A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity

Protein Engineering, Design and Selection

Volumn 25, Issue 1, 2012, Pages 1-6

  Liu, Wenhai ^a   Onda, Masanori ^a   Kim, Changhoon ^a,b   Xiang, Laiman ^a   Weldon, John E ^a   Lee, Byungkook ^a   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Yonsei University   (South Korea)

Author keywords

disulfide bond; immunogenicity; immunotoxin

Indexed keywords

ANTI-CANCER AGENTS; ANTI-TUMOR ACTIVITIES; CANCER CELLS; COMPUTER MODELING; CYTOTOXIC; DISULFIDE BONDS; IMMUNOGENICITY; IMMUNOTOXINS; PROTEIN MOLECULES; PROTEIN TOXINS;

AMINO ACIDS; BACTERIA; COVALENT BONDS; DISEASES; PROTEINS;

STABILITY;

CD22 ANTIGEN; IMMUNOTOXIN; LYSOSOME ENZYME; PSEUDOMONAS EXOTOXIN; TRYPSIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DISULFIDE BOND; FEMALE; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ADP RIBOSE TRANSFERASES; ANIMALS; BACTERIAL TOXINS; CELL LINE, TUMOR; CELL SURVIVAL; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXOTOXINS; FEMALE; HOT TEMPERATURE; HUMANS; IMMUNOTOXINS; LYMPHOMA; MICE; MICE, INBRED BALB C; MICE, SCID; MUTATION; PROTEIN ENGINEERING; PROTEIN STABILITY; RECOMBINANT PROTEINS; TIME FACTORS; VIRULENCE FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS; PSEUDOMONAS EXOTOXIN;

EID: 84555186831     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr053     Document Type: Article

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