메뉴 건너뛰기




Volumn 46, Issue 11, 1997, Pages 1725-1732

Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROINSULIN;

EID: 0030662718     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.11.1725     Document Type: Article
Times cited : (198)

References (50)
  • 3
    • 0022910962 scopus 로고
    • A sensitive radioimmunoassay for human proinsulin with sequential use of antisera to C-peptide and insulin
    • Ward WK, Paquette TL, Frank BH, Porte D Jr: A sensitive radioimmunoassay for human proinsulin with sequential use of antisera to C-peptide and insulin. Clin Chem 32:728-733, 1986
    • (1986) Clin Chem , vol.32 , pp. 728-733
    • Ward, W.K.1    Paquette, T.L.2    Frank, B.H.3    Porte Jr., D.4
  • 5
    • 0015416775 scopus 로고
    • Direct measurement of plasma proinsulin in normal and diabetic subjects
    • Duckworth WC, Kitabchi AE, Heinemann M: Direct measurement of plasma proinsulin in normal and diabetic subjects. Am J Med 53:418-427, 1972
    • (1972) Am J Med , vol.53 , pp. 418-427
    • Duckworth, W.C.1    Kitabchi, A.E.2    Heinemann, M.3
  • 6
    • 0016209121 scopus 로고
    • Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states
    • Gorden P, Hendricks CM, Roth J: Circulating proinsulin-like component in man: increased proportion in hypoinsulinemic states. Diabetolagia 10:469-474, 1974
    • (1974) Diabetolagia , vol.10 , pp. 469-474
    • Gorden, P.1    Hendricks, C.M.2    Roth, J.3
  • 7
    • 0017761172 scopus 로고
    • Circulating proinsulin in patients with maturity-onset diabetes
    • Mako ME, Starr JI, Rubenstein AH: Circulating proinsulin in patients with maturity-onset diabetes. Am J Med 63:865-869, 1977
    • (1977) Am J Med , vol.63 , pp. 865-869
    • Mako, M.E.1    Starr, J.I.2    Rubenstein, A.H.3
  • 8
    • 0023634652 scopus 로고
    • Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and experimental insulin resistance
    • Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte D Jr: Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and experimental insulin resistance. Diabetologia 30:698-702, 1987
    • (1987) Diabetologia , vol.30 , pp. 698-702
    • Ward, W.K.1    LaCava, E.C.2    Paquette, T.L.3    Beard, J.C.4    Wallum, B.J.5    Porte Jr., D.6
  • 9
    • 0023759449 scopus 로고
    • Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y: Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 31:355-360, 1988
    • (1988) Diabetologia , vol.31 , pp. 355-360
    • Yoshioka, N.1    Kuzuya, T.2    Matsuda, A.3    Taniguchi, M.4    Iwamoto, Y.5
  • 12
    • 0026587185 scopus 로고
    • Effect of insulin resistance and hyperglycemia on proinsulin release in a primate model of diabetes mellitus
    • Kahn SE, McCulloch DK, Schwartz MW, Palmer JP, Porte D Jr: Effect of insulin resistance and hyperglycemia on proinsulin release in a primate model of diabetes mellitus. J Clin Endocrinol Metab 74:192-197, 1992
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 192-197
    • Kahn, S.E.1    McCulloch, D.K.2    Schwartz, M.W.3    Palmer, J.P.4    Porte Jr., D.5
  • 13
    • 0027217510 scopus 로고
    • Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans
    • Kahn SE, Horber FF, Prigeon RL, Haymond MW, Porte D Jr. Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans. Diabetes 42:1082-1085, 1993
    • (1993) Diabetes , vol.42 , pp. 1082-1085
    • Kahn, S.E.1    Horber, F.F.2    Prigeon, R.L.3    Haymond, M.W.4    Porte Jr., D.5
  • 14
    • 0027434701 scopus 로고
    • Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance
    • Reaven GM, Chen Y-DI, Hollenbeck CB, Sheu WHH, Ostrega D, Polonsky KS: Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. J Clin Endocrinol Metab 76:44-48, 1993
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 44-48
    • Reaven, G.M.1    Chen, Y.-D.I.2    Hollenbeck, C.B.3    Sheu, W.H.H.4    Ostrega, D.5    Polonsky, K.S.6
