Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces

Journal of Pharmaceutical Sciences

Volumn 102, Issue 2, 2013, Pages 429-440

  Gerhardt, Alana ^a   Bonam, Kurt ^a   Bee, Jared S ^b   Carpenter, John F ^c   Randolph, Theodore W ^a  

^a UCB 450   (United States)

^b MEDIMMUNE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Adsorption; Calorimetry (DSC); Fluorescence spectroscopy; Protein aggregation; Protein formulation; Structure

Indexed keywords

IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; SILICONE OIL; TRYPTOPHAN; WATER;

ADSORPTION; ANTIBODY STRUCTURE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; FLUORESCENCE ANALYSIS; IONIC STRENGTH; PHOTOCHEMICAL QUENCHING; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; THERMAL STIMULATION;

EID: 84872490861     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23408     Document Type: Article

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