-
1
-
-
62149099451
-
Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4′-desmethoxyepisilvestrol
-
Adams T.E., El Sous M., Hawkins B.C., Hirner S., Holloway G., Khoo M.L., Owen D.J., Savage G.P., Scammells P.J., and Rizzacasa M.A. Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4′-desmethoxyepisilvestrol. J. Am. Chem. Soc. 131 (2009) 1607-1616
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 1607-1616
-
-
Adams, T.E.1
El Sous, M.2
Hawkins, B.C.3
Hirner, S.4
Holloway, G.5
Khoo, M.L.6
Owen, D.J.7
Savage, G.P.8
Scammells, P.J.9
Rizzacasa, M.A.10
-
5
-
-
84988044841
-
Assay development
-
Anonymous. Assay development. Nat. Rev. Drug Disc. 6 (2007) 681
-
(2007)
Nat. Rev. Drug Disc.
, vol.6
, pp. 681
-
-
-
6
-
-
42149091100
-
Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer
-
Bailey H.H., Attia S., Love R.R., Fass T., Chappell R., Tutsch K., Harris L., Jumonville A., Hansen R., Shapiro G.R., and Stewart J.A. Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. Cancer Chemother. Pharmacol. 62 (2008) 149-157
-
(2008)
Cancer Chemother. Pharmacol.
, vol.62
, pp. 149-157
-
-
Bailey, H.H.1
Attia, S.2
Love, R.R.3
Fass, T.4
Chappell, R.5
Tutsch, K.6
Harris, L.7
Jumonville, A.8
Hansen, R.9
Shapiro, G.R.10
Stewart, J.A.11
-
7
-
-
27844474247
-
Drug discovery from medicinal plants
-
Balunas M.J., and Kinghorn A.D. Drug discovery from medicinal plants. Life. Sci. 78 (2005) 431-441
-
(2005)
Life. Sci.
, vol.78
, pp. 431-441
-
-
Balunas, M.J.1
Kinghorn, A.D.2
-
8
-
-
0032254146
-
Perillyl alcohol: applications in oncology
-
Belanger J.T. Perillyl alcohol: applications in oncology. Altern. Med. Rev. 3 (1998) 448-457
-
(1998)
Altern. Med. Rev.
, vol.3
, pp. 448-457
-
-
Belanger, J.T.1
-
9
-
-
0035882369
-
Pure compound libraries: a new perspective for natural product based drug discovery
-
Bindseil K.U., Jakupovic J., Wolf D., Lavayre J., Leboul J., and van der Pyl D. Pure compound libraries: a new perspective for natural product based drug discovery. Drug Discov. Today 6 (2001) 840-847
-
(2001)
Drug Discov. Today
, vol.6
, pp. 840-847
-
-
Bindseil, K.U.1
Jakupovic, J.2
Wolf, D.3
Lavayre, J.4
Leboul, J.5
van der Pyl, D.6
-
10
-
-
46749097944
-
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
-
Bordeleau M.-E., Robert F., Gerard B., Lindqvist L., Chen S.M.H., Wendel H.G., Brem B., Greger H., Lowe S.W., Porco Jr. J.A., and Pelletier J. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. Clin. Investig. 118 (2008) 1-11
-
(2008)
Clin. Investig.
, vol.118
, pp. 1-11
-
-
Bordeleau, M.-E.1
Robert, F.2
Gerard, B.3
Lindqvist, L.4
Chen, S.M.H.5
Wendel, H.G.6
Brem, B.7
Greger, H.8
Lowe, S.W.9
Porco Jr., J.A.10
Pelletier, J.11
-
11
-
-
44249098800
-
Natural products to drugs: natural product-derived compounds in clinical trials
-
Butler M.S. Natural products to drugs: natural product-derived compounds in clinical trials. Nat. Prod. Rep. 25 (2008) 475-516
-
(2008)
Nat. Prod. Rep.
, vol.25
, pp. 475-516
-
-
Butler, M.S.1
-
12
-
-
48449089245
-
2 generation and topoisomerase II inhibition
-
2 generation and topoisomerase II inhibition. Free Radic. Biol. Med. 45 (2008) 627-635
-
(2008)
Free Radic. Biol. Med.
, vol.45
, pp. 627-635
-
-
Cai, Y.-J.1
Lu, J.J.2
Zhu, H.3
Xie, H.4
Huang, M.5
Lin, L.P.6
Zhang, X.-W.7
Ding, J.8
-
13
-
-
65549098672
-
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol
-
Cencic R., Carrier M., Galicia-Vázquez G., Bordeleau M.-E., Sukarieh R., Bourdeau A., Brem B., Teodoro J.G., Greger H., Tremblay M.L., Porco Jr. J.A., and Pelletier J. Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS ONE 4 4 (2009) e5223
-
(2009)
PLoS ONE
, vol.4
, Issue.4
-
-
Cencic, R.1
Carrier, M.2
Galicia-Vázquez, G.3
Bordeleau, M.-E.4
Sukarieh, R.5
Bourdeau, A.6
Brem, B.7
Teodoro, J.G.8
Greger, H.9
Tremblay, M.L.10
Porco Jr., J.A.11
Pelletier, J.12
-
14
-
-
33645635719
-
-
Brunton L.L., Laso J.S., and Parker K.L. (Eds), McGraw-Hill, New York
-
Chabner B.A., Amrein P.C., Druker B.J., Michaelson M.D., Mitsiades C.S., Gross P.E., Ryan D.P., Ramachandra S., Richardson P.G., Supko J.G., and Wilson W.H. In: Brunton L.L., Laso J.S., and Parker K.L. (Eds). Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11th ed. (2005), McGraw-Hill, New York 1315-1403
-
(2005)
Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11th ed.
, pp. 1315-1403
-
-
Chabner, B.A.1
Amrein, P.C.2
Druker, B.J.3
Michaelson, M.D.4
Mitsiades, C.S.5
Gross, P.E.6
Ryan, D.P.7
Ramachandra, S.8
Richardson, P.G.9
Supko, J.G.10
Wilson, W.H.11
-
15
-
-
0346881254
-
Chemical, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
-
Chichewicz R.H., and Kouzi S.A. Chemical, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med. Res. Rev. 24 (2004) 90-114
-
(2004)
Med. Res. Rev.
