-
1
-
-
0036550234
-
Signalling through IGF-I and insulin receptors: Where is the specificity?
-
Kim JJ, Accili D (2002) Signalling through IGF-I and insulin receptors: where is the specificity? Growth Horm IGF Res 12: 84-90.
-
(2002)
Growth Horm IGF Res
, vol.12
, pp. 84-90
-
-
Kim, J.J.1
Accili, D.2
-
2
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927.
-
(1999)
Genes Dev
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
3
-
-
59149104922
-
Growth factor control of pancreatic islet regeneration and function
-
Assmann A, Hinault C, Kulkarni RN (2009) Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes 10: 14-32.
-
(2009)
Pediatr Diabetes
, vol.10
, pp. 14-32
-
-
Assmann, A.1
Hinault, C.2
Kulkarni, R.N.3
-
4
-
-
0348048485
-
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice
-
Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, et al. (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286: E41-49.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.286
-
-
Otani, K.1
Kulkarni, R.N.2
Baldwin, A.C.3
Krutzfeldt, J.4
Ueki, K.5
-
5
-
-
0036578921
-
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass
-
Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, et al. (2002) beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 31: 111-115.
-
(2002)
Nat Genet
, vol.31
, pp. 111-115
-
-
Kulkarni, R.N.1
Holzenberger, M.2
Shih, D.Q.3
Ozcan, U.4
Stoffel, M.5
-
6
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
-
Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, et al. (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96: 329-339.
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
-
7
-
-
66349132198
-
Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2
-
Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN (2009) Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol 29: 3219-3228.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3219-3228
-
-
Assmann, A.1
Ueki, K.2
Winnay, J.N.3
Kadowaki, T.4
Kulkarni, R.N.5
-
8
-
-
34547482573
-
Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
-
Okada T, Liew CW, Hu J, Hinault C, Michael MD, et al. (2007) Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A 104: 8977-8982.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 8977-8982
-
-
Okada, T.1
Liew, C.W.2
Hu, J.3
Hinault, C.4
Michael, M.D.5
-
9
-
-
20244376316
-
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
-
Anello M, Lupi R, Spampinato D, Piro S, Masini M, et al. (2005) Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 48: 282-289.
-
(2005)
Diabetologia
, vol.48
, pp. 282-289
-
-
Anello, M.1
Lupi, R.2
Spampinato, D.3
Piro, S.4
Masini, M.5
-
10
-
-
0030067124
-
Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
-
Matschinsky FM (1996) Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45: 223-241.
-
(1996)
Diabetes
, vol.45
, pp. 223-241
-
-
Matschinsky, F.M.1
-
11
-
-
33644749337
-
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy
-
Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, et al. (2006) The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes 55: 1-12.
-
(2006)
Diabetes
, vol.55
, pp. 1-12
-
-
Matschinsky, F.M.1
Magnuson, M.A.2
Zelent, D.3
Jetton, T.L.4
Doliba, N.5
-
12
-
-
33646779855
-
Minireview: Implication of mitochondria in insulin secretion and action
-
Wiederkehr A, Wollheim CB (2006) Minireview: implication of mitochondria in insulin secretion and action. Endocrinology 147: 2643-2649.
-
(2006)
Endocrinology
, vol.147
, pp. 2643-2649
-
-
Wiederkehr, A.1
Wollheim, C.B.2
-
13
-
-
23944484541
-
Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: Potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell
-
Veluthakal R, Palanivel R, Zhao Y, McDonald P, Gruber S, et al. (2005) Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell. Apoptosis 10: 841-850.
-
(2005)
Apoptosis
, vol.10
, pp. 841-850
-
-
Veluthakal, R.1
Palanivel, R.2
Zhao, Y.3
McDonald, P.4
Gruber, S.5
-
14
-
-
0842281645
-
Cell death: Critical control points
-
Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116: 205-219.
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
15
-
-
33746840153
-
IGF-I mediated survival pathways in normal and malignant cells
-
Kurmasheva RT, Houghton PJ (2006) IGF-I mediated survival pathways in normal and malignant cells. Biochim Biophys Acta 1766: 1-22.
-
(2006)
Biochim Biophys Acta
, vol.1766
, pp. 1-22
-
-
Kurmasheva, R.T.1
Houghton, P.J.2
-
16
-
-
0041357164
-
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
-
Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424: 952-956.
