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Volumn 4, Issue 11, 2009, Pages

Insulin signaling regulates mitochondrial function in pancreatic β-cells

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOKINASE; INSULIN; INSULIN RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN P70S6K; SOMATOMEDIN RECEPTOR; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG; SERINE;

EID: 71049133592     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007983     Document Type: Article
Times cited : (51)

References (55)
  • 1
    • 0036550234 scopus 로고    scopus 로고
    • Signalling through IGF-I and insulin receptors: Where is the specificity?
    • Kim JJ, Accili D (2002) Signalling through IGF-I and insulin receptors: where is the specificity? Growth Horm IGF Res 12: 84-90.
    • (2002) Growth Horm IGF Res , vol.12 , pp. 84-90
    • Kim, J.J.1    Accili, D.2
  • 2
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 3
    • 59149104922 scopus 로고    scopus 로고
    • Growth factor control of pancreatic islet regeneration and function
    • Assmann A, Hinault C, Kulkarni RN (2009) Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes 10: 14-32.
    • (2009) Pediatr Diabetes , vol.10 , pp. 14-32
    • Assmann, A.1    Hinault, C.2    Kulkarni, R.N.3
  • 4
    • 0348048485 scopus 로고    scopus 로고
    • Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice
    • Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, et al. (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286: E41-49.
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Otani, K.1    Kulkarni, R.N.2    Baldwin, A.C.3    Krutzfeldt, J.4    Ueki, K.5
  • 5
    • 0036578921 scopus 로고    scopus 로고
    • beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass
    • Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, et al. (2002) beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 31: 111-115.
    • (2002) Nat Genet , vol.31 , pp. 111-115
    • Kulkarni, R.N.1    Holzenberger, M.2    Shih, D.Q.3    Ozcan, U.4    Stoffel, M.5
  • 6
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, et al. (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96: 329-339.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5
  • 7
    • 66349132198 scopus 로고    scopus 로고
    • Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2
    • Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN (2009) Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol 29: 3219-3228.
    • (2009) Mol Cell Biol , vol.29 , pp. 3219-3228
    • Assmann, A.1    Ueki, K.2    Winnay, J.N.3    Kadowaki, T.4    Kulkarni, R.N.5
  • 8
    • 34547482573 scopus 로고    scopus 로고
    • Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
    • Okada T, Liew CW, Hu J, Hinault C, Michael MD, et al. (2007) Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A 104: 8977-8982.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8977-8982
    • Okada, T.1    Liew, C.W.2    Hu, J.3    Hinault, C.4    Michael, M.D.5
  • 9
    • 20244376316 scopus 로고    scopus 로고
    • Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
    • Anello M, Lupi R, Spampinato D, Piro S, Masini M, et al. (2005) Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 48: 282-289.
    • (2005) Diabetologia , vol.48 , pp. 282-289
    • Anello, M.1    Lupi, R.2    Spampinato, D.3    Piro, S.4    Masini, M.5
  • 10
    • 0030067124 scopus 로고    scopus 로고
    • Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • Matschinsky FM (1996) Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45: 223-241.
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 11
    • 33644749337 scopus 로고    scopus 로고
    • The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy
    • Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, et al. (2006) The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes 55: 1-12.
    • (2006) Diabetes , vol.55 , pp. 1-12
    • Matschinsky, F.M.1    Magnuson, M.A.2    Zelent, D.3    Jetton, T.L.4    Doliba, N.5
  • 12
    • 33646779855 scopus 로고    scopus 로고
    • Minireview: Implication of mitochondria in insulin secretion and action
    • Wiederkehr A, Wollheim CB (2006) Minireview: implication of mitochondria in insulin secretion and action. Endocrinology 147: 2643-2649.
    • (2006) Endocrinology , vol.147 , pp. 2643-2649
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 13
    • 23944484541 scopus 로고    scopus 로고
    • Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: Potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell
    • Veluthakal R, Palanivel R, Zhao Y, McDonald P, Gruber S, et al. (2005) Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell. Apoptosis 10: 841-850.
    • (2005) Apoptosis , vol.10 , pp. 841-850
    • Veluthakal, R.1    Palanivel, R.2    Zhao, Y.3    McDonald, P.4    Gruber, S.5
  • 14
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116: 205-219.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 15
    • 33746840153 scopus 로고    scopus 로고
    • IGF-I mediated survival pathways in normal and malignant cells
    • Kurmasheva RT, Houghton PJ (2006) IGF-I mediated survival pathways in normal and malignant cells. Biochim Biophys Acta 1766: 1-22.
