Under-folded proteins: Conformational ensembles and their roles in protein folding, function, and pathogenesis

Biopolymers

Volumn 99, Issue 11, 2013, Pages 870-887

  Uversky, Vladimir N ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b INSTITUTE FOR BIOLOGICAL INSTRUMENTATION   (Russian Federation)

Author keywords

conformational ensemble; intrinsically disordered protein; protein folding; protein misfolding

Indexed keywords

AMINO ACID SEQUENCE; CONFORMATIONAL ENSEMBLE; FOLDING INTERMEDIATES; FUNCTIONAL PROTEINS; INTRINSICALLY DISORDERED PROTEINS; MISFOLDED PROTEINS; PROTEIN DENATURATION; PROTEIN MISFOLDING;

AMINO ACIDS; CRYSTAL STRUCTURE; PROTEIN FOLDING;

PROTEINS;

ALPHA SYNUCLEIN; AMINO ACID; AMYLOID PROTEIN; GLOBULAR PROTEIN; HYBRID PROTEIN; POLYMER; INTRINSICALLY DISORDERED PROTEIN; PROTEIN;

CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DEGENERATIVE DISEASE; HUMAN; INTRINSICALLY DISORDERED PROTEIN; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN UNFOLDING; REVIEW; CHEMICAL STRUCTURE; CHEMISTRY; PROTEIN SECONDARY STRUCTURE;

INTRINSICALLY DISORDERED PROTEINS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEINS;

EID: 84883190318     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22298     Document Type: Review

References (256)