, vol.24
, pp. 90-114
-
-
Chichewicz, R.H.1
Kouzi, S.A.2
-
16
-
-
33645547602
-
Phenoxodiol: isoflavone analog with antineoplastic activity
-
Choueiri T.K., Wesolowski R., and Mekhail T.M. Phenoxodiol: isoflavone analog with antineoplastic activity. Curr. Oncol. Rep. 8 (2006) 104-107
-
(2006)
Curr. Oncol. Rep.
, vol.8
, pp. 104-107
-
-
Choueiri, T.K.1
Wesolowski, R.2
Mekhail, T.M.3
-
17
-
-
77649238636
-
-
ClinicalTrials.gov, 2009a. Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid Cancer. Further information available at: http://clinicaltrials.gov/ct2/show/NCT00507429 (accessed October 2009).
-
ClinicalTrials.gov, 2009a. Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid Cancer. Further information available at: http://clinicaltrials.gov/ct2/show/NCT00507429 (accessed October 2009).
-
-
-
-
18
-
-
77649237552
-
-
ClinicalTrials.gov, 2009b. A Study to Assess the Effectiveness of the Combination of Carboplatin, Paclitaxel, Bevacizumab and Combretastatin (CA4P) in Patients With Chemotherapy Naïve Lung Cancer. Further information available at: http://clinicaltrials.gov/ct2/show/NCT00653939 (accessed October 2009).
-
ClinicalTrials.gov, 2009b. A Study to Assess the Effectiveness of the Combination of Carboplatin, Paclitaxel, Bevacizumab and Combretastatin (CA4P) in Patients With Chemotherapy Naïve Lung Cancer. Further information available at: http://clinicaltrials.gov/ct2/show/NCT00653939 (accessed October 2009).
-
-
-
-
19
-
-
0036765911
-
Phenoxodiol [2H-1-benzopyran-7-ol, 3-(4-hydroxyphenyl)], a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex
-
Constantinou A.I., and Husband A. Phenoxodiol [2H-1-benzopyran-7-ol, 3-(4-hydroxyphenyl)], a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex. Anticancer Res. 22 (2002) 2581-2585
-
(2002)
Anticancer Res.
, vol.22
, pp. 2581-2585
-
-
Constantinou, A.I.1
Husband, A.2
-
20
-
-
0003193707
-
Phase II clinical trial on meisoindigo in the treatment of chronic myelogenous leukemia
-
Cooperative Study Group of Phase III Clinical Trial on Meisoindigo
-
Cooperative Study Group of Phase III Clinical Trial on Meisoindigo, 1997. Phase II clinical trial on meisoindigo in the treatment of chronic myelogenous leukemia. Zhonghua Xueyexue Zazhi 18, 69-72.
-
(1997)
Zhonghua Xueyexue Zazhi
, vol.18
, pp. 69-72
-
-
-
21
-
-
34548279788
-
Molecular understanding and modern application of traditional medicines: triumphs and trials
-
Corson T.W., and Crews C.M. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 130 (2007) 769-774
-
(2007)
Cell
, vol.130
, pp. 769-774
-
-
Corson, T.W.1
Crews, C.M.2
-
22
-
-
0005706296
-
International collaboration in drug discovery and development: the NCI experience
-
Cragg G.M., Boyd M.R., Khanna R., Kneller R., Mays T.D., Mazan K.D., Newman D.J., and Sausville E.A. International collaboration in drug discovery and development: the NCI experience. Pure Appl. Chem. 71 (1999) 1619-1633
-
(1999)
Pure Appl. Chem.
, vol.71
, pp. 1619-1633
-
-
Cragg, G.M.1
Boyd, M.R.2
Khanna, R.3
Kneller, R.4
Mays, T.D.5
Mazan, K.D.6
Newman, D.J.7
Sausville, E.A.8
-
23
-
-
85055223076
-
-
Cragg G.M., Kingston D.G.I., and Newman D.J. (Eds), CRC/Taylor & Francis, Boca Raton, FL
-
In: Cragg G.M., Kingston D.G.I., and Newman D.J. (Eds). Anticancer Agents from Natural Products (2005), CRC/Taylor & Francis, Boca Raton, FL
-
(2005)
Anticancer Agents from Natural Products
-
-
-
24
-
-
33646067755
-
Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience
-
Cragg G.M., Newman D.J., and Yang S.S. Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience. J. Nat. Prod. 69 (2006) 488-498
-
(2006)
J. Nat. Prod.
, vol.69
, pp. 488-498
-
-
Cragg, G.M.1
Newman, D.J.2
Yang, S.S.3
-
25
-
-
67650675111
-
Impact of natural products on developing new anti-cancer agents
-
Cragg G.M., Grothaus P.G., and Newman D.J. Impact of natural products on developing new anti-cancer agents. Chem. Rev. 109 (2009) 3012-3043
-
(2009)
Chem. Rev.
, vol.109
, pp. 3012-3043
-
-
Cragg, G.M.1
Grothaus, P.G.2
Newman, D.J.3
-
26
-
-
70349338935
-
AVE8062: a new combretastatin derivative vascular disrupting agent
-
Delmonte A., and Sessa C. AVE8062: a new combretastatin derivative vascular disrupting agent. Expert Opin. Investig. Drugs 18 (2009) 1541-1548
-
(2009)
Expert Opin. Investig. Drugs
, vol.18
, pp. 1541-1548
-
-
Delmonte, A.1
Sessa, C.2
-
27
-
-
77649235045
-
Direct colorimetric method for determination of indigo and indirubin in Qingdai
-
Deng B. Direct colorimetric method for determination of indigo and indirubin in Qingdai. Zhong Cao Yao 17 (1986) 163-164
-
(1986)
Zhong Cao Yao
, vol.17
, pp. 163-164
-
-
Deng, B.1
-
28
-
-
0003998061
-
-
DeVita V.T., Hellman S., and Rosenberg S.A. (Eds), Lippincott-Williams & Wilkins, Philadelphia
-
In: DeVita V.T., Hellman S., and Rosenberg S.A. (Eds). Cancer: Principles and Practice of Oncology. 8th ed. (2008), Lippincott-Williams & Wilkins, Philadelphia
-
(2008)
Cancer: Principles and Practice of Oncology. 8th ed.
