous fatty liver. Lab Anim Sci 49 (1999) 269-275
20. Soga M., Kishimoto Y., Kawamura Y., Inagaki S., Makino S., and Saibara T. Spontaneous development of hepatocellular carcinomas in the FLS mice with hereditary fatty liver. Cancer Lett 196 (2003) 43-48
21. Song Y.K., Liu F., Zhang G., and Liu D. Hydrodynamics-based transfection: simple and efficient method for introducing and expressing transgenes in animals by intravenous injection of DNA. Methods Enzymol 346 (2002) 92-105
22. Uno M., Kurita S., Misu H., Ando H., Ota T., Matsuzawa-Nagata N., et al. Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. Hepatology 48 (2008) 109-118
23. Usui S., Hara Y., Hosaki S., and Okazaki M. A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC. J Lipid Res 43 (2002) 805-814
24. Wierzbicki A.S., Hardman T., and Prince W.T. Future challenges for microsomal transport protein inhibitors. Curr Vasc Pharmacol 7 (2009) 277-286