1. Anfinsen, C. B., Science 1973, 181, 223-230.
2. Anfinsen, C. B.,;, Haber, E.,;, Sela, M.,;, White, F. H., Jr., Proc Natl Acad Sci U S A 1961, 47, 1309-1314.
3. Fischer, E., Ber Dt Chem Ges 1894, 27, 2985-2993.
4. Berman, H. M.,;, Westbrook, J.,;, Feng, Z.,;, Gilliland, G.,;, Bhat, T. N.,;, Weissig, H.,;, Shindyalov, I. N.,;, Bourne, P. E., Nucleic Acids Res 2000, 28, 235-242.
5. Dobson, C. M., Trends Biochem Sci 1999, 24, 329-332.
6. Dobson, C. M., Biochem Soc Symp 2001, 1-26.
7. Dobson, C. M., Philos Trans R Soc Lond B Biol Sci 2001, 356, 133-145.
8. Dunker, A. K.,;, Brown, C. J.,;, Lawson, J. D.,;, Iakoucheva, L. M.,;, Obradovic, Z., Biochemistry 2002, 41, 6573-6582.
9. Dunker, A. K.,;, Brown, C. J.,;, Obradovic, Z., Adv Protein Chem 2002, 62, 25-49.
10. Dunker, A. K.,;, Cortese, M. S.,;, Romero, P.,;, Iakoucheva, L. M.,;, Uversky, V. N., FEBS J 2005, 272, 5129-5148.
11. Dunker, A. K.,;, Lawson, J. D.,;, Brown, C. J.,;, Williams, R. M.,;, Romero, P.,;, Oh, J. S.,;, Oldfield, C. J.,;, Campen, A. M.,;, Ratliff, C. M.,;, Hipps, K. W.,;, Ausio, J.,;, Nissen, M. S.,;, Reeves, R.,;, Kang, C.,;, Kissinger, C. R.,;, Bailey, R. W.,;, Griswold, M. D.,;, Chiu, W.,;, Garner, E. C.,;, Obradovic, Z., J Mol Graph Model 2001, 19, 26-59.
12. Dyson, H. J.,;, Wright, P. E., Curr Opin Struct Biol 2002, 12, 54-60.
13. Dyson, H. J.,;, Wright, P. E., Nat Rev Mol Cell Biol 2005, 6, 197-208.
14. Tompa, P., Trends Biochem Sci 2002, 27, 527-533.
15. Tompa, P., Curr Opin Struct Biol 2011, 21, 419-425.
16. Tompa, P.,;, Fuxreiter, M., Trends Biochem Sci 2008, 33, 2-8.
17. Uversky, V. N., Protein Sci 2002, 11, 739-756.
18. Uversky, V. N., Eur J Biochem 2002, 269, 2-12.
19. Uversky, V. N., Cell Mol Life Sci 2003, 60, 1852-1871.
20. Uversky, V. N., Int J Biochem Cell Biol 2011, 43, 1090-1103.
21. Uversky, V. N., Chem Soc Rev 2011, 40, 1623-1634.
22. Uversky, V. N., Curr Pharm Des 2013, 42, 4191-4213.
23. Uversky, V. N.,;, Dunker, A. K., Biochim Biophys Acta 2010, 1804, 1231-1264.
24. Uversky, V. N.,;, Gillespie, J. R.,;, Fink, A. L., Proteins 2000, 41, 415-427.
25. Wright, P. E.,;, Dyson, H. J., J Mol Biol 1999, 293, 321-331.
26. Wright, P. E.,;, Dyson, H. J., Curr Opin Struct Biol 2009, 19, 31-38.
27. Turoverov, K. K.,;, Kuznetsova, I. M.,;, Uversky, V. N., Prog Biophys Mol Biol 2010, 102, 73-84.
28. Dyson, H. J., Q Rev Biophys 2011, 44, 467-518.
29. Ben-Zvi, A. P.,;, Goloubinoff, P., J Struct Biol 2001, 135, 84-93.
30. Finkelstein, A. V.,;, Ptitsyn, O. B., Protein Physics: A Course of Lectures; Academic Press: London, UK; San Diego, CA, 2002.
31. Bryngelson, J. D.,;, Onuchic, J. N.,;, Socci, N. D.,;, Wolynes, P. G., Proteins 1995, 21, 167-195.
32. Dill, K. A.,;, Chan, H. S., Nat Struct Biol 1997, 4, 10-19.
33. Dobson, C. M.,;, Sali, A.,;, Karplus, M., Angew Chem-Int Ed 1998, 37, 868-893.
34. Dobson, C. M.,;, Karplus, M., Curr Opin Struct Biol 1999, 9, 92-101.
35. Dinner, A. R.,;, Sali, A.,;, Smith, L. J.,;, Dobson, C. M.,;, Karplus, M., Trends Biochem Sci 2000, 25, 331-339.
36. Fersht, A. R.,;, Daggett, V., Cell 2002, 108, 573-582.
37. Levinthal, C., J Chem Phys 1968, 65, 44-45.
38. Ptitsyn, O. B., Dokl Akad Nauk SSSR 1973, 210, 1213-1215.
39. Ohgushi, M.,;, Wada, A., FEBS Lett 1983, 164, 21-24.
40. Dolgikh, D. A.,;, Gilmanshin, R. I.,;, Brazhnikov, E. V.,;, Bychkova, V. E.,;, Semisotnov, G. V.,;, Venyaminov, S.,;, Ptitsyn, O. B., FEBS Lett 1981, 136, 311-315.
41. Radford, S. E., Trends Biochem Sci 2000, 25, 611-618.
42. Jahn, T. R.,;, Radford, S. E., FEBS J 2005, 272, 5962-5970.
