-
2
-
-
84865455090
-
The future of antibodies as cancer drugs
-
Reichert JM, Dhimolea E. The future of antibodies as cancer drugs. Drug Discov Today 2012; 17(17-18): 954-63.
-
(2012)
Drug Discov Today
, vol.17
, Issue.17-18
, pp. 954-963
-
-
Reichert, J.M.1
Dhimolea, E.2
-
3
-
-
79953012996
-
Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties
-
Pirie CM, Hackel BJ, Rosenblum MG, Wittrup KD. Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties. J Biol Chem 2011; 286(6): 4165-72.
-
(2011)
J Biol Chem
, vol.286
, Issue.6
, pp. 4165-4172
-
-
Pirie, C.M.1
Hackel, B.J.2
Rosenblum, M.G.3
Wittrup, K.D.4
-
4
-
-
79960820705
-
Immunotoxins and anticancer drug conjugate assemblies: The role of the linkage between components
-
Dosio F, Brusa P, Cattel L. Immunotoxins and anticancer drug conjugate assemblies: The role of the linkage between components. Toxins 2011; 3(7): 848-83.
-
(2011)
Toxins
, vol.3
, Issue.7
, pp. 848-883
-
-
Dosio, F.1
Brusa, P.2
Cattel, L.3
-
5
-
-
84869164607
-
Risks and untoward toxicities of antibody-based immunoconjugates
-
Litvak-Greenfeld D, Benhar I. Risks and untoward toxicities of antibody-based immunoconjugates. Adv Drug Deliv Rev 2012; 64(15): 1782-99.
-
(2012)
Adv Drug Deliv Rev
, vol.64
, Issue.15
, pp. 1782-1799
-
-
Litvak-Greenfeld, D.1
Benhar, I.2
-
6
-
-
79955104910
-
Human toxin-based recombinant immunotoxins/ chimeric proteins as a drug delivery system for targeted treatment of human diseases
-
Lorberboum-Galski H. Human toxin-based recombinant immunotoxins/ chimeric proteins as a drug delivery system for targeted treatment of human diseases. Exp Opin Drug Deliv 2011; 8(5): 605-21.
-
(2011)
Exp Opin Drug Deliv
, vol.8
, Issue.5
, pp. 605-621
-
-
Lorberboum-Galski, H.1
-
8
-
-
79952528150
-
Engineering toxins for 21st century therapies
-
Chaddock JA, Acharya KR. Engineering toxins for 21st century therapies. FEBS J 2011; 278(6): 899-904.
-
(2011)
FEBS J
, vol.278
, Issue.6
, pp. 899-904
-
-
Chaddock, J.A.1
Acharya, K.R.2
-
9
-
-
79958187876
-
Therapeutic potential of anticancer immunotoxins
-
Choudhary S, Mathew M, Verma RS. Therapeutic potential of anticancer immunotoxins. Drug Discov Today 2011; 16(11): 495-503.
-
(2011)
Drug Discov Today
, vol.16
, Issue.11
, pp. 495-503
-
-
Choudhary, S.1
Mathew, M.2
Verma, R.S.3
-
10
-
-
84864068407
-
Therapeutic targets and recent advances in protein immunotoxins
-
Madhumathi J, Verma RS. Therapeutic targets and recent advances in protein immunotoxins. Curr Opin Microbiol 2012; 15(3): 300-9.
-
(2012)
Curr Opin Microbiol
, vol.15
, Issue.3
, pp. 300-309
-
-
Madhumathi, J.1
Verma, R.S.2
-
11
-
-
60849116672
-
Pseudomonas exotoxin A: From virulence factor to anti-cancer agent
-
Wolf P, Elsasser-Beile U. Pseudomonas exotoxin A: From virulence factor to anti-cancer agent. Int J Med Microbiol 2009; 299(3): 161-76.
-
(2009)
Int J Med Microbiol
, vol.299
, Issue.3
, pp. 161-176
-
-
Wolf, P.1
Elsasser-Beile, U.2
-
12
-
-
67649933809
-
Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia
-
Kreitman RJ, Stetler-Stevenson M, Margulies I, Noel P, FitzGerald DJP, Wilson WH, et al. Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. J Clin Oncol 2009; 27(18): 2983-90.
-
(2009)
J Clin Oncol
, vol.27
, Issue.18
, pp. 2983-2990
-
-
Kreitman, R.J.1
Stetler-Stevenson, M.2
Margulies, I.3
Noel, P.4
Fitzgerald, D.J.P.5
Wilson, W.H.6
-
13
-
-
77949679970
-
Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: Preclinical studies and Phase I clinical trial
-
Wayne AS, Kreitman RJ, Findley HW, Lew G, Delbrook C, Steinberg SM, et al. Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: Preclinical studies and Phase I clinical trial. Clin Cancer Res 2010; 16(6): 1894-903.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.6
, pp. 1894-1903
-
-
Wayne, A.S.1
Kreitman, R.J.2
Findley, H.W.3
Lew, G.4
Delbrook, C.5
Steinberg, S.M.6
-
14
-
-
61349115036
-
CAT-8015: A second-generation Pseudomonas exotoxin abased immunotherapy targeting CD22-expressing hematologic malignancies
-
Alderson RF, Kreitman RJ, Chen T, Yeung P, Herbst R, Fox J, et al. CAT-8015: A second-generation Pseudomonas exotoxin abased immunotherapy targeting CD22-expressing hematologic malignancies. Clin Cancer Res 2009; 15(3): 832-9.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.3
, pp. 832-839
-
-
Alderson, R.F.1
Kreitman, R.J.2
Chen, T.3
Yeung, P.4
Herbst, R.5
Fox, J.6
-
15
-
-
0036554968
-
Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display
-
Salvatore G, Beers R, Margulies I, Kreitman RJ, Pastan I. Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display. Clin Cancer Res 2002; 8(4): 995-1002.
-
(2002)
Clin Cancer Res
, vol.8
, Issue.4
, pp. 995-1002
-
-
Salvatore, G.1
Beers, R.2
Margulies, I.3
Kreitman, R.J.4
Pastan, I.5
-
16
-
-
84901246833
-
-
WO2003027135
-
Pastan, I.H., Salvatore, G., Beers, R., Kreitman, R.J. Mutated anti- CD22 antibodies with increased affinity to CD22-expressing leukemia cells. WO2003027135 (2003).
-
(2003)
Mutated Anti- CD22 Antibodies With Increased Affinity to CD22-expressing Leukemia Cells
-
-
Pastan, I.H.1
Salvatore, G.2
Beers, R.3
Kreitman, R.J.4
-
17
-
-
84861542159
-
Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia
-
Kreitman RJ, Tallman MS, Robak T, Coutre S, Wilson WH, Stetler-Stevenson M, et al. Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. J Clin Oncol 2012; 30(15): 1822-8.
-
(2012)
J Clin Oncol
, vol.30
, Issue.15
, pp. 1822-1828
-
-
Kreitman, R.J.1
Tallman, M.S.2
Robak, T.3
Coutre, S.4
Wilson, W.H.5
Stetler-Stevenson, M.6
-
18
-
-
84901264843
-
Durability of complete remission by moxetumomab pasudotox (HA22 or CAT-8015) assessed by clone-specific real-time quantitative PCR (RQ-PCR)
-
Kreitman RJ, Arons E, Sapolsky J, Roth L, Zhou H, Wilson WH, et al. Durability of complete remission by moxetumomab pasudotox (HA22 or CAT-8015) assessed by clone-specific real-time quantitative PCR (RQ-PCR). J Clin Oncol 2012; 30: Abs 2503.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2503
-
-
Kreitman, R.J.1
Arons, E.2
Sapolsky, J.3
Roth, L.4
Zhou, H.5
Wilson, W.H.6
-
19
-
-
84901258919
-
-
US20120177567
-
Wayne, A.S., Pastan, I., Kaucic, K., Lechleider, R. Methods of treating pediatric acute lymphoblastic leukemia with an anti-CD22 immunotoxin. US20120177567 (2012).
-
(2012)
Methods of Treating Pediatric Acute Lymphoblastic Leukemia With An Anti-CD22 Immunotoxin
-
-
Wayne, A.S.1
Pastan, I.2
Kaucic, K.3
Lechleider, R.4
-
21
-
-
84901272734
-
-
WO2007016150
-
Pastan, I.H., Onda, M., Nagata, S., Fitzgerald, D., Kreitman, R., Lee, B. Mutated Pseudomonas exotoxins with reduced antigenicity. WO2007016150 (2007).
-
(2007)
Mutated Pseudomonas Exotoxins With Reduced Antigenicity
-
-
Pastan, I.H.1
Onda, M.2
Nagata, S.3
Fitzgerald, D.4
Kreitman, R.5
Lee, B.6
-
22
-
-
65549146468
-
A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
-
Weldon JE, Xiang L, Chertov O, Margulies I, Kreitman RJ, Fitzgerald DJ, et al. A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. Blood 2009; 113(16): 3792-800.
-
(2009)
Blood
, vol.113
, Issue.16
, pp. 3792-3800
-
-
Weldon, J.E.1
Xiang, L.2
Chertov, O.3
Margulies, I.4
Kreitman, R.J.5
Fitzgerald, D.J.6
-
25
-
-
84555186831
-
A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity
-
Liu WH, Onda M, Kim C, Xiang LM, Weldon JE, Lee B, et al. A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. Protein Eng Des Sel 2012; 25(1): 1-6.
-
(2012)
Protein Eng Des Sel
, vol.25
, Issue.1
, pp. 1-6
-
-
Liu, W.H.1
Onda, M.2
Kim, C.3
Xiang, L.M.4
Weldon, J.E.5
Lee, B.6
-
26
-
-
84863957822
-
Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes
-
Liu W, Onda M, Lee B, Kreitman RJ, Hassan R, Xiang L, et al. Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. Proc Nat Acad Sci USA 2012; 109(29): 11782-7.
-
(2012)
Proc Nat Acad Sci USA
, vol.109
, Issue.29
, pp. 11782-11787
-
-
Liu, W.1
Onda, M.2
Lee, B.3
Kreitman, R.J.4
Hassan, R.5
Xiang, L.6
-
28
-
-
84901277439
-
-
WO02040545
-
Pastan IH, Onda M, Nagata S, Tsutsumi Y, Vincent JJ, Kreitman RJ, Vasmatzis, G., Lee, B. Reduction of the nonspecific animal toxicity of immunotoxins by mutating the framework regions of the fv to lower the isoelectric point. WO02040545 (2002).
-
(2002)
Reduction of the Nonspecific Animal Toxicity of Immunotoxins By Mutating the Framework Regions of the Fv to Lower the Isoelectric Point
-
-
Pastan, I.H.1
Onda, M.2
Nagata, S.3
Tsutsumi, Y.4
Vincent, J.J.5
Kreitman, R.J.6
Vasmatzis, G.7
Lee, B.8
-
30
-
-
0034001076
-
Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies
-
Kreitman RJ, Wilson WH, White JD, Stetler-Stevenson M, Jaffe ES, Giardina S, et al. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol 2000; 18(8): 1622-36.
-
(2000)
J Clin Oncol
, vol.18
, Issue.8
, pp. 1622-1636
-
-
Kreitman, R.J.1
Wilson, W.H.2
White, J.D.3
Stetler-Stevenson, M.4
Jaffe, E.S.5
Giardina, S.6
-
31
-
-
84855431169
-
Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy
-
Singh R, Zhang Y, Pastan I, Kreitman RJ. Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy. Clin Cancer Res 2012; 18(1): 152-60.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.1
, pp. 152-160
-
-
Singh, R.1
Zhang, Y.2
Pastan, I.3
Kreitman, R.J.4
-
32
-
-
81555214408
-
A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
-
Weldon JE, Pastan I. A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. FEBS J 2011; 278(23): 4683-700.
-
(2011)
FEBS J
, vol.278
, Issue.23
, pp. 4683-4700
-
-
Weldon, J.E.1
Pastan, I.2
-
33
-
-
79954986910
-
Renal excretion of recombinant immunotoxins containing pseudomonas exotoxin
-
Traini R, Kreitman RJ. Renal excretion of recombinant immunotoxins containing pseudomonas exotoxin. Bioconjug Chem 2011; 22(4): 736-40.
-
(2011)
Bioconjug Chem
, vol.22
, Issue.4
, pp. 736-740
-
-
Traini, R.1
Kreitman, R.J.2
-
35
-
-
0036007596
-
Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia
-
Hamann PR, Hinman LM, Hollander I, Beyer CF, Lindh D, Holcomb R, et al. Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Bioconjug Chem 2002; 13(1): 47-58.
-
(2002)
Bioconjug Chem
, vol.13
, Issue.1
, pp. 47-58
-
-
Hamann, P.R.1
Hinman, L.M.2
Hollander, I.3
Beyer, C.F.4
Lindh, D.5
Holcomb, R.6
-
37
-
-
0030993628
-
In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin
-
Waurzyniak B, Schneider EA, Tumer N, Yanishevski Y, Gunther R, Chelstrom LM, et al. In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin. Clin Cancer Res 1997; 3(6): 881-90.
-
(1997)
Clin Cancer Res
, vol.3
, Issue.6
, pp. 881-890
-
-
Waurzyniak, B.1
Schneider, E.A.2
Tumer, N.3
Yanishevski, Y.4
Gunther, R.5
Chelstrom, L.M.6
-
38
-
-
0030847302
-
Therapy of patients with T-Cell lymphomas and leukemias using an anti-CD7 monoclonal antibody-ricin A chain immunotoxin
-
Frankel AE, Laver JH, Willingham MC, Burns LJ, Kersey JH, Vallera DA. Therapy of patients with T-Cell lymphomas and leukemias using an anti-CD7 monoclonal antibody-ricin A chain immunotoxin. Leuk Lymphoma 1997; 26(3-4): 287-98.
-
(1997)
Leuk Lymphoma
, vol.26
, Issue.3-4
, pp. 287-298
-
-
Frankel, A.E.1
Laver, J.H.2
Willingham, M.C.3
Burns, L.J.4
Kersey, J.H.5
Vallera, D.A.6
-
39
-
-
0032535057
-
Host-mediated antibody- dependent cellular cytotoxicity contributes to the in vivo therapeutic efficacy of an anti-CD7-saporin immunotoxin in a severe combined immunodeficient mouse model of human T-cell acute lymphoblastic leukemia
-
Flavell DJ, Warnes S, Noss A, Flavell SU. Host-mediated antibody- dependent cellular cytotoxicity contributes to the in vivo therapeutic efficacy of an anti-CD7-saporin immunotoxin in a severe combined immunodeficient mouse model of human T-cell acute lymphoblastic leukemia. Cancer Res 1998; 58(24): 5787-94.
-
(1998)
Cancer Res
, vol.58
, Issue.24
, pp. 5787-5794
-
-
Flavell, D.J.1
Warnes, S.2
Noss, A.3
Flavell, S.U.4
-
41
-
-
0037093199
-
A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells
-
Peipp M, Kupers H, Saul D, Schlierf B, Greil J, Zunino SJ, et al. A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells. Cancer Res 2002; 62(10): 2848-55.
-
(2002)
Cancer Res
, vol.62
, Issue.10
, pp. 2848-2855
-
-
Peipp, M.1
Kupers, H.2
Saul, D.3
Schlierf, B.4
Greil, J.5
Zunino, S.J.6
-
43
-
-
84858645667
-
A human recombinant autoantibody-based immunotoxin specific for the fetal acetylcholine receptor inhibits rhabdomyosarcoma growth in vitro and in a murine transplantation model
-
doi: 10.1155/2010/187621
-
Gattenlohner S, Jorissen H, Huhn M, Vincent A, Beeson D, Tzartos S, et al. A human recombinant autoantibody-based immunotoxin specific for the fetal acetylcholine receptor inhibits rhabdomyosarcoma growth in vitro and in a murine transplantation model. J Biomed Biotechnol 2010; 2010: 187621. doi: 10.1155/2010/187621.
-
(2010)
J Biomed Biotechnol
, pp. 2010
-
-
Gattenlohner, S.1
Jorissen, H.2
Huhn, M.3
Vincent, A.4
Beeson, D.5
Tzartos, S.6
-
45
-
-
84901285427
-
-
CN102206283
-
Zhao, Y., Ma, J., Chen, Z., Jiao, Y., Cui, B. Recombinant human PE38sBAFF immunotoxin and coding gene and use thereof. CN102206283 (2011).
-
(2011)
Recombinant Human PE38sBAFF Immunotoxin and Coding Gene and Use Thereof
-
-
Zhao, Y.1
Ma, J.2
Chen, Z.3
Jiao, Y.4
Cui, B.5
-
46
-
-
37249038187
-
Mesothelin targeted cancer immunotherapy
-
Hassan R, Ho M. Mesothelin targeted cancer immunotherapy. Eur J Cancer 2008; 44(1): 46-53.
-
(2008)
Eur J Cancer
, vol.44
, Issue.1
, pp. 46-53
-
-
Hassan, R.1
Ho, M.2
-
47
-
-
69349100450
-
Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P
-
Kreitman RJ, Hassan R, FitzGerald DJ, Pastan I. Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P. Clin Cancer Res 2009; 15(16): 5274-9.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.16
, pp. 5274-5279
-
-
Kreitman, R.J.1
Hassan, R.2
Fitzgerald, D.J.3
Pastan, I.4
-
48
-
-
34548858453
-
Phase I study of SS1P, a recombinant antimesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers
-
Hassan R, Bullock S, Premkumar A, Kreitman RJ, Kindler H, Willingham MC, et al. Phase I study of SS1P, a recombinant antimesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Clin Cancer Res 2007; 13(17): 5144-9.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.17
, pp. 5144-5149
-
-
Hassan, R.1
Bullock, S.2
Premkumar, A.3
Kreitman, R.J.4
Kindler, H.5
Willingham, M.C.6
-
49
-
-
84863575468
-
Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors
-
Pak Y, Zhang YJ, Pastan I, Lee B. Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors. Cancer Res 2012; 72(13): 3143-52.