    • (2006) Biochim Biophys Acta , vol.1766 , pp. 1-22
    • Kurmasheva, R.T.1    Houghton, P.J.2
  • 16
    • 0041357164 scopus 로고    scopus 로고
    • BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
    • Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424: 952-956.
    • (2003) Nature , vol.424 , pp. 952-956
    • Danial, N.N.1    Gramm, C.F.2    Scorrano, L.3    Zhang, C.Y.4    Krauss, S.5
  • 17
    • 56949108344 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: Glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells
    • Lee JW, Kim WH, Lim JH, Song EH, Song J, et al. (2009) Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells. Cell Signal 21: 69-78.
    • (2009) Cell Signal , vol.21 , pp. 69-78
    • Lee, J.W.1    Kim, W.H.2    Lim, J.H.3    Song, E.H.4    Song, J.5
  • 18
    • 24144490962 scopus 로고    scopus 로고
    • Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: Downregulation of glucokinase in pancreatic beta-cells
    • Kim WH, Lee JW, Suh YH, Hong SH, Choi JS, et al. (2005) Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells. Diabetes 54: 2602-2611.
    • (2005) Diabetes , vol.54 , pp. 2602-2611
    • Kim, W.H.1    Lee, J.W.2    Suh, Y.H.3    Hong, S.H.4    Choi, J.S.5
  • 19
    • 24744434956 scopus 로고    scopus 로고
    • New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass
    • Kulkarni RN (2005) New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Rev Endocr Metab Disord 6: 199-210.
    • (2005) Rev Endocr Metab Disord , vol.6 , pp. 199-210
    • Kulkarni, R.N.1
  • 20
    • 0036849192 scopus 로고    scopus 로고
    • Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
    • Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 3: 631-643.
    • (2002) Dev Cell , vol.3 , pp. 631-643
    • Datta, S.R.1    Ranger, A.M.2    Lin, M.Z.3    Sturgill, J.F.4    Ma, Y.C.5
  • 21
    • 0035425234 scopus 로고    scopus 로고
    • Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
    • Fernandez AM, Kim JK, Yakar S, Dupont J, Hernandez-Sanchez C, et al. (2001) Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev 15: 1926-1934.
    • (2001) Genes Dev , vol.15 , pp. 1926-1934
    • Fernandez, A.M.1    Kim, J.K.2    Yakar, S.3    Dupont, J.4    Hernandez-Sanchez, C.5
  • 22
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • Bonni A, Brunet A, West AE, Datta SR, Takasu MA, et al. (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286: 1358-1362.
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5
  • 23
    • 0035206813 scopus 로고    scopus 로고
    • 14-3-3 inhibits Bad-induced cell death through interaction with serine-136
    • Masters SC, Yang H, Datta SR, Greenberg ME, Fu H (2001) 14-3-3 inhibits Bad-induced cell death through interaction with serine-136. Mol Pharmacol 60: 1325-1331.
    • (2001) Mol Pharmacol , vol.60 , pp. 1325-1331
    • Masters, S.C.1    Yang, H.2    Datta, S.R.3    Greenberg, M.E.4    Fu, H.5
  • 24
    • 0035859956 scopus 로고    scopus 로고
    • p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
    • Harada H, Andersen JS, Mann M, Terada N, Korsmeyer SJ (2001) p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A 98: 9666-9670.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9666-9670
    • Harada, H.1    Andersen, J.S.2    Mann, M.3    Terada, N.4    Korsmeyer, S.J.5
  • 25
    • 0035877778 scopus 로고    scopus 로고
    • Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1)
    • Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, et al. (2001) Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem 276: 21110-21120.
    • (2001) J Biol Chem , vol.276 , pp. 21110-21120
    • Dickson, L.M.1    Lingohr, M.K.2    McCuaig, J.3    Hugl, S.R.4    Snow, L.5
  • 26
    • 10644248287 scopus 로고    scopus 로고
    • Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein
    • Wiltshire C, Gillespie DA, May GH (2004) Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein. Biochem Soc Trans 32: 1075-1077.
    • (2004) Biochem Soc Trans , vol.32 , pp. 1075-1077
    • Wiltshire, C.1    Gillespie, D.A.2    May, G.H.3
  • 27
    • 33747634058 scopus 로고    scopus 로고
    • The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation
    • Lin Y, Yang Q, Wang X, Liu ZG (2006) The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation. J Biol Chem 281: 23525-23532.