-
(2003)
Nature
, vol.424
, pp. 952-956
-
-
Danial, N.N.1
Gramm, C.F.2
Scorrano, L.3
Zhang, C.Y.4
Krauss, S.5
-
17
-
-
56949108344
-
Mitochondrial dysfunction: Glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells
-
Lee JW, Kim WH, Lim JH, Song EH, Song J, et al. (2009) Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells. Cell Signal 21: 69-78.
-
(2009)
Cell Signal
, vol.21
, pp. 69-78
-
-
Lee, J.W.1
Kim, W.H.2
Lim, J.H.3
Song, E.H.4
Song, J.5
-
18
-
-
24144490962
-
Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: Downregulation of glucokinase in pancreatic beta-cells
-
Kim WH, Lee JW, Suh YH, Hong SH, Choi JS, et al. (2005) Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells. Diabetes 54: 2602-2611.
-
(2005)
Diabetes
, vol.54
, pp. 2602-2611
-
-
Kim, W.H.1
Lee, J.W.2
Suh, Y.H.3
Hong, S.H.4
Choi, J.S.5
-
19
-
-
24744434956
-
New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass
-
Kulkarni RN (2005) New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Rev Endocr Metab Disord 6: 199-210.
-
(2005)
Rev Endocr Metab Disord
, vol.6
, pp. 199-210
-
-
Kulkarni, R.N.1
-
20
-
-
0036849192
-
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
-
Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 3: 631-643.
-
(2002)
Dev Cell
, vol.3
, pp. 631-643
-
-
Datta, S.R.1
Ranger, A.M.2
Lin, M.Z.3
Sturgill, J.F.4
Ma, Y.C.5
-
21
-
-
0035425234
-
Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
-
Fernandez AM, Kim JK, Yakar S, Dupont J, Hernandez-Sanchez C, et al. (2001) Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev 15: 1926-1934.
-
(2001)
Genes Dev
, vol.15
, pp. 1926-1934
-
-
Fernandez, A.M.1
Kim, J.K.2
Yakar, S.3
Dupont, J.4
Hernandez-Sanchez, C.5
-
22
-
-
0032698075
-
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
-
Bonni A, Brunet A, West AE, Datta SR, Takasu MA, et al. (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286: 1358-1362.
-
(1999)
Science
, vol.286
, pp. 1358-1362
-
-
Bonni, A.1
Brunet, A.2
West, A.E.3
Datta, S.R.4
Takasu, M.A.5
-
23
-
-
0035206813
-
14-3-3 inhibits Bad-induced cell death through interaction with serine-136
-
Masters SC, Yang H, Datta SR, Greenberg ME, Fu H (2001) 14-3-3 inhibits Bad-induced cell death through interaction with serine-136. Mol Pharmacol 60: 1325-1331.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 1325-1331
-
-
Masters, S.C.1
Yang, H.2
Datta, S.R.3
Greenberg, M.E.4
Fu, H.5
-
24
-
-
0035859956
-
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
-
Harada H, Andersen JS, Mann M, Terada N, Korsmeyer SJ (2001) p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A 98: 9666-9670.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 9666-9670
-
-
Harada, H.1
Andersen, J.S.2
Mann, M.3
Terada, N.4
Korsmeyer, S.J.5
-
25
-
-
0035877778
-
Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1)
-
Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, et al. (2001) Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem 276: 21110-21120.
-
(2001)
J Biol Chem
, vol.276
, pp. 21110-21120
-
-
Dickson, L.M.1
Lingohr, M.K.2
McCuaig, J.3
Hugl, S.R.4
Snow, L.5
-
26
-
-
10644248287
-
Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein
-
Wiltshire C, Gillespie DA, May GH (2004) Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein. Biochem Soc Trans 32: 1075-1077.
-
(2004)
Biochem Soc Trans
, vol.32
, pp. 1075-1077
-
-
Wiltshire, C.1
Gillespie, D.A.2
May, G.H.3
-
27
-
-
33747634058
-
The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation
-
Lin Y, Yang Q, Wang X, Liu ZG (2006) The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation. J Biol Chem 281: 23525-23532.