  • 16
    • 0026553510 scopus 로고
    • Immunoradiometric assay of insulin, intact proinsulin and 32-33 split proinsulin and radioimmunoassay of insulin in diet-treated type 2 (non-insulin-dependent) diabetic subjects
    • Clark PM, Levy JC, Cox L, Burnett M, Turner RC, Hales CN: Immunoradiometric assay of insulin, intact proinsulin and 32-33 split proinsulin and radioimmunoassay of insulin in diet-treated type 2 (non-insulin-dependent) diabetic subjects. Diabetologia 35:469-474, 1992
    • (1992) Diabetologia , vol.35 , pp. 469-474
    • Clark, P.M.1    Levy, J.C.2    Cox, L.3    Burnett, M.4    Turner, R.C.5    Hales, C.N.6
  • 17
    • 0024994251 scopus 로고
    • Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites
    • Tillil H, Frank BH, Pekar AH, Broelsch C, Rubenstein AH, Polonsky KS: Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites. Endocrinology 127:2418-2222, 1990
    • (1990) Endocrinology , vol.127 , pp. 2418-12222
    • Tillil, H.1    Frank, B.H.2    Pekar, A.H.3    Broelsch, C.4    Rubenstein, A.H.5    Polonsky, K.S.6
  • 18
    • 0013572294 scopus 로고
    • A comparison of insulin immunoassays
    • Samols E, Bilkus D: A comparison of insulin immunoassays. Proc Soc Exp Biol Med 115:79-84, 1964
    • (1964) Proc Soc Exp Biol Med , vol.115 , pp. 79-84
    • Samols, E.1    Bilkus, D.2
  • 19
    • 0000476083 scopus 로고
    • Immunoassay of insulin: Two antibody system: Plasma insulin levels of normal, subdiabetic, and diabetic rats
    • Morgan DR, Lazarow A: Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic, and diabetic rats. Diabetes 12:115-126, 1963
    • (1963) Diabetes , vol.12 , pp. 115-126
    • Morgan, D.R.1    Lazarow, A.2
  • 20
    • 0027197924 scopus 로고
    • Adaptation to supraphysiologic levels of insulin gene expression in transgenic mice: Evidence for the importance of postranscriptional regulation
    • Schnetzler B, Murakawa G, Abalos D, Halban PA, Selden R: Adaptation to supraphysiologic levels of insulin gene expression in transgenic mice: evidence for the importance of postranscriptional regulation. J Clin Invest 92:272-280, 1993
    • (1993) J Clin Invest , vol.92 , pp. 272-280
    • Schnetzler, B.1    Murakawa, G.2    Abalos, D.3    Halban, P.A.4    Selden, R.5
  • 24
    • 0024245270 scopus 로고
    • Oxidation of rat insulin II, but not I, leads to anomalous elution profiles upon HPLC analysis of insulin-related peptides
    • Gross D, Skvorak A, Hendrick G, Weir G, Villa-Komaroff L, Halban PA: Oxidation of rat insulin II, but not I, leads to anomalous elution profiles upon HPLC analysis of insulin-related peptides. FEBS Lett 241:205-208, 1988
    • (1988) FEBS Lett , vol.241 , pp. 205-208
    • Gross, D.1    Skvorak, A.2    Hendrick, G.3    Weir, G.4    Villa-Komaroff, L.5    Halban, P.A.6
  • 25
    • 0025784819 scopus 로고
    • Differential rates of conversion of rat proinsulins I and II: Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II
    • Sizonenko SV, Halban PA: Differential rates of conversion of rat proinsulins I and II: Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II. Biochem J 278:621-625, 1991
    • (1991) Biochem J , vol.278 , pp. 621-625
    • Sizonenko, S.V.1    Halban, P.A.2
  • 27
    • 0027957282 scopus 로고
    • Human proinsulin conversion in the regulated and the constitutive pathway of transfected AtT20 cells
    • Irminger JC, Vollenweider FM, Neerman-Arbez M, Halban PA: Human proinsulin conversion in the regulated and the constitutive pathway of transfected AtT20 cells. J Biol Chem 269:1756-1762, 1994
    • (1994) J Biol Chem , vol.269 , pp. 1756-1762
    • Irminger, J.C.1    Vollenweider, F.M.2    Neerman-Arbez, M.3    Halban, P.A.4
  • 28
    • 0023895049 scopus 로고
    • Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β-cell via two distinct site-specific endopeptidases