-
-
-
29
-
-
51649118928
-
Phase II trial of curcumin in patients with advanced pancreatic cancer
-
Dhillon N., Aggarwal B.B., Newman R.A., Wolff R.A., Kunnumakkara A.B., Abbruzzese J.L., Ng C.S., Badmaev V., and Kurzrock R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin. Cancer Res. 14 (2008) 4491-4499
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 4491-4499
-
-
Dhillon, N.1
Aggarwal, B.B.2
Newman, R.A.3
Wolff, R.A.4
Kunnumakkara, A.B.5
Abbruzzese, J.L.6
Ng, C.S.7
Badmaev, V.8
Kurzrock, R.9
-
30
-
-
8644224855
-
Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine
-
Eisenbrand G., Hippe F., Jakobs S., and Muehlbeyer S. Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine. J. Cancer Res. Clin. Oncol. 130 (2004) 627-635
-
(2004)
J. Cancer Res. Clin. Oncol.
, vol.130
, pp. 627-635
-
-
Eisenbrand, G.1
Hippe, F.2
Jakobs, S.3
Muehlbeyer, S.4
-
31
-
-
35348979221
-
Total synthesis of (-)-silvestrol and (-)-episilvestrol
-
El Sous M., Khoo M.L., Holloway G., Owen D., Scammells P.J., and Rizzacasa M.A. Total synthesis of (-)-silvestrol and (-)-episilvestrol. Angew. Chem. Int. Ed. 46 (2007) 7835-7838
-
(2007)
Angew. Chem. Int. Ed.
, vol.46
, pp. 7835-7838
-
-
El Sous, M.1
Khoo, M.L.2
Holloway, G.3
Owen, D.4
Scammells, P.J.5
Rizzacasa, M.A.6
-
32
-
-
33748774962
-
Endophytic fungal isolates from Podophyllum peltatum produce podophyllotoxin
-
Eyberger A.L., Dondapati R., and Porter J.R. Endophytic fungal isolates from Podophyllum peltatum produce podophyllotoxin. J. Nat. Prod. 69 (2006) 1121-1124
-
(2006)
J. Nat. Prod.
, vol.69
, pp. 1121-1124
-
-
Eyberger, A.L.1
Dondapati, R.2
Porter, J.R.3
-
33
-
-
0035044430
-
The value of plants used in traditional medicine for drug discovery
-
Fabricant D.S., and Farnsworth N.R. The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect. 109 (2001) 69-75
-
(2001)
Environ. Health Perspect.
, vol.109
, pp. 69-75
-
-
Fabricant, D.S.1
Farnsworth, N.R.2
-
34
-
-
0642287879
-
PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy
-
Fidler J.M., Li K., Chung C., Wei K., Ross J.A., Gao M., and Rosen G.D. PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. Mol. Cancer Ther. 2 (2003) 855-862
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 855-862
-
-
Fidler, J.M.1
Li, K.2
Chung, C.3
Wei, K.4
Ross, J.A.5
Gao, M.6
Rosen, G.D.7
-
35
-
-
33750481245
-
Biochemistry: directing biosynthesis
-
Fischbach M.A., and Walsh C.T. Biochemistry: directing biosynthesis. Science 314 (2006) 603-605
-
(2006)
Science
, vol.314
, pp. 603-605
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
36
-
-
0042975166
-
Natural products-a simple model to explain chemical diversity
-
Firn R.D., and Jones C.G. Natural products-a simple model to explain chemical diversity. Nat. Prod. Rep. 20 (2003) 382-391
-
(2003)
Nat. Prod. Rep.
, vol.20
, pp. 382-391
-
-
Firn, R.D.1
Jones, C.G.2
-
38
-
-
9444249285
-
National Cooperative Drug Discovery Groups (NCDDGs): a successful model for public private partnerships in cancer drug discovery
-
Hallock Y.F., and Cragg G.M. National Cooperative Drug Discovery Groups (NCDDGs): a successful model for public private partnerships in cancer drug discovery. Pharm. Biol. 41 Suppl. (2003) 78-91
-
(2003)
Pharm. Biol.
, vol.41
, Issue.SUPPL
, pp. 78-91
-
-
Hallock, Y.F.1
Cragg, G.M.2
-
40
-
-
0001595402
-
Components of podophyllin. V. The constitution of podophyllotoxin
-
Hartwell J.L., and Schrecker A.W. Components of podophyllin. V. The constitution of podophyllotoxin. J. Am. Chem. Soc. 73 (1951) 2909-2916
-
(1951)
J. Am. Chem. Soc.
, vol.73
, pp. 2909-2916
-
-
Hartwell, J.L.1
Schrecker, A.W.2
-
41
-
-
52049109838
-
Natural products in drug discovery
-
Harvey A.L. Natural products in drug discovery. Drug Discov. Today 13 (2008) 894-901
-
(2008)
Drug Discov. Today
, vol.13
, pp. 894-901
-
-
Harvey, A.L.1
-
42
-
-
0029067452
-
-
Hollingshead M.G., Alley M.C., Camalier R.F., Abbott B.J., Mayo J.G., Malspeis L., and Grever M.R. Life Sci. 57 (1995) 131-141
-
(1995)
Life Sci.
