The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cells

Journal of Clinical Investigation

Volumn 120, Issue 8, 2010, Pages 2876-2888

  Liew, Chong Wee ^a   Bochenski, Jacek ^a   Kawamori, Dan ^a   Hu, Jiang ^a   Leech, Colin A ^b   Wanic, Krzysztof ^a,c   Malecki, Maciej ^c   Warram, James H ^a   Qi, Ling ^d,e   Krolewski, Andrzej S ^a   Kulkarni, Rohit N ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^d Department of Obstetrics Gynecology   (United States)

^e SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; C PEPTIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INSULIN; PROINSULIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA POLYMORPHISM; ELECTRON MICROSCOPY; EXOCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN STABILITY; TRB3 GENE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIABETES MELLITUS, TYPE 2; DIETARY FATS; EXOCYTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; REPRESSOR PROTEINS;

EID: 77955284657     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI36849     Document Type: Article

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