-
(2006)
J Biol Chem
, vol.281
, pp. 23525-23532
-
-
Lin, Y.1
Yang, Q.2
Wang, X.3
Liu, Z.G.4
-
28
-
-
33644874708
-
Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells
-
Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE (2006) Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab 290: E143-E148.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.290
-
-
Heart, E.1
Corkey, R.F.2
Wikstrom, J.D.3
Shirihai, O.S.4
Corkey, B.E.5
-
29
-
-
34948890528
-
beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
-
Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, et al. (2007) beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes 56: 2569-2578.
-
(2007)
Diabetes
, vol.56
, pp. 2569-2578
-
-
Wikstrom, J.D.1
Katzman, S.M.2
Mohamed, H.3
Twig, G.4
Graf, S.A.5
-
30
-
-
0642318060
-
Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cells
-
Gollapudi S, McCormick MJ, Gupta S (2003) Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cells. Int J Oncol 22: 597-600.
-
(2003)
Int J Oncol
, vol.22
, pp. 597-600
-
-
Gollapudi, S.1
McCormick, M.J.2
Gupta, S.3
-
31
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, et al. (2001) Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105: 745-755.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
Krauss, S.4
Peroni, O.5
-
32
-
-
60549086405
-
Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)-gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells
-
Oberkofler H, Hafner M, Felder T, Krempler F, Patsch W (2009) Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)-gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells. J Mol Med 87: 299-306.
-
(2009)
J Mol Med
, vol.87
, pp. 299-306
-
-
Oberkofler, H.1
Hafner, M.2
Felder, T.3
Krempler, F.4
Patsch, W.5
-
33
-
-
30944450418
-
Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells
-
Oberkofler H, Klein K, Felder TK, Krempler F, Patsch W (2006) Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells. Endocrinology 147: 966-976.
-
(2006)
Endocrinology
, vol.147
, pp. 966-976
-
-
Oberkofler, H.1
Klein, K.2
Felder, T.K.3
Krempler, F.4
Patsch, W.5
-
35
-
-
38949140180
-
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
-
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, et al. (2008) Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med 14: 144-153.
-
(2008)
Nat Med
, vol.14
, pp. 144-153
-
-
Danial, N.N.1
Walensky, L.D.2
Zhang, C.Y.3
Choi, C.S.4
Fisher, J.K.5
-
36
-
-
63649106676
-
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart
-
Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, et al. (2009) Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation 119: 1272-1283.
-
(2009)
Circulation
, vol.119
, pp. 1272-1283
-
-
Boudina, S.1
Bugger, H.2
Sena, S.3
O'Neill, B.T.4
Zaha, V.G.5
-
37
-
-
67649641804
-
Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function
-
Pi J, Bai Y, Daniel KW, Liu D, Lyght O, et al. (2009) Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology 150: 3040-3048.
-
(2009)
Endocrinology
, vol.150
, pp. 3040-3048
-
-
Pi, J.1
Bai, Y.2
Daniel, K.W.3
Liu, D.4
Lyght, O.5
-
39
-
-
0030695837
-
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL
-
Kelekar A, Chang BS, Harlan JE, Fesik SW, Thompson CB (1997) Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol Cell Biol 17: 7040-7046.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 7040-7046
-
-
Kelekar, A.1
Chang, B.S.2
Harlan, J.E.3
Fesik, S.W.4
Thompson, C.B.5
-
40
-
-
33646351975
-
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
-
Ueki K, Okada T, Hu J, Liew CW, Assmann A, et al. (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 38: 583-588.
-
(2006)
Nat Genet
, vol.38
, pp. 583-588
-
-
Ueki, K.1
Okada, T.2
Hu, J.3
Liew, C.W.4
Assmann, A.5
-
42
-
-
0034624753
-
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
-
Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK (2000) Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404: 151-158.
-
(2000)
Nature
, vol.404
, pp. 151-158
-
-
Kim, A.S.1
Kakalis, L.T.2
Abdul-Manan, N.3
Liu, G.A.4
Rosen, M.K.5
-
43
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, et al. (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166: 213-223.
-
(2004)
J Cell Biol
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
-
44
-
-
0037155837
-
Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
-
Aoki H, Kang PM, Hampe J, Yoshimura K, Noma T, et al. (2002) Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem 277: 10244-10250.
-
(2002)
J Biol Chem
, vol.277
, pp. 10244-10250
-
-
Aoki, H.1
Kang, P.M.2
Hampe, J.3
Yoshimura, K.4
Noma, T.5
-
45
-
-
0037076787
-
Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: Role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression
-
Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, et al. (2002) Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression. Circ Res 90: 1222-1230.