    • (2006) J Biol Chem , vol.281 , pp. 23525-23532
    • Lin, Y.1    Yang, Q.2    Wang, X.3    Liu, Z.G.4
  • 28
    • 33644874708 scopus 로고    scopus 로고
    • Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells
    • Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE (2006) Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab 290: E143-E148.
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Heart, E.1    Corkey, R.F.2    Wikstrom, J.D.3    Shirihai, O.S.4    Corkey, B.E.5
  • 29
    • 34948890528 scopus 로고    scopus 로고
    • beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
    • Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, et al. (2007) beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes 56: 2569-2578.
    • (2007) Diabetes , vol.56 , pp. 2569-2578
    • Wikstrom, J.D.1    Katzman, S.M.2    Mohamed, H.3    Twig, G.4    Graf, S.A.5
  • 30
    • 0642318060 scopus 로고    scopus 로고
    • Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cells
    • Gollapudi S, McCormick MJ, Gupta S (2003) Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cells. Int J Oncol 22: 597-600.
    • (2003) Int J Oncol , vol.22 , pp. 597-600
    • Gollapudi, S.1    McCormick, M.J.2    Gupta, S.3
  • 31
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    • Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, et al. (2001) Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105: 745-755.
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1    Baffy, G.2    Perret, P.3    Krauss, S.4    Peroni, O.5
  • 32
    • 60549086405 scopus 로고    scopus 로고
    • Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)-gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells
    • Oberkofler H, Hafner M, Felder T, Krempler F, Patsch W (2009) Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)-gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells. J Mol Med 87: 299-306.
    • (2009) J Mol Med , vol.87 , pp. 299-306
    • Oberkofler, H.1    Hafner, M.2    Felder, T.3    Krempler, F.4    Patsch, W.5
  • 33
    • 30944450418 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells
    • Oberkofler H, Klein K, Felder TK, Krempler F, Patsch W (2006) Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells. Endocrinology 147: 966-976.
    • (2006) Endocrinology , vol.147 , pp. 966-976
    • Oberkofler, H.1    Klein, K.2    Felder, T.K.3    Krempler, F.4    Patsch, W.5
  • 35
    • 38949140180 scopus 로고    scopus 로고
    • Dual role of proapoptotic BAD in insulin secretion and beta cell survival
    • Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, et al. (2008) Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med 14: 144-153.
    • (2008) Nat Med , vol.14 , pp. 144-153
    • Danial, N.N.1    Walensky, L.D.2    Zhang, C.Y.3    Choi, C.S.4    Fisher, J.K.5
  • 36
    • 63649106676 scopus 로고    scopus 로고
    • Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart
    • Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, et al. (2009) Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation 119: 1272-1283.
    • (2009) Circulation , vol.119 , pp. 1272-1283
    • Boudina, S.1    Bugger, H.2    Sena, S.3    O'Neill, B.T.4    Zaha, V.G.5
  • 37
    • 67649641804 scopus 로고    scopus 로고
    • Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function
    • Pi J, Bai Y, Daniel KW, Liu D, Lyght O, et al. (2009) Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology 150: 3040-3048.
    • (2009) Endocrinology , vol.150 , pp. 3040-3048
    • Pi, J.1    Bai, Y.2    Daniel, K.W.3    Liu, D.4    Lyght, O.5
  • 39
    • 0030695837 scopus 로고    scopus 로고
    • Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL
    • Kelekar A, Chang BS, Harlan JE, Fesik SW, Thompson CB (1997) Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol Cell Biol 17: 7040-7046.
    • (1997) Mol Cell Biol , vol.17 , pp. 7040-7046
    • Kelekar, A.1    Chang, B.S.2    Harlan, J.E.3    Fesik, S.W.4    Thompson, C.B.5
  • 40
    • 33646351975 scopus 로고    scopus 로고
    • Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
    • Ueki K, Okada T, Hu J, Liew CW, Assmann A, et al. (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 38: 583-588.
    • (2006) Nat Genet , vol.38 , pp. 583-588
    • Ueki, K.1    Okada, T.2    Hu, J.3    Liew, C.W.4    Assmann, A.5
  • 42
    • 0034624753 scopus 로고    scopus 로고
    • Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
    • Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK (2000) Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404: 151-158.
    • (2000) Nature , vol.404 , pp. 151-158
    • Kim, A.S.1    Kakalis, L.T.2    Abdul-Manan, N.3    Liu, G.A.4    Rosen, M.K.5
  • 43
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, et al. (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166: 213-223.