43. Kim, P. S.,;, Baldwin, R. L., Annu Rev Biochem 1982, 51, 459-489.
44. Ikeguchi, M.,;, Kuwajima, K.,;, Mitani, M.,;, Sugai, S., Biochemistry 1986, 25, 6965-6972.
45. Hughson, F. M.,;, Wright, P. E.,;, Baldwin, R. L., Science 1990, 249, 1544-1548.
46. Ptitsyn, O. B.,;, Pain, R. H.,;, Semisotnov, G. V.,;, Zerovnik, E.,;, Razgulyaev, O. I., FEBS Lett 1990, 262, 20-24.
47. Goldberg, M. E.,;, Semisotnov, G. V.,;, Friguet, B.,;, Kuwajima, K.,;, Ptitsyn, O. B.,;, Sugai, S., FEBS Lett 1990, 263, 51-56.
48. Jennings, P. A.,;, Wright, P. E., Science 1993, 262, 892-896.
49. Loh, S. N.,;, Kay, M. S.,;, Baldwin, R. L., Proc Natl Acad Sci U S A 1995, 92, 5446-5450.
50. Balbach, J.,;, Forge, V.,;, van Nuland, N. A.,;, Winder, S. L.,;, Hore, P. J.,;, Dobson, C. M., Nat Struct Biol 1995, 2, 865-870.
51. Ptitsyn, O. B., Curr Opin Struct Biol 1995, 5, 74-78.
52. Ptitsyn, O. B., Adv Protein Chem 1995, 47, 83-229.
53. Ptitsyn, O. B.,;, Bychkova, V. E.,;, Uversky, V. N., Philos Trans R Soc Lond B Biol Sci 1995, 348, 35-41.
54. Fink, A. L., Subcell Biochem 1995, 24, 27-53.
55. Fink, A. L., Annu Rev Biophys Biomol Struct 1995, 24, 495-522.
56. Fink, A. L., Methods Mol Biol 1995, 40, 343-360.
57. Fink, A. L.,;, Oberg, K. A.,;, Seshadri, S., Fold Des 1998, 3, 19-25.
58. Uversky, V. N.,;, Karnoup, A. S.,;, Segel, D. J.,;, Seshadri, S.,;, Doniach, S.,;, Fink, A. L., J Mol Biol 1998, 278, 879-894.
59. Uversky, V. N.,;, Ptitsyn, O. B., Biochemistry 1994, 33, 2782-2791.
60. Uversky, V. N.,;, Ptitsyn, O. B., J Mol Biol 1996, 255, 215-228.
61. Tcherkasskaya, O.,;, Davidson, E. A.,;, Uversky, V. N., J Proteome Res 2003, 2, 37-42.
62. Tcherkasskaya, O.,;, Uversky, V. N., Proteins 2001, 44, 244-254.
63. Tcherkasskaya, O.,;, Uversky, V. N., Protein Pept Lett 2003, 10, 239-245.
64. Ptitsyn, O. B.,;, Volkenstein, M. V., J Biomol Struct Dyn 1986, 4, 137-156.
65. Lau, K. F.,;, Dill, K. A., Proc Natl Acad Sci U S A 1990, 87, 638-642.
66. Anson, M. L.,;, Mirsky, A. E., J Gen Physiol 1932, 15, 341-350.
67. Mirsky, A. E.,;, Pauling, L., Proc Natl Acad Sci U S A 1936, 22, 439-447.
68. Neurath, H.,;, Greenstein, J. P.,;, Putnam, F. W.,;, Erickson, J. O., Chem Rew 1944, 34, 157-265.
69. Tanford, C., Adv Protein Chem 1968, 23, 121-282.
70. Uversky, V. N.,;, Fink, A. L., Biochemistry (Mosc) 1999, 64, 552-555.
71. Baldwin, R. L., Trends Biochem Sci 1986, 11, 6-9.
72. Grossberg, A. Y.,;, Khohlov, A. R., Statistical Physics of Macromolecules; Nauka: Moscow, 1989.
73. Tanford, C., Physical Chemistry of Macromolecules; Willey: New York, 1961.
74. Kohn, J. E.,;, Millett, I. S.,;, Jacob, J.,;, Zagrovic, B.,;, Dillon, T. M.,;, Cingel, N.,;, Dothager, R. S.,;, Seifert, S.,;, Thiyagarajan, P.,;, Sosnick, T. R.,;, Hasan, M. Z.,;, Pande, V. S.,;, Ruczinski, I.,;, Doniach, S.,;, Plaxco, K. W., Proc Natl Acad Sci U S A 2004, 101, 12491-12496.
75. Miller, W. G.,;, Goebel, C. V., Biochemistry 1968, 7, 3925-3935.
76. Wang, Z.,;, Plaxco, K. W.,;, Makarov, D. E., Biopolymers 2007, 86, 321-328.
77. Fitzkee, N. C.,;, Rose, G. D., Proc Natl Acad Sci U S A 2004, 101, 12497-12502.
78. James, E.,;, Wu, P. G.,;, Stites, W.,;, Brand, L., Biochemistry 1992, 31, 10217-10225.
79. Alexandrescu, A. T.,;, Abeygunawardana, C.,;, Shortle, D., Biochemistry 1994, 33, 1063-1072.
80. Wang, Y.,;, Shortle, D., Protein Sci 1996, 5, 1898-1906.
81. Wang, Y.,;, Shortle, D., Biochemistry 1995, 34, 15895-15905.
82. Wang, Y.,;, Shortle, D., Fold Des 1997, 2, 93-100.
83. Gillespie, J. R.,;, Shortle, D., J Mol Biol 1997, 268, 170-184.
