Structural characterization of a mutated, ADCC-enhanced human Fc fragment

Molecular Immunology

Volumn 45, Issue 7, 2008, Pages 1872-1882

  Oganesyan, Vaheh ^a   Damschroder, Melissa M ^a   Leach, William ^a   Wu, Herren ^a   Dall'Acqua, William F ^a  

^a MEDIMMUNE   (United States)

Author keywords

Antibody dependent cellular cytotoxicity; Effector function; Fc; Immunoglobulin G; X ray crystal structure

Indexed keywords

CD16 ANTIGEN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; MUTANT PROTEIN;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IMMUNOGLOBULIN STRUCTURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; THERMOSTABILITY;

ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CALORIMETRY, DIFFERENTIAL SCANNING; CARBOHYDRATES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; LIGANDS; METALS; MODELS, MOLECULAR; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, IGG; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRANSITION TEMPERATURE;

EID: 39149106011     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.10.042     Document Type: Article

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