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Volumn 18, Issue 2, 2007, Pages 127-137

An enediyne-energized single-domain antibody-containing fusion protein shows potent antitumor activity

Author keywords

Antibody; Antitumor; Enediyne energized; Fusion protein; Lidamycin

Indexed keywords

ANTIBIOTIC C 1027; ANTIBODY; COLLAGENASE; HYBRID PROTEIN; LIDAMYCIN; MITOMYCIN; MONOCLONAL ANTIBODY; VH LDP AE PROTEIN;

EID: 33845718899     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e3280112779     Document Type: Article
Times cited : (24)

References (46)
  • 1
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • Adams GP, Weiner LM. Monoclonal antibody therapy of cancer. Nat Biotechnol 2005; 23:1147-1157.
    • (2005) Nat Biotechnol , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 2
    • 0033708769 scopus 로고    scopus 로고
    • Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity
    • Nielsen UB, Adams GP, Weiner LM, Marks JD. Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity. Cancer Res 2000; 60:6434-6440.
    • (2000) Cancer Res , vol.60 , pp. 6434-6440
    • Nielsen, U.B.1    Adams, G.P.2    Weiner, L.M.3    Marks, J.D.4
  • 3
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • Holliger P, Hudson PJ. Engineered antibody fragments and the rise of single domains. Nat. Biotechnol 2005; 23:1126-1136.
    • (2005) Nat Biotechnol , vol.23 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 4
    • 0024461313 scopus 로고
    • Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
    • Ward ES, Gussow D, Griffiths AD, Jones PT, Winter G. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 1989; 341:544-546.
    • (1989) Nature , vol.341 , pp. 544-546
    • Ward, E.S.1    Gussow, D.2    Griffiths, A.D.3    Jones, P.T.4    Winter, G.5
  • 6
    • 0029043683 scopus 로고
    • Antibody VH domains as small recognition units
    • Davies J, Riechmann L. Antibody VH domains as small recognition units. Biotechnology (New York) 1995; 13:475-479.
    • (1995) Biotechnology (New York) , vol.13 , pp. 475-479
    • Davies, J.1    Riechmann, L.2
  • 7
    • 0034519298 scopus 로고    scopus 로고
    • Clinical studies of new 'biologic' approaches to therapy of acute myeloid leukemia with monoclonal antibodies and immunoconjugates
    • Sievers EL. Clinical studies of new 'biologic' approaches to therapy of acute myeloid leukemia with monoclonal antibodies and immunoconjugates. Curr Opin Oncol 2000; 12:30-35.
    • (2000) Curr Opin Oncol , vol.12 , pp. 30-35
    • Sievers, E.L.1
  • 8
    • 0023767790 scopus 로고
    • A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity
    • Hu JL, Xue YC, Xie MY, Zhang R. A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity. J Antibiot (Tokyo) 1988; 41:1575-1579.
    • (1988) J Antibiot (Tokyo) , vol.41 , pp. 1575-1579
    • Hu, J.L.1    Xue, Y.C.2    Xie, M.Y.3    Zhang, R.4
  • 9
    • 0024315075 scopus 로고
    • A new macromolecular antitumor antibiotic, C-1027 III. Antitumor activity
    • Zhen YS, Ming XY, Yu B. A new macromolecular antitumor antibiotic, C-1027 III. Antitumor activity. J Antibiot 1989; 42:1294-1298.
    • (1989) J Antibiot , vol.42 , pp. 1294-1298
    • Zhen, Y.S.1    Ming, X.Y.2    Yu, B.3
  • 10
    • 0025679319 scopus 로고
    • Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells
    • Xu YJ, Li DD, Zhen YS. Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells. Cancer Chemother Pharmacol 1990; 27:41-46.
    • (1990) Cancer Chemother Pharmacol , vol.27 , pp. 41-46
    • Xu, Y.J.1    Li, D.D.2    Zhen, Y.S.3
  • 11
    • 0031219006 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by antitumor antibiotic C1027 and its effect on tumor metastasis
    • Zhen H, Xue Y, Zhen Y. Inhibition of angiogenesis by antitumor antibiotic C1027 and its effect on tumor metastasis. Natl Med J China 1997; 77:657-660.