84. Gillespie, J. R.,;, Shortle, D., J Mol Biol 1997, 268, 158-169.
85. Shortle, D.,;, Ackerman, M. S., Science 2001, 293, 487-489.
86. Saab-Rincon, G.,;, Froebe, C. L.,;, Matthews, C. R., Biochemistry 1993, 32, 13981-13990.
87. Saab-Rincon, G.,;, Gualfetti, P. J.,;, Matthews, C. R., Biochemistry 1996, 35, 1988-1994.
88. Neri, D.,;, Billeter, M.,;, Wider, G.,;, Wuthrich, K., Science 1992, 257, 1559-1563.
89. Neri, D.,;, Wider, G.,;, Wuthrich, K., Proc Natl Acad Sci U S A 1992, 89, 4397-4401.
90. Neri, D.,;, Wider, G.,;, Wuthrich, K., FEBS Lett 1992, 303, 129-135.
91. Wang, H. M.,;, Yu, C., Biophys J 2011, 100, 154-164.
92. Zhang, O.,;, Forman-Kay, J. D., Biochemistry 1995, 34, 6784-6794.
93. Zhang, O.,;, Forman-Kay, J. D., Biochemistry 1997, 36, 3959-3970.
94. Nolting, B.,;, Golbik, R.,;, Soler-Gonzalez, A. S.,;, Fersht, A. R., Biochemistry 1997, 36, 9899-9905.
95. Arcus, V. L.,;, Vuilleumier, S.,;, Freund, S. M.,;, Bycroft, M.,;, Fersht, A. R., J Mol Biol 1995, 254, 305-321.
96. Koepf, E. K.,;, Petrassi, H. M.,;, Sudol, M.,;, Kelly, J. W., Protein Sci 1999, 8, 841-853.
97. Gottfried, D. S.,;, Haas, E., Biochemistry 1992, 31, 12353-12362.
98. Amir, D.,;, Krausz, S.,;, Haas, E., Proteins 1992, 13, 162-173.
99. Kazmirski, S. L.,;, Wong, K. B.,;, Freund, S. M.,;, Tan, Y. J.,;, Fersht, A. R.,;, Daggett, V., Proc Natl Acad Sci U S A 2001, 98, 4349-4354.
100. Svensson, M.,;, Jonasson, P.,;, Freskgard, P. O.,;, Jonsson, B. H.,;, Lindgren, M.,;, Martensson, L. G.,;, Gentile, M.,;, Boren, K.,;, Carlsson, U., Biochemistry 1995, 34, 8606-8620.
101. Martensson, L. G.,;, Jonsson, B. H.,;, Freskgard, P. O.,;, Kihlgren, A.,;, Svensson, M.,;, Carlsson, U., Biochemistry 1993, 32, 224-231.
102. Hammarstrom, P.,;, Carlsson, U., Biochem Biophys Res Commun 2000, 276, 393-398.
103. Schwarzinger, S.,;, Wright, P. E.,;, Dyson, H. J., Biochemistry 2002, 41, 12681-12686.
104. Klein-Seetharaman, J.,;, Oikawa, M.,;, Grimshaw, S. B.,;, Wirmer, J.,;, Duchardt, E.,;, Ueda, T.,;, Imoto, T.,;, Smith, L. J.,;, Dobson, C. M.,;, Schwalbe, H., Science 2002, 295, 1719-1722.
105. Lee, B. C.,;, Kumauchi, M.,;, Hoff, W. D., J Biol Chem 2010, 285, 12579-12586.
106. Tafer, H.,;, Hiller, S.,;, Hilty, C.,;, Fernandez, C.,;, Wuthrich, K., Biochemistry 2004, 43, 860-869.
107. Romero-Beviar, M.,;, Martinez-Rodriguez, S.,;, Prieto, J.,;, Goormaghtigh, E.,;, Ariz, U.,;, Martinez-Chantar Mde, L.,;, Gomez, J.,;, Neira, J. L., Protein Eng Des Sel 2010, 23, 729-742.
108. Wirmer, J.,;, Berk, H.,;, Ugolini, R.,;, Redfield, C.,;, Schwalbe, H., Protein Sci 2006, 15, 1397-1407.
109. Ohnishi, S.,;, Lee, A. L.,;, Edgell, M. H.,;, Shortle, D., Biochemistry 2004, 43, 4064-4070.
110. Ropson, I. J.,;, Boyer, J. A.,;, Dalessio, P. M., Biochemistry 2006, 45, 2608-2617.
111. Santra, M. K.,;, Dasgupta, D.,;, Panda, D., Photochem Photobiol 2006, 82, 480-486.
112. Kogo, H.,;, Takeuchi, K.,;, Inoue, H.,;, Kihara, H.,;, Kojima, M.,;, Takahashi, K., Biochim Biophys Acta 2009, 1794, 70-74.
113. Mok, K. H.,;, Kuhn, L. T.,;, Goez, M.,;, Day, I. J.,;, Lin, J. C.,;, Andersen, N. H.,;, Hore, P. J., Nature 2007, 447, 106-109.
114. Ureta, D. B.,;, Craig, P. O.,;, Gomez, G. E.,;, Delfino, J. M., Biochemistry 2007, 46, 14567-14577.
115. Wallgren, M.,;, Aden, J.,;, Pylypenko, O.,;, Mikaelsson, T.,;, Johansson, L. B.,;, Rak, A.,;, Wolf-Watz, M., J Mol Biol 2008, 379, 845-858.
116. Ratcliff, K.,;, Marqusee, S., Biochemistry 2010, 49, 5167-5175.
117. Huang, J. R.,;, Grzesiek, S., J Am Chem Soc 2010, 132, 694-705.
