Crystal structure of a human prion protein fragment reveals a motif for oligomer formation

Journal of the American Chemical Society

Volumn 135, Issue 28, 2013, Pages 10202-10205

  Apostol, Marcin I ^a,c   Perry, Kay ^b   Surewicz, Witold K ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN PRION PROTEIN; OLIGOMER FORMATIONS; POSSIBLE MECHANISMS; PROTEIN AGGREGATES; SELFPROPAGATION; STRUCTURAL MOTIFS; STRUCTURAL TRANSITIONS; STRUCTURE CHARACTERISTIC;

PROTEINS;

OLIGOMERS;

AMYLOID; OLIGOMER; PRION PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISULFIDE BOND; PROTEIN CONFORMATION;

CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; PRIONS; PROTEIN CONFORMATION;

EID: 84880377094     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja403001q     Document Type: Article

References (29)

1. Haass, C.; Selkoe, D. J. Nat. Rev. Mol. Cell Biol. 2007, 8, 101
2. Sandberg, M. K.; Al-Doujaily, H.; Sharps, B.; Clarke, A. R.; Collinge, J. Nature 2011, 470, 540
3. Silveira, J. R.; Raymond, G. J.; Hughson, A. G.; Race, R. E.; Sim, V. L.; Hayes, S. F.; Caughey, B. Nature 2005, 437, 257
4. Nelson, R.; Sawaya, M. R.; Balbirnie, M.; Madsen, A. Ø.; Riekel, C.; Grothe, R.; Eisenberg, D. Nature 2005, 435, 773
5. Sawaya, M. R.; Sambashivan, S.; Nelson, R.; Ivanova, M. I.; Sievers, S. A.; Apostol, M. I.; Thompson, M. J.; Balbirnie, M.; Wiltzius, J. J. W.; McFarlane, H. T.; Madsen, A. Ø.; Riekel, C.; Eisenberg, D. Nature 2007, 447, 453
6. Wiltzius, J. J. W.; Sievers, S. A.; Sawaya, M. R.; Cascio, D.; Popov, D.; Riekel, C.; Eisenberg, D. Protein Sci. 2008, 17, 1467
7. Wiltzius, J. J. W.; Landau, M.; Nelson, R.; Sawaya, M. R.; Apostol, M. I.; Goldschmidt, L.; Soriaga, A. B.; Cascio, D.; Rajashankar, K.; Eisenberg, D. Nat. Struct. Mol. Biol. 2009, 16, 973
8. Ivanova, M. I.; Sievers, S. A.; Sawaya, M. R.; Wall, J. S.; Eisenberg, D. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 18990
9. Apostol, M. I.; Wiltzius, J. J. W.; Sawaya, M. R.; Cascio, D.; Eisenberg, D. Biochemistry 2011, 50, 2456
10. Colletier, J.-P.; Laganowsky, A.; Landau, M.; Zhao, M.; Soriaga, A. B.; Goldschmidt, L.; Flot, D.; Cascio, D.; Sawaya, M. R.; Eisenberg, D. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 16938
11. Apostol, M. I.; Sawaya, M. R.; Cascio, D.; Eisenberg, D. J. Biol. Chem. 2010, 285, 29671
12. Fändrich, M. J. Mol. Biol. 2012, 421, 427
13. Laganowsky, A.; Liu, C.; Sawaya, M. R.; Whitelegge, J. P.; Park, J.; Zhao, M.; Pensalfini, A.; Soriaga, A. B.; Landau, M.; Teng, P. K.; Cascio, D.; Glabe, C.; Eisenberg, D. Science 2012, 335, 1228
14. Cobb, N. J.; Sönnichsen, F. D.; McHaourab, H.; Surewicz, W. K. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 18946
15. Tycko, R.; Savtchenko, R.; Ostapchenko, V. G.; Makarava, N.; Baskakov, I. V. Biochemistry 2010, 49, 9488
16. Chakroun, N.; Prigent, S.; Dreiss, C. A.; Noinville, S.; Chapuis, C.; Fraternali, F.; Rezaei, H. FASEB J. 2010, 24, 3222
17. Smirnovas, V.; Baron, G. S.; Offerdahl, D. K.; Raymond, G. J.; Caughey, B.; Surewicz, W. K. Nat. Struct. Mol. Biol 2011, 18, 504
18. Govaerts, C.; Wille, H.; Prusiner, S. B.; Cohen, F. E. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 8342
19. DeMarco, M. L.; Daggett, V. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 2293
20. Liu, C.; Sawaya, M. R.; Cheng, P.-N.; Zheng, J.; Nowick, J. S.; Eisenberg, D. J. Am. Chem. Soc. 2011, 133, 6736
21. Shimizu, T.; Morikawa, K. Trends Biochem. Sci. 1996, 21, 3
22. Fändrich, M. J. Mol. Biol. 2012, 421, 427
23. Richardson, J. S.; Richardson, D. C. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 2754
24. Lu, X.; Wintrode, P. L.; Surewicz, W. K. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 1510
25. Kayed, R.; Head, E.; Thompson, J. L.; McIntire, T. M.; Milton, S. C.; Cotman, C. W.; Glabe, C. G. Science 2003, 300, 486
26. Jarrett, J. T.; Lansbury, P. T. Cell 1993, 73, 1055
27. Hall, D.; Edskes, H. J. Mol. Biol. 2004, 336, 775
28. Bett, C.; Joshi-Barr, S.; Lucero, M.; Trejo, M.; Liberski, P.; Kelly, J. W.; Masliah, E.; Sigurdson, C. J. PLoS Pathog. 2012, 8 e1002522
29. Legname, G.; Baskakov, I. V.; Nguyen, H.-O. B.; Riesner, D.; Cohen, F. E.; DeArmond, S. J.; Prusiner, S. B. Science 2004, 305, 673