-
(2012)
Cancer Res
, vol.72
, Issue.13
, pp. 3143-3152
-
-
Pak, Y.1
Zhang, Y.J.2
Pastan, I.3
Lee, B.4
-
50
-
-
80052845094
-
Killing of resistant cancer cells with low bak by a combination of an antimesothelin immunotoxin and a TRAIL receptor 2 agonist antibody
-
Du X, Xiang L, Mackall C, Pastan I. Killing of resistant cancer cells with low bak by a combination of an antimesothelin immunotoxin and a TRAIL receptor 2 agonist antibody. Clin Cancer Res 2011; 17(18): 5926-34.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.18
, pp. 5926-5934
-
-
Du, X.1
Xiang, L.2
Mackall, C.3
Pastan, I.4
-
51
-
-
0032837077
-
Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the ErbB2 receptor
-
Pai-Scherf LH, Villa J, Pearson D, Watson T, Liu E, Willingham MC, et al. Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the ErbB2 receptor. Clin Cancer Res 1999; 5(9): 2311-5.
-
(1999)
Clin Cancer Res
, vol.5
, Issue.9
, pp. 2311-2315
-
-
Pai-Scherf, L.H.1
Villa, J.2
Pearson, D.3
Watson, T.4
Liu, E.5
Willingham, M.C.6
-
52
-
-
25844517682
-
Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomas
-
von Minckwitz G, Harder S, Hovelmann S, Jager E, Al-Batran SE, Loibl S, et al. Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomas. Breast Cancer Res 2005; 7(5): R617-26.
-
(2005)
Breast Cancer Res
, vol.7
, Issue.5
-
-
von Minckwitz, G.1
Harder, S.2
Hovelmann, S.3
Jager, E.4
Al-Batran, S.E.5
Loibl, S.6
-
53
-
-
67651159855
-
A Phase I clinical study of VB4-845: Weekly intratumoral administration of an anti-EpCAM recombinant fusion protein in patients with squamous cell carcinoma of the head and neck
-
MacDonald GC, Rasamoelisolo M, Entwistle J, Cizeau J, Bosc D, Cuthbert W, et al. A Phase I clinical study of VB4-845: Weekly intratumoral administration of an anti-EpCAM recombinant fusion protein in patients with squamous cell carcinoma of the head and neck. Drug Des Devel Ther 2008; 2: 105-14.
-
(2008)
Drug Des Devel Ther
, vol.2
, pp. 105-114
-
-
Macdonald, G.C.1
Rasamoelisolo, M.2
Entwistle, J.3
Cizeau, J.4
Bosc, D.5
Cuthbert, W.6
-
54
-
-
79952483522
-
A Phase i study of an intravesically administered immunotoxin targeting EpCAM for the treatment of nonmuscleinvasive bladder cancer in BCG-refractory and BCG-intolerant patients
-
Kowalski M, Entwistle J, Cizeau J, Niforos D, Loewen S, Chapman W, et al. A Phase i study of an intravesically administered immunotoxin targeting EpCAM for the treatment of nonmuscleinvasive bladder cancer in BCG-refractory and BCG-intolerant patients. Drug Des Devel Ther 2010; 4: 313-20.
-
(2010)
Drug Des Devel Ther
, vol.4
, pp. 313-320
-
-
Kowalski, M.1
Entwistle, J.2
Cizeau, J.3
Niforos, D.4
Loewen, S.5
Chapman, W.6
-
55
-
-
84867401750
-
A Phase II study of oportuzumab monatox: An immunotoxin therapy for patients with noninvasive urothelial carcinoma in situ previously treated with bacillus Calmette-Guarin
-
Kowalski M, Guindon J, Brazas L, Moore C, Entwistle J, Cizeau J, et al. A Phase II study of oportuzumab monatox: An immunotoxin therapy for patients with noninvasive urothelial carcinoma in situ previously treated with bacillus Calmette-Guarin. J Urol 2012; 188(5): 1712-8.
-
(2012)
J Urol
, vol.188
, Issue.5
, pp. 1712-1718
-
-
Kowalski, M.1
Guindon, J.2
Brazas, L.3
Moore, C.4
Entwistle, J.5
Cizeau, J.6
-
58
-
-
84901261023
-
-
US20120076780
-
Barnea, I., Benhar, I., Ben-Yosef, R., Vexler, A. Recombinant fusion protein and polynucleotide construct for immunotoxin production. US20120076780 (2012).
-
(2012)
Recombinant Fusion Protein and Polynucleotide Construct For Immunotoxin Production
-
-
Barnea, I.1
Benhar, I.2
Ben-Yosef, R.3
Vexler, A.4
-
59
-
-
79952265972
-
Toxin-based therapeutic approaches
-
Shapira A, Benhar I. Toxin-based therapeutic approaches. Toxins 2010; 2(11): 2519-83.
-
(2010)
Toxins
, vol.2
, Issue.11
, pp. 2519-2583
-
-
Shapira, A.1
Benhar, I.2
-
60
-
-
0026486446
-
Selective inhibition of tumor cell growth by a recombinant single-chain antibody- toxin specific for the erbB-2 receptor
-
Wels W, Harwerth IM, Mueller M, Groner B, Hynes NE. Selective inhibition of tumor cell growth by a recombinant single-chain antibody- toxin specific for the erbB-2 receptor. Cancer Res 1992; 52(22): 6310-7.
-
(1992)
Cancer Res
, vol.52
, Issue.22
, pp. 6310-6317
-
-
Wels, W.1
Harwerth, I.M.2
Mueller, M.3
Groner, B.4
Hynes, N.E.5
-
62
-
-
77249117763
-
Clinical benefits of mastectomy on treatment of occult breast carcinoma presenting axillary metastases
-
Wang X, Zhao Y, Xuchen C. Clinical benefits of mastectomy on treatment of occult breast carcinoma presenting axillary metastases. Breast J 2010; 16(1): 32-7.
-
(2010)
Breast J
, vol.16
, Issue.1
, pp. 32-37
-
-
Wang, X.1
Zhao, Y.2
Xuchen, C.3
-
63
-
-
84901248021
-
-
CN101148475
-
Niu, R., Zhang, L., Wang, D., Shi, Y., Wei, X., Yang, Y., Huang, J., Niu, Y., Sun, B., Hao, X. Human breast cancer resisting recombination immunotoxin M4G3/ScFv-PE40. CN101148475 (2008).
-
(2008)
Human Breast Cancer Resisting Recombination Immunotoxin M4G3/ScFv-PE40
-
-
Niu, R.1
Zhang, L.2
Wang, D.3
Shi, Y.4
Wei, X.5
Yang, Y.6
Huang, J.7
Niu, Y.8
Sun, B.9
Hao, X.10
-
64
-
-
77953042515
-
Naptumomab estafenatox, an engineered antibody- superantigen fusion protein with low toxicity and reduced antigenicity
-
Forsberg G, Skartved NJ, Wallen-Ohman M, Nyhlen HC, Behm K, Hedlund G, et al. Naptumomab estafenatox, an engineered antibody- superantigen fusion protein with low toxicity and reduced antigenicity. J Immunother 2010; 33(5): 492-9.
-
(2010)
J Immunother
, vol.33
, Issue.5
, pp. 492-499
-
-
Forsberg, G.1
Skartved, N.J.2
Wallen-Ohman, M.3
Nyhlen, H.C.4
Behm, K.5
Hedlund, G.6
-
65
-
-
84901248300
-
-
US20090269343
-
Bigner, D., Kuan, C.-T., Pastan, I.H., Pegram, C.N. Dual specific immunotoxin for brain tumor therapy. US20090269343 (2009).
-
(2009)
Dual Specific Immunotoxin For Brain Tumor Therapy
-
-
Bigner, D.1
Kuan, C.-T.2
Pastan, I.H.3
Pegram, C.N.4
-
66
-
-
84901259702
-
-
WO2012075490
-
Bigner, D., Kuan, C.-T., Pastan, I.H., Chandramohan, V. Antipodoplanin antibodies and methods of use. WO2012075490 (2012).
-
(2012)
Antipodoplanin Antibodies and Methods of Use
-
-
Bigner, D.1
Kuan, C.-T.2
Pastan, I.H.3
Chandramohan, V.4
-
67
-
-
79960915225
-
Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx
-
Huber GF, Fritzsche FR, Zullig L, Storz M, Graf N, Haerle SK, et al. Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx. Int J Cancer 2011; 129(6): 1404-9.
-
(2011)
Int J Cancer
, vol.129
, Issue.6
, pp. 1404-1409
-
-
Huber, G.F.1
Fritzsche, F.R.2
Zullig, L.3
Storz, M.4
Graf, N.5
Haerle, S.K.6
-
68
-
-
78149479157
-
Phase III randomized trial of CED of IL13- PE38QQR vs Gliadel wafers for recurrent glioblastoma
-
Kunwar S, Chang S, Westphal M, Vogelbaum M, Sampson J, Barnett G, et al. Phase III randomized trial of CED of IL13- PE38QQR vs Gliadel wafers for recurrent glioblastoma. Neuro- Oncol 2010; 12(8): 871-81.
-
(2010)
Neuro- Oncol
, vol.12
, Issue.8
, pp. 871-881
-
-
Kunwar, S.1
Chang, S.2
Westphal, M.3
Vogelbaum, M.4
Sampson, J.5
Barnett, G.6
-
69
-
-
77955608850
-
Poor drug distribution as a possible ex planation for the results of the PRECISE trial
-
Sampson JH, Archer G, Pedain C, Wembacher-Schroder E, Westphal M, Kunwar S, et al. Poor drug distribution as a possible ex planation for the results of the PRECISE trial. J Neurosurg 2010; 113(2): 301-9.
-
(2010)
J Neurosurg
, vol.113
, Issue.2
, pp. 301-309
-
-
Sampson, J.H.1
Archer, G.2
Pedain, C.3
Wembacher-Schroder, E.4
Westphal, M.5
Kunwar, S.6
-
70
-
-
52949098192
-
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors
-
Sampson JH, Akabani G, Archer GE, Berger MS, Coleman RE, Friedman AH, et al. Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors. Neuro Oncol 2008; 10(3): 320-9.
-
(2008)
Neuro Oncol
, vol.10
, Issue.3
, pp. 320-329
-
-
Sampson, J.H.1
Akabani, G.2
Archer, G.E.3
Berger, M.S.4
Coleman, R.E.5
Friedman, A.H.6
-
72
-
-
84901288988
-
-
CN102603897
-
Hu, J., Yang, H., Li, J., Wei, Y., Guo, K. Fusion protein containing guide peptide and GnRH-PE39KDEL as well as nucleic acid and application thereof. CN102603897 (2012).
-
(2012)
Fusion Protein Containing Guide Peptide and GnRH-PE39KDEL As Well As Nucleic Acid and Application Thereof
-
-
Hu, J.1
Yang, H.2
Li, J.3
Wei, Y.4
Guo, K.5
-
73
-
-
0018167496
-
One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell
-
Yamaizumi M, Mekada E, Uchida T, Okada Y. One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 1978; 15(1): 245-50.
-
(1978)
Cell
, vol.15
, Issue.1
, pp. 245-250
-
-
Yamaizumi, M.1
Mekada, E.2
Uchida, T.3
Okada, Y.4
-
74
-
-
0023205060
-
Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity
-
Greenfield L, Johnson VG, Youle RJ. Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity. Science 1987; 238(4826): 536-9.
-
(1987)
Science
, vol.238
, Issue.4826
, pp. 536-539
-
-
Greenfield, L.1
Johnson, V.G.2
Youle, R.J.3
-
75
-
-
0025336716
-
Structure-function analysis of interleukin-2-toxin (DAB486-IL-2) - fragment-b sequences required for the delivery of fragment-a to the cytosol of target-cells
-
Williams DP, Snider CE, Strom TB, Murphy JR. Structure-function analysis of interleukin-2-toxin (DAB486-IL-2) - fragment-b sequences required for the delivery of fragment-a to the cytosol of target-cells. J Biol Chem 1990; 265(20): 11885-9.
-
(1990)
J Biol Chem
, vol.265
, Issue.20
, pp. 11885-11889
-
-
Williams, D.P.1
Snider, C.E.2
Strom, T.B.3
Murphy, J.R.4
-
77
-
-
51249107097
-
Targeted therapy of cancer using diphtheria toxin-derived immunotoxins
-
Potala S, Sahoo SK, Verma RS. Targeted therapy of cancer using diphtheria toxin-derived immunotoxins. Drug Discov Today 2008; 13(17-18): 807-15.
-
(2008)
Drug Discov Today
, vol.13
, Issue.17-18
, pp. 807-815
-
-
Potala, S.1
Sahoo, S.K.2
Verma, R.S.3
-
78
-
-
84901259526
-
-
WO01087982 (2001) & US7696338
-
Neville, D.M., Jr., Thompson, J.T., Hu, H., Woo, J.-H., Ma, S., Hexham, J.M., Digan, M.E. Immunotoxin fusion proteins and means for expression thereof. WO01087982 (2001) & US7696338 (2010).
-
(2010)
Immunotoxin Fusion Proteins and Means For Expression Thereof
-
-
Neville Jr., D.M.1
Thompson, J.T.2
Hu, H.3
Woo, J.-H.4
Ma, S.5
Hexham, J.M.6
Digan, M.E.7
-
79
-
-
70350645181
-
Denileukin diftitox: A novel immunotoxin
-
Manoukian G, Hagemeister F. Denileukin diftitox: A novel immunotoxin. Expert Opin Biol Ther 2009; 9(11): 1445-51.
-
(2009)
Expert Opin Biol Ther
, vol.9
, Issue.11
, pp. 1445-1451
-
-
Manoukian, G.1
Hagemeister, F.2
-
80
-
-
33846010137
-
Phase II trial of denileukin diftitox for relapsed/refractory T-cell non-Hodgkin lymphoma
-
Dang NH, Pro B, Hagemeister FB, Samaniego F, Jones D, Samuels BI, et al. Phase II trial of denileukin diftitox for relapsed/refractory T-cell non-Hodgkin lymphoma. Br J Haematol 2007; 136(3): 439-47.
-
(2007)
Br J Haematol
, vol.136
, Issue.3
, pp. 439-447
-
-
Dang, N.H.1
Pro, B.2
Hagemeister, F.B.3
Samaniego, F.4
Jones, D.5
Samuels, B.I.6
-
81
-
-
84861028258
-
Pilot study of denileukin diftitox alternate dosing regimen in patients with cutaneous peripheral t-cell lymphomas
-
Talpur R, Duvic M. Pilot study of denileukin diftitox alternate dosing regimen in patients with cutaneous peripheral t-cell lymphomas. Clin Lymphoma Myeloma Leuk 2012; 12(3): 180-5.
-
(2012)
Clin Lymphoma Myeloma Leuk
, vol.12
, Issue.3
, pp. 180-185
-
-
Talpur, R.1
Duvic, M.2
-
82
-
-
84862591399
-
Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates
-
Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, et al. Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates. J Immunol 2012; 188(12): 6063-70.
-
(2012)
J Immunol
, vol.188
, Issue.12
, pp. 6063-6070
-
-
Yamada, Y.1
Aoyama, A.2
Tocco, G.3
Boskovic, S.4
Nadazdin, O.5
Alessandrini, A.6
-
83
-
-
83255164934
-
Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma
-
Telang S, Rasku MA, Clem AL, Carter K, Klarer AC, Badger WR, et al. Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma. BMC Cancer 2011; 11.
-
(2011)
BMC Cancer
, pp. 11
-
-
Telang, S.1
Rasku, M.A.2
Clem, A.L.3
Carter, K.4
Klarer, A.C.5
Badger, W.R.6
-
84
-
-
77954455336
-
Modified DT-IL2 fusion toxin targeting uniquely IL2R alpha expressing leukemia cell lines - Construction and characterization
-
Potala S, Verma RS. Modified DT-IL2 fusion toxin targeting uniquely IL2R alpha expressing leukemia cell lines - Construction and characterization. J Biotechnol 2010; 148(2-3): 147-55.
-
(2010)
J Biotechnol
, vol.148
, Issue.2-3
, pp. 147-155
-
-
Potala, S.1
Verma, R.S.2
-
85
-
-
44249122848
-
Preclinical studies in rats and squirrel monkeys for safety evaluation of the bivalent anti-human T cell immunotoxin, A-dmDT390- bisFv(UCHT1)
-
Woo JH, Bour SH, Dang T, Lee YJ, Park SK, Andreas E, et al. Preclinical studies in rats and squirrel monkeys for safety evaluation of the bivalent anti-human T cell immunotoxin, A-dmDT390- bisFv(UCHT1). Cancer Immunol Immunother 2008; 57(8): 1225-39.