118. Dill, K. A.,;, Shortle, D., Annu Rev Biochem 1991, 60, 795-825.
119. Shortle, D. R., Curr Opin Struct Biol 1996, 6, 24-30.
120. Shortle, D., FASEB J 1996, 10, 27-34.
121. Baldwin, R. L.,;, Zimm, B. H., Proc Natl Acad Sci U S A 2000, 97, 12391-12392.
122. Plaxco, K. W.,;, Gross, M., Nat Struct Biol 2001, 8, 659-660.
123. Shimizu, S.,;, Chan, H. S., Proteins 2002, 49, 560-566.
124. Smith, L. J.,;, Fiebig, K. M.,;, Schwalbe, H.,;, Dobson, C. M., Fold Des 1996, 1, R95-106.
125. Ramachandran, G. N.,;, Sasisekharan, V., Adv Protein Chem 1968, 23, 283-438.
126. Shortle, D., Adv Protein Chem 2002, 62, 1-23.
127. Palleros, D. R.,;, Shi, L.,;, Reid, K. L.,;, Fink, A. L., Biochemistry 1993, 32, 4314-4321.
128. Zhang, Y. L.,;, Zhou, J. M.,;, Tsou, C. L., Biochim Biophys Acta 1996, 1295, 239-244.
129. Karnoup, A. S.,;, Uversky, V. N., Macromolecules 1997, 30, 7427-7434.
130. Bushmarina, N. A.,;, Kuznetsova, I. M.,;, Biktashev, A. G.,;, Turoverov, K. K.,;, Uversky, V. N., ChemBioChem 2001, 2, 813-821.
131. Kuznetsova, I. M.,;, Stepanenko, O. V.,;, Turoverov, K. K.,;, Zhu, L.,;, Zhou, J. M.,;, Fink, A. L.,;, Uversky, V. N., Biochim Biophys Acta 2002, 1596, 138-155.
132. Georlette, D.,;, Blaise, V.,;, Dohmen, C.,;, Bouillenne, F.,;, Damien, B.,;, Depiereux, E.,;, Gerday, C.,;, Uversky, V. N.,;, Feller, G., J Biol Chem 2003, 278, 49945-49953.
133. Georlette, D.,;, Damien, B.,;, Blaise, V.,;, Depiereux, E.,;, Uversky, V. N.,;, Gerday, C.,;, Feller, G., J Biol Chem 2003, 278, 37015-37023.
134. Eliezer, D.,;, Chiba, K.,;, Tsuruta, H.,;, Doniach, S.,;, Hodgson, K. O.,;, Kihara, H., Biophys J 1993, 65, 912-917.
135. Kataoka, M.,;, Hagihara, Y.,;, Mihara, K.,;, Goto, Y., J Mol Biol 1993, 229, 591-596.
136. Kataoka, M.,;, Kuwajima, K.,;, Tokunaga, F.,;, Goto, Y., Protein Sci 1997, 6, 422-430.
137. Semisotnov, G. V.,;, Kihara, H.,;, Kotova, N. V.,;, Kimura, K.,;, Amemiya, Y.,;, Wakabayashi, K.,;, Serdyuk, I. N.,;, Timchenko, A. A.,;, Chiba, K.,;, Nikaido, K.,;, Ikura, T.,;, Kuwajima, K., J Mol Biol 1996, 262, 559-574.
138. Baum, J.,;, Dobson, C. M.,;, Evans, P. A.,;, Hanley, C., Biochemistry 1989, 28, 7-13.
139. Bushnell, G. W.,;, Louie, G. V.,;, Brayer, G. D., J Mol Biol 1990, 214, 585-595.
140. Chyan, C. L.,;, Wormald, C.,;, Dobson, C. M.,;, Evans, P. A.,;, Baum, J., Biochemistry 1993, 32, 5681-5691.
141. Jeng, M. F.,;, Englander, S. W.,;, Elove, G. A.,;, Wand, A. J.,;, Roder, H., Biochemistry 1990, 29, 10433-10437.
142. Bose, H. S.,;, Whittal, R. M.,;, Baldwin, M. A.,;, Miller, W. L., Proc Natl Acad Sci U S A 1999, 96, 7250-7255.
143. Bracken, C., J Mol Graph Model 2001, 19, 3-12.
144. Eliezer, D.,;, Yao, J.,;, Dyson, H. J.,;, Wright, P. E., Nat Struct Biol 1998, 5, 148-155.
145. Wu, L. C.,;, Laub, P. B.,;, Elove, G. A.,;, Carey, J.,;, Roder, H., Biochemistry 1993, 32, 10271-10276.
146. Merrill, A. R.,;, Cohen, F. S.,;, Cramer, W. A., Biochemistry 1990, 29, 5829-5836.
147. Fontana, A.,;, Polverino de Laureto, P.,;, De Philipps, V., In Protein Stability and Stabilization;, van den Tweel, W.,;, Harder, A.,;, Buitelear, M., Eds.; Elsevier: Amsterdam, 1993; p 101-110.
148. Semisotnov, G. V.,;, Rodionova, N. A.,;, Razgulyaev, O. I.,;, Uversky, V. N.,;, Gripas, A. F.,;, Gilmanshin, R. I., Biopolymers 1991, 31, 119-128.
149. Uversky, V. N.,;, Winter, S.,;, Lober, G., Biophys Chem 1996, 60, 79-88.
150. Uversky, V. N., Biochemistry 1993, 32, 13288-13298.
151. Ptitsyn, O. B., J Prot Chem 1987, 6, 273-293.
152. Kuwajima, K., Proteins 1989, 6, 87-103.
153. Christensen, H.,;, Pain, R. H., Eur Biophys J 1991, 19, 221-229.
