메뉴 건너뛰기




Volumn 21, Issue 10, 2013, Pages 2138-2145

A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN C3; ASPARTATE AMINOTRANSFERASE; CYSTEINE; GLUCOSE; GLYCINE; LIPID; THREONINE;

EID: 84885381567     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20366     Document Type: Article
Times cited : (59)

References (40)
  • 1
    • 32144455202 scopus 로고    scopus 로고
    • The emerging epidemic of obesity in developing countries
    • Prentice AM,. The emerging epidemic of obesity in developing countries. Int J Epidemiol 2007; 35: 93-99.
    • (2007) Int J Epidemiol , vol.35 , pp. 93-99
    • Prentice, A.M.1
  • 2
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P,. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 3
    • 26044451626 scopus 로고    scopus 로고
    • Pathological features of NASH
    • Brunt EM, Tiniakos DG,. Pathological features of NASH. Front Biosci 2005; 10: 1475-1484.
    • (2005) Front Biosci , vol.10 , pp. 1475-1484
    • Brunt, E.M.1    Tiniakos, D.G.2
  • 4
    • 77649337140 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathology and pathogenesis
    • Tiniakos DG, Vos MB, Brunt EM,. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 2010; 5: 145-171.
    • (2010) Annu Rev Pathol , vol.5 , pp. 145-171
    • Tiniakos, D.G.1    Vos, M.B.2    Brunt, E.M.3
  • 5
    • 78650774076 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in Asia: Firmly entrenched and rapidly gaining ground
    • Chitturi S, Wong VW, Farrell G,. Nonalcoholic fatty liver disease in Asia: firmly entrenched and rapidly gaining ground. J Gastroenterol Hepatol 2011; 26: 163-172.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 163-172
    • Chitturi, S.1    Wong, V.W.2    Farrell, G.3
  • 6
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-1465.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 7
    • 79957462315 scopus 로고    scopus 로고
    • Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    • Sookoian S, Pirola CJ,. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011; 53: 1883-1894.
    • (2011) Hepatology , vol.53 , pp. 1883-1894
    • Sookoian, S.1    Pirola, C.J.2
  • 8
    • 67349174005 scopus 로고    scopus 로고
    • A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
    • Kotronen A, Johansson LE, Johansson LM, et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 2009; 52: 1056-1060.
    • (2009) Diabetologia , vol.52 , pp. 1056-1060
    • Kotronen, A.1    Johansson, L.E.2    Johansson, L.M.3
  • 9
    • 77349106712 scopus 로고    scopus 로고
    • A common variant in the adiponutrin gene influences liver enzyme values
    • Kollerits B, Coassin S, Kiechl S, et al. A common variant in the adiponutrin gene influences liver enzyme values. J Med Genet 2010; 47: 116-119.
    • (2010) J Med Genet , vol.47 , pp. 116-119
    • Kollerits, B.1    Coassin, S.2    Kiechl, S.3
  • 10
    • 77950607738 scopus 로고    scopus 로고
    • Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    • Valenti L, Al-Serri A, Daly AK, et al. Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 2010; 51: 1209-1217.
    • (2010) Hepatology , vol.51 , pp. 1209-1217
    • Valenti, L.1    Al-Serri, A.2    Daly, A.K.3
  • 11
    • 77956636268 scopus 로고    scopus 로고
    • The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    • NASH CRN.
    • Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ,; NASH CRN. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 2010; 52: 894-903.
    • (2010) Hepatology , vol.52 , pp. 894-903
    • Rotman, Y.1    Koh, C.2    Zmuda, J.M.3    Kleiner, D.E.4    Liang, T.J.5
  • 12
    • 77956630787 scopus 로고    scopus 로고
    • PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    • Speliotes EK, Butler JL, Palmer CD, et al. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. Hepatology 2010; 52: 904-912.
    • (2010) Hepatology , vol.52 , pp. 904-912
    • Speliotes, E.K.1    Butler, J.L.2    Palmer, C.D.3
  • 13
    • 77950202777 scopus 로고    scopus 로고
    • Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
    • Petersen KF, Dufour S, Hariri A, et al. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med 2010; 362: 1082-1089.
