Partial unfolding of a monoclonal antibody: Role of a single domain in driving protein aggregation

Biochemistry

Volumn 53, Issue 20, 2014, Pages 3367-3377

  Mehta, Shyam B ^a   Bee, Jared S ^b   Randolph, Theodore W ^c   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b MEDIMMUNE   (United States)

^c UCB 450   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRIFUGATION; CIRCULAR DICHROISM SPECTROSCOPY; DIFFERENTIAL SCANNING CALORIMETRY; DYNAMIC LIGHT SCATTERING; ISOTHERMS; MONOCLONAL ANTIBODIES; SIZE EXCLUSION CHROMATOGRAPHY;

ANALYTICAL ULTRACENTRIFUGATION; CONCENTRATION RANGES; GUANIDINE HYDROCHLORIDE; MONOCLONAL ANTIBODIES (MAB); PROTEIN-PROTEIN INTERACTIONS; SECOND VIRIAL COEFFICIENTS; SECONDARY STRUCTURES; STATIC LIGHT SCATTERING;

PROTEINS;

GUANIDINE; MONOCLONAL ANTIBODY; PROTEINASE K; TRYPTOPHAN;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; GEL PERMEATION CHROMATOGRAPHY; INCUBATION TEMPERATURE; LIGHT SCATTERING; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN UNFOLDING; SEDIMENTATION RATE; ULTRACENTRIFUGATION; ULTRAVIOLET SPECTROSCOPY;

ANTIBODIES, MONOCLONAL; GUANIDINE; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEIN UNFOLDING; SPECTROMETRY, FLUORESCENCE;

EID: 84901453181     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5002163     Document Type: Article

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