154. Rodionova, N. A.,;, Semisotnov, G. V.,;, Kutyshenko, V. P.,;, Uverskii, V. N.,;, Bolotina, I. A., Mol Biol (Mosk) 1989, 23, 683-692.
155. Ptitsyn, O. B.,;, Uversky, V. N., FEBS Lett 1994, 341, 15-18.
156. Uversky, V. N.,;, Ptitsyn, O. B., Fold Des 1996, 1, 117-122.
157. Hill, T. L., Thermodynamics of the Small Systems; Wiley: New York, 1963-1964.
158. Grosberg, A. Y.,;, Khokhlov, A. R., Statistical Physics of Macromolecules; Nauka: Moscow, 1989.
159. Uversky, V. N.,;, Semisotnov, G. V.,;, Pain, R. H.,;, Ptitsyn, O. B., FEBS Lett 1992, 314, 89-92.
160. Uversky, V. N., Biochim Biophys Acta 2012.
161. Uversky, V. N., Biochim Biophys Acta 2013, 1834, 932-951.
162. Lindberg, M. O.,;, Oliveberg, M., Curr Opin Struct Biol 2007, 17, 21-29.
163. Maity, H.,;, Maity, M.,;, Krishna, M. M.,;, Mayne, L.,;, Englander, S. W., Proc Natl Acad Sci U S A 2005, 102, 4741-4746.
164. Englander, S. W.,;, Mayne, L.,;, Krishna, M. M., Q Rev Biophys 2007, 40, 287-326.
165. Bedard, S.,;, Krishna, M. M.,;, Mayne, L.,;, Englander, S. W., Proc Natl Acad Sci U S A 2008, 105, 7182-7187.
166. Krishna, M. M.,;, Englander, S. W., Protein Sci 2007, 16, 449-464.
167. Dunker, A. K.,;, Garner, E.,;, Guilliot, S.,;, Romero, P.,;, Albrecht, K.,;, Hart, J.,;, Obradovic, Z.,;, Kissinger, C.,;, Villafranca, J. E., Pac Symp Biocomput 1998, 473-484.
168. Romero, P.,;, Obradovic, Z.,;, Li, X.,;, Garner, E. C.,;, Brown, C. J.,;, Dunker, A. K., Proteins 2001, 42, 38-48.
169. Garner, E.,;, Cannon, P.,;, Romero, P.,;, Obradovic, Z.,;, Dunker, A. K., Genome Inform Ser Workshop Genome Inform 1998, 9, 201-213.
170. Radivojac, P.,;, Iakoucheva, L. M.,;, Oldfield, C. J.,;, Obradovic, Z.,;, Uversky, V. N.,;, Dunker, A. K., Biophys J 2007, 92, 1439-1456.
171. Vacic, V.,;, Uversky, V. N.,;, Dunker, A. K.,;, Lonardi, S., BMC Bioinformatics 2007, 8, 211.
172. Oldfield, C. J.,;, Cheng, Y.,;, Cortese, M. S.,;, Romero, P.,;, Uversky, V. N.,;, Dunker, A. K., Biochemistry 2005, 44, 12454-12470.
173. Dunker, A. K.,;, Obradovic, Z.,;, Romero, P.,;, Garner, E. C.,;, Brown, C. J., Genome Inform Ser Workshop Genome Inform 2000, 11, 161-171.
174. Romero, P.,;, Obradovic, Z.,;, Kissinger, C. R.,;, Villafranca, J. E.,;, Garner, E.,;, Guilliot, S.,;, Dunker, A. K., Pac Symp Biocomput 1998, 437-448.
175. Ward, J. J.,;, Sodhi, J. S.,;, McGuffin, L. J.,;, Buxton, B. F.,;, Jones, D. T., J Mol Biol 2004, 337, 635-645.
176. Xue, B.,;, Dunker, A. K.,;, Uversky, V. N., J Biomol Struct Dyn 2012, 30, 137-149.
177. Iakoucheva, L. M.,;, Brown, C. J.,;, Lawson, J. D.,;, Obradovic, Z.,;, Dunker, A. K., J Mol Biol 2002, 323, 573-584.
178. Uversky, V. N.,;, Oldfield, C. J.,;, Dunker, A. K., J Mol Recognit 2005, 18, 343-384.
179. Xie, H.,;, Vucetic, S.,;, Iakoucheva, L. M.,;, Oldfield, C. J.,;, Dunker, A. K.,;, Uversky, V. N.,;, Obradovic, Z., J Proteome Res 2007, 6, 1882-1898.
180. Vucetic, S.,;, Xie, H.,;, Iakoucheva, L. M.,;, Oldfield, C. J.,;, Dunker, A. K.,;, Obradovic, Z.,;, Uversky, V. N., J Proteome Res 2007, 6, 1899-1916.
181. Liu, J.,;, Faeder, J. R.,;, Camacho, C. J., Proc Natl Acad Sci U S A 2009, 106, 19819-19823.
182. Kim, P. M.,;, Sboner, A.,;, Xia, Y.,;, Gerstein, M., Mol Syst Biol 2008, 4, 179.
183. Oldfield, C. J.,;, Meng, J.,;, Yang, J. Y.,;, Yang, M. Q.,;, Uversky, V. N.,;, Dunker, A. K., BMC Genomics 2008, 9 Suppl 1, S1.
184. Mohan, A.,;, Oldfield, C. J.,;, Radivojac, P.,;, Vacic, V.,;, Cortese, M. S.,;, Dunker, A. K.,;, Uversky, V. N., J Mol Biol 2006, 362, 1043-1059.