-
(2008)
Cancer Immunol Immunother
, vol.57
, Issue.8
, pp. 1225-1239
-
-
Woo, J.H.1
Bour, S.H.2
Dang, T.3
Lee, Y.J.4
Park, S.K.5
Andreas, E.6
-
88
-
-
67549102111
-
Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy
-
Vallera DA, Chen H, Sicheneder AR, Panoskaltsis-Mortari A, Taras EP. Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy. Leukemia Res 2009; 33(9): 1233-42.
-
(2009)
Leukemia Res
, vol.33
, Issue.9
, pp. 1233-1242
-
-
Vallera, D.A.1
Chen, H.2
Sicheneder, A.R.3
Panoskaltsis-Mortari, A.4
Taras, E.P.5
-
90
-
-
84901249555
-
-
CN1477129
-
Zhang, Z., Chai, Y., Yao, L., Chen, A. Recombinant vascular endothelial growth factor-diphtherin fusion protein, its preparation and application. CN1477129 (2004).
-
(2004)
Recombinant Vascular Endothelial Growth Factor-diphtherin Fusion Protein, Its Preparation and Application
-
-
Zhang, Z.1
Chai, Y.2
Yao, L.3
Chen, A.4
-
91
-
-
84901271586
-
-
CN1641035A
-
Zhang, L., Chen, W., Li, H., Jia, Y., Li, M. Plasmid of recombinant immunotoxin IP 10-DT 390 aimed at activating Th1 cell, and its preparing method and use. CN1641035A (2005).
-
(2005)
Plasmid of Recombinant Immunotoxin IP 10-DT 390 Aimed At Activating Th1 Cell, and Its Preparing Method and Use
-
-
Zhang, L.1
Chen, W.2
Li, H.3
Jia, Y.4
Li, M.5
-
92
-
-
33847043871
-
In vivo administration of plasmid DNA encoding recombinant immunotoxin DT390- IP-10 attenuates experimental autoimmune encephalomyelitis
-
Chen W, Li H, Jia Y, Lv M, Li M, Feng P, et al. In vivo administration of plasmid DNA encoding recombinant immunotoxin DT390- IP-10 attenuates experimental autoimmune encephalomyelitis. J Autoimmun 2007; 28(1): 30-40.
-
(2007)
J Autoimmun
, vol.28
, Issue.1
, pp. 30-40
-
-
Chen, W.1
Li, H.2
Jia, Y.3
Lv, M.4
Li, M.5
Feng, P.6
-
93
-
-
33748323288
-
Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES
-
Jia Y, Li H, Chen W, Li M, Lv M, Feng P, et al. Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES. Gene Ther 2006; 13(18): 1351-9.
-
(2006)
Gene Ther
, vol.13
, Issue.18
, pp. 1351-1359
-
-
Jia, Y.1
Li, H.2
Chen, W.3
Li, M.4
Lv, M.5
Feng, P.6
-
94
-
-
84901271586
-
-
CN1641023
-
Zhang, L., Jia, Y., Li, H., Chen, W., Li, M. Plasmid of recombinant immunotoxin Rantes-DT390 aimed at activating Th1 cell, and its preparing method and use. CN1641023 (2005).
-
(2005)
Plasmid of Recombinant Immunotoxin Rantes-DT390 Aimed At Activating Th1 Cell, and Its Preparing Method and Use
-
-
Zhang, L.1
Jia, Y.2
Li, H.3
Chen, W.4
Li, M.5
-
96
-
-
33846614679
-
The research on construction and expression of eukaryotic expression plasmid for a recombinant immunotoxin mMIP-1alpha-DT390
-
Lu ML, Li H, Liang WB, Chen WJ, Jia Y, Jiang ZH, et al. The research on construction and expression of eukaryotic expression plasmid for a recombinant immunotoxin mMIP-1alpha-DT390. Sichuan Da Xue Xue Bao Yi Xue Ban 2007; 38(1): 1-5.
-
(2007)
Sichuan Da Xue Xue Bao Yi Xue Ban
, vol.38
, Issue.1
, pp. 1-5
-
-
Lu, M.L.1
Li, H.2
Liang, W.B.3
Chen, W.J.4
Jia, Y.5
Jiang, Z.H.6
-
97
-
-
0344876636
-
Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) therapy of malignant gliomas
-
Weaver M, Laske DW. Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) therapy of malignant gliomas. J Neurooncol 2003; 65(1): 3-13.
-
(2003)
J Neurooncol
, vol.65
, Issue.1
, pp. 3-13
-
-
Weaver, M.1
Laske, D.W.2
-
98
-
-
58549106115
-
Genetically engineering transferrin to improve its in vitro ability to deliver cytotoxins
-
Yoon DJ, Chu DSH, Ng CW, Pham EA, Mason AB, Hudson DM, et al. Genetically engineering transferrin to improve its in vitro ability to deliver cytotoxins. J Control Release 2009; 133(3): 178-84.
-
(2009)
J Control Release
, vol.133
, Issue.3
, pp. 178-184
-
-
Yoon, D.J.1
Chu, D.S.H.2
Ng, C.W.3
Pham, E.A.4
Mason, A.B.5
Hudson, D.M.6
-
99
-
-
84901261892
-
-
WO2009149393
-
Kamei, D.T., Lao, B.J., Tsai, W.-L.P., Mashayekhi, F., Pham, E.A., Mason, A.B. Improved cancer drug delivery using modified transferrin. WO2009149393 (2009).
-
(2009)
Improved Cancer Drug Delivery Using Modified Transferrin
-
-
Kamei, D.T.1
Lao, B.J.2
Tsai, W.-L.P.3
Mashayekhi, F.4
Pham, E.A.5
Mason, A.B.6
-
100
-
-
38649092392
-
Anti-glioblastoma effect of a recombinant bispecific cytotoxin cotargeting human IL-13 and EGF receptors in a mouse xenograft model
-
Stish BJ, Oh S, Vallera DA. Anti-glioblastoma effect of a recombinant bispecific cytotoxin cotargeting human IL-13 and EGF receptors in a mouse xenograft model. J NeuroOncol 2008; 87(1): 51-61.
-
(2008)
J NeuroOncol
, vol.87
, Issue.1
, pp. 51-61
-
-
Stish, B.J.1
Oh, S.2
Vallera, D.A.3
-
101
-
-
84866021530
-
Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer
-
Huang J, Li YM, Massague J, Sicheneder A, Vallera DA, Hall WA. Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer. J Neuro Oncol 2012; 109(2): 229-38.
-
(2012)
J Neuro Oncol
, vol.109
, Issue.2
, pp. 229-238
-
-
Huang, J.1
Li, Y.M.2
Massague, J.3
Sicheneder, A.4
Vallera, D.A.5
Hall, W.A.6
-
102
-
-
0027716146
-
The c-kit receptor, stem cell factor, and mast cells: What each is teaching us about the others
-
Galli SJ, Tsai M, Wershil BK. The c-kit receptor, stem cell factor, and mast cells: What each is teaching us about the others. Am J Pathol 1993; 142(4): 965-74.
-
(1993)
Am J Pathol
, vol.142
, Issue.4
, pp. 965-974
-
-
Galli, S.J.1
Tsai, M.2
Wershil, B.K.3
-
103
-
-
79951581242
-
Targeting head and neck squamous cell carcinoma using a novel fusion toxin-diphtheria toxin/HN-1
-
Potala S, Verma RS. Targeting head and neck squamous cell carcinoma using a novel fusion toxin-diphtheria toxin/HN-1. Mol Biol Rep 2011; 38(2): 1389-97.
-
(2011)
Mol Biol Rep
, vol.38
, Issue.2
, pp. 1389-1397
-
-
Potala, S.1
Verma, R.S.2
-
105
-
-
0023100497
-
Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody
-
Blakey DC, Watson GJ, Knowles PP, Thorpe PE. Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody. Cancer Res 1987; 47(4): 947-52.
-
(1987)
Cancer Res
, vol.47
, Issue.4
, pp. 947-952
-
-
Blakey, D.C.1
Watson, G.J.2
Knowles, P.P.3
Thorpe, P.E.4
-
106
-
-
0028829967
-
CD30 (Ki-1) molecule - a new cytokine receptor of the tumornecrosis- factor receptor superfamily as a tool for diagnosis and immunotherapy
-
Falini B, Pileri S, Pizzolo G, Durkop H, Flenghi L, Stirpe F, et al. CD30 (Ki-1) molecule - a new cytokine receptor of the tumornecrosis- factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood 1995; 85(1): 1-14.
-
(1995)
Blood
, vol.85
, Issue.1
, pp. 1-14
-
-
Falini, B.1
Pileri, S.2
Pizzolo, G.3
Durkop, H.4
Flenghi, L.5
Stirpe, F.6
-
107
-
-
0013379930
-
Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma
-
Schnell R, Borchmann P, Staak JO, Schindler J, Ghetie V, Vitetta ES, et al. Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma. Ann Oncol 2003; 14(5): 729-36.
-
(2003)
Ann Oncol
, vol.14
, Issue.5
, pp. 729-736
-
-
Schnell, R.1
Borchmann, P.2
Staak, J.O.3
Schindler, J.4
Ghetie, V.5
Vitetta, E.S.6
-
108
-
-
0034090987
-
Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro
-
Herrera L, Farah RA, Pellegrini VA, Aquino DB, Sandler ES, Buchanan GR, et al. Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro. Leukemia 2000; 14(5): 853-8.
-
(2000)
Leukemia
, vol.14
, Issue.5
, pp. 853-858
-
-
Herrera, L.1
Farah, R.A.2
Pellegrini, V.A.3
Aquino, D.B.4
Sandler, E.S.5
Buchanan, G.R.6
-
110
-
-
73949122603
-
A Phase 1 study of combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia
-
Herrera L, Bostrom B, Gore L, Sandler E, Lew G, Schlegel PG, et al. A Phase 1 study of combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2009; 31(12): 936-41.
-
(2009)
J Pediatr Hematol Oncol
, vol.31
, Issue.12
, pp. 936-941
-
-
Herrera, L.1
Bostrom, B.2
Gore, L.3
Sandler, E.4
Lew, G.5
Schlegel, P.G.6
-
111
-
-
79960843919
-
A Phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia
-
Schindler J, Gajavelli S, Ravandi F, Shen Y, Parekh S, Braunchweig I, et al. A Phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia. Br J Haematol 2011; 154(4): 471-6.
-
(2011)
Br J Haematol
, vol.154
, Issue.4
, pp. 471-476
-
-
Schindler, J.1
Gajavelli, S.2
Ravandi, F.3
Shen, Y.4
Parekh, S.5
Braunchweig, I.6
-
112
-
-
64349108724
-
Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies
-
Kreitman RJ. Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies. Bio Drugs 2009; 23(1): 1-13.
-
(2009)
Bio Drugs
, vol.23
, Issue.1
, pp. 1-13
-
-
Kreitman, R.J.1
-
113
-
-
0037382907
-
Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice
-
Smallshaw JE, Ghetie V, Rizo J, Fulmer JR, Trahan LL, Ghetie MA, et al. Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice. Nature Biotechnol 2003; 21(4): 387-91.
-
(2003)
Nature Biotechnol
, vol.21
, Issue.4
, pp. 387-391
-
-
Smallshaw, J.E.1
Ghetie, V.2
Rizo, J.3
Fulmer, J.R.4
Trahan, L.L.5
Ghetie, M.A.6
-
114
-
-
84863025438
-
Immunotoxins constructed with chimeric, short-lived anti-CD22 monoclonal antibodies induce less vascular leak without loss of cytotoxicity
-
Liu XY, Pop LM, Schindler J, Vitetta ES. Immunotoxins constructed with chimeric, short-lived anti-CD22 monoclonal antibodies induce less vascular leak without loss of cytotoxicity. mAbs 2012; 4(1): 57-68.
-
(2012)
MAbs
, vol.4
, Issue.1
, pp. 57-68
-
-
Liu, X.Y.1
Pop, L.M.2
Schindler, J.3
Vitetta, E.S.4
-
115
-
-
3042515159
-
Cytotoxicity and toxicity to animals and humans of ribosome-inactivating proteins
-
Battelli MG. Cytotoxicity and toxicity to animals and humans of ribosome-inactivating proteins. Mini Rev Med Chem 2004; 4(5): 513-21.
-
(2004)
Mini Rev Med Chem
, vol.4
, Issue.5
, pp. 513-521
-
-
Battelli, M.G.1
-
119
-
-
33947274774
-
The growth factor fusion construct containing Blymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells
-
Nimmanapalli R, Lyu MA, Du M, Keating MJ, Rosenblum MG, Gandhi V. The growth factor fusion construct containing Blymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells. Blood 2007; 109(6): 2557-64.
-
(2007)
Blood
, vol.109
, Issue.6
, pp. 2557-2564
-
-
Nimmanapalli, R.1
Lyu, M.A.2
Du, M.3
Keating, M.J.4
Rosenblum, M.G.5
Gandhi, V.6
-
120
-
-
84864884196
-
Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin
-
Parameswaran R, Yu M, Lyu MA, Lim M, Rosenblum MG, Groffen J, et al. Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin. Leukemia 2012; 26(8): 1786-96.
-
(2012)
Leukemia
, vol.26
, Issue.8
, pp. 1786-1796
-
-
Parameswaran, R.1
Yu, M.2
Lyu, M.A.3
Lim, M.4
Rosenblum, M.G.5
Groffen, J.6
-
121
-
-
84867292358
-
Fusion toxin BLyS-gelonin inhibits growth of malignant human B cell lines in vitro and in vivo
-
Luster TA, Mukherjee I, Carrell JA, Cho YH, Gill J, Kelly L, et al. Fusion toxin BLyS-gelonin inhibits growth of malignant human B cell lines in vitro and in vivo. PLoS ONE 2012; 7(10): e47361
-
(2012)
PLoS ONE
, vol.7
, Issue.10
-
-
Luster, T.A.1
Mukherjee, I.2
Carrell, J.A.3
Cho, Y.H.4
Gill, J.5
Kelly, L.6
-
122
-
-
0031850006
-
Humanized M195 monoclonal antibody conjugated to recombinant gelonin: An anti-CD33 immunotoxin with antileukemic activity
-
Pagliaro LC, Liu BS, Munker R, Andreeff M, Freireich EJ, Scheinberg DA, et al. Humanized M195 monoclonal antibody conjugated to recombinant gelonin: An anti-CD33 immunotoxin with antileukemic activity. Clin Cancer Res 1998; 4(8): 1971-6.
-
(1998)
Clin Cancer Res
, vol.4
, Issue.8
, pp. 1971-1976
-
-
Pagliaro, L.C.1
Liu, B.S.2
Munker, R.3
Andreeff, M.4
Freireich, E.J.5
Scheinberg, D.A.6
-
123
-
-
79952273472
-
Phase I clinical trial of the anti-CD33 immunotoxin HuM195/rgel in patients with advanced myeloid malignancies
-
Dean A, Talpaz M, Kantarjian H, Faderl S, Jabbour E, Ravandi, KF, et al. Phase I clinical trial of the anti-CD33 immunotoxin HuM195/rgel in patients with advanced myeloid malignancies. J Clin Oncol 2010; 28: 6549.
-
(2010)
J Clin Oncol
, vol.28
, pp. 6549
-
-
Dean, A.1
Talpaz, M.2
Kantarjian, H.3
Faderl, S.4
Jabbour, E.5
Ravandi, K.F.6
-
124
-
-
0037062464
-
In vitro and in vivo studies of a VEGF 121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors
-
Veenendaal LM, Jin H, Ran S, Cheung L, Navone N, Marks JW, et al. In vitro and in vivo studies of a VEGF 121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors. Proc Natl Acad Sci USA 2002; 99(12): 7866-71.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.12
, pp. 7866-7871
-
-
Veenendaal, L.M.1
Jin, H.2
Ran, S.3
Cheung, L.4
Navone, N.5
Marks, J.W.6
-
125
-
-
80051661162
-
Cytotoxicity of VEGF 121/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2
-
Article No. 358
-
Mohamedali KA, Ran S, Gomez-Manzano C, Ramdas L, Xu J, Kim S, et al. Cytotoxicity of VEGF 121/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2. BMC Cancer 2011; 11: Article No. 358.
-
(2011)
BMC Cancer
, pp. 11
-
-
Mohamedali, K.A.1
Ran, S.2
Gomez-Manzano, C.3
Ramdas, L.4
Xu, J.5
Kim, S.6
-
126
-
-
79954606129
-
Inhibition of prostate cancer osteoblastic progression with VEGF 121/rGEL, a single agent targeting osteoblasts, osteoclasts, and tumor neovasculature
-
Mohamedali KA, Li ZG, Starbuck MW, Wan X, Yang J, Kim S, et al. Inhibition of prostate cancer osteoblastic progression with VEGF 121/rGEL, a single agent targeting osteoblasts, osteoclasts, and tumor neovasculature. Clin Cancer Res 2011; 17(8): 2328-38.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.8
, pp. 2328-2338
-
-
Mohamedali, K.A.1
Li, Z.G.2
Starbuck, M.W.3
Wan, X.4
Yang, J.5
Kim, S.6
-
127
-
-
33644878203
-
The vascular-targeting fusion toxin VEGF121/rGel inhibits the growth of orthotopic human bladder carcinoma tumors
-
Mohamedali KA, Kedar D, Sweeney P, Kamat A, Davis DW, Eve BY, et al. The vascular-targeting fusion toxin VEGF121/rGel inhibits the growth of orthotopic human bladder carcinoma tumors. Neoplasia 2005; 7(10): 912-20.
