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Volumn 83, Issue 2, 1998, Pages 604-608

Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLIBENCLAMIDE; GLIPIZIDE; GLUCOSE; INSULIN; PROINSULIN; SULFONYLUREA DERIVATIVE;

EID: 0031791047     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.2.604     Document Type: Article
Times cited : (221)

References (39)
  • 1
    • 0016209121 scopus 로고
    • Circulating proinsulin-like component in man. Increased proportion in hypoinsulinemic states
    • Gordon P, Hendricks CM, Roth J. 1974 Circulating proinsulin-like component in man. Increased proportion in hypoinsulinemic states. Diabetologia. 10:469-474.
    • (1974) Diabetologia , vol.10 , pp. 469-474
    • Gordon, P.1    Hendricks, C.M.2    Roth, J.3
  • 2
    • 0025268864 scopus 로고
    • Disproportionately elevated pro-insulin in Pima Indians with noninsulin-dependent diabetes mellitus
    • Saad MF, Kahn SE, Nelson RG, et al. 1990 Disproportionately elevated pro-insulin in Pima Indians with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 70:1247-1253.
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1247-1253
    • Saad, M.F.1    Kahn, S.E.2    Nelson, R.G.3
  • 3
    • 0024494876 scopus 로고
    • Insulin deficiency in non-insulin-dependent diabetes
    • Temple RC, Luzio SD, Schneider AE, et al. 1989 Insulin deficiency in non-insulin-dependent diabetes. Lancet. 1:293-295.
    • (1989) Lancet , vol.1 , pp. 293-295
    • Temple, R.C.1    Luzio, S.D.2    Schneider, A.E.3
  • 5
    • 0023634652 scopus 로고
    • Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance
    • Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte Jr D. 1987 Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia. 30:698-702.
    • (1987) Diabetologia , vol.30 , pp. 698-702
    • Ward, W.K.1    LaCava, E.C.2    Paquette, T.L.3    Beard, J.C.4    Wallum, B.J.5    Porte Jr., D.6
  • 6
    • 14444267336 scopus 로고
    • Intact proinsulin and conversion intermediates recently released from B-cell granules in NIDDM
    • Kahn SE, Halban PA. 1995 Intact proinsulin and conversion intermediates recently released from B-cell granules in NIDDM. Diabetes. 44(Suppl 1):86A.
    • (1995) Diabetes , vol.44 , Issue.1 SUPPL.
    • Kahn, S.E.1    Halban, P.A.2
  • 7
    • 0029128971 scopus 로고
    • Proinsulin immunoreactivity in identical twins discordant for non-insulin dependent diabetes mellitus
    • Roder ME, Vaag A, Hartling SG, et al. 1995 Proinsulin immunoreactivity in identical twins discordant for non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab. 80:2359-2363.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2359-2363
    • Roder, M.E.1    Vaag, A.2    Hartling, S.G.3
  • 8
    • 0026110135 scopus 로고
    • β-Cells in type 2 diabetes mellitus
    • Porte Jr D. 1991 β-Cells in type 2 diabetes mellitus. Diabetes. 40:166-180.
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte Jr., D.1
  • 9
    • 0021751981 scopus 로고
    • Diminished B cell secretory capacity in patients with non-insulin-dependent diabetes mellitus
    • Ward WK, Bolgiano DC, McKnight B, Halter JB, Porte Jr D. 1984 Diminished B cell secretory capacity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 74:1318-1328.
    • (1984) J Clin Invest , vol.74 , pp. 1318-1328
    • Ward, W.K.1    Bolgiano, D.C.2    McKnight, B.3    Halter, J.B.4    Porte Jr., D.5
  • 10
    • 0028967995 scopus 로고
    • Relationship of proinsulin and insulin with non-insulin dependent diabetes mellitus and coronary heart disease in Japanese-American men: Impact of obesity-Clinical Research Center study
    • Kahn SE, Leonetti DL, Prigeon RL, Boyko EJ, Bergstrom RW, Fujimoto WY. 1495 Relationship of proinsulin and insulin with non-insulin dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity-Clinical Research Center study. J Clin Endocrinol Metab. 80:1399-1406.