    • (2010) N Engl J Med , vol.362 , pp. 1082-1089
    • Petersen, K.F.1    Dufour, S.2    Hariri, A.3
  • 14
    • 0022362415 scopus 로고
    • Distribution of apolipoprotein A-I, C-II, C-III, and e mRNA in fetal human tissues. Time-dependent induction of apolipoprotein e mRNA by cultures of human monocyte-macrophages
    • Zannis VI, Cole FS, Jackson CL, Kurnit DM, Karathanasis SK,. Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages. Biochemistry 1985; 24: 4450-4455.
    • (1985) Biochemistry , vol.24 , pp. 4450-4455
    • Zannis, V.I.1    Cole, F.S.2    Jackson, C.L.3    Kurnit, D.M.4    Karathanasis, S.K.5
  • 15
    • 0025030698 scopus 로고
    • Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice
    • Ito Y, Azrolan N, O'Connell A, Walsh A, Breslow JL,. Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science 1990; 249: 790-793.
    • (1990) Science , vol.249 , pp. 790-793
    • Ito, Y.1    Azrolan, N.2    O'Connell, A.3    Walsh, A.4    Breslow, J.L.5
  • 16
    • 79952119879 scopus 로고    scopus 로고
    • Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia
    • Caron S, Verrijken A, Mertens I, et al. Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia. Arterioscler Thromb Vasc Biol 2011; 31: 513-519.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 513-519
    • Caron, S.1    Verrijken, A.2    Mertens, I.3
  • 17
    • 79251523832 scopus 로고    scopus 로고
    • Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance
    • Kozlitina J, Boerwinkle E, Cohen JC, Hobbs HH,. Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance. Hepatology 2011; 53: 467-474.
    • (2011) Hepatology , vol.53 , pp. 467-474
    • Kozlitina, J.1    Boerwinkle, E.2    Cohen, J.C.3    Hobbs, H.H.4
  • 18
    • 79958160803 scopus 로고    scopus 로고
    • Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans
    • Sentinelli F, Romeo S, Maglio C, et al. Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans. Lip Health Dis 2011; 10: 93.
    • (2011) Lip Health Dis , vol.10 , pp. 93
    • Sentinelli, F.1    Romeo, S.2    Maglio, C.3
  • 19
    • 81255198296 scopus 로고    scopus 로고
    • The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver
    • Valenti L, Nobili V, Al-Serri A, et al. The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver. J Hepatol 2011; 55: 1409-1414.
    • (2011) J Hepatol , vol.55 , pp. 1409-1414
    • Valenti, L.1    Nobili, V.2    Al-Serri, A.3
  • 20
    • 84860246794 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 but not APOC3 influences liver fat in NAFLD
    • Hyysalo J, Stojkovic I, Kotronen A, et al. Genetic variation in PNPLA3 but not APOC3 influences liver fat in NAFLD. J Gastroenterol Hepatol 2012; 27: 951-956.
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 951-956
    • Hyysalo, J.1    Stojkovic, I.2    Kotronen, A.3
  • 21
    • 84857398069 scopus 로고    scopus 로고
    • Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
    • Santoro N, Zhang CK, Zhao H, et al. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. Hepatology 2012; 55: 781-789.
    • (2012) Hepatology , vol.55 , pp. 781-789
    • Santoro, N.1    Zhang, C.K.2    Zhao, H.3
  • 22
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS,. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 23
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC,. Homeostasis model assessment: insulin resistance and β-cell function from fasting glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 24
    • 0027321961 scopus 로고
    • Techniques for the measurement of visceral fat: A practical guide
    • van der Kooy K, Seidell JC,. Techniques for the measurement of visceral fat: a practical guide. Int J Obes Relat Metab Disord 1993; 17: 187-196.
    • (1993) Int J Obes Relat Metab Disord , vol.17 , pp. 187-196
    • Van Der Kooy, K.1    Seidell, J.C.2
  • 26
    • 0026562356 scopus 로고
    • Aminopyrine breath test in the prognostic evaluation of patients with cirrhosis
    • Merkel C, Bolognesi M, Bellon S, Bianco S, Honisch B, Lampe H,. Aminopyrine breath test in the prognostic evaluation of patients with cirrhosis. Gut 1992; 33: 836-842.
