메뉴 건너뛰기




Volumn 9, Issue SUPPL. 2, 2007, Pages 133-139

Sterol regulatory element-binding protein-1c and pancreatic β-cell dysfunction

Author keywords

Fatty acids; Insulin secretion; Lipotoxicity; Transcription factors

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; GLUCOSE; GRANUPHILIN; ICOSAPENTAENOIC ACID; INSULIN RECEPTOR SUBSTRATE 2; ION CHANNEL; PALMITIC ACID; POLYUNSATURATED FATTY ACID; POTASSIUM; PROTEIN KINASE B; SATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

EID: 35148874217     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2007.00779.x     Document Type: Conference Paper
Times cited : (31)

References (38)
  • 1
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
    • Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 2003; 46: 3-19.
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 2
    • 3142559901 scopus 로고    scopus 로고
    • Beta-cell failure in the pathogenesis of type 2 diabetes mellitus
    • Steppel JH, Horton ES. Beta-cell failure in the pathogenesis of type 2 diabetes mellitus. Curr Diab Rep 2004; 4: 169-175.
    • (2004) Curr Diab Rep , vol.4 , pp. 169-175
    • Steppel, J.H.1    Horton, E.S.2
  • 3
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995; 44: 863-870.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 4
    • 0033544940 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
    • Shimano H, Yahagi N, Amemiya-Kudo M et al. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem 1999; 274: 35832-35839.
    • (1999) J Biol Chem , vol.274 , pp. 35832-35839
    • Shimano, H.1    Yahagi, N.2    Amemiya-Kudo, M.3
  • 5
    • 0029797604 scopus 로고    scopus 로고
    • Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    • Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 1996; 98: 1575-1584.
    • (1996) J Clin Invest , vol.98 , pp. 1575-1584
    • Shimano, H.1    Horton, J.D.2    Hammer, R.E.3    Shimomura, I.4    Brown, M.S.5    Goldstein, J.L.6
  • 6
    • 0036047655 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism
    • Shimano H. Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism. Vitam Horm 2002; 65: 167-194.
    • (2002) Vitam Horm , vol.65 , pp. 167-194
    • Shimano, H.1
  • 7
    • 34247884330 scopus 로고    scopus 로고
    • SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling
    • Shimano H. SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling. J Mol Med 2007; 85: 437-444.
    • (2007) J Mol Med , vol.85 , pp. 437-444
    • Shimano, H.1
  • 8
    • 0032568557 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
    • Horton JD, Bashmakov Y, Shimomura I, Shimano H. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci U S A 1998; 95: 5987-5992.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5987-5992
    • Horton, J.D.1    Bashmakov, Y.2    Shimomura, I.3    Shimano, H.4
  • 9
    • 10744228031 scopus 로고    scopus 로고
    • Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice
    • Matsuzaka T, Shimano H, Yahagi N et al. Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice. Diabetes 2004; 53: 560-569.
    • (2004) Diabetes , vol.53 , pp. 560-569
    • Matsuzaka, T.1    Shimano, H.2    Yahagi, N.3
  • 10
    • 19944430411 scopus 로고    scopus 로고
    • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    • Lin J, Yang R, Tarr PT et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell 2005; 120: 261-273.
    • (2005) Cell , vol.120 , pp. 261-273
    • Lin, J.1    Yang, R.2    Tarr, P.T.3
  • 11
    • 0033544869 scopus 로고    scopus 로고
    • A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
    • Yahagi N, Shimano H, Hasty AH et al. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J Biol Chem 1999; 274: 35840-35844.
    • (1999) J Biol Chem , vol.274 , pp. 35840-35844
    • Yahagi, N.1    Shimano, H.2    Hasty, A.H.3
  • 12
    • 0035830840 scopus 로고    scopus 로고
    • Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells
    • Hannah VC, Ou J, Luong A, Goldstein JL, Brown MS. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. J Biol Chem 2001; 276: 4365-4372.
    • (2001) J Biol Chem , vol.276 , pp. 4365-4372