185. Vacic, V.,;, Oldfield, C. J.,;, Mohan, A.,;, Radivojac, P.,;, Cortese, M. S.,;, Uversky, V. N.,;, Dunker, A. K., J Proteome Res 2007, 6, 2351-2366.
186. Meszaros, B.,;, Simon, I.,;, Dosztanyi, Z., PLoS Comput Biol 2009, 5, e1000376.
187. Dosztanyi, Z.,;, Meszaros, B.,;, Simon, I., Bioinformatics 2009, 25, 2745-2746.
188. Hsu, W. L.,;, Oldfield, C.,;, Meng, J.,;, Huang, F.,;, Xue, B.,;, Uversky, V. N.,;, Romero, P.,;, Dunker, A. K., Pac Symp Biocomput 2012, 116-127.
189. Meszaros, B.,;, Simon, I.,;, Dosztanyi, Z., Phys Biol 2011, 8, 035003.
190. Hazy, E.,;, Tompa, P., ChemPhysChem 2009, 10, 1415-1419.
191. Gsponer, J.,;, Futschik, M. E.,;, Teichmann, S. A.,;, Babu, M. M., Science 2008, 322, 1365-1368.
192. Uversky, V. N.,;, Dunker, A. K., Science 2008, 322, 1340-1341.
193. Uversky, V. N.,;, Oldfield, C. J.,;, Dunker, A. K., Annu Rev Biophys 2008, 37, 215-246.
194. Uversky, V. N.,;, Oldfield, C. J.,;, Midic, U.,;, Xie, H.,;, Xue, B.,;, Vucetic, S.,;, Iakoucheva, L. M.,;, Obradovic, Z.,;, Dunker, A. K., BMC Genomics 2009, 10 Suppl 1, S7.
195. Kelly, J. W., Curr Opin Struct Biol 1998, 8, 101-106.
196. Uversky, V. N.,;, Talapatra, A.,;, Gillespie, J. R.,;, Fink, A. L., Med Sci Monitor 1999, 5, 1238-1254.
197. Uversky, V. N.,;, Talapatra, A.,;, Gillespie, J. R.,;, Fink, A. L., Med Sci Monitor 1999, 5, 1001-1012.
198. Bellotti, V.,;, Mangione, P.,;, Stoppini, M., Cell Mol Life Sci 1999, 55, 977-991.
199. Rochet, J. C.,;, Lansbury, P. T., Jr., Curr Opin Struct Biol 2000, 10, 60-68.
200. Sunde, M.,;, Serpell, L. C.,;, Bartlam, M.,;, Fraser, P. E.,;, Pepys, M. B.,;, Blake, C. C., J Mol Biol 1997, 273, 729-739.
201. Uversky, V. N.,;, Fink, A. L., Biochim Biophys Acta 2004, 1698, 131-153.
202. Lansbury, P. T., Jr., Proc Natl Acad Sci U S A 1999, 96, 3342-3344.
203. Fink, A. L., Fold Des 1998, 3, R9-23.
204. Zerovnik, E., Eur J Biochem 2002, 269, 3362-3371.
205. Kelly, J. W., Curr Opin Struct Biol 1996, 6, 11-17.
206. Wetzel, R., Adv Protein Chem 1997, 50, 183-242.
207. Canet, D.,;, Sunde, M.,;, Last, A. M.,;, Miranker, A.,;, Spencer, A.,;, Robinson, C. V.,;, Dobson, C. M., Biochemistry 1999, 38, 6419-6427.
208. Lashuel, H. A.,;, Wurth, C.,;, Woo, L.,;, Kelly, J. W., Biochemistry 1999, 38, 13560-13573.
209. Saraiva, M. J., FEBS Lett 2001, 498, 201-203.
210. Heegaard, N. H.,;, Sen, J. W.,;, Kaarsholm, N. C.,;, Nissen, M. H., J Biol Chem 2001, 276, 32657-32662.
211. Colon, W.,;, Lai, Z.,;, McCutchen, S. L.,;, Miroy, G. J.,;, Strang, C.,;, Kelly, J. W., Ciba Found Symp 1996, 199, 228-238; discussion 239-242.
212. Chiti, F.,;, Taddei, N.,;, Stefani, M.,;, Dobson, C. M.,;, Ramponi, G., Protein Sci 2001, 10, 879-886.
213. Miroy, G. J.,;, Lai, Z.,;, Lashuel, H. A.,;, Peterson, S. A.,;, Strang, C.,;, Kelly, J. W., Proc Natl Acad Sci U S A 1996, 93, 15051-15056.
214. Nielsen, L.,;, Khurana, R.,;, Coats, A.,;, Frokjaer, S.,;, Brange, J.,;, Vyas, S.,;, Uversky, V. N.,;, Fink, A. L., Biochemistry 2001, 40, 6036-6046.
215. Uversky, V. N., Front Biosci 2009, 14, 5188-5238.
216. Uversky, V. N., Curr Alzheimer Res 2008, 5, 260-287.
217. Uversky, V. N.,;, Li, J.,;, Fink, A. L., FEBS Lett 2001, 509, 31-35.
218. Pavlov, N. A.,;, Cherny, D. I.,;, Heim, G.,;, Jovin, T. M.,;, Subramaniam, V., FEBS Lett 2002, 517, 37-40.
219. Teplow, D. B., Amyloid 1998, 5, 121-142.
220. Kayed, R.,;, Bernhagen, J.,;, Greenfield, N.,;, Sweimeh, K.,;, Brunner, H.,;, Voelter, W.,;, Kapurniotu, A., J Mol Biol 1999, 287, 781-796.
221. Schweers, O.,;, Schonbrunn-Hanebeck, E.,;, Marx, A.,;, Mandelkow, E., J Biol Chem 1994, 269, 24290-24297.
