Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 22, 2014, Pages

  Liew, Chong Wee ^a,b   Assmann, Anke ^a   Templin, Andrew T ^c   Raum, Jeffrey C ^d   Lipson, Kathryn L ^e,j   Rajan, Sindhu ^f   Qiang, Guifen ^b   Hu, Jiang ^a   Kawamori, Dan ^a   Lindberg, Iris ^g   Philipson, Louis H ^f   Sonenberg, Nahum ^h   Goldfine, Allison B ^a   Stoffers, Doris A ^d   Mirmira, Raghavendra G ^c   Urano, Fumihiko ⁱ   Kulkarni, Rohit N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^h MCGILL UNIVERSITY   (Canada)

ⁱ WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j WESTERN NEW ENGLAND UNIVERSITY   (United States)

more..

Author keywords

bIRKO; ER stress; GWAS; Prohormone

Indexed keywords

CARBOXYPEPTIDASE H; INITIATION FACTOR; INITIATION FACTOR 4; INSULIN; PROINSULIN; SCAFFOLD PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOREACTIVITY; LIPID DIET; LONGITUDINAL STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; TRANSLATION INITIATION; UPREGULATION; WESTERN BLOTTING;

BIRKO; ER STRESS; GWAS; PROHORMONE;

ANIMALS; CARBOXYPEPTIDASE H; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-4G; GENOME-WIDE ASSOCIATION STUDY; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN BIOSYNTHESIS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANS-ACTIVATORS;

EID: 84901856227     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323066111     Document Type: Article

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