, vol.57
, pp. 131-141
-
-
Hollingshead, M.G.1
Alley, M.C.2
Camalier, R.F.3
Abbott, B.J.4
Mayo, J.G.5
Malspeis, L.6
Grever, M.R.7
-
43
-
-
2442561376
-
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris
-
Hwang B.Y., Su B.N., Chai H.-B., Mi Q., Kardono L.B.S., Afriastini J.J., Riswan S., Santarsiero B.D., Mesecar A.D., Wild R., Fairchild C.R., Vite G.D., Rose W.C., Farnsworth N.R., Cordell G.A., Pezzuto J.M., Swanson S.M., and Kinghorn A.D. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J. Org. Chem. 69 (2004) 3350-3358
-
(2004)
J. Org. Chem.
, vol.69
, pp. 3350-3358
-
-
Hwang, B.Y.1
Su, B.N.2
Chai, H.-B.3
Mi, Q.4
Kardono, L.B.S.5
Afriastini, J.J.6
Riswan, S.7
Santarsiero, B.D.8
Mesecar, A.D.9
Wild, R.10
Fairchild, C.R.11
Vite, G.D.12
Rose, W.C.13
Farnsworth, N.R.14
Cordell, G.A.15
Pezzuto, J.M.16
Swanson, S.M.17
Kinghorn, A.D.18
-
44
-
-
4344668945
-
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris
-
Hwang B.Y., Su B.N., Chai H.-B., Mi Q., Kardono L.B.S., Afriastini J.J., Riswan S., Santarsiero B.D., Mesecar A.D., Wild R., Fairchild C.R., Vite G.D., Rose W.C., Farnsworth N.R., Cordell G.A., Pezzuto J.M., Swanson S.M., and Kinghorn A.D. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J. Org. Chem. 69 (2004) 6156
-
(2004)
J. Org. Chem.
, vol.69
, pp. 6156
-
-
Hwang, B.Y.1
Su, B.N.2
Chai, H.-B.3
Mi, Q.4
Kardono, L.B.S.5
Afriastini, J.J.6
Riswan, S.7
Santarsiero, B.D.8
Mesecar, A.D.9
Wild, R.10
Fairchild, C.R.11
Vite, G.D.12
Rose, W.C.13
Farnsworth, N.R.14
Cordell, G.A.15
Pezzuto, J.M.16
Swanson, S.M.17
Kinghorn, A.D.18
-
45
-
-
85018859632
-
Homoharringtonine and related compounds
-
Cragg G.M., Kingston D.G.I., and Newman D.J. (Eds), CRC/Taylor & Francis, Boca Raton, FL
-
Itokawa H., Wang X., and Lee K.-H. Homoharringtonine and related compounds. In: Cragg G.M., Kingston D.G.I., and Newman D.J. (Eds). Anticancer Agents from Natural Products (2005), CRC/Taylor & Francis, Boca Raton, FL 47-70
-
(2005)
Anticancer Agents from Natural Products
, pp. 47-70
-
-
Itokawa, H.1
Wang, X.2
Lee, K.-H.3
-
46
-
-
0035883408
-
Homoharringtonine: history, current research, and future direction
-
Kantarjian H.M., Talpaz M., Santini V., Murgo A., Cheson B., and O'Brien S.M. Homoharringtonine: history, current research, and future direction. Cancer 92 (2001) 1591-1605
-
(2001)
Cancer
, vol.92
, pp. 1591-1605
-
-
Kantarjian, H.M.1
Talpaz, M.2
Santini, V.3
Murgo, A.4
Cheson, B.5
O'Brien, S.M.6
-
48
-
-
0020422866
-
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta[b]benzofuran from Aglaia elliptifolia
-
King M.L., Chiang C.C., Ling H.C., Fukita E., Ochiai M., and McPhail A.T. X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta[b]benzofuran from Aglaia elliptifolia. J. Chem. Soc., Chem. Commun. 20 (1982) 1150-1151
-
(1982)
J. Chem. Soc., Chem. Commun.
, Issue.20
, pp. 1150-1151
-
-
King, M.L.1
Chiang, C.C.2
Ling, H.C.3
Fukita, E.4
Ochiai, M.5
McPhail, A.T.6
-
49
-
-
62149114357
-
Drug discovery from natural products
-
Lemke R., and Williams D.A. (Eds), Walters Kluwer/Lippincott-Williams & Wilkins, Baltimore
-
Kinghorn A.D. Drug discovery from natural products. In: Lemke R., and Williams D.A. (Eds). Foye's Principles of Medicinal Chemistry. 6th ed. (2008), Walters Kluwer/Lippincott-Williams & Wilkins, Baltimore 12-25
-
(2008)
Foye's Principles of Medicinal Chemistry. 6th ed.
, pp. 12-25
-
-
Kinghorn, A.D.1
-
50
-
-
0001596447
-
Novel strategies for the discovery of plant-derived anticancer agents
-
Kinghorn A.D., Farnsworth N.R., Soejarto D.D., Cordell G.A., Pezzuto J.M., Udeani G.O., Wani M.C., Wall M.E., Navarro H.A., Kramer R.A., Menendez A.T., Fairchild C.R., Lane K.E., Forenza S., Vyas D.M., Lam K.S., and Shu Y.-Z. Novel strategies for the discovery of plant-derived anticancer agents. Pure Appl. Chem. 71 (1999) 611-1618
-
(1999)
Pure Appl. Chem.
, vol.71
, pp. 611-1618
-
-
Kinghorn, A.D.1
Farnsworth, N.R.2
Soejarto, D.D.3
Cordell, G.A.4
Pezzuto, J.M.5
Udeani, G.O.6
Wani, M.C.7
Wall, M.E.8
Navarro, H.A.9
Kramer, R.A.10
Menendez, A.T.11
Fairchild, C.R.12
Lane, K.E.13
Forenza, S.14
Vyas, D.M.15
Lam, K.S.16
Shu, Y.-Z.17
-
51
-
-
9444260948
-
Novel strategies for the discovery of plant-derived anticancer agents
-
Kinghorn A.D., Farnsworth N.R., Soejarto D.D., Cordell G.A., Swanson S.M., Pezzuto J.M., Wani M.C., Wall M.E., Oberlies N.H., Kroll D.J., Kramer R.A., Rose W.C., Vite G.D., Fairchild C.R., Peterson R.W., and Wild R. Novel strategies for the discovery of plant-derived anticancer agents. Pharm. Biol. 41 Suppl. (2003) 53-67
-
(2003)
Pharm. Biol.
