Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly

Diabetes

Volumn 61, Issue 11, 2012, Pages 2711-2717

  Flannery, Clare ^a   Dufour, Sylvie ^a   Rabøl, Rasmus ^a   Shulman, Gerald I ^a   Petersen, Kitt Falk ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; URIC ACID;

AGED; AGING; ARTICLE; CALORIMETRY; CARBOHYDRATE INTAKE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; FATTY LIVER; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCOGEN SYNTHESIS; HEPATIC DE NOVO LIPOGENESIS; HUMAN; HYPERLIPIDEMIA; INSULIN RESISTANCE; LIPOGENESIS; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEDENTARY LIFESTYLE; SKELETAL MUSCLE;

ADULT; AGED; AGING; DIETARY CARBOHYDRATES; FATTY LIVER; FEMALE; GLYCOGEN; HUMANS; HYPERLIPIDEMIAS; INSULIN RESISTANCE; LIPOGENESIS; LIVER; MALE; METABOLIC SYNDROME X; MUSCLE, SKELETAL; POSTPRANDIAL PERIOD; TRIGLYCERIDES; YOUNG ADULT;

EID: 84868014062     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0206     Document Type: Article

References (27)

1. Hildrum B, Mykletun A, Hole T, Midthjell K, Dahl AA. Age-specific prevalence of the metabolic syndrome defined by the International Diabetes Federation and the National Cholesterol Education Program: the Norwegian HUNT 2 study. BMC Public Health 2007;7:220
2. Rodriguez A, Muller DC, Metter EJ, et al. Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab 2007;92:3568-3572
3. Petersen KF, Dufour S, Savage DB, et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci USA 2007;104:12587-12594
4. Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc Natl Acad Sci USA 2011;108:13705-13709
5. Petersen KF, Befroy D, Dufour S, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003;300:1140-1142
6. Previs SF, Hazey JW, Diraison F, Beylot M, David F, Brunengraber H. Assay of the deuterium enrichment of water via acetylene. J Mass Spectrom 1996;31:639-642
7. Diraison F, Pachiaudi C, Beylot M. Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/mass spectrometric techniques. J Mass Spectrom 1997;32:81-86
8. Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982;36:936-942
9. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1470
10. Shen J, Rothman DL. Fast automatic adjustment of on-axis shims for highresolution NMR. J Magn Reson 1997;127:229-232
11. Petersen KF, Dufour S, Feng J, et al. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci USA 2006;103:18273-18277
12. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509
13. Petersen KF, Dufour S, Hariri A, et al. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med 2010;362:1082-1089
14. Le Floch JP, Escuyer P, Baudin E, Baudon D, Perlemuter L. Blood glucose area under the curve. Methodological aspects. Diabetes Care 1990;13:172-175
15. Dumortier M, Thöni G, Brun JF, Mercier J. Substrate oxidation during exercise: impact of time interval from the last meal in obese women. Int J Obes (Lond) 2005;29:966-974
16. Karakelides H, Nair KS. Sarcopenia of aging and its metabolic impact. Curr Top Dev Biol 2005;68:123-148
17. Boumezbeur F, Mason GF, de Graaf RA, et al. Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J Cereb Blood Flow Metab 2010;30:211-221
18. Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999;48:1270-1274
19. Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002;277:50230-50236
20. Petersen KF, Price T, Cline GW, Rothman DL, Shulman GI. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am J Physiol 1996;270:E186-E191
21. 13C NMR. Science 1991;254:573-576
22. Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 1997;99:846-854
23. Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci USA 2004; 101:11245-11250
24. Shimano H. SREBPs: novel aspects of SREBPs in the regulation of lipid synthesis. FEBS J 2009;276:615
25. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005;115:1343-1351
26. Krauss RM, Siri PW. Metabolic abnormalities: triglyceride and low-density lipoprotein. Endocrinol Metab Clin North Am 2004;33:405-415
27. Berrougui H, Khalil A. Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity. Rejuvenation Res 2009;12: 117-126