    • Davidson HW, Rhodes CJ, Hutton JC: Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β-cell via two distinct site-specific endopeptidases. Nature 333:93-96, 1988
    • (1988) Nature , vol.333 , pp. 93-96
    • Davidson, H.W.1    Rhodes, C.J.2    Hutton, J.C.3
  • 29
    • 0018702014 scopus 로고
    • Glucose intolerance of aging: Evidence for tissue insensitivity to insulin
    • DeFronzo RA: Glucose intolerance of aging: evidence for tissue insensitivity to insulin. Diabetes 28:1095-1101, 1979
    • (1979) Diabetes , vol.28 , pp. 1095-1101
    • DeFronzo, R.A.1
  • 30
    • 0020159899 scopus 로고
    • Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus
    • Olefsky JM, Kolterman OG, Scarlett JA: Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol 243:E15-E30, 1982
    • (1982) Am J Physiol , vol.243
    • Olefsky, J.M.1    Kolterman, O.G.2    Scarlett, J.A.3
  • 31
    • 0026100893 scopus 로고
    • Proinsulin conversion intermediates: A possible source of confusion
    • Halban PA: Proinsulin conversion intermediates: a possible source of confusion (Letter). Diabetologia 34:202-203, 1991
    • (1991) Diabetologia , vol.34 , pp. 202-203
    • Halban, P.A.1
  • 32
    • 0026475382 scopus 로고
    • Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase: Implication of a favored route for prohormone processing
    • Rhodes CJ, Lincoln B, Shoelson SE: Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase: implication of a favored route for prohormone processing. J Biol Chem 267:22719-22727, 1992
    • (1992) J Biol Chem , vol.267 , pp. 22719-22727
    • Rhodes, C.J.1    Lincoln, B.2    Shoelson, S.E.3
  • 33
    • 0028967995 scopus 로고
    • Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese American men: Impact of obesity
    • Kahn SE, Leonetti DL, Prigeon RL, Bergstrom RW, Fujimoto WY: Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese American men: impact of obesity. J Clin Endocrinol Metab 80:1399-1406, 1995
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1399-1406
    • Kahn, S.E.1    Leonetti, D.L.2    Prigeon, R.L.3    Bergstrom, R.W.4    Fujimoto, W.Y.5
  • 35
    • 0026787567 scopus 로고
    • A rapid and sensitive radioimmunoassay for the measurement of proinsulin in human serum
    • Bowsher RR, Wolny JD, Frank BH: A rapid and sensitive radioimmunoassay for the measurement of proinsulin in human serum. Diabetes 41:1084-1090, 1992
    • (1992) Diabetes , vol.41 , pp. 1084-1090
    • Bowsher, R.R.1    Wolny, J.D.2    Frank, B.H.3
  • 36
    • 0023940801 scopus 로고
    • Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy
    • Leahy JL, Bonner-Weir S, Weir GC: Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 81:1407-1414, 1988
    • (1988) J Clin Invest , vol.81 , pp. 1407-1414
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 37
    • 0025736943 scopus 로고
    • Relative hypersecretion of proinsulin in rat model of NIDDM
    • Leahy JL, Halban PA, Weir GC: Relative hypersecretion of proinsulin in rat model of NIDDM. Diabetes 40:985-989, 1991
    • (1991) Diabetes , vol.40 , pp. 985-989
    • Leahy, J.L.1    Halban, P.A.2    Weir, G.C.3
  • 38
    • 0019450010 scopus 로고
    • Responses of neonatal islets to streptozotocin: Limited B-cell regeneration and hyperglycemia
    • Bonner-Weir S, Trent DF, Honey RN, Weir GC: Responses of neonatal islets to streptozotocin: limited B-cell regeneration and hyperglycemia. Diabetes 30:64-69, 1981
    • (1981) Diabetes , vol.30 , pp. 64-69
    • Bonner-Weir, S.1    Trent, D.F.2    Honey, R.N.3    Weir, G.C.4
  • 39
    • 0025133270 scopus 로고
    • Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats
    • S. B-W
    • Thorens B, Weir GC, Leahy JL, Lodish HF, S. B-W: Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. Proc Natl. Acad Sci U S A 87:6492-6496, 1990
    • (1990) Proc Natl. Acad Sci U S A , vol.87 , pp. 6492-6496
    • Thorens, B.1    Weir, G.C.2    Leahy, J.L.3    Lodish, H.F.4