, vol.41
, Issue.SUPPL
, pp. 53-67
-
-
Kinghorn, A.D.1
Farnsworth, N.R.2
Soejarto, D.D.3
Cordell, G.A.4
Swanson, S.M.5
Pezzuto, J.M.6
Wani, M.C.7
Wall, M.E.8
Oberlies, N.H.9
Kroll, D.J.10
Kramer, R.A.11
Rose, W.C.12
Vite, G.D.13
Fairchild, C.R.14
Peterson, R.W.15
Wild, R.16
-
52
-
-
67650218872
-
Discovery of anticancer agents of diverse natural origin
-
Kinghorn A.D., Carcache-Blanco E.J., Chai H.-B., Orjala J., Farnsworth N.R., Soejarto D.D., Oberlies N.H., Wani M.C., Kroll D.J., Pearce C.J., Swanson S.M., Kramer R.A., Rose W.C., Fairchild C.R., Emanuel S., Vite G.D., Jarjoura D., and Cope F.O. Discovery of anticancer agents of diverse natural origin. Pure Appl. Chem. 81 (2009) 1051-1063
-
(2009)
Pure Appl. Chem.
, vol.81
, pp. 1051-1063
-
-
Kinghorn, A.D.1
Carcache-Blanco, E.J.2
Chai, H.-B.3
Orjala, J.4
Farnsworth, N.R.5
Soejarto, D.D.6
Oberlies, N.H.7
Wani, M.C.8
Kroll, D.J.9
Pearce, C.J.10
Swanson, S.M.11
Kramer, R.A.12
Rose, W.C.13
Fairchild, C.R.14
Emanuel, S.15
Vite, G.D.16
Jarjoura, D.17
Cope, F.O.18
-
53
-
-
0036023433
-
Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells
-
Kiviharju T.M., Lecane P.S., Sellers R.G., and Peehl D.M. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin. Cancer Res. 8 (2002) 2666-2674
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2666-2674
-
-
Kiviharju, T.M.1
Lecane, P.S.2
Sellers, R.G.3
Peehl, D.M.4
-
54
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn F.E., and Carter G.T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 4 (2005) 206-220
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
55
-
-
33646734515
-
Ginsenoside 20(S)-protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells
-
Li G., Wang Z.H., Sun Y.X., Liu K., and Wang Z. Ginsenoside 20(S)-protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells. Basic Clin. Pharmacol. Toxicol. 98 (2006) 588-592
-
(2006)
Basic Clin. Pharmacol. Toxicol.
, vol.98
, pp. 588-592
-
-
Li, G.1
Wang, Z.H.2
Sun, Y.X.3
Liu, K.4
Wang, Z.5
-
56
-
-
67650436176
-
Drug discovery and natural products: end of an era or an endless frontier?
-
Li J.H.-W., and Vederas J.G. Drug discovery and natural products: end of an era or an endless frontier?. Science 325 (2009) 161-165
-
(2009)
Science
, vol.325
, pp. 161-165
-
-
Li, J.H.-W.1
Vederas, J.G.2
-
57
-
-
33947394746
-
20S-Protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways
-
Liu G.Y., Bu X., Yan H., and Jia W.W.G. 20S-Protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J. Nat. Prod. 70 (2007) 259-265
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 259-265
-
-
Liu, G.Y.1
Bu, X.2
Yan, H.3
Jia, W.W.G.4
-
58
-
-
62149149441
-
The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo
-
Lucas D.M., Edwards R.B., Lozanski G., West D.A., Shin J.D., Vargo M.A., Davis M.E., Rozewski D.M., Johnson A.J., Su B.N., Goettl V.M., Heerema N.A., Lin T.S., Lehman A., Zhang X.L., Jarjoura D., Newman D.J., Byrd J.C., Kinghorn A.D., and Grever M.R. The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo. Blood 113 (2009) 4656-4666
-
(2009)
Blood
, vol.113
, pp. 4656-4666
-
-
Lucas, D.M.1
Edwards, R.B.2
Lozanski, G.3
West, D.A.4
Shin, J.D.5
Vargo, M.A.6
Davis, M.E.7
Rozewski, D.M.8
Johnson, A.J.9
Su, B.N.10
Goettl, V.M.11
Heerema, N.A.12
Lin, T.S.13
Lehman, A.14
Zhang, X.L.15
Jarjoura, D.16
Newman, D.J.17
Byrd, J.C.18
Kinghorn, A.D.19
Grever, M.R.20
more..
-
59
-
-
5444238462
-
Homoharringtonine: a new treatment option for myeloid leukemia
-
Luo C.Y., Tang J.Y., and Wang Y.P. Homoharringtonine: a new treatment option for myeloid leukemia. Hematology 9 (2004) 259-270
-
(2004)
Hematology
, vol.9
, pp. 259-270
-
-
Luo, C.Y.1
Tang, J.Y.2
Wang, Y.P.3
-
60
-
-
55049088474
-
Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
-
Meng H., Yang C., Jin J., Zhou Y., and Qian W. Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Leuk. Lymph. 49 (2008) 1954-1962
-
(2008)
Leuk. Lymph.
, vol.49
, pp. 1954-1962
-
-
Meng, H.1
Yang, C.2
Jin, J.3
Zhou, Y.4
Qian, W.5
-
61
-
-
34547818377
-
Therapeutic Compounds and Methods
-
U.S. Patent 6710075
-
Meurer-Grimes, B.M., Yu, J., Vairo, G.L., 2004. Therapeutic Compounds and Methods. U.S. Patent 6710075.