222. Eliezer, D.,;, Kutluay, E.,;, Bussell, R., Jr.,;, Browne, G., J Mol Biol 2001, 307, 1061-1073.
223. Uversky, V. N., J Biomol Struct Dyn 2003, 21, 211-234.
224. Norris, E. H.,;, Giasson, B. I.,;, Lee, V. M., Curr Top Dev Biol 2004, 60, 17-54.
225. Jellinger, K. A., Mov Disord 2003, 18 Suppl 6, S2-12.
226. Dev, K. K.,;, Hofele, K.,;, Barbieri, S.,;, Buchman, V. L.,;, van der Putten, H., Neuropharmacology 2003, 45, 14-44.
227. Duda, J. E.,;, Lee, V. M.,;, Trojanowski, J. Q., J Neurosci Res 2000, 61, 121-127.
228. Mitra, K.,;, Gangopadhaya, P. K.,;, Das, S. K., Neurol India 2003, 51, 183-188.
229. Marti, M. J.,;, Tolosa, E.,;, Campdelacreu, J., Mov Disord 2003, 18 Suppl 6, S21-27.
230. Trojanowski, J. Q.,;, Lee, V. M., Ann N Y Acad Sci 2003, 991, 107-110.
231. Dickson, D. W., Curr Opin Neurol 2001, 14, 423-432.
232. Goedert, M., Clin Chem Lab Med 2001, 39, 308-312.
233. Spillantini, M. G.,;, Goedert, M., Ann N Y Acad Sci 2000, 920, 16-27.
234. Galvin, J. E.,;, Lee, V. M.,;, Trojanowski, J. Q., Arch Neurol 2001, 58, 186-190.
235. Goedert, M., Philos Trans R Soc Lond B Biol Sci 1999, 354, 1101-1118.
236. Munishkina, L. A.,;, Phelan, C.,;, Uversky, V. N.,;, Fink, A. L., Biochemistry 2003, 42, 2720-2730.
237. Uversky, V. N.,;, Li, J.,;, Fink, A. L., J Biol Chem 2001, 276, 44284-44296.
238. Munishkina, L. A.,;, Henriques, J.,;, Uversky, V. N.,;, Fink, A. L., Biochemistry 2004, 43, 3289-3300.
239. Uversky, V. N.,;, Li, J.,;, Fink, A. L., FEBS Lett 2001, 500, 105-108.
240. Uversky, V. N.,;, Li, J.,;, Bower, K.,;, Fink, A. L., Neurotoxicology 2002, 23, 527-536.
241. Manning-Bog, A. B.,;, McCormack, A. L.,;, Li, J.,;, Uversky, V. N.,;, Fink, A. L.,;, Di Monte, D. A., J Biol Chem 2002, 277, 1641-1644.
242. Cohlberg, J. A.,;, Li, J.,;, Uversky, V. N.,;, Fink, A. L., Biochemistry 2002, 41, 1502-1511.
243. Goers, J.,;, Uversky, V. N.,;, Fink, A. L., Protein Sci 2003, 12, 702-707.
244. Uversky, V. N.,;, Lee, H. J.,;, Li, J.,;, Fink, A. L.,;, Lee, S. J., J Biol Chem 2001, 276, 43495-43498.
245. Uversky, V. N.,;, Yamin, G.,;, Souillac, P. O.,;, Goers, J.,;, Glaser, C. B.,;, Fink, A. L., FEBS Lett 2002, 517, 239-244.
246. Uversky, V. N., FEBS J 2010, 277, 2940-2953.
247. Uversky, V. N.,;, Roman, A.,;, Oldfield, C. J.,;, Dunker, A. K., J Proteome Res 2006, 5, 1829-1842.
248. Cheng, Y.,;, LeGall, T.,;, Oldfield, C. J.,;, Dunker, A. K.,;, Uversky, V. N., Biochemistry 2006, 45, 10448-10460.
249. Mohan, A.,;, Sullivan, W. J., Jr.,;, Radivojac, P.,;, Dunker, A. K.,;, Uversky, V. N., Mol Biosyst 2008, 4, 328-340.
250. Midic, U.,;, Oldfield, C. J.,;, Dunker, A. K.,;, Obradovic, Z.,;, Uversky, V. N., BMC Genomics 2009, 10 (suppl. 1), S12.
251. Goh, K. I.,;, Cusick, M. E.,;, Valle, D.,;, Childs, B.,;, Vidal, M.,;, Barabasi, A. L., Proc Natl Acad Sci U S A 2007, 104, 8685-8690.
252. Xie, H.,;, Vucetic, S.,;, Iakoucheva, L. M.,;, Oldfield, C. J.,;, Dunker, A. K.,;, Obradovic, Z.,;, Uversky, V. N., J Proteome Res 2007, 6, 1917-1932.
253. Wells, M.,;, Tidow, H.,;, Rutherford, T. J.,;, Markwick, P.,;, Jensen, M. R.,;, Mylonas, E.,;, Svergun, D. I.,;, Blackledge, M.,;, Fersht, A. R., Proc Natl Acad Sci U S A 2008, 105, 5762-5767.
254. Mittag, T.,;, Orlicky, S.,;, Choy, W. Y.,;, Tang, X.,;, Lin, H.,;, Sicheri, F.,;, Kay, L. E.,;, Tyers, M.,;, Forman-Kay, J. D., Proc Natl Acad Sci U S A 2008, 105, 17772-17777.
255. Mittag, T.,;, Kay, L. E.,;, Forman-Kay, J. D., J Mol Recognit 2010, 23, 105-116.
256. McDowell, C.,;, Chen, J., J Mol Biol 2013, 425, 999-1010.