    • (1992) Gut , vol.33 , pp. 836-842
    • Merkel, C.1    Bolognesi, M.2    Bellon, S.3    Bianco, S.4    Honisch, B.5    Lampe, H.6
  • 27
    • 84885380800 scopus 로고    scopus 로고
    • Farrell G.C. George J. de la M. Hall P. McCullough A.J. editors. 1st ed. Massachusetts: Blackwell Publishing;.
    • Farrell GC, George J, de la M, Hall P, McCullough AJ, editors. Fatty Liver Disease: NASH and Related Disorders. 1st ed. Massachusetts: Blackwell Publishing; 2005. pp 1-12.
    • (2005) Fatty Liver Disease: NASH and Related Disorders , pp. 1-12
  • 28
    • 84885376493 scopus 로고
    • Cosgrove D.O. Meire H. Dewbury K. editors. 3rd ed. New York: Churchill Livingstone;.
    • Cosgrove DO, Meire H, Dewbury K, editors. Abdominal and General Ultrasound. 3rd ed. New York: Churchill Livingstone; 1994. pp 227-242.
    • (1994) Abdominal and General Ultrasound , pp. 227-242
  • 29
    • 0022645750 scopus 로고
    • Ultrasound scanning in the detection of hepatic fibrosis and steatosis
    • Saverymuttu SH, Joseph AE, Maxwell JD,. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J (Clin Res Ed) 1986; 292: 13-15.
    • (1986) Br Med J (Clin Res Ed) , vol.292 , pp. 13-15
    • Saverymuttu, S.H.1    Joseph, A.E.2    Maxwell, J.D.3
  • 30
    • 0037726668 scopus 로고    scopus 로고
    • Diagnosis of fatty liver disease: Is biopsy necessary?
    • Joy D, Thava VR, Scott BB,. Diagnosis of fatty liver disease: is biopsy necessary? Eur J Gastroenterol Hepatol 2003; 15: 539-543.
    • (2003) Eur J Gastroenterol Hepatol , vol.15 , pp. 539-543
    • Joy, D.1    Thava, V.R.2    Scott, B.B.3
  • 31
    • 79952231349 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: Distinct clinicopathologic meanings
    • NASH Clinical Research Network (CRN).
    • Brunt EM, Kleiner DE, Wilson LA, Belt P, Neuschwander-Tetri BA,; NASH Clinical Research Network (CRN). Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology 2011; 53: 810-820.
    • (2011) Hepatology , vol.53 , pp. 810-820
    • Brunt, E.M.1    Kleiner, D.E.2    Wilson, L.A.3    Belt, P.4    Neuschwander-Tetri, B.A.5
  • 32
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 33
    • 0024284028 scopus 로고    scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller SA, Dykes DD, Polesky HF,. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1998; 16: 1215.
    • (1998) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 34
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N,. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 37
    • 80054806707 scopus 로고    scopus 로고
    • Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease
    • Huang Y, Cohen JC, Hobbs HH,. Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. J Biol Chem 2011; 286: 37085-37093.
    • (2011) J Biol Chem , vol.286 , pp. 37085-37093
    • Huang, Y.1    Cohen, J.C.2    Hobbs, H.H.3
  • 38
    • 69249111667 scopus 로고    scopus 로고
    • A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
    • Sookoian S, Castaño GO, Burgueño AL, Gianotti TF, Rosselli MS, Pirola CJ,. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res 2009; 50: 2111-2116.
    • (2009) J Lipid Res , vol.50 , pp. 2111-2116
    • Sookoian, S.1    Castaño, G.O.2    Burgueño, A.L.3    Gianotti, T.F.4    Rosselli, M.S.5    Pirola, C.J.6
  • 39
    • 79953745343 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    • Speliotes EK, Yerges-Armstrong LM, Wu J, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genetics 2011; 7: e1001324.
    • (2011) PLoS Genetics , vol.7
    • Speliotes, E.K.1    Yerges-Armstrong, L.M.2    Wu, J.3
  • 40
    • 70349773095 scopus 로고    scopus 로고
    • Histopathology of non-alcoholic fatty liver disease
    • Brunt EM,. Histopathology of non-alcoholic fatty liver disease. Clin Liver Dis 2009; 13: 533-544.
    • (2009) Clin Liver Dis , vol.13 , pp. 533-544
    • Brunt, E.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.