-
(2005)
Neoplasia
, vol.7
, Issue.10
, pp. 912-920
-
-
Mohamedali, K.A.1
Kedar, D.2
Sweeney, P.3
Kamat, A.4
Davis, D.W.5
Eve, B.Y.6
-
128
-
-
84862907829
-
Single-chain antibody-based immunotoxins targeting her2/neu: Design optimization and impact of affinity on antitumor efficacy and off-target toxicity
-
Cao Y, Marks JD, Huang Q, Rudnick SI, Xiong C, Hittelman WN, et al. Single-chain antibody-based immunotoxins targeting her2/neu: Design optimization and impact of affinity on antitumor efficacy and off-target toxicity. Mol Cancer Ther 2012; 11(1): 143-53.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.1
, pp. 143-153
-
-
Cao, Y.1
Marks, J.D.2
Huang, Q.3
Rudnick, S.I.4
Xiong, C.5
Hittelman, W.N.6
-
129
-
-
0032904481
-
Recombinant immunotoxins directed against the c-erb-2/HER2/neu oncogene product: In vitro cytotoxicity, pharmacokinetics, and in vivo efficacy studies in xenograft models
-
Rosenblum MG, Shawver LK, Marks JW, Brink J, Cheung L, Langton-Webster B. Recombinant immunotoxins directed against the c-erb-2/HER2/neu oncogene product: In vitro cytotoxicity, pharmacokinetics, and in vivo efficacy studies in xenograft models. Clin Cancer Res 1999; 5(4): 865-74.
-
(1999)
Clin Cancer Res
, vol.5
, Issue.4
, pp. 865-874
-
-
Rosenblum, M.G.1
Shawver, L.K.2
Marks, J.W.3
Brink, J.4
Cheung, L.5
Langton-Webster, B.6
-
130
-
-
71549169552
-
Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: In vitro and in vivo studies
-
Cao Y, Marks JD, Marks JW, Cheung LH, Kim S, Rosenblum MG. Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: In vitro and in vivo studies. Cancer Res 2009; 69(23): 8987-95.
-
(2009)
Cancer Res
, vol.69
, Issue.23
, pp. 8987-8995
-
-
Cao, Y.1
Marks, J.D.2
Marks, J.W.3
Cheung, L.H.4
Kim, S.5
Rosenblum, M.G.6
-
131
-
-
84901285363
-
-
WO2012094653
-
Pirie, C.M., Liu, D.V., Yang, N., Wittrup, K.D. Compositions and methods for macromolecular drug delivery. WO2012094653 (2012).
-
(2012)
Compositions and Methods For Macromolecular Drug Delivery
-
-
Pirie, C.M.1
Liu, D.V.2
Yang, N.3
Wittrup, K.D.4
-
133
-
-
84864334668
-
In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin
-
Zhou X, Qiu J, Wang Z, Huang N, Li X, Li Q, et al. In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin. J Cancer Res Clin Oncol 2012; 138(7): 1081-90.
-
(2012)
J Cancer Res Clin Oncol
, vol.138
, Issue.7
, pp. 1081-1090
-
-
Zhou, X.1
Qiu, J.2
Wang, Z.3
Huang, N.4
Li, X.5
Li, Q.6
-
135
-
-
84901285024
-
Immunotoxγn fusions comprising an antibody fragment and a plant toxin linked by protease cleavable linkers
-
WO2008052322
-
Cizeau, J., MacDonald, G. Immunotoxγn fusions comprising an antibody fragment and a plant toxin linked by protease cleavable linkers. WO2008052322 (2008).
-
(2008)
-
-
Cizeau, J.1
Macdonald, G.2
-
136
-
-
67651163873
-
Engineering and biological characterization of VB6-845, an Anti- EpCAM immunotoxin containing a t-cell epitope-depleted variant of the plant toxin bouganin
-
Cizeau J, Grenkow DM, Brown JG, Entwistle J, MacDonald GC. Engineering and biological characterization of VB6-845, an Anti- EpCAM immunotoxin containing a t-cell epitope-depleted variant of the plant toxin bouganin. J Immunother 2009; 32(6): 574-84.
-
(2009)
J Immunother
, vol.32
, Issue.6
, pp. 574-584
-
-
Cizeau, J.1
Grenkow, D.M.2
Brown, J.G.3
Entwistle, J.4
Macdonald, G.C.5
-
137
-
-
15644366464
-
New ribosome-inactivating proteins with polynucleotide: Adenosine glycosidase and antiviral activities from Basella rubra L. and Bougainvillea spectabilis Willd
-
Bolognesi A, Polito L, Olivieri F, Valbonesi P, Barbieri L, Battelli MG, et al. New ribosome-inactivating proteins with polynucleotide: Adenosine glycosidase and antiviral activities from Basella rubra L. and Bougainvillea spectabilis Willd. Planta 1997; 203(4): 422-9.
-
(1997)
Planta
, vol.203
, Issue.4
, pp. 422-429
-
-
Bolognesi, A.1
Polito, L.2
Olivieri, F.3
Valbonesi, P.4
Barbieri, L.5
Battelli, M.G.6
-
138
-
-
70349772981
-
A Phase I study of VB6-845, an anti-EpCAM fusion protein targeting advanced solid tumours of epithelial origin: Preliminary results
-
Kowalski M, Brazas L, Zaretsky R, Rasamoelisolo M, MacDonald G, Cuthbert W, et al. A Phase I study of VB6-845, an anti-EpCAM fusion protein targeting advanced solid tumours of epithelial origin: Preliminary results. J Clin Oncol 2008; 26(suppl): 14663.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
, pp. 14663
-
-
Kowalski, M.1
Brazas, L.2
Zaretsky, R.3
Rasamoelisolo, M.4
Macdonald, G.5
Cuthbert, W.6
-
139
-
-
70350180245
-
Ribonucleases and immunoRNAses as anticancer drugs
-
Rybak SM, Arndt MAE, Schirrmann T, Dübel S, Krauss J. Ribonucleases and immunoRNAses as anticancer drugs. Curr Pharm Des 2009; 15(23): 2665-75.
-
(2009)
Curr Pharm Des
, vol.15
, Issue.23
, pp. 2665-2675
-
-
Rybak, S.M.1
Arndt, M.A.E.2
Schirrmann, T.3
Dübel, S.4
Krauss, J.5
-
140
-
-
0035893923
-
Human angiogenin fused to human CD30 ligand (Ang- CD30L) exhibits specific cytotoxicity against CD30-positive lymphoma
-
Huhn M, Sasse S, Tur MK, Matthey B, Schinköthe T, Rybak SM, et al. Human angiogenin fused to human CD30 ligand (Ang- CD30L) exhibits specific cytotoxicity against CD30-positive lymphoma. Cancer Res 2001; 61(24): 8737-42.
-
(2001)
Cancer Res
, vol.61
, Issue.24
, pp. 8737-8742
-
-
Huhn, M.1
Sasse, S.2
Tur, M.K.3
Matthey, B.4
Schinköthe, T.5
Rybak, S.M.6
-
141
-
-
33344475705
-
Ribonucleases as a novel pro-apoptotic anticancer strategy: Review of the preclinical and clinical data for ranpirnase
-
Costanzi J, Sidransky D, Navon A, Goldsweig H. Ribonucleases as a novel pro-apoptotic anticancer strategy: Review of the preclinical and clinical data for ranpirnase. Cancer Invest 2005; 23(7): 643-50.
-
(2005)
Cancer Invest
, vol.23
, Issue.7
, pp. 643-650
-
-
Costanzi, J.1
Sidransky, D.2
Navon, A.3
Goldsweig, H.4
-
142
-
-
45549103591
-
Ranpirnase (Onconase®), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy
-
Lee I. Ranpirnase (Onconase®), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy. Expert Opin Biol Ther 2008; 8(6): 813-27.
-
(2008)
Expert Opin Biol Ther
, vol.8
, Issue.6
, pp. 813-827
-
-
Lee, I.1
-
143
-
-
79955562300
-
Review on clinical trials of targeted treatments in malignant mesothelioma
-
Jakobsen JN, Sorensen JB. Review on clinical trials of targeted treatments in malignant mesothelioma. Cancer Chemother Pharmacol 2011; 68(1): 1-15.
-
(2011)
Cancer Chemother Pharmacol
, vol.68
, Issue.1
, pp. 1-15
-
-
Jakobsen, J.N.1
Sorensen, J.B.2
-
144
-
-
0035863726
-
Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin lymphoma
-
Newton DL, Hansen HJ, Mikulski SM, Goldenberg DM, Rybak SM. Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin lymphoma. Blood 2001; 97(2): 528-35.
-
(2001)
Blood
, vol.97
, Issue.2
, pp. 528-535
-
-
Newton, D.L.1
Hansen, H.J.2
Mikulski, S.M.3
Goldenberg, D.M.4
Rybak, S.M.5
-
145
-
-
28844468487
-
Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG4 antibody immunotoxin
-
Chang CH, Sapra P, Vanama SS, Hansen HJ, Horak ID, Goldenberg DM. Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG4 antibody immunotoxin. Blood 2005; 106(13): 4308-14.
-
(2005)
Blood
, vol.106
, Issue.13
, pp. 4308-4314
-
-
Chang, C.H.1
Sapra, P.2
Vanama, S.S.3
Hansen, H.J.4
Horak, I.D.5
Goldenberg, D.M.6
-
146
-
-
84901275649
-
-
WO2005080586
-
Goldenberg, D.M., Hansen, H.J., Chang, C.-H., Vanama, S., Rossi, E.A. Fusion proteins containing recombinant cytotoxic RNAses. WO2005080586 (2005).
-
(2005)
Fusion Proteins Containing Recombinant Cytotoxic RNAses
-
-
Goldenberg, D.M.1
Hansen, H.J.2
Chang, C.-H.3
Vanama, S.4
Rossi, E.A.5
-
147
-
-
77955480479
-
Ranpirnase (frog RNase) targeted with a humanized, internalizing, anti-trop-2 antibody has potent cytotoxicity against diverse epithelial cancer cells
-
Chang CH, Gupta P, Michel R, Loo M, Wang Y, Cardillo TM, et al. Ranpirnase (frog RNase) targeted with a humanized, internalizing, anti-trop-2 antibody has potent cytotoxicity against diverse epithelial cancer cells. Mol Cancer Ther 2010; 9(8): 2276-86.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.8
, pp. 2276-2286
-
-
Chang, C.H.1
Gupta, P.2
Michel, R.3
Loo, M.4
Wang, Y.5
Cardillo, T.M.6
-
148
-
-
38649112304
-
TROP2: A novel prognostic marker in squamous cell carcinoma of the oral cavity
-
Fong D, Spizzo G, Gostner JM, Gastl G, Moser P, Krammel C, et al. TROP2: A novel prognostic marker in squamous cell carcinoma of the oral cavity. Mod Pathol 2008; 21(2): 186-91.
-
(2008)
Mod Pathol
, vol.21
, Issue.2
, pp. 186-191
-
-
Fong, D.1
Spizzo, G.2
Gostner, J.M.3
Gastl, G.4
Moser, P.5
Krammel, C.6
-
149
-
-
33744800782
-
Clinical significance of TROP2 expression in colorectal cancer
-
Ohmachi T, Tanaka F, Mimori K, Inoue H, Yanaga K, Mori M. Clinical significance of TROP2 expression in colorectal cancer. Clin Cancer Res 2006; 12(10): 3057-63.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.10
, pp. 3057-3063
-
-
Ohmachi, T.1
Tanaka, F.2
Mimori, K.3
Inoue, H.4
Yanaga, K.5
Mori, M.6
-
150
-
-
53849132678
-
High expression of TROP2 correlates with poor prognosis in pancreatic cancer
-
Fong D, Moser P, Krammel C, Gostner JM, Margreiter R, Mitterer M, et al. High expression of TROP2 correlates with poor prognosis in pancreatic cancer. British J Cancer 2008; 99(8): 1290-5.
-
(2008)
British J Cancer
, vol.99
, Issue.8
, pp. 1290-1295
-
-
Fong, D.1
Moser, P.2
Krammel, C.3
Gostner, J.M.4
Margreiter, R.5
Mitterer, M.6
-
151
-
-
80755159321
-
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody
-
Article No. 106
-
Raji R, Guzzo F, Carrara L, Varughese J, Cocco E, Bellone S, et al. Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody. J Exp Clin Cancer Res 2011; 30: Article No. 106.
-
(2011)
J Exp Clin Cancer Res
, pp. 30
-
-
Raji, R.1
Guzzo, F.2
Carrara, L.3
Varughese, J.4
Cocco, E.5
Bellone, S.6
-
152
-
-
84901260670
-
Compositions and methods of use of immunotoxins comprising ranpirnase (RAP) show potent cytotoxic activity
-
Chang, C.-H., Goldenberg, D.M., Rossi, E.A. Compositions and methods of use of immunotoxins comprising ranpirnase (RAP) show potent cytotoxic activity. WO2011026026 (2011).
-
(2011)
WO2011026026
-
-
Chang, C.-H.1
Goldenberg, D.M.2
Rossi, E.A.3
-
153
-
-
84901254350
-
A novel ribonuclease-based immunotoxin comprising quadruple ranpirnase (RAP) site-specifically conjugated to an anti-CD22 IgG showing potent anti-lymphoma activity
-
December 5-8, New Orleans, LA, USA
-
Rossi EA, Chan E, Gupta P, Goldenberg DM, Chang CH. A novel ribonuclease-based immunotoxin comprising quadruple ranpirnase (RAP) site-specifically conjugated to an anti-CD22 IgG showing potent anti-lymphoma activity. 51st ASH Annual Meeting and Exposition; December 5-8, 2009; New Orleans, LA, USA.
-
(2009)
51st ASH Annual Meeting and Exposition
-
-
Rossi, E.A.1
Chan, E.2
Gupta, P.3
Goldenberg, D.M.4
Chang, C.H.5
-
159
-
-
84865212772
-
Complex and defined biostructures with the dock-and-lock method
-
Rossi EA, Goldenberg DM, Chang CH. Complex and defined biostructures with the dock-and-lock method. Trends Pharmacol Sci 2012; 33(9): 474-81.
-
(2012)
Trends Pharmacol Sci
, vol.33
, Issue.9
, pp. 474-481
-
-
Rossi, E.A.1
Goldenberg, D.M.2
Chang, C.H.3
-
160
-
-
80054912018
-
Cell death pathology: The war against cancer
-
Rufini A, Melino G. Cell death pathology: The war against cancer. Biochem Biophys Res Commun 2011; 414(3): 445-50.
-
(2011)
Biochem Biophys Res Commun
, vol.414
, Issue.3
, pp. 445-450
-
-
Rufini, A.1
Melino, G.2
-
161
-
-
77950963954
-
Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence
-
Wang F, Ren J, Qiu XC, Wang LF, Zhu Q, Zhang YQ, et al. Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence. Clin Cancer Res 2010; 16(8): 2284-94.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.8
, pp. 2284-2294
-
-
Wang, F.1
Ren, J.2
Qiu, X.C.3
Wang, L.F.4
Zhu, Q.5
Zhang, Y.Q.6
-
162
-
-
8444220527
-
Molecular mechanisms of caspase regulation during apoptosis
-
Riedl SJ, Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 2004; 5(11): 897-907.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, Issue.11
, pp. 897-907
-
-
Riedl, S.J.1
Shi, Y.2
-
163
-
-
77749320442
-
Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein
-
Zhang DX, Zhao PT, Xia L, Liu LL, Liang J, Zhai HH, et al. Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein. Gut 2010; 59(3): 292-9.
-
(2010)
Gut
, vol.59
, Issue.3
, pp. 292-299
-
-
Zhang, D.X.1
Zhao, P.T.2
Xia, L.3
Liu, L.L.4
Liang, J.5
Zhai, H.H.6
-
164
-
-
68849111552
-
A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma
-
Wang LF, Zhou Y, Xu YM, Qiu XC, Zhou BG, Wang F, et al. A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma. Cancer Invest 2009; 27(7): 774-80.
-
(2009)
Cancer Invest
, vol.27
, Issue.7
, pp. 774-780
-
-
Wang, L.F.1
Zhou, Y.2
Xu, Y.M.3
Qiu, X.C.4
Zhou, B.G.5
Wang, F.6
-
165
-
-
77951687835
-
Delivery and therapeutic potential of human granzyme B
-
Kurschus FC, Jenne DE. Delivery and therapeutic potential of human granzyme B. Immunol Rev 2010; 235(1): 159-71.
-
(2010)
Immunol Rev
, vol.235
, Issue.1
, pp. 159-171
-
-
Kurschus, F.C.1
Jenne, D.E.2
-
168
-
-
77955312203
-
Antibody-drug conjugates: Targeted drug delivery for cancer
-
Alley SC, Okeley NM, Senter PD. Antibody-drug conjugates: Targeted drug delivery for cancer. Curr Opin Cell Biol 2010; 14(4): 529-37.
-
(2010)
Curr Opin Cell Biol
, vol.14
, Issue.4
, pp. 529-537
-
-
Alley, S.C.1
Okeley, N.M.2
Senter, P.D.3
-
169
-
-
84901246439
-
-
WO03053473
-
Ulbrich, K., Etrych, T., Rihova, B., Jelinkova, M., Kovar, M. pHsensitive polymeric conjugates of an anthracycline drug. WO03053473 (2003).