  • 40
    • 0023865083 scopus 로고
    • Evolution of abnormal insulin secretory responses during 48-h in vivo hyperglycemia
    • Leahy JL, Weir GC: Evolution of abnormal insulin secretory responses during 48-h in vivo hyperglycemia Diabetes 37:217-222, 1988
    • (1988) Diabetes , vol.37 , pp. 217-222
    • Leahy, J.L.1    Weir, G.C.2
  • 41
    • 0027389774 scopus 로고
    • Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats
    • Leahy JL: Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats. Diabetes 42:22-27, 1993
    • (1993) Diabetes , vol.42 , pp. 22-27
    • Leahy, J.L.1
  • 43
    • 0026511753 scopus 로고
    • Beta-cell dysfunction induced by chronic hyperglycemia: Current ideas on mechanism of impaired glucose-induced insulin secretion
    • Leahy JL, Bonner-Weir S, Weir GC: Beta-cell dysfunction induced by chronic hyperglycemia: current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care 15:442-455, 1992
    • (1992) Diabetes Care , vol.15 , pp. 442-455
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 44
    • 0029091212 scopus 로고
    • Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the beta-cell
    • Gadot M, Ariav Y, Cerasi E, Kaiser N, Gross DJ: Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the beta-cell. Endocrinology 136:4218-4223, 1995
    • (1995) Endocrinology , vol.136 , pp. 4218-4223
    • Gadot, M.1    Ariav, Y.2    Cerasi, E.3    Kaiser, N.4    Gross, D.J.5
  • 45
    • 0028912883 scopus 로고
    • Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non insulin dependent diabetes mellitus
    • Alarcon C, Leahy JL, Schuppin GT, Rhodes CJ: Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non insulin dependent diabetes mellitus. J Clin Invest 95:1032-1039, 1995
    • (1995) J Clin Invest , vol.95 , pp. 1032-1039
    • Alarcon, C.1    Leahy, J.L.2    Schuppin, G.T.3    Rhodes, C.J.4
  • 46
    • 0028329930 scopus 로고
    • Sorting and processing of secretory proteins
    • Halban PA, Irminger JC: Sorting and processing of secretory proteins. Biochem J 299:1-18, 1994
    • (1994) Biochem J , vol.299 , pp. 1-18
    • Halban, P.A.1    Irminger, J.C.2
  • 47
    • 0028850065 scopus 로고
    • Processing of proinsulin by furin, PC2, and PC3 in (co) transfected COS (monkey kidney) cells
    • Vollenweider F, Kaufmann J, Irminger JC, Halban PA: Processing of proinsulin by furin, PC2, and PC3 in (co) transfected COS (monkey kidney) cells. Diabetes 44:1075-1080, 1995
    • (1995) Diabetes , vol.44 , pp. 1075-1080
    • Vollenweider, F.1    Kaufmann, J.2    Irminger, J.C.3    Halban, P.A.4
  • 48
    • 0027317264 scopus 로고
    • Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PC1/3 in transformed beta cells
    • Neerman-Arbez M, Sizonenko SV, Halban PA: Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PC1/3 in transformed beta cells. J Biol Chem 268:16098-16100, 1993
    • (1993) J Biol Chem , vol.268 , pp. 16098-16100
    • Neerman-Arbez, M.1    Sizonenko, S.V.2    Halban, P.A.3
  • 49
    • 0028335225 scopus 로고
    • Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells
    • Neerman-Arbez M, Cirulli V, Halban PA: Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells. Biochem J 300:57-61, 1994
    • (1994) Biochem J , vol.300 , pp. 57-61
    • Neerman-Arbez, M.1    Cirulli, V.2    Halban, P.A.3
  • 50
    • 0029841510 scopus 로고    scopus 로고
    • Proinsulin processing in the rat insulinoma cell line INS after overexpression of the endoproteases PC2 or PC3 by recombinant adenovirus
    • Irminger JC, Meyer K, Halban P: Proinsulin processing in the rat insulinoma cell line INS after overexpression of the endoproteases PC2 or PC3 by recombinant adenovirus. Biochem J 320:11-15, 1996
    • (1996) Biochem J , vol.320 , pp. 11-15
    • Irminger, J.C.1    Meyer, K.2    Halban, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.