    • Hannah, V.C.1    Ou, J.2    Luong, A.3    Goldstein, J.L.4    Brown, M.S.5
  • 13
    • 0035932990 scopus 로고    scopus 로고
    • Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
    • Ou J, Tu H, Shan B et al. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci U S A 2001; 98: 6027-6032.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6027-6032
    • Ou, J.1    Tu, H.2    Shan, B.3
  • 14
    • 18544388579 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
    • Yoshikawa T, Shimano H, Yahagi N et al. Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem 2002; 277: 1705-1711.
    • (2002) J Biol Chem , vol.277 , pp. 1705-1711
    • Yoshikawa, T.1    Shimano, H.2    Yahagi, N.3
  • 15
    • 0345448923 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
    • Sekiya M, Yahagi N, Matsuzaka T et al. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology 2003; 38: 1529-1539.
    • (2003) Hepatology , vol.38 , pp. 1529-1539
    • Sekiya, M.1    Yahagi, N.2    Matsuzaka, T.3
  • 16
    • 2342483040 scopus 로고    scopus 로고
    • SREBPs suppress IRS-2-mediated insulin signalling in the liver
    • Ide T, Shimano H, Yahagi N et al. SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol 2004; 6: 351-357.
    • (2004) Nat Cell Biol , vol.6 , pp. 351-357
    • Ide, T.1    Shimano, H.2    Yahagi, N.3
  • 17
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton JD, Shah NA, Warrington JA et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A 2003; 100: 12027-12032.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12027-12032
    • Horton, J.D.1    Shah, N.A.2    Warrington, J.A.3
  • 18
    • 26444519176 scopus 로고    scopus 로고
    • Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor
    • Inoue N, Shimano H, Nakakuki M et al. Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor. Mol Cell Biol 2005; 25: 8938-8947.
    • (2005) Mol Cell Biol , vol.25 , pp. 8938-8947
    • Inoue, N.1    Shimano, H.2    Nakakuki, M.3
  • 19
    • 0037044822 scopus 로고    scopus 로고
    • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid
    • Medvedev AV, Robidoux J, Bai X et al. Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. J Biol Chem 2002; 277: 42639-42644.
    • (2002) J Biol Chem , vol.277 , pp. 42639-42644
    • Medvedev, A.V.1    Robidoux, J.2    Bai, X.3
  • 20
    • 0037593946 scopus 로고    scopus 로고
    • The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction
    • Wang H, Maechler P, Antinozzi PA et al. The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction. J Biol Chem 2003; 278: 16622-16629.
    • (2003) J Biol Chem , vol.278 , pp. 16622-16629
    • Wang, H.1    Maechler, P.2    Antinozzi, P.A.3
  • 21
    • 3843145012 scopus 로고    scopus 로고
    • Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c
    • Yamashita T, Eto K, Okazaki Y et al. Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. Endocrinology 2004; 145: 3566-3577.
    • (2004) Endocrinology , vol.145 , pp. 3566-3577
    • Yamashita, T.1    Eto, K.2    Okazaki, Y.3
  • 22
    • 19944433866 scopus 로고    scopus 로고
    • Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells
    • Takahashi A, Motomura K, Kato T et al. Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells. Diabetes 2005; 54: 492-499.
    • (2005) Diabetes , vol.54 , pp. 492-499
    • Takahashi, A.1    Motomura, K.2    Kato, T.3
  • 23
    • 0021254228 scopus 로고
    • The mechanism of insulin secretion
    • Howell SL. The mechanism of insulin secretion. Diabetologia 1984; 26: 319-327.
    • (1984) Diabetologia , vol.26 , pp. 319-327
    • Howell, S.L.1
  • 24
    • 0030748260 scopus 로고    scopus 로고
    • Signal transduction mechanisms in nutrient-induced insulin secretion
    • Prentki M, Tornheim K, Corkey BE. Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia 1997; 40 (Suppl. 2): S32-S41.
    • (1997) Diabetologia , vol.40 , Issue.SUPPL. 2
    • Prentki, M.1    Tornheim, K.2    Corkey, B.E.3
  • 25
    • 33748766900 scopus 로고    scopus 로고
    • Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice
    • Kato T, Shimano H, Yamamoto T et al. Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell Metab 2006; 4: 143-154.
    • (2006) Cell Metab , vol.4 , pp. 143-154
    • Kato, T.1    Shimano, H.2    Yamamoto, T.3
  • 26
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999; 96: 329-339.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 27
    • 0035210374 scopus 로고    scopus 로고
    • Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
    • Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 2001; 108: 1631-1638.
    • (2001) J Clin Invest , vol.108 , pp. 1631-1638
    • Bernal-Mizrachi, E.1    Wen, W.2    Stahlhut, S.3    Welling, C.M.4    Permutt, M.A.5
  • 28
    • 9644270397 scopus 로고    scopus 로고
    • Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
    • Bernal-Mizrachi E, Fatrai S, Johnson JD et al. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest 2004; 114: 928-936.
    • (2004) J Clin Invest , vol.114 , pp. 928-936
    • Bernal-Mizrachi, E.1    Fatrai, S.2    Johnson, J.D.3
  • 29
    • 9644260563 scopus 로고    scopus 로고
    • Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
    • Lin X, Taguchi A, Park S et al. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 2004; 114: 908-916.
    • (2004) J Clin Invest , vol.114 , pp. 908-916
    • Lin, X.1    Taguchi, A.2    Park, S.3
  • 30
    • 0036181537 scopus 로고    scopus 로고
    • The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules
    • Yi Z, Yokota H, Torii S et al. The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol 2002; 22: 1858-1867.
    • (2002) Mol Cell Biol , vol.22 , pp. 1858-1867
    • Yi, Z.1    Yokota, H.2    Torii, S.3
  • 31
    • 26444479437 scopus 로고    scopus 로고
    • Granuphilin molecularly docks insulin granules to the fusion machinery
    • Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T. Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol 2005; 171: 99-109.
    • (2005) J Cell Biol , vol.171 , pp. 99-109
    • Gomi, H.1    Mizutani, S.2    Kasai, K.3    Itohara, S.4    Izumi, T.5
  • 32
    • 32344449615 scopus 로고    scopus 로고
    • Functional analysis of Rab27a effector granuphilin in insulin exocytosis
    • Izumi T, Gomi H, Torii S. Functional analysis of Rab27a effector granuphilin in insulin exocytosis. Methods Enzymol 2005; 403: 216-229.
    • (2005) Methods Enzymol , vol.403 , pp. 216-229
    • Izumi, T.1    Gomi, H.2    Torii, S.3
  • 33
    • 20144373742 scopus 로고    scopus 로고
    • Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
    • Kasai K, Ohara-Imaizumi M, Takahashi N et al. Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J Clin Invest 2005; 115: 388-396.
    • (2005) J Clin Invest , vol.115 , pp. 388-396
    • Kasai, K.1    Ohara-Imaizumi, M.2    Takahashi, N.3
  • 35
    • 2542463861 scopus 로고    scopus 로고
    • Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a
    • Torii S, Takeuchi T, Nagamatsu S, Izumi T. Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. J Biol Chem 2004; 279: 22532-22538.
    • (2004) J Biol Chem , vol.279 , pp. 22532-22538
    • Torii, S.1    Takeuchi, T.2    Nagamatsu, S.3    Izumi, T.4
  • 36
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    • Zhang CY, Baffy G, Perret P et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 2001; 105: 745-755.
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1    Baffy, G.2    Perret, P.3
  • 37
    • 0035078830 scopus 로고    scopus 로고
    • Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion?
    • Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F. Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 2001; 50: 803-809.
    • (2001) Diabetes , vol.50 , pp. 803-809
    • Lameloise, N.1    Muzzin, P.2    Prentki, M.3    Assimacopoulos-Jeannet, F.4
  • 38
    • 0036829870 scopus 로고    scopus 로고
    • Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
    • Joseph JW, Koshkin V, Zhang CY et al. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 2002; 51: 3211-3219.
    • (2002) Diabetes , vol.51 , pp. 3211-3219
    • Joseph, J.W.1    Koshkin, V.2    Zhang, C.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.