Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4165-4172

  Pirie, Christopher M ^a   Hackel, Benjamin J ^a   Rosenblum, Michael G ^c   Wittrup, K Dane ^a,b  

^a USA   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN EXPRESSION; CARCINOEMBRYONIC ANTIGEN; CELL LINES; CYTOTOXIC; EQUIVALENT CONCENTRATIONS; EXPERIMENTAL CONDITIONS; EXPOSURE-TIME; EXTRACELLULAR; FIBRONECTIN DOMAINS; HT-1080; IMMUNOTOXINS; RATE-LIMITING STEPS; RECEPTOR-MEDIATED ENDOCYTOSIS; SINGLE-CHAIN ANTIBODIES; TARGET CELLS; TUMOR ANTIGEN; VARIABLE FRAGMENT;

ANTIGENS; CELL CULTURE; FLOW CYTOMETRY; MOLECULAR BIOLOGY;

CYTOTOXICITY;

CARCINOEMBRYONIC ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; GELONIN; FIBRONECTIN; GEL PROTEIN, GELONIUM MULTIFLORUM; HYBRID PROTEIN; IMMUNOTOXIN; RIBOSOME INACTIVATING PROTEIN 1; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CANCER THERAPY; CELL MIGRATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; INTERNALIZATION; KINETICS; PINOCYTOSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; DRUG SCREENING; GENETICS; IMMUNOLOGY; METHODOLOGY; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FIBRONECTINS; HUMANS; IMMUNOTOXINS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; RIBOSOME INACTIVATING PROTEINS, TYPE 1; SINGLE-CHAIN ANTIBODIES;

EID: 79953012996     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.186973     Document Type: Article

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