High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: Thermodynamics, kinetics, and application to accelerated formulation studies

Protein Science

Volumn 14, Issue 9, 2005, Pages 2258-2266

  Seefeldt, Matthew B ^a   Kim, Yong Sung ^b   Tolley, Kevin P ^c   Seely, Jim ^c   Carpenter, John F ^d   Randolph, Theodore W ^a  

^a UCB 450   (United States)

^b Ajou University   (South Korea)

^c AMGEN INC   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Coefficient of adiabatic compressibility; Disulfide bonds; Protein structure folding; Specific volume

Indexed keywords

CYSTEINE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT PROTEIN; SOLVENT;

ARTICLE; CROSS LINKING; DISULFIDE BOND; ENERGY; HYDROSTATIC PRESSURE; KINETICS; OXIDATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; THERMODYNAMICS;

DISULFIDES; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; KINETICS; OXIDATION-REDUCTION; PRESSURE; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SIALOGLYCOPROTEINS; THERMODYNAMICS;

EID: 24344491042     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.051490205     Document Type: Article

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