    • (1997) Natl Med J China , vol.77 , pp. 657-660
    • Zhen, H.1    Xue, Y.2    Zhen, Y.3
  • 12
    • 24144471782 scopus 로고    scopus 로고
    • Antitumor efficacy of lidamycin on hepatoma and active moiety of its molecule
    • Huang YH, Shang BY, Zhen YS. Antitumor efficacy of lidamycin on hepatoma and active moiety of its molecule. World J Gastroenterol 2005; 11:3980-3984.
    • (2005) World J Gastroenterol , vol.11 , pp. 3980-3984
    • Huang, Y.H.1    Shang, B.Y.2    Zhen, Y.S.3
  • 13
    • 0028240985 scopus 로고
    • C1027 chromophore, a potent new enediyne antitumor antibiotic, induces sequence-specific double-strand DNA cleavage
    • Xu YJ, Zhen YS, Goldberg IH. C1027 chromophore, a potent new enediyne antitumor antibiotic, induces sequence-specific double-strand DNA cleavage. Biochemistry 1994; 33:5947-5954.
    • (1994) Biochemistry , vol.33 , pp. 5947-5954
    • Xu, Y.J.1    Zhen, Y.S.2    Goldberg, I.H.3
  • 14
    • 0031030330 scopus 로고    scopus 로고
    • Enediyne C1027 induces the formation of novel convalent DNA interstrand cross-links and monoadducts
    • Xu Y, Zhen Y, Goldberg IH. Enediyne C1027 induces the formation of novel convalent DNA interstrand cross-links and monoadducts. J Am Chem Soc 1997; 119:1133-1134.
    • (1997) J Am Chem Soc , vol.119 , pp. 1133-1134
    • Xu, Y.1    Zhen, Y.2    Goldberg, I.H.3
  • 15
    • 0030734671 scopus 로고    scopus 로고
    • Mechanism of formation of novel covalent drug-DNA interstrand cross-links and monoadducts by enediyne antitumor antibiotics
    • Xu Y, Xi Z, Zhen Y, Goldberg IH. Mechanism of formation of novel covalent drug-DNA interstrand cross-links and monoadducts by enediyne antitumor antibiotics. Biochemistry 1997; 36:14975-14984.
    • (1997) Biochemistry , vol.36 , pp. 14975-14984
    • Xu, Y.1    Xi, Z.2    Zhen, Y.3    Goldberg, I.H.4
  • 16
    • 20444502590 scopus 로고    scopus 로고
    • The antitumor enediyne C-1027 alters cell cycle progression and induces chromosomal aberrations and telomere dysfunction
    • McHugh MM, Gawron LS, Matsui S, Beerman TA. The antitumor enediyne C-1027 alters cell cycle progression and induces chromosomal aberrations and telomere dysfunction. Cancer Res 2005; 65:5344-5351.
    • (2005) Cancer Res , vol.65 , pp. 5344-5351
    • McHugh, M.M.1    Gawron, L.S.2    Matsui, S.3    Beerman, T.A.4
  • 17
    • 0028901279 scopus 로고
    • Induction of apoptosis by enediyne antitumor antibiotic C1027 in HL-60 human promyelocytic leukemia cells
    • Jiang B, Li D, Zhen Y. Induction of apoptosis by enediyne antitumor antibiotic C1027 in HL-60 human promyelocytic leukemia cells. Biochem Biophys Res Commun 1995; 208:238-244.
    • (1995) Biochem Biophys Res Commun , vol.208 , pp. 238-244
    • Jiang, B.1    Li, D.2    Zhen, Y.3
  • 18
    • 0036480101 scopus 로고    scopus 로고
    • Characteristics of mitotic cell death induced by enediyne antibiotic lidamycin in human epithelial tumor cells
    • He QY, Liang YY, Wang DS, Li DD. Characteristics of mitotic cell death induced by enediyne antibiotic lidamycin in human epithelial tumor cells. Int J Oncol 2002; 20:261-266.
