Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13 C magnetic resonance spectroscopy

Nature Medicine

Volumn 20, Issue 1, 2014, Pages 98-102

  Befroy, Douglas E ^a   Perry, Rachel J ^a   Jain, Nimit ^a   Dufour, Sylvie ^a   Cline, Gary W ^a   Trimmer, Jeff K ^b   Brosnan, Julia ^b   Rothman, Douglas L ^a   Petersen, Kitt Falk ^a,c   Shulman, Gerald I ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c Capital Region   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; CARBON 13; GLUTAMIC ACID; TRICARBOXYLIC ACID;

ADULT; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; CONTROLLED STUDY; GLUCONEOGENESIS; HEPATOBILIARY PARAMETERS; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; LIVER METABOLISM; LIVER MITOCHONDRION; MALE; METABOLIC RATE; MITOCHONDRIAL RESPIRATION; NON INVASIVE PROCEDURE; NONHUMAN; OXIDATION KINETICS; PRIORITY JOURNAL; RAT;

CARBON RADIOISOTOPES; CITRIC ACID CYCLE; COMPUTER SIMULATION; DIABETES MELLITUS, TYPE 2; FATTY LIVER; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLIC NETWORKS AND PATHWAYS; MITOCHONDRIA, LIVER; MONTE CARLO METHOD; OXIDATION-REDUCTION; STAINING AND LABELING;

EID: 84891859110     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3415     Document Type: Article

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