-
(2003)
PHsensitive Polymeric Conjugates of An Anthracycline Drug
-
-
Ulbrich, K.1
Etrych, T.2
Rihova, B.3
Jelinkova, M.4
Kovar, M.5
-
170
-
-
52049105453
-
Recent trends in targeted anticancer prodrug and conjugate design
-
Singh Y, Palombo M, Sinko PJ. Recent trends in targeted anticancer prodrug and conjugate design. Curr Med Chem 2008; 15(18): 1802-26.
-
(2008)
Curr Med Chem
, vol.15
, Issue.18
, pp. 1802-1826
-
-
Singh, Y.1
Palombo, M.2
Sinko, P.J.3
-
171
-
-
0036131908
-
Synthesis of novel paclitaxel prodrugs designed for bioreductive activation in hypoxic tumour tissue
-
Damen EWP, Nevalainen TJ, van den Bergh TJM, de Groot FMH, Scheeren HW. Synthesis of novel paclitaxel prodrugs designed for bioreductive activation in hypoxic tumour tissue. Bioorg Med Chem 2002; 10(1): 71-7.
-
(2002)
Bioorg Med Chem
, vol.10
, Issue.1
, pp. 71-77
-
-
Damen, E.W.P.1
Nevalainen, T.J.2
van den Bergh, T.J.M.3
de Groot, F.M.H.4
Scheeren, H.W.5
-
172
-
-
80054037204
-
Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates
-
FitzGerald DJ, Wayne AS, Kreitman RJ, Pastan I. Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer Res 2011; 71(20): 6300-9.
-
(2011)
Cancer Res
, vol.71
, Issue.20
, pp. 6300-6309
-
-
Fitzgerald, D.J.1
Wayne, A.S.2
Kreitman, R.J.3
Pastan, I.4
-
173
-
-
0024322591
-
Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I
-
Lee MD, Manning JK, Williams DR, Kuck NA, Testa RT, Borders DB. Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I. J Antibiot (Tokyo) 1989; 42(7): 1070-87.
-
(1989)
J Antibiot (Tokyo)
, vol.42
, Issue.7
, pp. 1070-1087
-
-
Lee, M.D.1
Manning, J.K.2
Williams, D.R.3
Kuck, N.A.4
Testa, R.T.5
Borders, D.B.6
-
174
-
-
0023228110
-
Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin. gamma.1I
-
Lee MD, Dunne TS, Siegel MM, Chang CC, Morton GO, Borders DB. Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin. gamma.1I. J Am Chem Soc 1987; 109(11): 3464-6.
-
(1987)
J Am Chem Soc
, vol.109
, Issue.11
, pp. 3464-3466
-
-
Lee, M.D.1
Dunne, T.S.2
Siegel, M.M.3
Chang, C.C.4
Morton, G.O.5
Borders, D.B.6
-
175
-
-
0023181171
-
Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin. gamma.1I
-
Lee MD, Dunne TS, Chang CC, Ellestad GA, Siegel MM, Morton GO, et al. Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin. gamma.1I. J Am Chem Soc 1987; 109(11): 3466-8.
-
(1987)
J Am Chem Soc
, vol.109
, Issue.11
, pp. 3466-3468
-
-
Lee, M.D.1
Dunne, T.S.2
Chang, C.C.3
Ellestad, G.A.4
Siegel, M.M.5
Morton, G.O.6
-
177
-
-
80054113954
-
Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin
-
Ricart AD. Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin. Clin Cancer Res 2011; 17(20): 6417-27.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.20
, pp. 6417-6427
-
-
Ricart, A.D.1
-
178
-
-
0034753903
-
Mylotarg: Antibody-targeted chemotherapy comes of age
-
Sievers EL, Linenberger M. Mylotarg: Antibody-targeted chemotherapy comes of age. Curr Op Oncol 2001; 13(6): 522-7.
-
(2001)
Curr Op Oncol
, vol.13
, Issue.6
, pp. 522-527
-
-
Sievers, E.L.1
Linenberger, M.2
-
179
-
-
84863522871
-
Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia
-
Burnett AK, Russell NH, Hills RK, Kell J, Freeman S, Kjeldsen L, et al. Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia. J Clin Oncol 2012; 30(32): 3924-31.
-
(2012)
J Clin Oncol
, vol.30
, Issue.32
, pp. 3924-3931
-
-
Burnett, A.K.1
Russell, N.H.2
Hills, R.K.3
Kell, J.4
Freeman, S.5
Kjeldsen, L.6
-
180
-
-
84859911350
-
Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, Phase 3 study
-
Castaigne S, Pautas C, Terré C, Raffoux E, Bordessoule D, Bastie JN, et al. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, Phase 3 study. Lancet 2012; 379(9825): 1508-16.
-
(2012)
Lancet
, vol.379
, Issue.9825
, pp. 1508-1516
-
-
Castaigne, S.1
Pautas, C.2
Terré, C.3
Raffoux, E.4
Bordessoule, D.5
Bastie, J.N.6
-
181
-
-
84901253286
-
-
US2006002942
-
Kunz, A., Moran, J.K., Rubino, J., Jain, N., Boghaert, E.R., Hamann, P.R., Ruppen, M.E., Damle, N., Vidunas, E. Calicheamicin conjugates. US2006002942 (2006).
-
(2006)
Calicheamicin Conjugates
-
-
Kunz, A.1
Moran, J.K.2
Rubino, J.3
Jain, N.4
Boghaert, E.R.5
Hamann, P.R.6
Ruppen, M.E.7
Damle, N.8
Vidunas, E.9
-
183
-
-
71849107086
-
Transarterial chemotherapy alone versus transarterial chemoembolization for hepatocellular carcinoma: A randomized Phase III trial
-
Okusaka T, Kasugai H, Shioyama Y, Tanaka K, Kudo M, Saisho H, et al. Transarterial chemotherapy alone versus transarterial chemoembolization for hepatocellular carcinoma: A randomized Phase III trial. J Hepatol 2009; 51(6): 1030-6.
-
(2009)
J Hepatol
, vol.51
, Issue.6
, pp. 1030-1036
-
-
Okusaka, T.1
Kasugai, H.2
Shioyama, Y.3
Tanaka, K.4
Kudo, M.5
Saisho, H.6
-
184
-
-
58349094536
-
C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells
-
Beerman TA, Gawron LS, Shin S, Shen B, McHugh MM. C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells. Cancer Res 2009; 69(2): 593-8.
-
(2009)
Cancer Res
, vol.69
, Issue.2
, pp. 593-598
-
-
Beerman, T.A.1
Gawron, L.S.2
Shin, S.3
Shen, B.4
McHugh, M.M.5
-
185
-
-
41649113407
-
Enediyne anticancer antibiotic lidamycin: Chemistry, biology and pharmacology
-
Shao RG, Zhen YS. Enediyne anticancer antibiotic lidamycin: Chemistry, biology and pharmacology. Anticancer Agents Med Chem 2008; 8(2): 123-31.
-
(2008)
Anticancer Agents Med Chem
, vol.8
, Issue.2
, pp. 123-131
-
-
Shao, R.G.1
Zhen, Y.S.2
-
186
-
-
84864028073
-
Factor VII light chain-targeted lidamycin shows intensified therapeutic efficacy for liver cancer
-
Zhang Q, Liu X, Xu S, Li C, Zhang Y, Yang J, et al. Factor VII light chain-targeted lidamycin shows intensified therapeutic efficacy for liver cancer. Cancer Biother Radiopharm 2012; 27(6): 384-91.
-
(2012)
Cancer Biother Radiopharm
, vol.27
, Issue.6
, pp. 384-391
-
-
Zhang, Q.1
Liu, X.2
Xu, S.3
Li, C.4
Zhang, Y.5
Yang, J.6
-
187
-
-
84867088042
-
A cell penetrating peptide-integrated and enediyne-energized fusion protein shows potent antitumor activity
-
Ru Q, Shang BY, Miao QF, Li L, Wu SY, Gao RJ, et al. A cell penetrating peptide-integrated and enediyne-energized fusion protein shows potent antitumor activity. Eur J Pharm Sci 2012; 47(4): 781-9.
-
(2012)
Eur J Pharm Sci
, vol.47
, Issue.4
, pp. 781-789
-
-
Ru, Q.1
Shang, B.Y.2
Miao, Q.F.3
Li, L.4
Wu, S.Y.5
Gao, R.J.6
-
188
-
-
84863163784
-
Inhibitory effects of the immunoconjugate composed of anti-type IV collagenase antibody Fab' fragment and lidamycin on tumor invasion and metastasis
-
Feng Y, He HW, Li BW, Zhang ZX, Chen X, Li XF. Inhibitory effects of the immunoconjugate composed of anti-type IV collagenase antibody Fab' fragment and lidamycin on tumor invasion and metastasis. Yao Xue Xue Bao 2011; 46(12): 1462-5.
-
(2011)
Yao Xue Xue Bao
, vol.46
, Issue.12
, pp. 1462-1465
-
-
Feng, Y.1
He, H.W.2
Li, B.W.3
Zhang, Z.X.4
Chen, X.5
Li, X.F.6
-
189
-
-
33845718899
-
An enediyneenergized single-domain antibody-containing fusion protein shows potent antitumor activity
-
Miao QF, Liu XY, Shang BY, Ouyang ZG, Zhen YS. An enediyneenergized single-domain antibody-containing fusion protein shows potent antitumor activity. Anticancer Drugs 2007; 18(2): 127-37.
-
(2007)
Anticancer Drugs
, vol.18
, Issue.2
, pp. 127-137
-
-
Miao, Q.F.1
Liu, X.Y.2
Shang, B.Y.3
Ouyang, Z.G.4
Zhen, Y.S.5
-
190
-
-
79952848306
-
Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin
-
Fang H, Miao QF, Zhang SH, Cheng X, Xiong DS, Zhen YS. Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin. Sci China Life Sci 2011; 54(3): 255-62.
-
(2011)
Sci China Life Sci
, vol.54
, Issue.3
, pp. 255-262
-
-
Fang, H.1
Miao, Q.F.2
Zhang, S.H.3
Cheng, X.4
Xiong, D.S.5
Zhen, Y.S.6
-
191
-
-
0021319952
-
Preliminary toxicity studies with the DNA-binding antibiotic, CC-1065
-
McGovren JP, Clarke GL, Pratt EA, DeKoning TF. Preliminary toxicity studies with the DNA-binding antibiotic, CC-1065. J Antibiot (Tokyo) 1984; 37(1): 63-70.
-
(1984)
J Antibiot (Tokyo)
, vol.37
, Issue.1
, pp. 63-70
-
-
McGovren, J.P.1
Clarke, G.L.2
Pratt, E.A.3
Dekoning, T.F.4
-
192
-
-
0026069784
-
Duocarmycins, new antitumor antibiotics produced by streptomyces; Producing organisms and improved production
-
Ichimura M, Ogawa T, Katsumata S, Takahashi KI, Takahashi I, Nakano H. Duocarmycins, new antitumor antibiotics produced by streptomyces; Producing organisms and improved production. J Antibiot (Tokyo) 1991; 44(10): 1045-53.
-
(1991)
J Antibiot (Tokyo)
, vol.44
, Issue.10
, pp. 1045-1053
-
-
Ichimura, M.1
Ogawa, T.2
Katsumata, S.3
Takahashi, K.I.4
Takahashi, I.5
Nakano, H.6
-
193
-
-
84901250028
-
-
WO2006043839
-
Denny, W.A., Wilson, W.R., Stevenson, R.J., Tercel, M., Atwell, G.J., Yang, S., Patterson, A.V., Pruijn, F.B. Nitrobenzindoles and their use in cancer therapy. WO2006043839 (2006).
-
(2006)
Nitrobenzindoles and Their Use In Cancer Therapy
-
-
Denny, W.A.1
Wilson, W.R.2
Stevenson, R.J.3
Tercel, M.4
Atwell, G.J.5
Yang, S.6
Patterson, A.V.7
Pruijn, F.B.8
-
195
-
-
74249120351
-
Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products
-
Ghosh N, Sheldrake HM, Searcey M, Pors K. Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products. Curr Top Med Chem 2009; 9(16): 1494-524.
-
(2009)
Curr Top Med Chem
, vol.9
, Issue.16
, pp. 1494-1524
-
-
Ghosh, N.1
Sheldrake, H.M.2
Searcey, M.3
Pors, K.4
-
196
-
-
70349641991
-
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065
-
MacMillan KS, Boger DL. Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065. J Med Chem 2009; 52(19): 5771-80.
-
(2009)
J Med Chem
, vol.52
, Issue.19
, pp. 5771-5780
-
-
Macmillan, K.S.1
Boger, D.L.2
-
197
-
-
0028920020
-
An efficient synthesis of 1,2,9,9atetrahydrocyclopropa[ c]benz[e]indol-4-one (CBI): An enhanced and simplified analog of the CC-1065 and duocarmycin alkylation subunits
-
Boger DL, McKie JA. An efficient synthesis of 1,2,9,9atetrahydrocyclopropa[ c]benz[e]indol-4-one (CBI): An enhanced and simplified analog of the CC-1065 and duocarmycin alkylation subunits. J Org Chem 1995; 60(5): 1271-5.
-
(1995)
J Org Chem
, vol.60
, Issue.5
, pp. 1271-1275
-
-
Boger, D.L.1
McKie, J.A.2
-
198
-
-
44849128346
-
Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC- 1065 analog
-
Wang Y, Jiang J, Jiang X, Cai S, Han H, Li L, et al. Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC- 1065 analog. Bioorg Med Chem 2008; 16(13): 6552-9.
-
(2008)
Bioorg Med Chem
, vol.16
, Issue.13
, pp. 6552-6559
-
-
Wang, Y.1
Jiang, J.2
Jiang, X.3
Cai, S.4
Han, H.5
Li, L.6
-
199
-
-
20144367846
-
Design, synthesis, and in vitro evaluation of dipeptide-based antibody minor groove binder conjugates
-
Jeffrey SC, Torgov MY, Andreyka JB, Boddington L, Cerveny CG, Denny WA, et al. Design, synthesis, and in vitro evaluation of dipeptide-based antibody minor groove binder conjugates. J Med Chem 2005; 48(5): 1344-58.
-
(2005)
J Med Chem
, vol.48
, Issue.5
, pp. 1344-1358
-
-
Jeffrey, S.C.1
Torgov, M.Y.2
Andreyka, J.B.3
Boddington, L.4
Cerveny, C.G.5
Denny, W.A.6
-
200
-
-
84865311602
-
-
WO2011133039
-
Beusker, P.H., Coumans, R.G.E., Elgersma, R.C., Menge, W.M.P.B., Joosten, J.A.F., Spijker, H.J., De Groot, F.M.H. Novel conjugates of CC-1065 analogs and bifunctional linkers. WO2011133039 (2011).
-
(2011)
Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers
-
-
Beusker, P.H.1
Coumans, R.G.E.2
Elgersma, R.C.3
Menge, W.M.P.B.4
Joosten, J.A.F.5
Spijker, H.J.6
de Groot, F.M.H.7
-
201
-
-
84901260705
-
-
WO2009017394
-
Beusker, P.H., Spijker, H.J., Joosten, J.A.F., Huijbregts, T., De Groot, F.M.H. Substituted CC-1065 analogs and their conjugates. WO2009017394 (2009).
-
(2009)
Substituted CC-1065 Analogs and Their Conjugates
-
-
Beusker, P.H.1
Spijker, H.J.2
Joosten, J.A.F.3
Huijbregts, T.4
de Groot, F.M.H.5
-
203
-
-
84901253457
-
-
WO02096910
-
Ng, H.P., McGee, D.P.C., Wu, G., Li, Z., Gangwar, S., Saunders, O.L., Martichonok, V., Astafieva, I., Moore, J., Yarranton, G.T., King, D.J., Boyd, S., Lobl, T.J. Cytotoxins, prodrugs, linkers and stabilizers useful therefor. WO02096910 (2002).
-
(2002)
Cytotoxins, Prodrugs, Linkers and Stabilizers Useful Therefor
-
-
Ng, H.P.1
McGee, D.P.C.2
Wu, G.3
Li, Z.4
Gangwar, S.5
Saunders, O.L.6
Martichonok, V.7
Astafieva, I.8
Moore, J.9
Yarranton, G.T.10
King, D.J.11
Boyd, S.12
Lobl, T.J.13
-
204
-
-
0029093035
-
Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation
-
Chari RVJ, Jackel KA, Bourret LA, Derr SM, Tadayoni BM, Mattocks KM, et al. Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation. Cancer Res 1995; 55(18): 4079-84.
-
(1995)
Cancer Res
, vol.55
, Issue.18
, pp. 4079-4084
-
-
Chari, R.V.J.1
Jackel, K.A.2
Bourret, L.A.3
Derr, S.M.4
Tadayoni, B.M.5
Mattocks, K.M.6
-
206
-
-
84856373074
-
Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer
-
Zhao RY, Erickson HK, Leece BA, Reid EE, Goldmacher VS, Lambert JM, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem 2012; 55(2): 766-82.
-
(2012)
J Med Chem
, vol.55
, Issue.2
, pp. 766-782
-
-
Zhao, R.Y.1
Erickson, H.K.2
Leece, B.A.3
Reid, E.E.4
Goldmacher, V.S.5
Lambert, J.M.6
-
208
-
-
84901286438
-
Enzymology of the mechanism of action for MDX-1203 antibody drug conjugate
-
Mar 31-Apr 4, Chicago, USA
-
Derwin DW, Passmore D, Zhang Q, Sufi B, Pan C, Rao C, Huber M, et al. Enzymology of the mechanism of action for MDX-1203 antibody drug conjugate. AACR 103rd Annual Meeting, Mar 31-Apr 4, 2012; Chicago, USA.