    • (2002) Int J Oncol , vol.20 , pp. 261-266
    • He, Q.Y.1    Liang, Y.Y.2    Wang, D.S.3    Li, D.D.4
  • 19
    • 0347513092 scopus 로고    scopus 로고
    • Lidamycin inhibits proliferation and induces apoptosis in endothelial cells
    • Wang X, Wu S, Zhen Y. Lidamycin inhibits proliferation and induces apoptosis in endothelial cells. Chin J Antibiot 2003; 28:605-612.
    • (2003) Chin J Antibiot , vol.28 , pp. 605-612
    • Wang, X.1    Wu, S.2    Zhen, Y.3
  • 20
    • 0036788504 scopus 로고    scopus 로고
    • New enzymes for 'warheads'
    • Sherman DH. New enzymes for 'warheads'. Nat Biotechnol 2002; 20:984-985.
    • (2002) Nat Biotechnol , vol.20 , pp. 984-985
    • Sherman, D.H.1
  • 21
    • 0347721776 scopus 로고    scopus 로고
    • Biosynthesis of the enediyne antitumor antibiotic C-1027
    • Liu W, Christenson SD, Standage S, Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027. Science 2002; 297:1170-1173.
    • (2002) Science , vol.297 , pp. 1170-1173
    • Liu, W.1    Christenson, S.D.2    Standage, S.3    Shen, B.4
  • 23
    • 0034900174 scopus 로고    scopus 로고
    • Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
    • Bross PF, Beitz J, Chen G, Chen XH, Duffy E, Kieffer L, et al. Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res 2001; 7:1490-1496.
    • (2001) Clin Cancer Res , vol.7 , pp. 1490-1496
    • Bross, P.F.1    Beitz, J.2    Chen, G.3    Chen, X.H.4    Duffy, E.5    Kieffer, L.6
  • 24
    • 31644432176 scopus 로고    scopus 로고
    • Antitumor effects of molecule-downsized imunoconjugate composed of lidamycin and Fab' fragment of monoclonal antibody directed against type IV collagenase
    • Wang F, Shang B, Zhen Y. Antitumor effects of molecule-downsized imunoconjugate composed of lidamycin and Fab' fragment of monoclonal antibody directed against type IV collagenase. Sci China C Life Sci 2004; 47:66-73.
    • (2004) Sci China C Life Sci , vol.47 , pp. 66-73
    • Wang, F.1    Shang, B.2    Zhen, Y.3
  • 25
    • 23844547996 scopus 로고    scopus 로고
    • Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma
    • Li L, Huang YH, Li Y, Wang FQ, Shang BY, Zhen YS. Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma. World J Gastroenterol 2005; 11:4478-4483.
    • (2005) World J Gastroenterol , vol.11 , pp. 4478-4483
    • Li, L.1    Huang, Y.H.2    Li, Y.3    Wang, F.Q.4    Shang, B.Y.5    Zhen, Y.S.6
  • 26
    • 0026934220 scopus 로고
    • Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene
    • Sakata N, Ikeno S, Hori M, Hamada M, Otani T. Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene. Biosci. Biotechnol Biochem 1992; 56:1592-1595.
    • (1992) Biosci Biotechnol Biochem , vol.56 , pp. 1592-1595
    • Sakata, N.1    Ikeno, S.2    Hori, M.3    Hamada, M.4    Otani, T.5
  • 27
    • 0035946947 scopus 로고    scopus 로고
    • Solution structures of C-1027 apoprotein and its complex with the aromatized chromophore
    • Tanaka T, Fukuda-Ishisaka S, Hirama M, Otani T. Solution structures of C-1027 apoprotein and its complex with the aromatized chromophore. J Mol Biol 2001; 309:267-283.