    • (1495) J Clin Endocrinol Metab , vol.80 , pp. 1399-1406
    • Kahn, S.E.1    Leonetti, D.L.2    Prigeon, R.L.3    Boyko, E.J.4    Bergstrom, R.W.5    Fujimoto, W.Y.6
  • 11
    • 0026587185 scopus 로고
    • Effect of insulin resistance, and hyperglycemia on proinsulin release in a primate model of diabetes mellitus
    • Kahn SE, McCulloch DK, Schwartz MW, Palmer JP, Porte Jr D. 1992 Effect of insulin resistance, and hyperglycemia on proinsulin release in a primate model of diabetes mellitus. J Clin Endocrinol Metab. 74:192-197.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 192-197
    • Kahn, S.E.1    McCulloch, D.K.2    Schwartz, M.W.3    Palmer, J.P.4    Porte Jr., D.5
  • 12
    • 0028607474 scopus 로고
    • Disproportionately elevated proinsulin levels precede the onset of IDDM in siblings with low first-phase insulin responses
    • Røder ME, Knip M, Hartling SG, Karjalainen J, Åkerblom HK, Binder C. 1994 Disproportionately elevated proinsulin levels precede the onset of IDDM in siblings with low first-phase insulin responses. J Clin Endocrinol Metab. 79:1570-1575.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1570-1575
    • Røder, M.E.1    Knip, M.2    Hartling, S.G.3    Karjalainen, J.4    Åkerblom, H.K.5    Binder, C.6
  • 13
    • 0025297306 scopus 로고
    • Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging
    • Kahn SE, Larson VG, Beard JC, et al. 1990 Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. Am J Physiol 258:E937-E943.
    • (1990) Am J Physiol , vol.258
    • Kahn, S.E.1    Larson, V.G.2    Beard, J.C.3
  • 14
    • 0022910962 scopus 로고
    • A sensitive radioimmunoassay for human proinsulin, with sequential use of antisera to C-peptide, and insulin
    • Ward WK, Paquette TL, Frank BH, Porte Jr D. 1986 A sensitive radioimmunoassay for human proinsulin, with sequential use of antisera to C-peptide, and insulin. Clin Chem. 32:728-733.
    • (1986) Clin Chem , vol.32 , pp. 728-733
    • Ward, W.K.1    Paquette, T.L.2    Frank, B.H.3    Porte Jr., D.4
  • 15
    • 0000476083 scopus 로고
    • Immunoassay of insulin: Two antibody system: plasma insulin levels of normal, subdiabetic, and diabetic rats
    • Morgan DR, Lazarow A. 1963 Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic, and diabetic rats. Diabetes. 12:115-126.
    • (1963) Diabetes , vol.12 , pp. 115-126
    • Morgan, D.R.1    Lazarow, A.2
  • 16
    • 0027375768 scopus 로고
    • Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function
    • Kahn SE, Prigeon RL, McCulloch DK, et al. 1993 Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function. Diabetes. 42:1663-1672.
    • (1993) Diabetes , vol.42 , pp. 1663-1672
    • Kahn, S.E.1    Prigeon, R.L.2    McCulloch, D.K.3
  • 17
    • 0023759449 scopus 로고
    • Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y. 1988 Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 31:355-360.
    • (1988) Diabetologia , vol.31 , pp. 355-360
    • Yoshioka, N.1    Kuzuya, T.2    Matsuda, A.3    Taniguchi, M.4    Iwamoto, Y.5
  • 18
    • 0022996695 scopus 로고
    • The effect of exogenous hyperinsulinemia on proinsulin secretion in normal man, obese subjects, and patients with insulinoma
    • Koivisto VA, Yki-Järvinen H, Hartling SG, Pelkonen R. 1986 The effect of exogenous hyperinsulinemia on proinsulin secretion in normal man, obese subjects, and patients with insulinoma. J Clin Endocrinol Metab. 63:1117-1120.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 1117-1120
    • Koivisto, V.A.1    Yki-Järvinen, H.2    Hartling, S.G.3    Pelkonen, R.4
  • 19
    • 0028916235 scopus 로고
    • Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy
    • Vestergaard H, Klein HH, Hansen T, et al. 1995 Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy. J Clin Invest. 95:1925-1932.