-
(2012)
AACR 103rd Annual Meeting
-
-
Derwin, D.W.1
Passmore, D.2
Zhang, Q.3
Sufi, B.4
Pan, C.5
Rao, C.6
Huber, M.7
-
209
-
-
0015377787
-
Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin
-
Arima K, Kosaka M, Tamura G, Imanaka H, Sakai H. Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J Antibiot (Tokyo) 1972; 25(8): 437-44.
-
(1972)
J Antibiot (Tokyo)
, vol.25
, Issue.8
, pp. 437-444
-
-
Arima, K.1
Kosaka, M.2
Tamura, G.3
Imanaka, H.4
Sakai, H.5
-
210
-
-
79955867207
-
The development of pyrrolobenzodiazepines as antitumour agents
-
Hartley JA. The development of pyrrolobenzodiazepines as antitumour agents. Expert Opin Investig Drugs 2011; 20(6): 733-44.
-
(2011)
Expert Opin Investig Drugs
, vol.20
, Issue.6
, pp. 733-744
-
-
Hartley, J.A.1
-
211
-
-
84881591402
-
-
EP2019104
-
Gauzy, L., Bouchard, H., Commercon, A., Deng, Y., Chari, R.V.J. Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use. EP2019104 (2009).
-
(2009)
Cytotoxic Agents Comprising New Tomaymycin Derivatives and Their Therapeutic Use
-
-
Gauzy, L.1
Bouchard, H.2
Commercon, A.3
Deng, Y.4
Chari, R.V.J.5
-
212
-
-
84901278209
-
-
WO2011130613
-
Howard, P.W., Jeffrey, S., Burke, P., Senter, P. Targeted pyrrolobenzodiazapine conjugates. WO2011130613 (2011).
-
(2011)
Targeted Pyrrolobenzodiazapine Conjugates
-
-
Howard, P.W.1
Jeffrey, S.2
Burke, P.3
Senter, P.4
-
213
-
-
84901272498
-
SGN-CD33A: A Novel CD33-directed Antibodydrug Conjugate, Utilizing Pyrrolobenzodiazepine Dimers, Demonstrates Preclinical Antitumor Activity Against Multi-drug Resistant Human AML
-
Atlanta, GA, USA
-
Sutherland MSK, Walter RB, Jeffrey SC, Burke, PJ, Yu C, Harrington KH, et al. SGN-CD33A: A novel CD33-directed antibodydrug conjugate, utilizing pyrrolobenzodiazepine dimers, demonstrates preclinical antitumor activity against multi-drug resistant human AML.54th ASH Annual Meeting and Exposition; December 8-11, 2012; Atlanta, GA, USA.
-
(2012)
54th ASH Annual Meeting and Exposition
-
-
Sutherland, M.S.K.1
Walter, R.B.2
Jeffrey, S.C.3
Burke, P.J.4
Yu, C.5
Harrington, K.H.6
-
214
-
-
0030624552
-
-
Fortschr Chem Org Naturst
-
Pettit GR. The dolastatins. Fortschr Chem Org Naturst 1997; 70: 1-79.
-
(1997)
The Dolastatins
, vol.70
, pp. 1-79
-
-
Pettit, G.R.1
-
215
-
-
0031948608
-
Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1
-
Mohammad RM, Varterasian ML, Almatchy VP Hannoudi GN.,Pettit GR., Al-Katib A. Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1. Clin Cancer Res 1998; 4(5): 1337-43.
-
(1998)
Clin Cancer Res
, vol.4
, Issue.5
, pp. 1337-1343
-
-
Mohammad, R.M.1
Varterasian, M.L.2
Almatchy, V.P.3
Hannoudi, G.N.4
Pettit, G.R.5
Al-Katib, A.6
-
216
-
-
0031960723
-
Treatment of human prostate cancer cells with dolastatin 10, a peptide isolated from a marine shell-less mollusc
-
Turner T, Jackson WH, Pettit GR, Wells A, Kraft AS. Treatment of human prostate cancer cells with dolastatin 10, a peptide isolated from a marine shell-less mollusc. Prostate 1998; 34(3): 175-81.
-
(1998)
Prostate
, vol.34
, Issue.3
, pp. 175-181
-
-
Turner, T.1
Jackson, W.H.2
Pettit, G.R.3
Wells, A.4
Kraft, A.S.5
-
217
-
-
0034093431
-
Phase II study of dolastatin-10 in patients with advanced non-small-cell lung cancer
-
Krug LM, Miller VA, Kalemkerian GP, Kraut MJ, Ng KK, Heelan RT, et al. Phase II study of dolastatin-10 in patients with advanced non-small-cell lung cancer. Ann Oncol 2000; 11(2): 227-8.
-
(2000)
Ann Oncol
, vol.11
, Issue.2
, pp. 227-228
-
-
Krug, L.M.1
Miller, V.A.2
Kalemkerian, G.P.3
Kraut, M.J.4
Ng, K.K.5
Heelan, R.T.6
-
218
-
-
0033739893
-
Phase II study of dolastatin-10 in patients with hormonerefractory metastatic prostate adenocarcinoma
-
Vaishampayan U, Glode M, Du W, Kraft A, Hudes G, Wright J, et al. Phase II study of dolastatin-10 in patients with hormonerefractory metastatic prostate adenocarcinoma. Clin Cancer Res 2000; 6(11): 4205-8.
-
(2000)
Clin Cancer Res
, vol.6
, Issue.11
, pp. 4205-4208
-
-
Vaishampayan, U.1
Glode, M.2
Du, W.3
Kraft, A.4
Hudes, G.5
Wright, J.6
-
219
-
-
35148827486
-
a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models
-
Shnyder SD, Cooper PA, Millington NJ, Pettit GR, Bibby MC. Auristatin PYE, a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models. Int J Oncol 2007; 31(2): 353-60.
-
(2007)
Int J Oncol
, vol.31
, Issue.2
, pp. 353-360
-
-
Shnyder, S.D.1
Cooper, P.A.2
Millington, N.J.3
Pettit, G.R.4
Bibby, M.C.5
Auristatin, P.Y.E.6
-
220
-
-
7144263706
-
Antineoplastic agents 365. Dolastatin 10 SAR probes
-
Pettit GR, Srirangam JK, Barkoczy J, Williams MD, Boyd MR, Hamel E, et al. Antineoplastic agents 365. Dolastatin 10 SAR probes. Anticancer Drug Des 1998; 13(4): 243-77.
-
(1998)
Anticancer Drug Des
, vol.13
, Issue.4
, pp. 243-277
-
-
Pettit, G.R.1
Srirangam, J.K.2
Barkoczy, J.3
Williams, M.D.4
Boyd, M.R.5
Hamel, E.6
-
221
-
-
84901289711
-
-
US20070258987
-
Francisco, J.A., Risdon, G., Wahl, A.F., Siegall, C., Senter, P.D., Svetlana, D., Toki, B.E. Recombinant anti-CD30 antibodies and uses thereof. US20070258987 (2007).
-
(2007)
Recombinant Anti-CD30 Antibodies and Uses Thereof
-
-
Francisco, J.A.1
Risdon, G.2
Wahl, A.F.3
Siegall, C.4
Senter, P.D.5
Svetlana, D.6
Toki, B.E.7
-
222
-
-
0033857963
-
TZT-1027, an antimicrotubule agent, attacks tumor vasculature and induces tumor cell death
-
Otani M, Natsume T, Watanabe J, Kobayashi M, Murakoshi M, Mikami T, et al. TZT-1027, an antimicrotubule agent, attacks tumor vasculature and induces tumor cell death. Jpn J Cancer Res 2000; 91(8): 837-44.
-
(2000)
Jpn J Cancer Res
, vol.91
, Issue.8
, pp. 837-844
-
-
Otani, M.1
Natsume, T.2
Watanabe, J.3
Kobayashi, M.4
Murakoshi, M.5
Mikami, T.6
-
223
-
-
84855789037
-
Brentuximab Vedotin (SGN-35), an antibody-drug conjugate for the treatment of CD30-positive malignancies
-
Gualberto A. Brentuximab Vedotin (SGN-35), an antibody-drug conjugate for the treatment of CD30-positive malignancies. Expert Opin Investig Drugs 2012; 21(2): 205-16.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, Issue.2
, pp. 205-216
-
-
Gualberto, A.1
-
224
-
-
84863688504
-
The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma
-
Senter PD, Sievers EL. The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Nat Biotechnol 2012; 30(7): 631-7.
-
(2012)
Nat Biotechnol
, vol.30
, Issue.7
, pp. 631-637
-
-
Senter, P.D.1
Sievers, E.L.2
-
226
-
-
49449087300
-
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
-
Junutula JR, Raab H, Clark S, Bhakta S, Leipold DD, Weir S, et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol 2008; 26(8): 925-32.
-
(2008)
Nat Biotechnol
, vol.26
, Issue.8
, pp. 925-932
-
-
Junutula, J.R.1
Raab, H.2
Clark, S.3
Bhakta, S.4
Leipold, D.D.5
Weir, S.6
-
227
-
-
70350494468
-
Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
-
Dornan D, Bennett F, Chen Y, Dennis M, Eaton D, Elkins K, et al. Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma. Blood 2009; 114(13): 2721-9.
-
(2009)
Blood
, vol.114
, Issue.13
, pp. 2721-2729
-
-
Dornan, D.1
Bennett, F.2
Chen, Y.3
Dennis, M.4
Eaton, D.5
Elkins, K.6
-
228
-
-
84901253555
-
-
WO2009012268
-
Chen, Y., Dennis, M., Dornan, D., Elkins, K., Junutula, J.R., Polson, A., Zheng, B. Anti-CD79B antibodies and immunoconjugates and methods of use. WO2009012268 (2009).
-
(2009)
Anti-CD79B Antibodies and Immunoconjugates and Methods of Use
-
-
Chen, Y.1
Dennis, M.2
Dornan, D.3
Elkins, K.4
Junutula, J.R.5
Polson, A.6
Zheng, B.7
-
229
-
-
0032874633
-
Quantitative analysis of CD79b, CD5 and CD19 in mature B-cell lymphoproliferative disorders
-
Cabezudo E, Carrara P, Morilla R, Matutes E. Quantitative analysis of CD79b, CD5 and CD19 in mature B-cell lymphoproliferative disorders. Haematologica 1999; 84(5): 413-8.
-
(1999)
Haematologica
, vol.84
, Issue.5
, pp. 413-418
-
-
Cabezudo, E.1
Carrara, P.2
Morilla, R.3
Matutes, E.4
-
231
-
-
84855702068
-
The use of an antibody drug conjugate, glembatumumab vedotin (CDX-011), for the treatment of breast cancer
-
Keir CH, Vahdat LT. The use of an antibody drug conjugate, glembatumumab vedotin (CDX-011), for the treatment of breast cancer. Expert Opin Biol Ther 2012; 12(2): 259-63.
-
(2012)
Expert Opin Biol Ther
, vol.12
, Issue.2
, pp. 259-263
-
-
Keir, C.H.1
Vahdat, L.T.2
-
232
-
-
84901279375
-
Phase I trial of ASG-5ME in metastatic castration- resistant prostate cancer (CRPC)
-
June 1-5, Chicago, USA
-
Morris MJ, Yang BJ, Reyno LM, Anand B, Hartford A, Jelaca- Maxwell K, et al. Phase I trial of ASG-5ME in metastatic castration- resistant prostate cancer (CRPC). American Society of Clinical Oncology Annual Meeting; June 1-5, Chicago, USA (2012)
-
(2012)
American Society of Clinical Oncology Annual Meeting
-
-
Morris, M.J.1
Yang, B.J.2
Reyno, L.M.3
Anand, B.4
Hartford, A.5
Jelaca-Maxwell, K.6
-
233
-
-
69249154583
-
Identification of Nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer
-
Takano A, Ishikawa N, Nishino R, Masuda K, Yasui W, Inai K, et al. Identification of Nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer Res 2009; 69(16): 6694-703.
-
(2009)
Cancer Res
, vol.69
, Issue.16
, pp. 6694-6703
-
-
Takano, A.1
Ishikawa, N.2
Nishino, R.3
Masuda, K.4
Yasui, W.5
Inai, K.6
-
234
-
-
84901256580
-
The Investigational Drug MLN0264 First-in-human, First in Class ADC Targeting GCC: Phase I Dose-escalation Study and Supportive Scientific Rationale
-
Veiby P, Zhang J, Yang J, McDonald A, Fasanmade A, Wyant T, et al. The Investigational Drug MLN0264 First-in-human, First in Class ADC Targeting GCC: Phase I Dose-escalation Study and Supportive Scientific Rationale. 24th EORTC-NCI-AACR Symposium on 'Molecular Targets and Cancer Therapeutics'; November 6-9; Dublin 2012; 329.
-
(2012)
24th EORTC-NCI-AACR Symposium On 'Molecular Targets and Cancer Therapeutics'; November 6-9; Dublin
, pp. 329
-
-
Veiby, P.1
Zhang, J.2
Yang, J.3
McDonald, A.4
Fasanmade, A.5
Wyant, T.6
-
235
-
-
84901254209
-
Novel anti-CD38 antibodies for the treatment of cancer
-
Park, P.U., Bartle, L., Skaletskaya, A., Golmakher, V., Tavares, D., Deckert, J., Milol, V., Blanc, V. Novel anti-CD38 antibodies for the treatment of cancer. US20110262454 (2011).
-
(2011)
US20110262454
-
-
Park, P.U.1
Bartle, L.2
Skaletskaya, A.3
Golmakher, V.4
Tavares, D.5
Deckert, J.6
Milol, V.7
Blanc, V.8
-
236
-
-
64249119444
-
Targeted therapies for prostate cancer against the prostate specific membrane antigen
-
Elsasser-Beile U, Buhler P, Wolf P. Targeted therapies for prostate cancer against the prostate specific membrane antigen. Curr Drug Targets 2009; 10(2): 118-25.
-
(2009)
Curr Drug Targets
, vol.10
, Issue.2
, pp. 118-125
-
-
Elsasser-Beile, U.1
Buhler, P.2
Wolf, P.3
-
237
-
-
34250847132
-
Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo
-
Challita-Eid PM, Morrison K, Etessami S, An ZL, Morrison KJ, Perez-Villar JJ, et al. Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo. Cancer Res 2007; 67(12): 5798-805.
-
(2007)
Cancer Res
, vol.67
, Issue.12
, pp. 5798-5805
-
-
Challita-Eid, P.M.1
Morrison, K.2
Etessami, S.3
An, Z.L.4
Morrison, K.J.5
Perez-Villar, J.J.6
-
238
-
-
84901248127
-
-
EP2502938
-
Dennis, M., Rubinfeld, B., Polakis, P., Jakobovits, A. Antibodies and immunoconjugates and uses therefor. EP2502938 (2012).
-
(2012)
Antibodies and Immunoconjugates and Uses Therefor
-
-
Dennis, M.1
Rubinfeld, B.2
Polakis, P.3
Jakobovits, A.4
-
239
-
-
84901275904
-
-
US20120078028
-
Satpayev, D., Morrison, R.K., Morrison, K.J.M., Gudas, J., Jakobovits, A., Torgov, M., An, Z. Antibody drug conjugates (ADC) that bind to 191P4D12 proteins. US20120078028 (2012).
-
(2012)
Antibody Drug Conjugates (ADC) That Bind to 191P4D12 Proteins
-
-
Satpayev, D.1
Morrison, R.K.2
Morrison, K.J.M.3
Gudas, J.4
Jakobovits, A.5
Torgov, M.6
An, Z.7
-
240
-
-
84901271235
-
Use of AGS-16M8F as a novel antibody drug conjugate (ADC) for treating renal cancers
-
Chicago, USA
-
Gudas JM, Torgov M, An Z, Jia XCJ, Morrison K, Morrison RK, et al. Ed. Use of AGS-16M8F as a novel antibody drug conjugate (ADC) for treating renal cancers. American Society of Clinical Oncology Annual Meeting June 3-7, Chicago, USA (2010).
-
(2010)
American Society of Clinical Oncology Annual Meeting June 3-7
-
-
Gudas, J.M.1
Torgov, M.2
An, Z.3
Jia, X.C.J.4
Morrison, K.5
Morrison, R.K.6
-
241
-
-
77955983472
-
Targeting pancreatic and ovarian carcinomas using the auristatin- based anti-CD70 antibody-drug conjugate SGN-75
-
Ryan MC, Kostner H, Gordon KA, Duniho S, Sutherland MK, Yu C, et al. Targeting pancreatic and ovarian carcinomas using the auristatin- based anti-CD70 antibody-drug conjugate SGN-75. Br J Cancer 2010; 103(5): 676-84.
-
(2010)
Br J Cancer
, vol.103
, Issue.5
, pp. 676-684
-
-
Ryan, M.C.1
Kostner, H.2
Gordon, K.A.3
Duniho, S.4
Sutherland, M.K.5
Yu, C.6
-
242
-
-
84863116661
-
Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9
-
Petrul HM, Schatz CA, Kopitz CC, Adnane L, McCabe TJ, Trail P, et al. Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther 2012; 11(2): 340-9.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.2
, pp. 340-349
-
-
Petrul, H.M.1
Schatz, C.A.2
Kopitz, C.C.3
Adnane, L.4
McCabe, T.J.5
Trail, P.6
-
243
-
-
0015520389
-
Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus
-
Kupchan SM, Komoda Y, Court WA, Thomas GJ, Smith RM, Karim A, et al. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. J Am Chem Soc 1972; 94(4): 1354-6.