    • (2001) J Mol Biol , vol.309 , pp. 267-283
    • Tanaka, T.1    Fukuda-Ishisaka, S.2    Hirama, M.3    Otani, T.4
  • 28
    • 0029177274 scopus 로고
    • Relationship between the molecular composition of C1027, a new macromolecular antibiotic with enediyne chromophore, and its antitumor activity
    • Shao RG, Zhen YS. Relationship between the molecular composition of C1027, a new macromolecular antibiotic with enediyne chromophore, and its antitumor activity. Acta Pharm Sin 1995; 30:336-342.
    • (1995) Acta Pharm Sin , vol.30 , pp. 336-342
    • Shao, R.G.1    Zhen, Y.S.2
  • 29
    • 18144370787 scopus 로고    scopus 로고
    • Antimetastatic activity of a novel mechanism-based gelatinase inhibitor
    • Kruger A, Arlt MJ, Gerg M, Kopitz C, Bernardo MM, Chang M, et al. Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. Cancer Res 2005; 65:3523-3526.
    • (2005) Cancer Res , vol.65 , pp. 3523-3526
    • Kruger, A.1    Arlt, M.J.2    Gerg, M.3    Kopitz, C.4    Bernardo, M.M.5    Chang, M.6
  • 30
    • 0036014874 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: Do they have a place in anticancer therapy?
    • Rudek MA, Venitz J, Figg WD. Matrix metalloproteinase inhibitors: do they have a place in anticancer therapy? Pharmacotherapy 2002; 22:705-720.
    • (2002) Pharmacotherapy , vol.22 , pp. 705-720
    • Rudek, M.A.1    Venitz, J.2    Figg, W.D.3
  • 31
    • 15244348390 scopus 로고    scopus 로고
    • Gelatinases (MMP-2 and -9) and their natural inhibitors as prognostic indicators in solid cancers
    • Turpeenniemi-Hujanen T. Gelatinases (MMP-2 and -9) and their natural inhibitors as prognostic indicators in solid cancers. Biochimie 2005; 87:287-297.
    • (2005) Biochimie , vol.87 , pp. 287-297
    • Turpeenniemi-Hujanen, T.1
  • 32
    • 0032191701 scopus 로고    scopus 로고
    • Highly efficient recovery of functional single-chain Fv fragments from inclusion bodies overexpressed in Escherichia coli by controlled introduction of oxidizing reagent: Application to a human single-chain Fv fragment
    • Tsumoto K, Shinoki K, Kondo H, Uchikawa M, Juji T, Kumagai I. Highly efficient recovery of functional single-chain Fv fragments from inclusion bodies overexpressed in Escherichia coli by controlled introduction of oxidizing reagent: application to a human single-chain Fv fragment. J Immunol Methods 1998; 219:119-129.
    • (1998) J Immunol Methods , vol.219 , pp. 119-129
    • Tsumoto, K.1    Shinoki, K.2    Kondo, H.3    Uchikawa, M.4    Juji, T.5    Kumagai, I.6
  • 33
    • 0037047012 scopus 로고    scopus 로고
    • Solution structure of a llama single-domain antibody with hydrophobic residues typical of the VH/VL interface
    • Vranken W. Solution structure of a llama single-domain antibody with hydrophobic residues typical of the VH/VL interface. Biochemistry 2002; 41:8570-8579.
    • (2002) Biochemistry , vol.41 , pp. 8570-8579
    • Vranken, W.1
  • 34
    • 0026270455 scopus 로고
    • The minimal antigen-binding fragment of antibodies: Fv fragment
    • Givol D. The minimal antigen-binding fragment of antibodies: Fv fragment. Mol Immunol 1991; 28:1379-1386.
    • (1991) Mol Immunol , vol.28 , pp. 1379-1386
    • Givol, D.1
  • 36
    • 0032558362 scopus 로고    scopus 로고
    • Mutual stabilization of VL and VH in single-chain antibody fragments, investigated with mutants engineered for stability
    • Worn A, Pluckthun A. Mutual stabilization of VL and VH in single-chain antibody fragments, investigated with mutants engineered for stability. Biochemistry 1998; 37:13120-13127.