-
(2004)
-
-
Meurer-Grimes, B.M.1
Yu, J.2
Vairo, G.L.3
-
62
-
-
65249104523
-
Use of the in vivo hollow fiber assay in natural products drug discovery
-
Mi Q., Pezzuto J.M., Farnsworth N.R., Wani M.C., Kinghorn A.D., and Swanson S.M. Use of the in vivo hollow fiber assay in natural products drug discovery. J. Nat. Prod. 72 (2009) 573-580
-
(2009)
J. Nat. Prod.
, vol.72
, pp. 573-580
-
-
Mi, Q.1
Pezzuto, J.M.2
Farnsworth, N.R.3
Wani, M.C.4
Kinghorn, A.D.5
Swanson, S.M.6
-
63
-
-
0038206850
-
Cytotoxicity, apoptosis induction and downregulation of MDR-1 expression by the anti-topoisomerase II agent, salvicine, in multidrug-resistant tumor cells
-
Miao Z.H., Tang T., Zhang Y.X., Zhang J.S., and Ding J. Cytotoxicity, apoptosis induction and downregulation of MDR-1 expression by the anti-topoisomerase II agent, salvicine, in multidrug-resistant tumor cells. Int. J. Cancer 106 (2003) 108-115
-
(2003)
Int. J. Cancer
, vol.106
, pp. 108-115
-
-
Miao, Z.H.1
Tang, T.2
Zhang, Y.X.3
Zhang, J.S.4
Ding, J.5
-
64
-
-
33745146190
-
Phenoxodiol, a novel approach for the treatment of ovarian cancer
-
Mor G., Fu H.H., and Alvero A.B. Phenoxodiol, a novel approach for the treatment of ovarian cancer. Curr. Opin. Investig. Drugs 7 (2006) 542-548
-
(2006)
Curr. Opin. Investig. Drugs
, vol.7
, pp. 542-548
-
-
Mor, G.1
Fu, H.H.2
Alvero, A.B.3
-
65
-
-
33646071153
-
Developments and future trends in anticancer natural products drug discovery
-
Cragg G.M., Kingston D.G.I., and Newman D.J. (Eds), CRC Taylor & Francis, Boca Raton, FL
-
Newman D.J., and Cragg G.M. Developments and future trends in anticancer natural products drug discovery. In: Cragg G.M., Kingston D.G.I., and Newman D.J. (Eds). Anticancer Agents from Natural Products (2005), CRC Taylor & Francis, Boca Raton, FL 553-571
-
(2005)
Anticancer Agents from Natural Products
, pp. 553-571
-
-
Newman, D.J.1
Cragg, G.M.2
-
66
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman D.J., and Cragg G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod. 70 (2007) 461-477
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
67
-
-
0345439156
-
Vinca alkaloids. XI. Structures of leurocristine and vincaleukoblastine
-
Neuss N., Gorman M., Boaz H.W., and Cone N.J. Vinca alkaloids. XI. Structures of leurocristine and vincaleukoblastine. J. Am. Chem. Soc. 84 (1962) 1509-1510
-
(1962)
J. Am. Chem. Soc.
, vol.84
, pp. 1509-1510
-
-
Neuss, N.1
Gorman, M.2
Boaz, H.W.3
Cone, N.J.4
-
68
-
-
49749194803
-
Further biological activities of vincaleukoblastine-an alkaloid isolated from Vinca rosea (L.)
-
Noble R.H., Cutts J.H., and Beer C.H. Further biological activities of vincaleukoblastine-an alkaloid isolated from Vinca rosea (L.). Biochem. Pharmacol. 1 (1958) 347-348
-
(1958)
Biochem. Pharmacol.
, vol.1
, pp. 347-348
-
-
Noble, R.H.1
Cutts, J.H.2
Beer, C.H.3
-
69
-
-
77649233128
-
-
PanaGin Pharmaceuticals Inc, available at:, accessed October 2009
-
PanaGin Pharmaceuticals Inc., 2009. Further information available at: http://www.panagin.com (accessed October 2009).
-
(2009)
Further information
-
-
-
70
-
-
34548028294
-
Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells
-
Peffley D.M., Sharma C., Hentosh P., and Buechler R.D. Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. Arch. Biochem. Biophys. 465 (2007) 266-273
-
(2007)
Arch. Biochem. Biophys.
, vol.465
, pp. 266-273
-
-
Peffley, D.M.1
Sharma, C.2
Hentosh, P.3
Buechler, R.D.4
-
71
-
-
0019988507
-
Isolation and structure of combretastatin
-
Pettit G.R., Cragg G.M., Herald D.L., Schmidt J.M., and Lohavanijaya P. Isolation and structure of combretastatin. Can. J. Chem. 60 (1982) 1374-1376
-
(1982)
Can. J. Chem.
, vol.60
, pp. 1374-1376
-
-
Pettit, G.R.1
Cragg, G.M.2
Herald, D.L.3
Schmidt, J.M.4
Lohavanijaya, P.5
-
72
-
-
0023065565
-
Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of tubulin assembly, derived from Combretum caffrum
-
Pettit G.R., Singh S.B., Niven M.L., Hamel E., and Schmidt J.M. Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of tubulin assembly, derived from Combretum caffrum. J. Nat. Prod. 50 (1987) 119-131
-
(1987)
J. Nat. Prod.
, vol.50
, pp. 119-131
-
-
Pettit, G.R.1
Singh, S.B.2
Niven, M.L.3
Hamel, E.4
Schmidt, J.M.5
-
73
-
-
85008389252
-
The discovery and development of the combretastatins
-
Cragg G.M., Kingston D.G.I., and Newman D.J. (Eds), CRC Taylor & Francis, Boca Raton, FL
-
Pinney K.G., Jelinek C., Edvardsen K., Chaplin D.J., and Pettit G.R. The discovery and development of the combretastatins. In: Cragg G.M., Kingston D.G.I., and Newman D.J. (Eds). Anticancer Agents from Natural Products (2005), CRC Taylor & Francis, Boca Raton, FL 23-46
-
(2005)
Anticancer Agents from Natural Products
, pp. 23-46
-
-
Pinney, K.G.1
Jelinek, C.2
Edvardsen, K.3
Chaplin, D.J.4
Pettit, G.R.5
-
74
-
-
0028847024
-
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
-
Pisha E., Chai H., Lee I.-S., Chagwedera T.E., Farnsworth N.R., Cordell G.A., Beecher C.W.W., Fong H.H.S., Kinghorn A.D., Brown D.M., Wani M.C., Wall M.E., Heijken T.E., Das Gupta T.K., and Pezzuto J.M. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nature (Med.) 1 (1995) 1046-1051
-
(1995)
Nature (Med.)