    • (1995) J Clin Invest , vol.95 , pp. 1925-1932
    • Vestergaard, H.1    Klein, H.H.2    Hansen, T.3
  • 20
    • 0024463227 scopus 로고
    • Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet β-cell dysfunction?
    • Porte Jr D, Kahn SE 1989 Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet β-cell dysfunction? Diabetes. 38:1333-1336.
    • (1989) Diabetes , vol.38 , pp. 1333-1336
    • Porte Jr., D.1    Kahn, S.E.2
  • 21
    • 0028230040 scopus 로고
    • What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism
    • Rhodes CJ, Alarcon C. 1994 What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes. 43:511-517.
    • (1994) Diabetes , vol.43 , pp. 511-517
    • Rhodes, C.J.1    Alarcon, C.2
  • 22
    • 0020451348 scopus 로고
    • Chronic chlorpropamide therapy of noninsulin-dependent diabetes augments basal, and stimulated insulin secretion by increasing islet sensitivity to glucose
    • Judzewitsch RG, Pfeiffer MA, Best JD, Beard JC, Halter JB, Porte Jr D. 1982 Chronic chlorpropamide therapy of noninsulin-dependent diabetes augments basal, and stimulated insulin secretion by increasing islet sensitivity to glucose. J Clin Endocrinol Metab. 55:321-328.
    • (1982) J Clin Endocrinol Metab , vol.55 , pp. 321-328
    • Judzewitsch, R.G.1    Pfeiffer, M.A.2    Best, J.D.3    Beard, J.C.4    Halter, J.B.5    Porte Jr., D.6
  • 24
    • 0005495525 scopus 로고
    • Split proinsulin is an early marker of non-insulin-dependent diabetes mellitus
    • Berne C, Lithell H, Clark PMS, Hales CN. 1994 Split proinsulin is an early marker of non-insulin-dependent diabetes mellitus. Diabetologia. 37(Suppl 1):A57.
    • (1994) Diabetologia , vol.37 , Issue.1 SUPPL.
    • Berne, C.1    Lithell, H.2    Clark, P.M.S.3    Hales, C.N.4
  • 26
    • 0029834356 scopus 로고    scopus 로고
    • Effect of sulfonylurea withdrawal on proinsulin levels, B-cell function, and glucose disposal in subjects with non-insulin dependent diabetes mellitus
    • Prigeon RL, Jacobson RK, Porte Jr D, Kahn SE. 1996 Effect of sulfonylurea withdrawal on proinsulin levels, B-cell function, and glucose disposal in subjects with non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab 81:3295-3298.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3295-3298
    • Prigeon, R.L.1    Jacobson, R.K.2    Porte Jr., D.3    Kahn, S.E.4
  • 27
    • 0028314832 scopus 로고
    • Effect of sulphonylurea therapy on plasma insulin, intact and 32/33 split proinsulin in subjects with type 2 diabetes mellitus
    • Davies MJ, Metcalfe J, Day JL, Grenfell A, Hales CN, Gray IP. 1993 Effect of sulphonylurea therapy on plasma insulin, intact and 32/33 split proinsulin in subjects with type 2 diabetes mellitus. Diabetic Med. 10:293-298.
    • (1993) Diabetic Med , vol.10 , pp. 293-298
    • Davies, M.J.1    Metcalfe, J.2    Day, J.L.3    Grenfell, A.4    Hales, C.N.5    Gray, I.P.6
  • 28
    • 0017236889 scopus 로고
    • Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests
    • Brunzell JD, Robertson RP, Lerner RL, et al. 1976 Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J Clin Endocrinol Metab. 42:222-229.