    • (1998) Biochemistry , vol.37 , pp. 13120-13127
    • Worn, A.1    Pluckthun, A.2
  • 37
    • 0029070931 scopus 로고
    • Solution properties of Escherichia coli-expressed VH domain of antineuraminidase antibody NC41
    • Kortt AA, Guthrie RE, Hinds MG, Power BE, Ivancic N, Caldwell JB, et al. Solution properties of Escherichia coli-expressed VH domain of antineuraminidase antibody NC41. J Protein Chem 1995; 14:167-178.
    • (1995) J Protein Chem , vol.14 , pp. 167-178
    • Kortt, A.A.1    Guthrie, R.E.2    Hinds, M.G.3    Power, B.E.4    Ivancic, N.5    Caldwell, J.B.6
  • 38
    • 0026514561 scopus 로고
    • High-level temperature-induced synthesis of an antibody VH-domain in Escherichia coli using the PelB secretion signal
    • Power BE, Ivancic N, Harley VR, Webster RG, Kortt AA, Irving RA, et al. High-level temperature-induced synthesis of an antibody VH-domain in Escherichia coli using the PelB secretion signal. Gene1992; 113:95-99.
    • (1992) Gene , vol.113 , pp. 95-99
    • Power, B.E.1    Ivancic, N.2    Harley, V.R.3    Webster, R.G.4    Kortt, A.A.5    Irving, R.A.6
  • 39
    • 0025699942 scopus 로고
    • Antibodies from E. coli
    • Plückthun A. Antibodies from E. coli. Nature 1990; 347:497-498.
    • (1990) Nature , vol.347 , pp. 497-498
    • Plückthun, A.1
  • 41
    • 0027173034 scopus 로고
    • Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin
    • Brinkmann U, Lee BK, Pastan I. Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin. J Immunol 1993; 150:2774-2782.
    • (1993) J Immunol , vol.150 , pp. 2774-2782
    • Brinkmann, U.1    Lee, B.K.2    Pastan, I.3
  • 43
    • 0042674300 scopus 로고    scopus 로고
    • Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin
    • Rosenblum MG, Cheung HL, Liu Y, Marks JW. Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin. Cancer Res 2003; 63:3995-4002.
    • (2003) Cancer Res , vol.63 , pp. 3995-4002
    • Rosenblum, M.G.1    Cheung, H.L.2    Liu, Y.3    Marks, J.W.4
  • 44
    • 0024349836 scopus 로고
    • A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin
    • Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I. A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature 1989; 339:394-397.
    • (1989) Nature , vol.339 , pp. 394-397
    • Chaudhary, V.K.1    Queen, C.2    Junghans, R.P.3    Waldmann, T.A.4    FitzGerald, D.J.5    Pastan, I.6
  • 45
    • 0032531080 scopus 로고    scopus 로고
    • Treatment of B-cell lymphoma with chimeric IgG and single-chain Fv antibody-interleukin-2 fusion proteins
    • Liu SJ, Sher YP, Ting CC, Liao KW, Yu CP, Tao MH. Treatment of B-cell lymphoma with chimeric IgG and single-chain Fv antibody-interleukin-2 fusion proteins. Blood 1998; 92:2103-2112.
    • (1998) Blood , vol.92 , pp. 2103-2112
    • Liu, S.J.1    Sher, Y.P.2    Ting, C.C.3    Liao, K.W.4    Yu, C.P.5    Tao, M.H.6
  • 46
    • 0036194917 scopus 로고    scopus 로고
    • Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature
    • Halin C, Rondini S, Nilsson F, Berndt A, Kosmehl H, Zardi L, et al. Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nat Biotechnol 2002; 20:264-269.
    • (2002) Nat Biotechnol , vol.20 , pp. 264-269
    • Halin, C.1    Rondini, S.2    Nilsson, F.3    Berndt, A.4    Kosmehl, H.5    Zardi, L.6


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