Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor

Protein Science

Volumn 12, Issue 5, 2003, Pages 903-913

  Chi, Eva Y ^a   Krishnan, Sampathkumar ^b   Kendrick, Brent S ^b   Chang, Byeong S ^b   Carpenter, John F ^c   Randolph, Theodore W ^a  

^a UCB 450   (United States)

^b AMGEN INC   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Activation energy; Light scattering; Non native protein aggregation; Osmotic second virial coefficient; Protein formulation strategy; Protein interactions; Protein stability; RhGCSF

Indexed keywords

RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ALPHA HELIX; ARTICLE; COLLOID; COLLOIDAL STABILITY; CONFORMATIONAL STABILITY; CONFORMATIONAL TRANSITION; LIGHT SCATTERING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; OSMOTIC SECOND VIRIAL COEFFICIENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; REFRACTION INDEX;

COLLOIDS; DIMERIZATION; DRUG STABILITY; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; PROTEIN CONFORMATION; PROTEIN DENATURATION; RECOMBINANT PROTEINS; SOLUTIONS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMODYNAMICS;

EID: 0242515822     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.0235703     Document Type: Article

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