, vol.1
, pp. 1046-1051
-
-
Pisha, E.1
Chai, H.2
Lee, I.-S.3
Chagwedera, T.E.4
Farnsworth, N.R.5
Cordell, G.A.6
Beecher, C.W.W.7
Fong, H.H.S.8
Kinghorn, A.D.9
Brown, D.M.10
Wani, M.C.11
Wall, M.E.12
Heijken, T.E.13
Das Gupta, T.K.14
Pezzuto, J.M.15
-
75
-
-
0036403187
-
Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line
-
Popovich D.G., and Kitts D.D. Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch. Biochem. Biophys. 406 (2002) 1-8
-
(2002)
Arch. Biochem. Biophys.
, vol.406
, pp. 1-8
-
-
Popovich, D.G.1
Kitts, D.D.2
-
76
-
-
33646499702
-
Natural products in drug discovery-concepts and approaches for tracking bioactivity
-
Potterat O., and Hamburger M. Natural products in drug discovery-concepts and approaches for tracking bioactivity. Curr. Org. Chem. 10 (2006) 899-920
-
(2006)
Curr. Org. Chem.
, vol.10
, pp. 899-920
-
-
Potterat, O.1
Hamburger, M.2
-
77
-
-
0015381726
-
Antitumor alkaloids from Cephalotaxus harringtonia: structure and activity
-
Powell R.G., Weisleder D., and Smith C.R. Antitumor alkaloids from Cephalotaxus harringtonia: structure and activity. J. Pharm. Sci. 61 (1972) 1227-1230
-
(1972)
J. Pharm. Sci.
, vol.61
, pp. 1227-1230
-
-
Powell, R.G.1
Weisleder, D.2
Smith, C.R.3
-
78
-
-
30544436426
-
An endophytic fungus from Nothapodytes foetida that produces camptothecin
-
Puri S.C., Verma V., Amna T., Qazi G.N., and Spiteller M. An endophytic fungus from Nothapodytes foetida that produces camptothecin. J. Nat. Prod. 68 (2005) 1717-1719
-
(2005)
J. Nat. Prod.
, vol.68
, pp. 1717-1719
-
-
Puri, S.C.1
Verma, V.2
Amna, T.3
Qazi, G.N.4
Spiteller, M.5
-
79
-
-
33846261532
-
Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy
-
Quintas-Cardama A., Kantarjian H., Garcia-Manero G., O'Brien S., Faderl S., Estrov Z., Giles F., Murgo A., Ladie N., Verstovsek S., and Cortes J. Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy. Cancer 109 (2007) 248-255
-
(2007)
Cancer
, vol.109
, pp. 248-255
-
-
Quintas-Cardama, A.1
Kantarjian, H.2
Garcia-Manero, G.3
O'Brien, S.4
Faderl, S.5
Estrov, Z.6
Giles, F.7
Murgo, A.8
Ladie, N.9
Verstovsek, S.10
Cortes, J.11
-
80
-
-
0034098722
-
Traditional Chinese medicines as immunosuppressive agents
-
Ramgolam V., Ang S.G., Lai Y.H., Loh C.S., and Yap H.K. Traditional Chinese medicines as immunosuppressive agents. Ann. Acad. Med. Singapore 29 (2000) 11-16
-
(2000)
Ann. Acad. Med. Singapore
, vol.29
, pp. 11-16
-
-
Ramgolam, V.1
Ang, S.G.2
Lai, Y.H.3
Loh, C.S.4
Yap, H.K.5
-
81
-
-
39049161898
-
Antileukemic activity of genistein, a major isoflavone present in soy products
-
Raynal N.J.-M., Momparler L., Charbonneau M., and Momparler R.L. Antileukemic activity of genistein, a major isoflavone present in soy products. J. Nat. Prod. 71 (2008) 3-7
-
(2008)
J. Nat. Prod.
, vol.71
, pp. 3-7
-
-
Raynal, N.J.-M.1
Momparler, L.2
Charbonneau, M.3
Momparler, R.L.4
-
82
-
-
39149137869
-
Plant-derived compounds in clinical trials
-
Saklani A., and Kutty S.K. Plant-derived compounds in clinical trials. Drug Discov. Today 13 (2008) 161-171
-
(2008)
Drug Discov. Today
, vol.13
, pp. 161-171
-
-
Saklani, A.1
Kutty, S.K.2
-
83
-
-
65249142193
-
A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products
-
Sashidhara K.V., White K.N., and Crews P. A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products. J. Nat. Prod. 71 (2009) 588-603
-
(2009)
J. Nat. Prod.
, vol.71
, pp. 588-603
-
-
Sashidhara, K.V.1
White, K.N.2
Crews, P.3
-
84
-
-
67649619170
-
Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs
-
Silasi D.-A., Alvero A.B., Rutherford T.J., Brown D., and Mor G. Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs. Exp. Opin. Pharmacother. 10 (2009) 1059-1067
-
(2009)
Exp. Opin. Pharmacother.
, vol.10
, pp. 1059-1067
-
-
Silasi, D.-A.1
Alvero, A.B.2
Rutherford, T.J.3
Brown, D.4
Mor, G.5
-
85
-
-
34548227773
-
From exotic spice to modern drug?
