Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor

Journal of Pharmaceutical Sciences

Volumn 95, Issue 7, 2006, Pages 1480-1497

  Thirumangalathu, Renuka ^a   Krishnan, Sampathkumar ^b   Brems, David N ^b   Randolph, Theodore W ^c   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b AMGEN INC   (United States)

^c University of Colorado at Boulder   (United States)

Author keywords

Aggregation; Benzyl alcohol; pH; rhGCSF; Temperature

Indexed keywords

BENZYL ALCOHOL; PHOSPHATE BUFFERED SALINE; RECOMBINANT CYTOKINE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SUCROSE;

ARTICLE; DENATURATION; DEUTERIUM HYDROGEN EXCHANGE; ENERGY TRANSFER; MOLECULAR INTERACTION; PH; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; SPECTROSCOPY; TEMPERATURE; THERMOSTABILITY;

EID: 33745876259     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20619     Document Type: Article

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