TZT-1027, an antimicrotubule agent, attacks tumor vasculature and induces tumor cell death

Japanese Journal of Cancer Research

Volumn 91, Issue 8, 2000, Pages 837-844

  Otani, Masashi ^a   Natsume, Tsugitaka ^a   Watanabe, Jun Ichi ^a   Kobayashi, Motohiro ^a   Murakoshi, Masanori ^a   Mikami, Takashi ^a   Nakayama, Takaharu ^a  

^a Grelan Pharmaceutical Co Ltd   (Japan)

Author keywords

Advanced tumor; Antimicrotubule agent; Tumor cell death; Tumoral vascular collapse; TZT 1027

Indexed keywords

AURISTATIN PE; DOLASTATIN 10; DYE; HEMOGLOBIN; K 252A; PROTEIN KINASE INHIBITOR; VINCRISTINE;

ADVANCED CANCER; ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLEEDING; BLOOD VESSEL INJURY; CANCER THERAPY; CELL CULTURE; CELL DEATH; CELL MEMBRANE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG STRUCTURE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR BLOOD FLOW; TUMOR CELL; TUMOR MODEL; TUMOR NECROSIS; TUMOR REGRESSION; TUMOR VASCULARIZATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; ENDOTHELIUM, VASCULAR; FEMALE; HEMOGLOBINS; HUMANS; MICE; MICE, INBRED BALB C; MICROTUBULES; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; OLIGOPEPTIDES; PERMEABILITY; TUMOR CELLS, CULTURED;

EID: 0033857963     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb01022.x     Document Type: Article

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