-
Singh S. From exotic spice to modern drug?. Cell 130 (2007) 765-768
-
(2007)
Cell
, vol.130
, pp. 765-768
-
-
Singh, S.1
-
87
-
-
0020022202
-
Current status of the NCI plant and animal program
-
Suffness M., and Douros J. Current status of the NCI plant and animal program. J. Nat. Prod. 45 (1982) 1-14
-
(1982)
J. Nat. Prod.
, vol.45
, pp. 1-14
-
-
Suffness, M.1
Douros, J.2
-
88
-
-
70449286540
-
Alkaloids of Vinca rosea (Catharanthus roseus). V. Preparation and characterization of alkaloids
-
Svoboda G.H., Neuss N., and Gorman M. Alkaloids of Vinca rosea (Catharanthus roseus). V. Preparation and characterization of alkaloids. J. Am. Pharm. Soc., Sci. Ed. 48 (1959) 659-666
-
(1959)
J. Am. Pharm. Soc., Sci. Ed.
, vol.48
, pp. 659-666
-
-
Svoboda, G.H.1
Neuss, N.2
Gorman, M.3
-
89
-
-
0000826940
-
Alkaloids of Vinca rosea (Catharanthus roseus). IX. Extraction and characterization of leurosidine and leurocristine
-
Svoboda G.H. Alkaloids of Vinca rosea (Catharanthus roseus). IX. Extraction and characterization of leurosidine and leurocristine. Lloydia 24 (1961) 173-178
-
(1961)
Lloydia
, vol.24
, pp. 173-178
-
-
Svoboda, G.H.1
-
91
-
-
77649233434
-
-
The Rocky Mountain Blood and Marrow Transplant Program (RMBMTP), 2009. Initial Patients Treated in Multinational Phase 2/3 Study of Ceflatonin 09-20-2006. Further information available at: http://www.rockymountainbmt.com/news/Initial-Patients-Treated-in-Multinational-Phase-23-Study-of-Ceflatonin-4682.html (accessed October 2009).
-
The Rocky Mountain Blood and Marrow Transplant Program (RMBMTP), 2009. Initial Patients Treated in Multinational Phase 2/3 Study of Ceflatonin 09-20-2006. Further information available at: http://www.rockymountainbmt.com/news/Initial-Patients-Treated-in-Multinational-Phase-23-Study-of-Ceflatonin-4682.html (accessed October 2009).
-
-
-
-
93
-
-
2942566175
-
Natural products in the process of finding new drug candidates
-
Vuorelaa P., Leinonenb M., Saikkuc P., Tammelaa P., Rauhad J.P., Wennberge T., and Vuorela H. Natural products in the process of finding new drug candidates. Curr. Med. Chem. 11 (2004) 1375-1389
-
(2004)
Curr. Med. Chem.
, vol.11
, pp. 1375-1389
-
-
Vuorelaa, P.1
Leinonenb, M.2
Saikkuc, P.3
Tammelaa, P.4
Rauhad, J.P.5
Wennberge, T.6
Vuorela, H.7
-
94
-
-
7144248725
-
Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata
-
Wall M.E., Wani M.C., Cook C.E., Palmer K.H., McPhail A.I., and Sim G.A. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc. 88 (1966) 3888-3890
-
(1966)
J. Am. Chem. Soc.
, vol.88
, pp. 3888-3890
-
-
Wall, M.E.1
Wani, M.C.2
Cook, C.E.3
Palmer, K.H.4
McPhail, A.I.5
Sim, G.A.6
-
95
-
-
0015211527
-
Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
-
Wani M.C., Taylor H.L., Wall M.E., Coggon P., and McPhail A.T. Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc. 93 (1971) 2325-2327
-
(1971)
J. Am. Chem. Soc.
, vol.93
, pp. 2325-2327
-
-
Wani, M.C.1
Taylor, H.L.2
Wall, M.E.3
Coggon, P.4
McPhail, A.T.5
-
97
-
-
35148831822
-
Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells
-
Yeruva L., Pierre K.J., Elegbede A., Wang R.C., and Carper S.W. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer Lett. 257 (2007) 216-226
-
(2007)
Cancer Lett.
, vol.257
, pp. 216-226
-
-
Yeruva, L.1
Pierre, K.J.2
Elegbede, A.3
Wang, R.C.4
Carper, S.W.5
-
98
-
-
4544277194
-
Combretastatin A4 phosphate: background and current clinical status
-
Young S.L., and Chaplin D.J. Combretastatin A4 phosphate: background and current clinical status. Expert Opin. Investig. Drugs 13 (2004) 171-1182
-
(2004)
Expert Opin. Investig. Drugs
, vol.13
, pp. 171-1182
-
-
Young, S.L.1
Chaplin, D.J.2
-
99
-
-
0033588854
-
Synthesis and antitumor activity of novel diterpene quinone salvicine and the analogs
-
Zhang J.-S., Ding J., Tang Q.-M., Li M., Zhao M., Lu L.-J., Chen L.-J., and Yuan S.-T. Synthesis and antitumor activity of novel diterpene quinone salvicine and the analogs. Bioorg. Med. Chem. Lett. 9 (1999) 2731-2736
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 2731-2736
-
-
Zhang, J.-S.1
Ding, J.2
Tang, Q.-M.3
Li, M.4
Zhao, M.5
Lu, L.-J.6
Chen, L.-J.7
Yuan, S.-T.8
-
100
-
-
77649233128
-
-
available at:, accessed October 2009
-
Zhongyaoshijia, 2009. Further information available at: http://www.zysj.com.cn/zhongyaocai/yaocai_q/qingdai.html#399 (accessed October 2009).
-
(2009)
Further information
-
-
Zhongyaoshijia1
-
101
-
-
59349095464
-
The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo
-
Zuo M., Li Y., Wang H., Zhou J., Li H., Liu H., Liu H., Xin H., Zhang S., and Chen X. The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo. J. Chemother. 20 (2008) 728-733
-
(2008)
J. Chemother.
, vol.20
, pp. 728-733
-
-
Zuo, M.1
Li, Y.2
Wang, H.3
Zhou, J.4
Li, H.5
Liu, H.6
Liu, H.7
Xin, H.8
Zhang, S.9
Chen, X.10
|