Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: Insights into the roles of particles in the protein aggregation pathway

Journal of Pharmaceutical Sciences

Volumn 100, Issue 2, 2011, Pages 492-503

  Barnard, James G ^a   Singh, Satish ^b   Randolph, Theodore W ^c   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b PFIZER INC   (United States)

^c University of Colorado   (United States)

Author keywords

Infrared spectroscopy; Liquid chromatography; Particle size; Protein aggregation; Protein formulation

Indexed keywords

HISTIDINE; MONOCLONAL ANTIBODY; PHOSPHATE BUFFERED SALINE; PROTEIN;

ANALYTIC METHOD; ARTICLE; FREEZE THAWING; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MASS; MICROFLOW IMAGING; PARTICLE SIZE; PH; PROTEIN AGGREGATION; SENSITIVITY ANALYSIS;

EID: 78650577461     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22305     Document Type: Article

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