    • (2004) J Cell Biol , vol.166 , pp. 213-223
    • Harrington, L.S.1    Findlay, G.M.2    Gray, A.3    Tolkacheva, T.4    Wigfield, S.5
  • 44
    • 0037155837 scopus 로고    scopus 로고
    • Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
    • Aoki H, Kang PM, Hampe J, Yoshimura K, Noma T, et al. (2002) Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem 277: 10244-10250.
    • (2002) J Biol Chem , vol.277 , pp. 10244-10250
    • Aoki, H.1    Kang, P.M.2    Hampe, J.3    Yoshimura, K.4    Noma, T.5
  • 45
    • 0037076787 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: Role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression
    • Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, et al. (2002) Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression. Circ Res 90: 1222-1230.
    • (2002) Circ Res , vol.90 , pp. 1222-1230
    • Che, W.1    Lerner-Marmarosh, N.2    Huang, Q.3    Osawa, M.4    Ohta, S.5
  • 47
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, et al. (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 100: 8466-8471.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3    Cusi, K.4    Berria, R.5
  • 48
    • 20044375212 scopus 로고    scopus 로고
    • Myocardial insulin resistance and cardiac complications of diabetes
    • Abel ED (2005) Myocardial insulin resistance and cardiac complications of diabetes. Curr Drug Targets Immune Endocr Metabol Disord 5: 219-226.
    • (2005) Curr Drug Targets Immune Endocr Metabol Disord , vol.5 , pp. 219-226
    • Abel, E.D.1
  • 49
    • 0033379267 scopus 로고    scopus 로고
    • Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines
    • Kulkarni RN, Winnay JN, Daniels M, Bruning JC, Flier SN, et al. (1999) Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 104: R69-75.
    • (1999) J Clin Invest , vol.104
    • Kulkarni, R.N.1    Winnay, J.N.2    Daniels, M.3    Bruning, J.C.4    Flier, S.N.5
  • 50
    • 19944428470 scopus 로고    scopus 로고
    • Rescue purification maximizes the use of human islet preparations for transplantation
    • Ichii H, Pileggi A, Molano RD, Baidal DA, Khan A, et al. (2005) Rescue purification maximizes the use of human islet preparations for transplantation. Am J Transplant 5: 21-30.
    • (2005) Am J Transplant , vol.5 , pp. 21-30
    • Ichii, H.1    Pileggi, A.2    Molano, R.D.3    Baidal, D.A.4    Khan, A.5
  • 51
    • 0037872709 scopus 로고    scopus 로고
    • Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
    • Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, et al. (2003) Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 52: 1528-1534.
    • (2003) Diabetes , vol.52 , pp. 1528-1534
    • Kulkarni, R.N.1    Almind, K.2    Goren, H.J.3    Winnay, J.N.4    Ueki, K.5
  • 52
    • 0141450254 scopus 로고    scopus 로고
    • Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
    • Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, et al. (2003) Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 23: 7222-7229.
    • (2003) Mol Cell Biol , vol.23 , pp. 7222-7229
    • Rosen, E.D.1    Kulkarni, R.N.2    Sarraf, P.3    Ozcan, U.4    Okada, T.5
  • 53
    • 0030963661 scopus 로고    scopus 로고
    • Cell-specific expression and regulation of a glucokinase gene locus transgene
    • Niswender KD, Postic C, Jetton TL, Bennett BD, Piston DW, et al. (1997) Cell-specific expression and regulation of a glucokinase gene locus transgene. J Biol Chem 272: 22564-22569.
    • (1997) J Biol Chem , vol.272 , pp. 22564-22569
    • Niswender, K.D.1    Postic, C.2    Jetton, T.L.3    Bennett, B.D.4    Piston, D.W.5
  • 54
    • 58149330628 scopus 로고    scopus 로고
    • Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3
    • Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, et al. (2008) Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes 57: 2924-2932.
    • (2008) Diabetes , vol.57 , pp. 2924-2932
    • Bugger, H.1    Boudina, S.2    Hu, X.X.3    Tuinei, J.4    Zaha, V.G.5
  • 55
    • 42749094176 scopus 로고    scopus 로고
    • Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations
    • Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, et al. (2008) Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol 211: 115-127.
    • (2008) Exp Neurol , vol.211 , pp. 115-127
    • Amiott, E.A.1    Lott, P.2    Soto, J.3    Kang, P.B.4    McCaffery, J.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.