-
(1972)
J Am Chem Soc
, vol.94
, Issue.4
, pp. 1354-1356
-
-
Kupchan, S.M.1
Komoda, Y.2
Court, W.A.3
Thomas, G.J.4
Smith, R.M.5
Karim, A.6
-
244
-
-
0017769750
-
The maytansinoids. Isolation, structural elucidation, and chemical interrelation of novel ansa macrolides
-
Kupchan SM, Komoda Y, Branfman AR, Sneden AT, Court WA, Thomas GJ, et al. The maytansinoids. Isolation, structural elucidation, and chemical interrelation of novel ansa macrolides. J Org Chem 1977; 42(14): 2349-57.
-
(1977)
J Org Chem
, vol.42
, Issue.14
, pp. 2349-2357
-
-
Kupchan, S.M.1
Komoda, Y.2
Branfman, A.R.3
Sneden, A.T.4
Court, W.A.5
Thomas, G.J.6
-
246
-
-
0026593928
-
Immunoconjugates containing novel maytansinoids: Promising anticancer drugs
-
Chari RV, Martell BA, Gross JL, Cook SB, Shah SA, Blattler WA, et al. Immunoconjugates containing novel maytansinoids: promising anticancer drugs. Cancer Res 1992; 52(1): 127-31.
-
(1992)
Cancer Res
, vol.52
, Issue.1
, pp. 127-131
-
-
Chari, R.V.1
Martell, B.A.2
Gross, J.L.3
Cook, S.B.4
Shah, S.A.5
Blattler, W.A.6
-
247
-
-
80054989315
-
Trastuzumab emtansine (T-DM1): A novel agent for targeting HER2(+) breast cancer
-
Burris HA, Tibbitts J, Holden SN, Sliwkowski MX, Phillips GDL. Trastuzumab emtansine (T-DM1): A novel agent for targeting HER2(+) breast cancer. Clin Breast Cancer 2011; 11(5): 275-82.
-
(2011)
Clin Breast Cancer
, vol.11
, Issue.5
, pp. 275-282
-
-
Burris, H.A.1
Tibbitts, J.2
Holden, S.N.3
Sliwkowski, M.X.4
Phillips, G.D.L.5
-
248
-
-
0032895235
-
Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer
-
Goldenberg MM. Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer. Clin Ther 1999; 21(2): 309-18.
-
(1999)
Clin Ther
, vol.21
, Issue.2
, pp. 309-318
-
-
Goldenberg, M.M.1
-
249
-
-
84872296413
-
Primary results from EMILIA, a Phase III study of trastuzumab emtansine (T-DM1) versus capecitabine (X) and lapatinib (L) in HER2-positive locally advanced or metastatic breast cancer (MBC) previously treated with trastuzumab (T) and a taxane
-
June 1-5, Chicago, USA
-
Blackwell KL, Miles G, Gianni L, Krop IE, Weslau M, Baselga J, et al. Ed. Primary results from EMILIA, a Phase III study of trastuzumab emtansine (T-DM1) versus capecitabine (X) and lapatinib (L) in HER2-positive locally advanced or metastatic breast cancer (MBC) previously treated with trastuzumab (T) and a taxane. American Society of Clinical Oncology Annual Meeting; June 1-5, Chicago, USA (2012)
-
(2012)
American Society of Clinical Oncology Annual Meeting
-
-
Blackwell, K.L.1
Miles, G.2
Gianni, L.3
Krop, I.E.4
Weslau, M.5
Baselga, J.6
-
250
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012; 367(19): 1783-91.
-
(2012)
N Engl J Med
, vol.367
, Issue.19
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
Krop, I.E.4
Welslau, M.5
Baselga, J.6
-
251
-
-
84901264566
-
-
WO2012138537
-
Whiteman, K.R., O'Leary, J.J., Lutz, R.J. Compositions and methods for treatment of ovarian, peritoneal, and fallopian tube cancer. WO2012138537 (2012).
-
(2012)
Compositions and Methods For Treatment of Ovarian, Peritoneal, and Fallopian Tube Cancer
-
-
Whiteman, K.R.1
O'Leary, J.J.2
Lutz, R.J.3
-
252
-
-
79952992903
-
Immunoconjugates against solid tumors: Mind the gap
-
Ricart AD. Immunoconjugates against solid tumors: Mind the gap. Clin Pharmacol Ther 2011; 89(4): 513-23.
-
(2011)
Clin Pharmacol Ther
, vol.89
, Issue.4
, pp. 513-523
-
-
Ricart, A.D.1
-
253
-
-
84866763985
-
Potent B-cell depletion by IMGN529, a CD37-targeting antibodymaytansinoid conjugate for the treatment of B-cell malignancies
-
Deckert J, Chicklas S, Yi Y, Li M, Pinkas J, Chittenden T, et al. Potent B-cell depletion by IMGN529, a CD37-targeting antibodymaytansinoid conjugate for the treatment of B-cell malignancies. Blood 2011; 118(21): 1591-2.
-
(2011)
Blood
, vol.118
, Issue.21
, pp. 1591-1592
-
-
Deckert, J.1
Chicklas, S.2
Yi, Y.3
Li, M.4
Pinkas, J.5
Chittenden, T.6
-
254
-
-
84901259334
-
-
WO2011112978
-
Deckert, J., Park, P., Tavares, D., Rui, L. CD37-binding molecules and immunoconjugates thereof. WO2011112978 (2011).
-
(2011)
CD37-binding Molecules and Immunoconjugates Thereof
-
-
Deckert, J.1
Park, P.2
Tavares, D.3
Rui, L.4
-
255
-
-
84862513344
-
Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy
-
Gan HK, Burgess AW, Clayton AHA, Scott AM. Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy. Cancer Res 2012; 72(12): 2924-30.
-
(2012)
Cancer Res
, vol.72
, Issue.12
, pp. 2924-2930
-
-
Gan, H.K.1
Burgess, A.W.2
Clayton, A.H.A.3
Scott, A.M.4
-
256
-
-
84901284178
-
-
WO2005012479
-
Weber R, Feng X, Foord O, Green L, Gudas J, Keyt B, Liu, Y., Rathanaswami, P., Raya, R., Yang, X.D., Corvalan, J., Foltz, I., Jia, X.-C., Kang, J., King, C.T., Klakamp, S.L., Qiaojuan, J.S. Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof. WO2005012479 (2005).
-
(2005)
Antibodies Directed to The Deletion Mutants of Epidermal Growth Factor Receptor and Uses Thereof
-
-
Weber, R.1
Feng, X.2
Foord, O.3
Green, L.4
Gudas, J.5
Keyt, B.6
Liu, Y.7
Rathanaswami, P.8
Raya, R.9
Yang, X.D.10
Corvalan, J.11
Foltz, I.12
Jia, X.-C.13
Kang, J.14
King, C.T.15
Klakamp, S.L.16
Qiaojuan, J.S.17
-
257
-
-
84872657718
-
AMG595, a novel antibody drug conjugate approach for targeting EGFRvIII- expressing glioblastoma
-
Hamblett KJ, Kozlosky CJ, Liu H, Siu S, Arora T, Retter MW, et al. AMG595, a novel antibody drug conjugate approach for targeting EGFRvIII- expressing glioblastoma. Neuro Oncol 2011; 13: 115.
-
(2011)
Neuro Oncol
, vol.13
, pp. 115
-
-
Hamblett, K.J.1
Kozlosky, C.J.2
Liu, H.3
Siu, S.4
Arora, T.5
Retter, M.W.6
-
258
-
-
84901280920
-
-
WO2011106528
-
Ab, O., Tavares, D., Rui, L., Payne, G., Goldmakher, V.S. Folate receptor 1 antibodies and immunoconjugates and uses thereof. WO2011106528 (2011).
-
(2011)
Folate Receptor 1 Antibodies and Immunoconjugates and Uses Thereof
-
-
Ab, O.1
Tavares, D.2
Rui, L.3
Payne, G.4
Goldmakher, V.S.5
-
259
-
-
84861325993
-
High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and mutation
-
Nunez MI, Behrens C, Woods DM, Lin H, Suraokar M, Kadara H, et al. High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and mutation. J Thorac Oncol 2012; 7(5): 833-40.
-
(2012)
J Thorac Oncol
, vol.7
, Issue.5
, pp. 833-840
-
-
Nunez, M.I.1
Behrens, C.2
Woods, D.M.3
Lin, H.4
Suraokar, M.5
Kadara, H.6
-
261
-
-
84901289987
-
-
WO2006062779
-
Chen, Q., Trikha, M., Lutz, R.J., Steeves, R.M., Amphlett, G. Antiintegrin immunoconjugates, methods and uses. WO2006062779 (2006).
-
(2006)
Antiintegrin Immunoconjugates, Methods and Uses
-
-
Chen, Q.1
Trikha, M.2
Lutz, R.J.3
Steeves, R.M.4
Amphlett, G.5
-
262
-
-
84862686491
-
Integrins as therapeutic targets
-
Goodman SL, Picard M. Integrins as therapeutic targets. Trends Pharmacol Sci 2012; 33(7): 405-12.
-
(2012)
Trends Pharmacol Sci
, vol.33
, Issue.7
, pp. 405-412
-
-
Goodman, S.L.1
Picard, M.2
-
263
-
-
84952981119
-
SAR-3419. Antibody-drug immunoconjugate, Oncolytic
-
Tuszynski JA. SAR-3419. Antibody-drug immunoconjugate, Oncolytic. Drugs Fut 2012; 37(6): 419-22.
-
(2012)
Drugs Fut
, vol.37
, Issue.6
, pp. 419-422
-
-
Tuszynski, J.A.1
-
265
-
-
84901289611
-
-
US20120195912
-
Sanicola-Nadel, M., Williams, K., Schiffer, S.G., Rayhorn, P. Cripto blocking antibodies and uses thereof. US20120195912 (2012).
-
(2012)
Cripto Blocking Antibodies and Uses Thereof
-
-
Sanicola-Nadel, M.1
Williams, K.2
Schiffer, S.G.3
Rayhorn, P.4
-
266
-
-
79959947572
-
An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours
-
Kelly RK, Olson DL, Sun YP, Wen DY, Wortham KA, Antognetti G, et al. An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours. Eur J Cancer 2011; 47(11): 1736-46.
-
(2011)
Eur J Cancer
, vol.47
, Issue.11
, pp. 1736-1746
-
-
Kelly, R.K.1
Olson, D.L.2
Sun, Y.P.3
Wen, D.Y.4
Wortham, K.A.5
Antognetti, G.6
-
267
-
-
84902658881
-
-
WO2009068204
-
Kahnert, A., Light, D., Schneider, D., Parry, R., Satozawa, N., Heitner, T., Steidl, S., Schubert, U. Anti-mesothelin antibodies and uses therefor. WO2009068204 (2009).
-
(2009)
Anti-mesothelin Antibodies and Uses Therefor
-
-
Kahnert, A.1
Light, D.2
Schneider, D.3
Parry, R.4
Satozawa, N.5
Heitner, T.6
Steidl, S.7
Schubert, U.8
-
268
-
-
84859379903
-
Mesothelin-targeted agents in clinical trials and in preclinical development
-
Kelly RJ, Sharon E, Pastan I, Hassan R. Mesothelin-targeted agents in clinical trials and in preclinical development. Mol Cancer Ther 2012; 11(3): 517-25.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.3
, pp. 517-525
-
-
Kelly, R.J.1
Sharon, E.2
Pastan, I.3
Hassan, R.4
-
273
-
-
84901265596
-
-
WO2012024223
-
Chang, C.-H., Goldenberg, D.M., Rossi, E.A. Combination therapy with anti-CD74 antibodies provides enhanced toxicity to malignancies, autoimmune disease and other diseases. WO2012024223 (2012).
-
(2012)
Combination Therapy With Anti-CD74 Antibodies Provides Enhanced Toxicity to Malignancies, Autoimmune Disease and Other Diseases
-
-
Chang, C.-H.1
Goldenberg, D.M.2
Rossi, E.A.3
-
274
-
-
34848917110
-
CD74: A new candidate target for the immunotherapy of Bcell neoplasms
-
Stein R, Mattes MJ, Cardillo TM, Hansen HJ, Chang CH, Burton J, et al. CD74: A new candidate target for the immunotherapy of Bcell neoplasms. Clin Cancer Res 2007; 13(18 Pt 2): 5556s-63s.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.18 Pt 2
-
-
Stein, R.1
Mattes, M.J.2
Cardillo, T.M.3
Hansen, H.J.4
Chang, C.H.5
Burton, J.6
-
275
-
-
70349175559
-
Trop2: A possible therapeutic target for late stage epithelial carcinomas
-
Cubas R, Li M, Chen C, Yao Q. Trop2: A possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta 2009; 1796(2): 309-14.
-
(2009)
Biochim Biophys Acta
, vol.1796
, Issue.2
, pp. 309-314
-
-
Cubas, R.1
Li, M.2
Chen, C.3
Yao, Q.4
-
277
-
-
70349685092
-
CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates
-
Govindan SV, Cardillo TM, Moon SJ, Hansen HJ, Goldenberg DM. CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates. Clin Cancer Res 2009; 15(19): 6052-61.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.19
, pp. 6052-6061
-
-
Govindan, S.V.1
Cardillo, T.M.2
Moon, S.J.3
Hansen, H.J.4
Goldenberg, D.M.5
-
279
-
-
79952081834
-
The medicinal potential of promising marine macrolides with anticancer activity
-
Qi, Y., Ma, S. The medicinal potential of promising marine macrolides with anticancer activity. ChemMedChem 2011; 6(3): 399-409.
-
(2011)
ChemMedChem
, vol.6
, Issue.3
, pp. 399-409
-
-
Qi, Y.1
Ma, S.2
-
280
-
-
80053301623
-
Recently confirmed apoptosisinducing lead compounds isolated from marine sponge of potential relevance in cancer treatment
-
Essack M, Bajic VB, Archer JAC. Recently confirmed apoptosisinducing lead compounds isolated from marine sponge of potential relevance in cancer treatment. Mar Drugs 2011; 9(9): 1580-606.
-
(2011)
Mar Drugs
, vol.9
, Issue.9
, pp. 1580-1606
-
-
Essack, M.1
Bajic, V.B.2
Archer, J.A.C.3
-
281
-
-
77649235468
-
The continuing search for antitumor agents from higher plants
-
Pan L, Chai H, Kinghorn AD. The continuing search for antitumor agents from higher plants. Phytochem Lett 2010; 3(1): 1-8.
-
(2010)
Phytochem Lett
, vol.3
, Issue.1
, pp. 1-8
-
-
Pan, L.1
Chai, H.2
Kinghorn, A.D.3
-
282
-
-
79953299183
-
that target dynamic microtubules: A new molecular perspective
-
Stanton RA, Gernert KM, Nettles JH, Aneja R. Drugs that target dynamic microtubules: A new molecular perspective. Med Res Rev 2011; 31(3): 443-81.
-
(2011)
Med Res Rev
, vol.31
, Issue.3
, pp. 443-481
-
-
Stanton, R.A.1
Gernert, K.M.2
Nettles, J.H.3
Drugs, A.R.4
-
283
-
-
80052253646
-
Anticancer prodrugs: An overview of major strategies and recent developments
-
Arpicco S, Dosio F, Stella B, Cattel L. Anticancer prodrugs: An overview of major strategies and recent developments. Curr Top Med Chem 2011; 11(18): 2346-81.
-
(2011)
Curr Top Med Chem
, vol.11
, Issue.18
, pp. 2346-2381
-
-
Arpicco, S.1
Dosio, F.2
Stella, B.3
Cattel, L.4
-
284
-
-
0028141462
-
Cryptophycin: A new antimicrotubule agent active against drugresistant cells
-
Smith CD, Zhang X, Mooberry SL, Patterson GML, Moore RE. Cryptophycin: A new antimicrotubule agent active against drugresistant cells. Cancer Res 1994; 54(14): 3779-84.
-
(1994)
Cancer Res
, vol.54
, Issue.14
, pp. 3779-3784
-
-
Smith, C.D.1
Zhang, X.2
Mooberry, S.L.3
Patterson, G.M.L.4
Moore, R.E.5
-
285
-
-
84881592069
-
-
US20120225089
-
Bouchard, H., Brun, M.-P., Commercon, A., Zhang, J. Novel conjugates, preparation thereof, and therapeutic use thereof. US20120225089 (2012).
-
(2012)
Novel Conjugates, Preparation Thereof, and Therapeutic Use Thereof
-
-
Bouchard, H.1
Brun, M.-P.2
Commercon, A.3
Zhang, J.4
-
287
-
-
84867297809
-
Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives
-
Rath S, Liebl J, Forst R, Ullrich A, Burkhart JL, Kazmaier U, et al. Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives. Br J Pharmacol 2012; 167(5): 1048-61.
-
(2012)
Br J Pharmacol
, vol.167
, Issue.5
, pp. 1048-1061
-
-
Rath, S.1
Liebl, J.2
Forst, R.3
Ullrich, A.4
Burkhart, J.L.5
Kazmaier, U.6
-
288
-
-
79957762179
-
The multiple multicomponent approach to natural product mimics: Tubugis, N-substituted anticancer peptides with picomolar activity
-
Pando O, Stark S, Denkert A, Porzel A, Preusentanz R, Wessjohann LA. The multiple multicomponent approach to natural product mimics: Tubugis, N-substituted anticancer peptides with picomolar activity. J Am Chem Soc 2011; 133(20): 7692-5.