    • (1976) J Clin Endocrinol Metab , vol.42 , pp. 222-229
    • Brunzell, J.D.1    Robertson, R.P.2    Lerner, R.L.3
  • 29
    • 0026511753 scopus 로고
    • β-Cell dysfunction induced by chronic hyperglycemia
    • Leahy JL, Bonner-Weir S, Weir GC. 1442 β-Cell dysfunction induced by chronic hyperglycemia. Diabetes Care. 15:442-455.
    • (1442) Diabetes Care , vol.15 , pp. 442-455
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 30
    • 0020032191 scopus 로고
    • Islet changes induced by hyperglycemia in rats. Effect of insulin or chlorpropamide therapy
    • Clark A, Bown E, King T, Vanhegan RI, Turner RC. 1982 Islet changes induced by hyperglycemia in rats. Effect of insulin or chlorpropamide therapy. Diabetes. 31:319-325.
    • (1982) Diabetes , vol.31 , pp. 319-325
    • Clark, A.1    Bown, E.2    King, T.3    Vanhegan, R.I.4    Turner, R.C.5
  • 31
    • 0021961644 scopus 로고
    • Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes
    • Unger RH, Grundy S. 1985 Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia. 28:119-121.
    • (1985) Diabetologia , vol.28 , pp. 119-121
    • Unger, R.H.1    Grundy, S.2
  • 32
    • 0026043872 scopus 로고
    • Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin
    • Nauck MA, Siegel EG, Creutzfeldt W. 1991 Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin. Pancreas. 6:645-652.
    • (1991) Pancreas , vol.6 , pp. 645-652
    • Nauck, M.A.1    Siegel, E.G.2    Creutzfeldt, W.3
  • 33
    • 0030030164 scopus 로고    scopus 로고
    • Proinsulin, C-peptide and insulin in normal subjects during eight hours hyperglycemic clamp
    • Hartling SG, Røder ME, Dinesen B, Binder C. 1996 Proinsulin, C-peptide and insulin in normal subjects during eight hours hyperglycemic clamp. Eur J Endocrinol. 134:197-200.
    • (1996) Eur J Endocrinol , vol.134 , pp. 197-200
    • Hartling, S.G.1    Røder, M.E.2    Dinesen, B.3    Binder, C.4
  • 34
    • 0024435846 scopus 로고
    • Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity
    • Hartling SG, Lindgren F, Dahlqvist G, Persson B, Binder C. 1989 Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes. 38:1271-1274.
    • (1989) Diabetes , vol.38 , pp. 1271-1274
    • Hartling, S.G.1    Lindgren, F.2    Dahlqvist, G.3    Persson, B.4    Binder, C.5
  • 35
    • 0023932360 scopus 로고
    • Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients
    • Heaton DA, Millward BA, Gray IP, et al. 1988 Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. Diabetologia. 31:182-184.
    • (1988) Diabetologia , vol.31 , pp. 182-184
    • Heaton, D.A.1    Millward, B.A.2    Gray, I.P.3
  • 36
    • 0027217510 scopus 로고
    • Effect of glucocorticoid, and growth hormone treatment on proinsulin levels in humans
    • Kahn SE, Horber FF, Prigeon RL, Haymond MW, Porte Jr D. 1993 Effect of glucocorticoid, and growth hormone treatment on proinsulin levels in humans. Diabetes. 42:1082-1085.
    • (1993) Diabetes , vol.42 , pp. 1082-1085
    • Kahn, S.E.1    Horber, F.F.2    Prigeon, R.L.3    Haymond, M.W.4    Porte Jr., D.5
  • 38
    • 0024538602 scopus 로고
    • Increased β-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance
    • Kahn SE, Beard JC, Schwartz MW, et al. 1989 Increased β-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes. 38:562-568.
    • (1989) Diabetes , vol.38 , pp. 562-568
    • Kahn, S.E.1    Beard, J.C.2    Schwartz, M.W.3
  • 39


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.