-
(2002)
Circ Res
, vol.90
, pp. 1222-1230
-
-
Che, W.1
Lerner-Marmarosh, N.2
Huang, Q.3
Osawa, M.4
Ohta, S.5
-
46
-
-
34548850040
-
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy
-
O'Neill BT KJ, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED (2007) A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab 6: 294-306.
-
(2007)
Cell Metab
, vol.6
, pp. 294-306
-
-
O'Neill1
BT, K.J.2
Wende, A.R.3
Theobald, H.A.4
Tuinei, J.5
Buchanan, J.6
Guo, A.7
Zaha, V.G.8
Davis, D.K.9
Schell, J.C.10
Boudina, S.11
Wayment, B.12
Litwin, S.E.13
Shioi, T.14
Izumo, S.15
Birnbaum, M.J.16
Abel, E.D.17
-
47
-
-
0037477855
-
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
-
Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, et al. (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 100: 8466-8471.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8466-8471
-
-
Patti, M.E.1
Butte, A.J.2
Crunkhorn, S.3
Cusi, K.4
Berria, R.5
-
48
-
-
20044375212
-
Myocardial insulin resistance and cardiac complications of diabetes
-
Abel ED (2005) Myocardial insulin resistance and cardiac complications of diabetes. Curr Drug Targets Immune Endocr Metabol Disord 5: 219-226.
-
(2005)
Curr Drug Targets Immune Endocr Metabol Disord
, vol.5
, pp. 219-226
-
-
Abel, E.D.1
-
49
-
-
0033379267
-
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines
-
Kulkarni RN, Winnay JN, Daniels M, Bruning JC, Flier SN, et al. (1999) Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 104: R69-75.
-
(1999)
J Clin Invest
, vol.104
-
-
Kulkarni, R.N.1
Winnay, J.N.2
Daniels, M.3
Bruning, J.C.4
Flier, S.N.5
-
50
-
-
19944428470
-
Rescue purification maximizes the use of human islet preparations for transplantation
-
Ichii H, Pileggi A, Molano RD, Baidal DA, Khan A, et al. (2005) Rescue purification maximizes the use of human islet preparations for transplantation. Am J Transplant 5: 21-30.
-
(2005)
Am J Transplant
, vol.5
, pp. 21-30
-
-
Ichii, H.1
Pileggi, A.2
Molano, R.D.3
Baidal, D.A.4
Khan, A.5
-
51
-
-
0037872709
-
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
-
Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, et al. (2003) Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 52: 1528-1534.
-
(2003)
Diabetes
, vol.52
, pp. 1528-1534
-
-
Kulkarni, R.N.1
Almind, K.2
Goren, H.J.3
Winnay, J.N.4
Ueki, K.5
-
52
-
-
0141450254
-
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
-
Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, et al. (2003) Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 23: 7222-7229.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7222-7229
-
-
Rosen, E.D.1
Kulkarni, R.N.2
Sarraf, P.3
Ozcan, U.4
Okada, T.5
-
53
-
-
0030963661
-
Cell-specific expression and regulation of a glucokinase gene locus transgene
-
Niswender KD, Postic C, Jetton TL, Bennett BD, Piston DW, et al. (1997) Cell-specific expression and regulation of a glucokinase gene locus transgene. J Biol Chem 272: 22564-22569.
-
(1997)
J Biol Chem
, vol.272
, pp. 22564-22569
-
-
Niswender, K.D.1
Postic, C.2
Jetton, T.L.3
Bennett, B.D.4
Piston, D.W.5
-
54
-
-
58149330628
-
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3
-
Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, et al. (2008) Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes 57: 2924-2932.
-
(2008)
Diabetes
, vol.57
, pp. 2924-2932
-
-
Bugger, H.1
Boudina, S.2
Hu, X.X.3
Tuinei, J.4
Zaha, V.G.5
-
55
-
-
42749094176
-
Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations
-
Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, et al. (2008) Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol 211: 115-127.
-
(2008)
Exp Neurol
, vol.211
, pp. 115-127
-
-
Amiott, E.A.1
Lott, P.2
Soto, J.3
Kang, P.B.4
McCaffery, J.M.5
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