-
(2011)
J Am Chem Soc
, vol.133
, Issue.20
, pp. 7692-7695
-
-
Pando, O.1
Stark, S.2
Denkert, A.3
Porzel, A.4
Preusentanz, R.5
Wessjohann, L.A.6
-
289
-
-
78650549894
-
Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in C26 tumor bearing mice
-
Floyd WC, Datta GK, Imamura S, Kieler-Ferguson HM, Jerger K, Patterson AW, et al. Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in C26 tumor bearing mice. ChemMedchem 2011; 6(1): 49-53.
-
(2011)
ChemMedchem
, vol.6
, Issue.1
, pp. 49-53
-
-
Floyd, W.C.1
Datta, G.K.2
Imamura, S.3
Kieler-Ferguson, H.M.4
Jerger, K.5
Patterson, A.W.6
-
290
-
-
58849101367
-
Polymeric tubulysin-peptide nanoparticles with potent antitumor activity
-
Schluep T, Gunawan P, Ling M, Jensen GS, Duringer J, Hinton S, et al. Polymeric tubulysin-peptide nanoparticles with potent antitumor activity. Clin Cancer Res 2009; 15(1): 181-9.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.1
, pp. 181-189
-
-
Schluep, T.1
Gunawan, P.2
Ling, M.3
Jensen, G.S.4
Duringer, J.5
Hinton, S.6
-
291
-
-
70350070854
-
In vivo structural activity and optimization studies of folatetubulysin conjugates
-
Reddy JA, Dorton R, Dawson A, Vetzel M, Parker N, Nicoson JS, et al. In vivo structural activity and optimization studies of folatetubulysin conjugates. Mol Pharm 2009; 6(5): 1518-25.
-
(2009)
Mol Pharm
, vol.6
, Issue.5
, pp. 1518-1525
-
-
Reddy, J.A.1
Dorton, R.2
Dawson, A.3
Vetzel, M.4
Parker, N.5
Nicoson, J.S.6
-
292
-
-
77957374075
-
Microtubule-binding agents: A dynamic field of cancer therapeutics
-
Dumontet C, Jordan MA. Microtubule-binding agents: A dynamic field of cancer therapeutics. Nat Rev Drug Discov 2010; 9(10): 790-803.
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.10
, pp. 790-803
-
-
Dumontet, C.1
Jordan, M.A.2
-
293
-
-
68049118844
-
DNA minor groove binders: Back in the groove
-
Cai X, Gray Jr PJ, Von Hoff DD. DNA minor groove binders: Back in the groove. Cancer Treat Rev 2009; 35(5): 437-50.
-
(2009)
Cancer Treat Rev
, vol.35
, Issue.5
, pp. 437-450
-
-
Cai, X.1
Gray, P.J.2
von Hoff, D.D.3
-
294
-
-
84856009982
-
Natural product DNA major groove binders
-
Hamilton PL, Arya DP. Natural product DNA major groove binders. Nat Prod Rep 2012; 29(2): 134-43.
-
(2012)
Nat Prod Rep
, vol.29
, Issue.2
, pp. 134-143
-
-
Hamilton, P.L.1
Arya, D.P.2
-
295
-
-
0018111845
-
Amatoxins, phallotoxins, phallolysin, and antamanide: The biologically active components of poisonous Amanita mushrooms
-
Wieland T, Faulstich H. Amatoxins, phallotoxins, phallolysin, and antamanide: The biologically active components of poisonous Amanita mushrooms. CRC Crit Rev Biochem 1978; 5(3): 185-260.
-
(1978)
CRC Crit Rev Biochem
, vol.5
, Issue.3
, pp. 185-260
-
-
Wieland, T.1
Faulstich, H.2
-
296
-
-
84901247986
-
-
WO2012119787
-
Simon, W., Lutz, C., Anderl, J., Mueller, C. Amatoxin-conjugates with improved linkages. WO2012119787 (2012).
-
(2012)
Amatoxin-conjugates With Improved Linkages
-
-
Simon, W.1
Lutz, C.2
Anderl, J.3
Mueller, C.4
-
298
-
-
84860142832
-
Therapeutic potential of amanitin-conjugated antiepithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma
-
Moldenhauer G, Salnikov AV, Luttgau S, Herr I, Anderl J, Faulstich H. Therapeutic potential of amanitin-conjugated antiepithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma. J Natl Cancer Inst 2012; 104(8): 622-34.
-
(2012)
J Natl Cancer Inst
, vol.104
, Issue.8
, pp. 622-634
-
-
Moldenhauer, G.1
Salnikov, A.V.2
Luttgau, S.3
Herr, I.4
Anderl, J.5
Faulstich, H.6
-
299
-
-
49449119098
-
Antibody-drug conjugates for cancer therapy
-
Carter PJ, Senter PD. Antibody-drug conjugates for cancer therapy. Cancer J 2008; 14(3): 154-69.
-
(2008)
Cancer J
, vol.14
, Issue.3
, pp. 154-169
-
-
Carter, P.J.1
Senter, P.D.2
-
300
-
-
84901256895
-
-
WO2012149412
-
Guidi, C.J., Zhou, H.X., Zhang, C., Tavares, D., Park, P. Antiendoglin (CD105) antibodies, immunoconjugates, and uses thereof. WO2012149412 (2012).
-
(2012)
Antiendoglin (CD105) Antibodies, Immunoconjugates, and Uses Thereof
-
-
Guidi, C.J.1
Zhou, H.X.2
Zhang, C.3
Tavares, D.4
Park, P.5
-
301
-
-
84901288815
-
-
WO2012131527
-
Gerber, H.-P., Dijoseph, J.F., Khandke, K.M., Marquette, K.A., Sapra, P., Tchistiakova, L.G. Antibody-drug conjugates. WO2012131527 (2012).
-
(2012)
Antibody-drug Conjugates
-
-
Gerber, H.-P.1
Dijoseph, J.F.2
Khandke, K.M.3
Marquette, K.A.4
Sapra, P.5
Tchistiakova, L.G.6
-
302
-
-
84873053339
-
Antibody-drug conjugates in cancer therapy
-
Sievers EL, Senter PD. Antibody-drug conjugates in cancer therapy. Annu Rev Med 2013; 64: 15-29.
-
(2013)
Annu Rev Med
, vol.64
, pp. 15-29
-
-
Sievers, E.L.1
Senter, P.D.2
-
303
-
-
84901268719
-
-
GB2455449
-
Daugherty, P., Stagliano, N.E., Jerry, T.W., Kamath, K., West, J., Khare, S. Activatable binding polypeptides and methods of indentifcation and use thereof. GB2455449 (2009).
-
(2009)
Activatable Binding Polypeptides and Methods of Indentifcation and Use Thereof
-
-
Daugherty, P.1
Stagliano, N.E.2
Jerry, T.W.3
Kamath, K.4
West, J.5
Khare, S.6
-
304
-
-
84901287318
-
-
AU20110203353
-
Stagliano, N.E., West, J.W., Kamath, K., Bessette, P.H., Gluck, F., Sagert, J., Daugherty, P. Variable frequency drive system apparatus and method for reduced ground leakage current and transistor protection. AU20110203353 (2011).
-
(2011)
Variable Frequency Drive System Apparatus and Method For Reduced Ground Leakage Current and Transistor Protection
-
-
Stagliano, N.E.1
West, J.W.2
Kamath, K.3
Bessette, P.H.4
Gluck, F.5
Sagert, J.6
Daugherty, P.7
-
305
-
-
84901274797
-
-
AU2010215761 (2011) & US20130101555
-
Stagliano, N.E., West, J.W., Kamath, K., Bessette, P.H., Gluck, F., Sagert, J. Proproteins and methods of use thereof. AU2010215761 (2011) & US20130101555 (2013).
-
(2013)
Proproteins and Methods of Use Thereof
-
-
Stagliano, N.E.1
West, J.W.2
Kamath, K.3
Bessette, P.H.4
Gluck, F.5
Sagert, J.6
-
306
-
-
77956291596
-
Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease Nexin-1
-
Xu D, McKee CM, Cao Y, Ding Y, Kessler BM, Muschel RJ. Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease Nexin-1. Cancer Res 2010; 70(17): 6988-98.
-
(2010)
Cancer Res
, vol.70
, Issue.17
, pp. 6988-6998
-
-
Xu, D.1
McKee, C.M.2
Cao, Y.3
Ding, Y.4
Kessler, B.M.5
Muschel, R.J.6
-
307
-
-
84871362496
-
Antibody-drug conjugates for the treatment of cancer
-
Flygare JA, Pillow TH, Aristoff P. Antibody-drug conjugates for the treatment of cancer. Chem Biol Drug Des 2013; 81(1):113-21.
-
(2013)
Chem Biol Drug Des
, vol.81
, Issue.1
, pp. 113-121
-
-
Flygare, J.A.1
Pillow, T.H.2
Aristoff, P.3
-
308
-
-
84873398897
-
Development of a native nanoelectrospray mass spectrometry method for determination of the drug-to-antibody ratio of antibody-drug conjugates
-
Chen J, Yin S, Wu Y, Ouyang J. Development of a native nanoelectrospray mass spectrometry method for determination of the drug-to-antibody ratio of antibody-drug conjugates. Anal Chem 2013; 85(3): 1699-704.
-
(2013)
Anal Chem
, vol.85
, Issue.3
, pp. 1699-1704
-
-
Chen, J.1
Yin, S.2
Wu, Y.3
Ouyang, J.4
-
309
-
-
84855379223
-
Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues
-
Lyon RP, Meyer DL, Setter JR, Senter PD. Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues. Methods Enzymol 2012; 502: 123-38.
-
(2012)
Methods Enzymol
, vol.502
, pp. 123-138
-
-
Lyon, R.P.1
Meyer, D.L.2
Setter, J.R.3
Senter, P.D.4
-
310
-
-
77957590621
-
Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer
-
Junutula JR, Flagella KM, Graham RA, Parsons KL, Ha E, Raab H, et al. Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer. Clin Cancer Res 2010; 16(19): 4769-78.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.19
, pp. 4769-4778
-
-
Junutula, J.R.1
Flagella, K.M.2
Graham, R.A.3
Parsons, K.L.4
Ha, E.5
Raab, H.6
-
311
-
-
84901289651
-
-
WO2010141902
-
Chennamsetty, N., Helk, B., Kayser, V., Trout, B., Voynov, V. Methods for identification of sites for IgG conjugation. WO2010141902 (2010).
-
(2010)
Methods For Identification of Sites For IgG Conjugation
-
-
Chennamsetty, N.1
Helk, B.2
Kayser, V.3
Trout, B.4
Voynov, V.5
-
312
-
-
77049123763
-
Design and application of antibody cysteine variants
-
Voynov V, Chennamsetty N, Kayser V, Wallny HJ, Helk B, Trout BL. Design and application of antibody cysteine variants. Bioconj Chem 2010; 21(2): 385-92.
-
(2010)
Bioconj Chem
, vol.21
, Issue.2
, pp. 385-392
-
-
Voynov, V.1
Chennamsetty, N.2
Kayser, V.3
Wallny, H.J.4
Helk, B.5
Trout, B.L.6
-
313
-
-
84863012529
-
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
-
Shen BQ, Xu K, Liu L, Raab H, Bhakta S, Kenrick M, et al. Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nat Biotechnol 2012; 30(2): 184-9.
-
(2012)
Nat Biotechnol
, vol.30
, Issue.2
, pp. 184-189
-
-
Shen, B.Q.1
Xu, K.2
Liu, L.3
Raab, H.4
Bhakta, S.5
Kenrick, M.6
-
314
-
-
84871597721
-
An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: Case study of TENB2
-
Boswell CA, Mundo EE, Firestein R, Zhang C, Mao W, Gill H, et al. An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: Case study of TENB2. Br J Pharmacol 2013; 168 (2):445-57.
-
(2013)
Br J Pharmacol
, vol.168
, Issue.2
, pp. 445-457
-
-
Boswell, C.A.1
Mundo, E.E.2
Firestein, R.3
Zhang, C.4
Mao, W.5
Gill, H.6
-
315
-
-
67749111952
-
Design of therapeutic proteins with enhanced stability
-
Chennamsetty N, Voynov V, Kayser V, Helk B, Trout BL. Design of therapeutic proteins with enhanced stability. Proc Natl Acad Sci USA 2009; 106(29): 11937-42.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.29
, pp. 11937-11942
-
-
Chennamsetty, N.1
Voynov, V.2
Kayser, V.3
Helk, B.4
Trout, B.L.5
-
316
-
-
50449091735
-
An engineered selenocysteine defines a unique class of antibody derivatives
-
Hofer T, Thomas JD, Burke Jr TR, Rader C. An engineered selenocysteine defines a unique class of antibody derivatives. Proc Natl Acad Sci USA 2008; 105(34): 12451-6.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.34
, pp. 12451-12456
-
-
Hofer, T.1
Thomas, J.D.2
Burke, T.R.3
Rader, C.4
-
317
-
-
84901276832
-
-
US2010048871
-
Cho, H., Daniel, T., Hays, A.-M., Wilson, T., Litzinger, D., Mariani, R., Kimmel, B., Keefe, W. Biosynthetic polypeptides utilizing non-naturally encoded amino acids. US2010048871 (2010).
-
(2010)
Biosynthetic Polypeptides Utilizing Non-naturally Encoded Amino Acids
-
-
Cho, H.1
Daniel, T.2
Hays, A.-M.3
Wilson, T.4
Litzinger, D.5
Mariani, R.6
Kimmel, B.7
Keefe, W.8
-
318
-
-
84867040452
-
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids
-
Axup JY, Bajjuri KM, Ritland M, Hutchins BM, Kim CH, Kazane SA, et al. Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc Natl Acad Sci USA 2012; 109(40): 16101-6.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.40
, pp. 16101-16106
-
-
Axup, J.Y.1
Bajjuri, K.M.2
Ritland, M.3
Hutchins, B.M.4
Kim, C.H.5
Kazane, S.A.6
-
319
-
-
84874298141
-
-
WO2012059882 (2012) & US20130230543
-
Strop, P., Dorywalska, M.G., Rajpal, A., Shelton, D., Liu, S.-H., Pons, J., Dushin, R. Engineered polypeptide conjugates and methods for making thereof using transglutaminase. WO2012059882 (2012) & US20130230543 (2013).
-
(2013)
Engineered Polypeptide Conjugates and Methods For Making Thereof Using Transglutaminase
-
-
Strop, P.1
Dorywalska, M.G.2
Rajpal, A.3
Shelton, D.4
Liu, S.-H.5
Pons, J.6
Dushin, R.7
-
321
-
-
84883619780
-
-
WO2012113847
-
Ducry, L., Stump, B., Wong, H., She, J., Phillips, G. Branched linker for protein drug conjugates. WO2012113847 (2012).
-
(2012)
Branched Linker For Protein Drug Conjugates
-
-
Ducry, L.1
Stump, B.2
Wong, H.3
She, J.4
Phillips, G.5
-
326
-
-
84869797748
-
Fourth World Antibody-Drug Conjugate Summit: February 29th March 1, 2012, Frankfurt, Germany
-
Beck A, Lambert J, Sun M, Lin K. Fourth World Antibody-Drug Conjugate Summit: February 29th March 1, 2012, Frankfurt, Germany. mAbs 2012; 4(6): 637-47.
-
(2012)
MAbs
, vol.4
, Issue.6
, pp. 637-647
-
-
Beck, A.1
Lambert, J.2
Sun, M.3
Lin, K.4
-
327
-
-
84868515110
-
Targeted drug delivery for cancer therapy: The other side of antibodies
-
Firer MA, Gellerman G. Targeted drug delivery for cancer therapy: The other side of antibodies. J Hematol Oncol 2012; 5: 16.
-
(2012)
J Hematol Oncol
, vol.5
, pp. 16
-
-
Firer, M.A.1
Gellerman, G.2
-
328
-
-
84884367429
-
Polymeric nanomedicines as a promising vehicle for solid tumor therapy and targeting
-
Gupta M, Agrawal GP, Vyas SP. Polymeric nanomedicines as a promising vehicle for solid tumor therapy and targeting. Curr Mol Med 2013; 13(1): 179-204.
-
(2013)
Curr Mol Med
, vol.13
, Issue.1
, pp. 179-204
-
-
Gupta, M.1
Agrawal, G.P.2
Vyas, S.P.3
-
329
-
-
84870415996
-
Immunoliposomes
-
Paszko E, Senge MO. Immunoliposomes. Curr Med Chem 2012; 19(31): 5239-77.
-
(2012)
Curr Med Chem
, vol.19
, Issue.31
, pp. 5239-5277
-
-
Paszko, E.1
Senge, M.O.2
-
330
-
-
84871698293
-
Drug conjugates such as antibody drug conjugates (ADCs), immunotoxins and immunoliposomes challenge daily clinical practice
-
Janthur WD, Cantoni N, Mamot C. Drug conjugates such as antibody drug conjugates (ADCs), immunotoxins and immunoliposomes challenge daily clinical practice. Int J Mol Sci 2012; 13(12): 16785-95.
-
(2012)
Int J Mol Sci
, vol.13
, Issue.12
, pp. 16785-16795
-
-
Janthur, W.D.1
Cantoni, N.2
Mamot, C.3
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